{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,30]],"date-time":"2026-05-30T04:04:43Z","timestamp":1780113883694,"version":"3.54.0"},"reference-count":35,"publisher":"Pharmaceutical Society of Japan","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biological & Pharmaceutical Bulletin","Biol. Pharm. Bull."],"published-print":{"date-parts":[[2026,5,29]]},"DOI":"10.1248\/bpb.b25-00792","type":"journal-article","created":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T22:10:10Z","timestamp":1780006210000},"page":"888-895","source":"Crossref","is-referenced-by-count":0,"title":["Fluvoxamine Exerts Anti-influenza A Virus Effects through Inhibiting Apoptosis Pathway"],"prefix":"10.1248","volume":"49","author":[{"given":"Zhaoyan","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Pharmacy, Hebei North University, Zhangjiakou 075000, China"},{"name":"Hebei Key Laboratory of Neuropharmacology, Zhangjiakou 075000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huan","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Hebei North University, Zhangjiakou 075000, China"},{"name":"Hebei Key Laboratory of Neuropharmacology, Zhangjiakou 075000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Ren","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Air Force Medical Center, PLA, Air Force Medical University, Beijing 100142, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenqiao","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Air Force Medical Center, PLA, Air Force Medical University, Beijing 100142, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"163","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"1) Javaid W, Ehni J, Gonzalez-Reiche AS, et al<\/i>. Real-time investigation of a large nosocomial influenza A outbreak informed by genomic epidemiology. Clin. Infect. Dis.<\/i>, 73<\/b>, e4375\u2013e4383 (2021).","DOI":"10.1093\/cid\/ciaa1781"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2) Uyeki TM, Hui DS, Zambon M, Wentworth DE, Monto AS. Influenza. Lancet<\/i>, 400<\/b>, 693\u2013706 (2022).","DOI":"10.1016\/S0140-6736(22)00982-5"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3) Krammer F, Smith GJD, Fouchier RAM, Peiris M, Kedzierska K, Doherty PC, Palese P, Shaw ML, Treanor J, Webster RG, Garc\u00eda-Sastre A. Influenza. Nat. Rev. Dis. Primers<\/i>, 4<\/b>, 3 (2018).","DOI":"10.1038\/s41572-018-0002-y"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4) Yin BF, Li ZL, Yan ZQ, Guo Z, Liang JW, Wang Q, Zhao ZD, Li PL, Hao RC, Han MY, Li XT, Mao N, Ding L, Chen DF, Gao Y, Zhu H. Correction to: psoralen alleviates radiation-induced bone injury by rescuing skeletal stem cell stemness through AKT mediated up-regulation of GSK-3\u03b2 and NRF2. Stem Cell Res. Ther.<\/i>, 13<\/b>, 361 (2022).","DOI":"10.1186\/s13287-022-03081-x"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5) Rockman S, Laurie KL, Parkes S, Wheatley A, Barr IG. New technologies for influenza vaccines. Microorganisms<\/i>, 8<\/b>, 1745 (2020).","DOI":"10.3390\/microorganisms8111745"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6) Javanian M, Barary M, Ghebrehewet S, Koppolu V, Vasigala V, Ebrahimpour S. A brief review of influenza virus infection. J. Med. Virol.<\/i>, 93<\/b>, 4638\u20134646 (2021).","DOI":"10.1002\/jmv.26990"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7) Armando RG, Mengual G\u00f3mez DL, Gomez DE. New drugs are not enough-drug repositioning in oncology: an update. Int. J. Oncol.