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Polypharmacy in older adults: a narrative review of definitions, epidemiology and consequences. Eur. Geriatr. Med.<\/i>, 12<\/b>, 443\u2013452 (2021).","DOI":"10.1007\/s41999-021-00479-3"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2) Nwadiugwu MC. Frailty and the risk of polypharmacy in the older person: enabling and preventative approaches. J. Aging Res.<\/i>, 2020<\/b>, 6759521 (2020).","DOI":"10.1155\/2020\/6759521"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3) Katsimpris A, Linseisen J, Meisinger C, Volaklis K. The association between polypharmacy and physical function in older adults: a systematic review. J. Gen. Intern. Med.<\/i>, 34<\/b>, 1865\u20131873 (2019).","DOI":"10.1007\/s11606-019-05106-3"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4) Masnoon N, Shakib S, Kalisch-Ellett L, Caughey GE. What is polypharmacy? A systematic review of definitions. BMC Geriatr.<\/i>, 17<\/b>, 230 (2017).","DOI":"10.1186\/s12877-017-0621-2"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5) Juola AL, Juola AL, Pylkkanen S, Kautiainen H, Bell JS, Bjorkman MP, Soveri HF, Soini H, Pitk\u00e4l\u00e4 KH. Burden of potentially harmful medications and the association with quality of life and mortality among institutionalized older people. J. Am. Med. Dir. Assoc.<\/i>, 17<\/b>, 276.e9\u2013276.e14 (2016).","DOI":"10.1016\/j.jamda.2015.12.011"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6) Cruz-Jentoft AJ, Sayer AA. Sarcopenia. Lancet<\/i>, 393<\/b>, 2636\u20132646 (2019).","DOI":"10.1016\/S0140-6736(19)31138-9"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7) Yeung SSY, Reijnierse EM, Pham VK, Trappenburg MC, Lim WK, Meskers CGM, Maier AB. Sarcopenia and its association with falls and fractures in older adults: A systematic review and meta-analysis. J. Cachexia Sarcopenia Muscle<\/i>, 10<\/b>, 485\u2013500 (2019).","DOI":"10.1002\/jcsm.12411"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8) Beaudart C, Zaaria M, Pasleau F, Reginster J-Y, Bruy\u00e8re O. Health outcomes of sarcopenia: a systematic review and meta-analysis. PLOS ONE<\/i>, 12<\/b>, e0169548 (2017).","DOI":"10.1371\/journal.pone.0169548"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9) Dent E, Morley JE, Cruz-Jentoft AJ, et al<\/i>. International clinical practice guidelines for sarcopenia (ICFSR): screening, diagnosis and management. J. Nutr. Health Aging<\/i>, 22<\/b>, 1148\u20131161 (2018).","DOI":"10.1007\/s12603-018-1139-9"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10) Yoshimura Y, Bise T, Shimazu S, Tanoue M, Tomioka Y, Araki M, Nishino T, Kuzuhara A, Takatsuki F. Effects of a leucine-enriched amino acid supplement on muscle mass, muscle strength, and physical function in post-stroke patients with sarcopenia: A randomized controlled trial. Nutrition<\/i>, 58<\/b>, 1\u20136 (2019).","DOI":"10.1016\/j.nut.2018.05.028"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11) Takeuchi I, Yoshimura Y, Shimazu S, Jeong S, Yamaga M, Koga H. Effects of branched-chain amino acids and vitamin D supplementation on physical function, muscle mass and strength, and nutritional status in sarcopenic older adults undergoing hospital-based rehabilitation: A multicenter randomized controlled trial. Geriatr. Gerontol. Int.<\/i>, 19<\/b>, 12\u201317 (2019).","DOI":"10.1111\/ggi.13547"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12) Arai H, Wakabayashi H, Yoshimura Y, Yamada M, Kim H, Harada A. Chapter 4 Treatment of Sarcopenia. Geriatr. Gerontol. Int.