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Pharmacol.<\/i>, 69<\/b>, 195\u2013206 (2006).","DOI":"10.1124\/mol.105.017400"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6) Gong C, Deng S, Wu Q, Xiang M, Wei X, Li L, Gao X, Wang B, Sun L, Chen Y, Li Y, Liu L, Qian Z, Wei Y. Improving antiangiogenesis and anti-tumor activity of curcumin by biodegradable polymeric micelles. Biomaterials<\/i>, 34<\/b>, 1413\u20131432 (2013).","DOI":"10.1016\/j.biomaterials.2012.10.068"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7) Wilken R, Veena MS, Wang MB, Srivatsan ES. Curcumin: a review of anti-cancer properties and therapeutic activity in head and neck squamous cell carcinoma. Mol. Cancer<\/i>, 10<\/b>, 12 (2011).","DOI":"10.1186\/1476-4598-10-12"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8) Liu Z, Ying Y. The inhibitory effect of curcumin on virus-induced cytokine storm and its potential use in the associated severe pneumonia. Vol. Front. Cell Dev. 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Dietary curcumin: correlation between bioavailability and health potential. Nutrients<\/i>, 11<\/b>, 2147 (2019).","DOI":"10.3390\/nu11092147"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13) Kohyama A, Yamakoshi H, Hongo S, Kanoh N, Shibata H, Iwabuchi Y. Structure-activity relationships of the antitumor C5-Curcuminoid GO-Y030. Molecules<\/i>, 20<\/b>, 15374\u201315391 (2015).","DOI":"10.3390\/molecules200815374"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14) Adeluola A, Zulfiker AHM, Brazeau D, Amin ARMR. Perspectives for synthetic curcumins in chemoprevention and treatment of cancer: an update with promising analogues. Eur J Pharmacol.<\/i>, 906<\/b>, 174266 (2021).","DOI":"10.1016\/j.ejphar.2021.174266"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15) Maruyama T, Yamakoshi H, Iwabuchi Y, Shibata H. Mono-carbonyl curcumin analogs for cancer therapy. Biol. Pharm. 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