<\/i>, 56<\/b>, 651\u2013684 (2020).","DOI":"10.3892\/ijo.2020.4966"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8) Bai Z, Huang C, Xu H, Wang Y, Liao Z, Shen P, Ni Z, Huangfu C, Sun D, Hu Y, Wang N, Zhang P, Zhou L, Zhou W, Gao Y. Cannabidiol restores hematopoietic stem cell stemness in mouse through Atf2-Lrp6 axis after acute irradiation. MedComm<\/i>, 6<\/b>, e70092 (2025).","DOI":"10.1002\/mco2.70092"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9) Hardoy MC, Carta MG. Strategy to accelerate or augment the antidepressant response and for an early onset of SSRI activity. Adjunctive amisulpride to fluvoxamine in major depressive disorder. Clin. Pract. Epidemiol. Ment. Health<\/i>, 6<\/b>, 1\u20133 (2010).","DOI":"10.2174\/17450179010060100001"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10) Xu HH, Wang NN, Jiang ZH, Sun YT, Xu LL, Ma ZC, Gao Y. Sharing and helping: regularity and characteristics of pathogenesis of a widely used transgene initiated murine acute promyelocytic leukemia model. Stem Cells Dev.<\/i>, 30<\/b>, 39\u201348 (2021).","DOI":"10.1089\/scd.2020.0125"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11) Aksak T, Satar DA, Bagci R, G\u00fcltekin EO, Coskun A, Demi Rdelen U. Investigation of the effect of COVID-19 on sperm count, motility, and morphology. J. Med. Virol.<\/i>, 94<\/b>, 5201\u20135205 (2022).","DOI":"10.1002\/jmv.27971"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12) Nyirenda JL, Sofroniou M, Toews I, Mikolajewska A, Lehane C, Monsef I, Abu-Taha A, Maun A, Stegemann M, Schmucker C. Fluvoxamine for the treatment of COVID-19. Cochrane Database Syst. Rev.<\/i>, 9<\/b>, CD015391 (2022).","DOI":"10.1002\/14651858.CD015391"},{"key":"13","unstructured":"13) Reis G, Dos Santos Moreira-Silva EA, Silva DCM, et al<\/i>. Effect of early treatment with fluvoxamine on risk of emergency care and hospitalisation among patients with COVID-19: the TOGETHER randomised, platform clinical trial. Lancet Glob. Health<\/i>, 10<\/b>, e42\u2013e51 (2022)."},{"key":"14","doi-asserted-by":"crossref","unstructured":"14) Wang R, Ma S, Yang J, Luo K, Qian Q, Pan J, Liang K, Wang Y, Gao Y, Li M. Sodium hydrosulfide protects rats from hypobaric-hypoxia-induced acute lung injury. Int. J. Mol. Sci.<\/i>, 25<\/b>, 10734 (2024).","DOI":"10.3390\/ijms251910734"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15) Yan Z, Li Y, Xia T, Wang K, Liao Z, Zhang L, Wang Y, Shen P, Bai Z, Wang N, Zhou W, Ni Z, Dou Y, Gao Y. Revitalizing gut health: Liangxue Guyuan Yishen Decoction promotes Akkermansia muciniphila-induced intestinal stem cell recovery post-radiation in mice. Phytomedicine<\/i>, 132<\/b>, 155888 (2024).","DOI":"10.1016\/j.phymed.2024.155888"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16) Feys S, Carvalho A, Clancy CJ, Gangneux JP, Hoenigl M, Lagrou K, Rijnders BJA, Seldeslachts L, Vanderbeke L, van de Veerdonk FL, Verweij PE, Wauters J. Influenza-associated and COVID-19-associated pulmonary aspergillosis in critically ill patients. Lancet Respir. Med.