<\/i>, 18<\/b> (Suppl. 1), 28\u201344 (2018).","DOI":"10.1111\/ggi.13322"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13) Wakabayashi H, Sakuma K. Rehabilitation nutrition for sarcopenia with disability: a combination of both rehabilitation and nutrition care management. J. Cachexia Sarcopenia Muscle<\/i>, 5<\/b>, 269\u2013277 (2014).","DOI":"10.1007\/s13539-014-0162-x"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14) Prokopidis K, Giannos P, Reginster JY, et al<\/i>. Sarcopenia is associated with a greater risk of polypharmacy and number of medications: a systematic review and meta-analysis. J. Cachexia Sarcopenia Muscle<\/i>, 14<\/b>, 671\u2013683 (2023).","DOI":"10.1002\/jcsm.13190"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15) Tanaka T, Akishita M, Kojima T, Son BK, Iijima K. Polypharmacy with potentially inappropriate medications as a risk factor of new onset sarcopenia among community-dwelling Japanese older adults: a 9-year Kashiwa cohort study. BMC Geriatr.<\/i>, 23<\/b>, 390 (2023).","DOI":"10.1186\/s12877-023-04012-y"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16) Matsumoto A, Yoshimura Y, Nagano F, Bise T, Kido Y, Shimazu S, Shiraishi A. Polypharmacy and its association with dysphagia and malnutrition among stroke patients with sarcopenia. Nutrients<\/i>, 14<\/b>, 4251 (2022).","DOI":"10.3390\/nu14204251"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17) Matsumoto A, Yoshimura Y, Wakabayashi H, Kose E, Nagano F, Bise T, Kido Y, Shimazu S, Shiraishi A. Deprescribing leads to improved energy intake among hospitalized older sarcopenic adults with polypharmacy after stroke. Nutrients<\/i>, 14<\/b>, 443 (2022).","DOI":"10.3390\/nu14030443"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18) Kose E, Matsumoto A, Yoshimura Y. Association between deprescribing from polypharmacy and functional recovery and home discharge among older patients with sarcopenia after stroke. Nutrition<\/i>, 111<\/b>, 112040 (2023).","DOI":"10.1016\/j.nut.2023.112040"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19) Kose E, Matsumoto A, Yoshimura Y. Deprescribing psychotropic medications is associated with improvements in activities of daily living in post-stroke patients. Geriatr. Gerontol. Int.<\/i>, 24<\/b>, 275\u2013282 (2024).","DOI":"10.1111\/ggi.14811"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20) Kose E, Hirai T, Seki T, Yasuno N. The impact of decreasing potentially inappropriate medications on activities of daily living in a convalescent rehabilitation setting. Int. J. Clin. Pharm.<\/i>, 43<\/b>, 577\u2013585 (2021).","DOI":"10.1007\/s11096-020-01165-3"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21) Nakahara S, Takasaki M, Abe S, Kakitani C, Nishioka S, Wakabayashi H, Maeda K. Aggressive nutrition therapy in malnutrition and sarcopenia. Nutrition<\/i>, 84<\/b>, 111109 (2021).","DOI":"10.1016\/j.nut.2020.111109"},{"key":"22","doi-asserted-by":"crossref","unstructured":"22) Charlson ME, Pompei P, Ales KL, MacKenzie CR. A new method of classifying prognostic comorbidity in longitudinal studies: development and validation. J. Chronic Dis.<\/i>, 40<\/b>, 373\u2013383 (1987).","DOI":"10.1016\/0021-9681(87)90171-8"},{"key":"23","doi-asserted-by":"crossref","unstructured":"23) Banks JL, Marotta CA. Outcomes validity and reliability of the modified Rankin scale: implications for stroke clinical trials: a literature review and synthesis. 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Assoc.