<\/i>, 12<\/b>, 728\u2013742 (2024).","DOI":"10.1016\/S2213-2600(24)00151-6"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17) Osman M, Klopfenstein T, Belfeki N, Gendrin V, Zayet S. A Comparative systematic review of COVID-19 and influenza. Viruses<\/i>, 13<\/b>, 452 (2021).","DOI":"10.3390\/v13030452"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18) Sukhdeo S, Lee N. Influenza: clinical aspects, diagnosis, and treatment. Curr. Opin. Pulm. Med.<\/i>, 28<\/b>, 199\u2013204 (2022).","DOI":"10.1097\/MCP.0000000000000860"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19) Sun X, Chen J, Shi Y, Zeng Q, Wei N, Xie R, Chang C, Du W. Measuring health literacy regarding infectious respiratory diseases: a new skills-based instrument. PLOS ONE<\/i>, 8<\/b>, e64153 (2013).","DOI":"10.1371\/journal.pone.0064153"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20) Liu Q, Zhou YH, Yang ZQ. The cytokine storm of severe influenza and development of immunomodulatory therapy. Cell. Mol. Immunol.<\/i>, 13<\/b>, 3\u201310 (2016).","DOI":"10.1038\/cmi.2015.74"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21) Kedzierski L, Linossi EM, Kolesnik TB, Day EB, Bird NL, Kile BT, Belz GT, Metcalf D, Nicola NA, Kedzierska K, Nicholson SE. Suppressor of cytokine signaling 4 (SOCS4) protects against severe cytokine storm and enhances viral clearance during influenza infection. PLoS Pathog.<\/i>, 10<\/b>, e1004134 (2014).","DOI":"10.1371\/journal.ppat.1004134"},{"key":"22","doi-asserted-by":"crossref","unstructured":"22) Schneider MA, Heeb L, Beffinger MM, Pantelyushin S, Linecker M, Roth L, Lehmann K, Ungeth\u00fcm U, Kobold S, Graf R, van den Broek M, Vom Berg J, Gupta A, Clavien PA. Attenuation of peripheral serotonin inhibits tumor growth and enhances immune checkpoint blockade therapy in murine tumor models. Sci. Transl. Med.<\/i>, 13<\/b>, eabc8188 (2021).","DOI":"10.1126\/scitranslmed.abc8188"},{"key":"23","doi-asserted-by":"crossref","unstructured":"23) Beurel E, Toups M, Nemeroff CB. The bidirectional relationship of depression and inflammation: double trouble. Neuron<\/i>, 107<\/b>, 234\u2013256 (2020).","DOI":"10.1016\/j.neuron.2020.06.002"},{"key":"24","doi-asserted-by":"crossref","unstructured":"24) Zhang Z, Yang L, Huang X, Gao Y. Metabolomics profiling of Polygoni Multiflori Radix and Polygoni Multiflori Radix Preparata extracts using UPLC-Q\/TOF-MS. Chin. Med.<\/i>, 14<\/b>, 46 (2019).","DOI":"10.1186\/s13020-019-0268-3"},{"key":"25","unstructured":"25) Dobrodeeva V, Abdyrahmanova A, Astafeva D, Smirnova D, Cumming P, De Sousa A, Davydkin I, Yashikhina A, Shnayder N, Nasyrova R. Pharmacogenetic aspects of COVID-19 management and post-COVID-19 depression treatment with fluvoxamine. Psychiatr. Danub.<\/i>, 34<\/b> (Suppl. 8), 25\u201330 (2022)."},{"key":"26","doi-asserted-by":"crossref","unstructured":"26) Wu Z, Tu B, Li S, Chen J, Shen P, Zhou W, Ma Z, Tang X, Xiao C, Wang Y, Gao Y. Safety assessment and exploration of the mechanism of toxic effects of diallyl trisulfide: Based on acute and subacute toxicity and proteomics experiments. J. Ethnopharmacol.<\/i>, 338<\/b>, 119102 (2025).","DOI":"10.1016\/j.jep.2024.119102"},{"key":"27","doi-asserted-by":"crossref","unstructured":"27) Naji Esfahani H, Rafiee L, Haghjooy Javanmard S. Evaluation of the effect of antidepressant drug, fluvoxamine, on cyclooxygenase-2 protein expression in lipopolysaccharide-stimulated macrophages. Adv. Biomed. Res.<\/i>, 8<\/b>, 5 (2019).","DOI":"10.4103\/abr.abr_141_18"},{"key":"28","doi-asserted-by":"crossref","unstructured":"28) Yan J, Ruan P, Ge Y, Gao J, Tan H, Xiao C, Gao Q, Zhang Z, Gao Y. Mechanisms and molecular targets of compound Danshen dropping pill for heart disease caused by high altitude based on network pharmacology and molecular docking. ACS Omega<\/i>, 6<\/b>, 26942\u201326951 (2021).","DOI":"10.1021\/acsomega.1c03282"},{"key":"29","doi-asserted-by":"crossref","unstructured":"29) Iba\u00f1ez LI, Martinez VP, Iglesias AA, Bellomo CM, Alonso DO, Coelho RM, Martinez Peralta L, Periolo N. Decreased expression of surfactant protein-C and CD74 in alveolar epithelial cells during influenza virus A(H1N1)pdm09 and H3N2 infection. Microb. Pathog.<\/i>, 176<\/b>, 106017 (2023).","DOI":"10.1016\/j.micpath.2023.106017"},{"key":"30","doi-asserted-by":"crossref","unstructured":"30) Zheng Y, He D, Zuo W, Wang W, Wu K, Wu H, Yuan Y, Huang Y, Li H, Lu Y, Zhao L, Wang X, Wang J, Zhang Y, Zou G, Li H, Wang Z, Cao B. Influenza A virus dissemination and infection leads to tissue resident cell injury and dysfunction in viral sepsis. EBioMedicine<\/i>, 116<\/b>, 105738 (2025).","DOI":"10.1016\/j.ebiom.2025.105738"},{"key":"31","doi-asserted-by":"crossref","unstructured":"31) Herold S, Becker C, Ridge KM, Budinger GR. Influenza virus-induced lung injury: pathogenesis and implications for treatment. Eur. Respir. J.<\/i>, 45<\/b>, 1463\u20131478 (2015).","DOI":"10.1183\/09031936.00186214"},{"key":"32","doi-asserted-by":"crossref","unstructured":"32) Wei Z, Gao R, Sun Z, Yang W, He Q, Wang C, Zhang J, Zhang X, Guo L, Wang S. Baicalin inhibits influenza A (H1N1)-induced pyroptosis of lung alveolar epithelial cells via<\/i> caspase-3\/GSDME pathway. J. Med. Virol.<\/i>, 95<\/b>, e28790 (2023).","DOI":"10.1002\/jmv.28790"},{"key":"33","doi-asserted-by":"crossref","unstructured":"33) D\u2019Elia RV, Harrison K, Oyston PC, Lukaszewski R, Clark GC. Targeting the \u201ccytokine storm\u201d for therapeutic benefit. Clin. Vaccine Immunol.<\/i>, 20<\/b>, 319\u2013327 (2013).","DOI":"10.1128\/CVI.00636-12"},{"key":"34","doi-asserted-by":"crossref","unstructured":"34) Guo H, Koehler HS, Dix RD, Mocarski ES. Programmed cell death-dependent host defense in ocular herpes simplex virus infection. Front. Microbiol.<\/i>, 13<\/b>, 869064 (2022).","DOI":"10.3389\/fmicb.2022.869064"},{"key":"35","doi-asserted-by":"crossref","unstructured":"35) Liu Y, Fang Y, Chen X, Wang Z, Liang X, Zhang T, Liu M, Zhou N, Lv J, Tang K, Xie J, Gao Y, Cheng F, Zhou Y, Zhang Z, Hu Y, Zhang X, Gao Q, Zhang Y, Huang B. Gasdermin E-mediated target cell pyroptosis by CAR T cells triggers cytokine release syndrome. Sci. Immunol.<\/i>, 5<\/b>, eaax7969 (2020).","DOI":"10.1126\/sciimmunol.aax7969"}],"container-title":["Biological and Pharmaceutical Bulletin"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/bpb\/49\/5\/49_b25-00792\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,30]],"date-time":"2026-05-30T03:39:11Z","timestamp":1780112351000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/bpb\/49\/5\/49_b25-00792\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,29]]},"references-count":35,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026]]}},"URL":"https:\/\/doi.org\/10.1248\/bpb.b25-00792","relation":{},"ISSN":["0918-6158","1347-5215"],"issn-type":[{"value":"0918-6158","type":"print"},{"value":"1347-5215","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,29]]},"article-number":"b25-00792"}}