<\/i>, 21<\/b>, 300\u2013307.e2 (2020).","DOI":"10.1016\/j.jamda.2019.12.012"},{"key":"27","doi-asserted-by":"crossref","unstructured":"27) Yoshimura Y, Matsumoto A, Momosaki R. Pharmacotherapy and the role of pharmacists in rehabilitation medicine. Prog. Rehabil. Med.<\/i>, 14<\/b>, 20220025 (2022).","DOI":"10.2490\/prm.20220025"},{"key":"28","doi-asserted-by":"crossref","unstructured":"28) Matsumoto A, Yoshimura Y, Shimazu S, Nagano F, Bise T, Kido Y, Shiraishi A, Sunahara T. Association of polypharmacy at hospital discharge with nutritional intake, muscle strength, and activities of daily living among older patients undergoing convalescent rehabilitation after stroke. Jpn. J. Compr. Rehabil. Sci.<\/i>, 13<\/b>, 41\u201348 (2022).","DOI":"10.11336\/jjcrs.13.41"},{"key":"29","doi-asserted-by":"crossref","unstructured":"29) Kose E, Hirai T, Seki T, Yasuno N. Anticholinergic load and nutritional status in older individuals. J. Nutr. 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Repurposing drugs for diabetes mellitus as potential pharmacological treatments for sarcopenia\u2014a narrative review. Drugs Aging<\/i>, 40<\/b>, 703\u2013719 (2023).","DOI":"10.1007\/s40266-023-01042-4"},{"key":"39","doi-asserted-by":"crossref","unstructured":"39) Massimino E, Izzo A, Riccardi G, Della Pepa G. The impact of glucose lowering drugs on sarcopenia in type 2 diabetes: current evidence and underlying mechanisms. Cells<\/i>, 10<\/b>, 1958 (2021).","DOI":"10.3390\/cells10081958"},{"key":"40","doi-asserted-by":"crossref","unstructured":"40) Zhang S, Qi Z, Wang Y, Song D, Zhu D. Effect of sodium-glucose transporter 2 inhibitors on sarcopenia in patients with type 2 diabetes mellitus: a systematic review and meta-analysis. Front. Endocrinol.<\/i>, 14<\/b>, 1203666 (2023).","DOI":"10.3389\/fendo.2023.1203666"},{"key":"41","doi-asserted-by":"crossref","unstructured":"41) Xia C, Han Y, Yin C, Geng R, Liu Z, Du Y, Yu M. Relationship between sodium-glucose cotransporter-2 inhibitors and muscle atrophy in patients with type 2 diabetes mellitus: a systematic review and meta-analysis. Front. Endocrinol.<\/i>, 14<\/b>, 1220516 (2023).","DOI":"10.3389\/fendo.2023.1220516"},{"key":"42","doi-asserted-by":"crossref","unstructured":"42) Mele A, Calzolaro S, Cannone G, Cetrone M, Conte D, Tricarico D. Database search of spontaneous reports and pharmacological investigations on the sulfonylureas and glinides-induced atrophy in skeletal muscle. Pharmacol. Res. Perspect.<\/i>, 2<\/b>, e00028 (2014).","DOI":"10.1002\/prp2.28"},{"key":"43","doi-asserted-by":"crossref","unstructured":"43) Wakabayashi H. Rehabilitation pharmacotherapy: A combination of rehabilitation and pharmacotherapy. J. Gen. Fam. Med.<\/i>, 19<\/b>, 43\u201344 (2018).","DOI":"10.1002\/jgf2.163"},{"key":"44","doi-asserted-by":"crossref","unstructured":"44) Kose E, Wakabayashi H. Rehabilitation pharmacotherapy: A scoping review. Geriatr. Gerontol. Int.<\/i>, 20<\/b>, 655\u2013663 (2020).","DOI":"10.1111\/ggi.13975"},{"key":"45","doi-asserted-by":"crossref","unstructured":"45) Kuzuya M. Drug-related sarcopenia as a secondary sarcopenia. Geriatr. Gerontol. Int.<\/i>, 24<\/b>, 195\u2013203 (2024).","DOI":"10.1111\/ggi.14770"},{"key":"46","doi-asserted-by":"crossref","unstructured":"46) Scott IA, Hilmer SN, Reeve E, Potter K, Le Couteur D, Rigby D, Gnjidic D, Del Mar CB, Roughead EE, Page A, Jansen J, Martin JH. Reducing inappropriate polypharmacy: the process of deprescribing. JAMA Intern. 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