{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T04:03:52Z","timestamp":1784347432136,"version":"3.55.0"},"reference-count":42,"publisher":"Pharmaceutical Society of Japan","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biological &amp; Pharmaceutical Bulletin","Biol. Pharm. Bull."],"published-print":{"date-parts":[[2026,7,15]]},"DOI":"10.1248\/bpb.b25-00808","type":"journal-article","created":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T22:15:11Z","timestamp":1784067311000},"page":"1108-1118","source":"Crossref","is-referenced-by-count":0,"title":["&lt;i&gt;Vladimiria souliei&lt;\/i&gt; Ameliorated Aspirin-Induced Gastric Mucosal Injury by Activation Nrf2 and Inhibition RIP1 Signaling Pathways"],"prefix":"10.1248","volume":"49","author":[{"given":"Binjing","family":"Zhao","sequence":"first","affiliation":[{"name":"Guangxi Key Laboratory of Drug Discovery and Optimization, School of Pharmacy, Guilin Medical University, Guilin 541199, Guangxi, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyi","family":"Jiang","sequence":"first","affiliation":[{"name":"Guangxi Key Laboratory of Drug Discovery and Optimization, School of Pharmacy, Guilin Medical University, Guilin 541199, Guangxi, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaojing","family":"Wei","sequence":"additional","affiliation":[{"name":"Guangxi Key Laboratory of Drug Discovery and Optimization, School of Pharmacy, Guilin Medical University, Guilin 541199, Guangxi, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lunli","family":"Lan","sequence":"additional","affiliation":[{"name":"Guangxi Key Laboratory of Drug Discovery and Optimization, School of Pharmacy, Guilin Medical University, Guilin 541199, Guangxi, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Wang","sequence":"additional","affiliation":[{"name":"Guangxi Key Laboratory of Drug Discovery and Optimization, School of Pharmacy, Guilin Medical University, Guilin 541199, Guangxi, China"},{"name":"Guilin Layn Natural Ingredients Corporation, Guilin 541199, Guangxi, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanyuan","family":"Li","sequence":"additional","affiliation":[{"name":"Guilin Layn Natural Ingredients Corporation, Guilin 541199, Guangxi, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"163","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"1) Braun J, Baraliakos X, Westhoff T. Nonsteroidal anti-inflammatory drugs and cardiovascular risk\u2014a matter of indication. <i>Semin. Arthritis Rheum.<\/i>, <b>50<\/b>, 285\u2013288 (2020).","DOI":"10.1016\/j.semarthrit.2019.07.012"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2) Kadu\u0161evi\u010dius E. Novel applications of NSAIDs: insight and future perspectives in cardiovascular, neurodegenerative, diabetes and cancer disease therapy. <i>Int. J. Mol. Sci.<\/i>, <b>22<\/b>, 6637 (2021).","DOI":"10.3390\/ijms22126637"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3) Sostres C, Gargallo CJ, Lanas A. Nonsteroidal anti-inflammatory drugs and upper and lower gastrointestinal mucosal damage. <i>Arthritis Res. Ther.<\/i>, <b>15<\/b> (Suppl. 3), S3 (2013).","DOI":"10.1186\/ar4175"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4) Islam H, Siddiqui A, Islam R, Islam T, Ahmed S, Fahim M, Khalid M, Malik G, Imtiaz H. NSAID-induced gastric ulcer disease: a deleterious connection. <i>Discov. Med.<\/i>, <b>36<\/b>, 1789\u20131799 (2024).","DOI":"10.24976\/Discov.Med.202436188.165"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5) Boltin D, Niv Y. Pharmacological and alimentary alteration of the gastric barrier. <i>Best Pract. Res. Clin. Gastroenterol.<\/i>, <b>28<\/b>, 981\u2013994 (2014).","DOI":"10.1016\/j.bpg.2014.09.001"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6) Almadi MA, Lu Y, Alali AA, Barkun AN. Peptic ulcer disease. <i>Lancet<\/i>, <b>404<\/b>, 68\u201381 (2024).","DOI":"10.1016\/S0140-6736(24)00155-7"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7) Bindu S, Mazumder S, Bandyopadhyay U. Non-steroidal anti-inflammatory drugs (NSAIDs) and organ damage: a current perspective. <i>Biochem. Pharmacol.<\/i>, <b>180<\/b>, 114147 (2020).","DOI":"10.1016\/j.bcp.2020.114147"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8) Guo D, Zhang W, Yang H, Bi J, Xie Y, Cheng B, Wang Y, Chen S. Celastrol induces necroptosis and ameliorates inflammation <i>via<\/i> targeting biglycan in human gastric carcinoma. <i>Int. J. Mol. Sci.<\/i>, <b>20<\/b>, 5716 (2019).","DOI":"10.3390\/ijms20225716"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9) Yuan J, Amin P, Ofengeim D. Necroptosis and RIPK1-mediated neuroinflammation in CNS diseases. <i>Nat. Rev. Neurosci.<\/i>, <b>20<\/b>, 19\u201333 (2019).","DOI":"10.1038\/s41583-018-0093-1"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10) Castellana C, Pecere S, Furnari M, Telese A, Matteo MV, Haidry R, Eusebi LH. Side effects of long-term use of proton pump inhibitors: practical considerations. <i>Pol. Arch. Intern. Med.<\/i>, <b>131<\/b>, 541\u2013549 (2021).","DOI":"10.20452\/pamw.15997"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11) Yang L, Xu W. A disproportionality analysis of FDA adverse event reporting system events for misoprostol. <i>Sci. Rep.<\/i>, <b>15<\/b>, 2452 (2025).","DOI":"10.1038\/s41598-025-86422-z"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12) Bi WP, Man HB, Man MQ. Efficacy and safety of herbal medicines in treating gastric ulcer: a review. <i>World J. Gastroenterol.<\/i>, <b>20<\/b>, 17020\u201317028 (2014).","DOI":"10.3748\/wjg.v20.i45.17020"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13) Gong H, Zhao N, Zhu C, Luo L, Liu S. Treatment of gastric ulcer, traditional Chinese medicine may be a better choice. <i>J. Ethnopharmacol.<\/i>, <b>324<\/b>, 117793 (2024).","DOI":"10.1016\/j.jep.2024.117793"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14) Zhuang K, Xia Q, Zhang S, Maharajan K, Liu K, Zhang Y. A comprehensive chemical and pharmacological review of three confusable Chinese herbal medicine-Aucklandiae radix, Vladimiriae radix, and Inulae radix. <i>Phytother. Res.<\/i>, <b>35<\/b>, 6655\u20136689 (2021).","DOI":"10.1002\/ptr.7250"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15) Yan X, Wang W, Chen Z, Xie Y, Li Q, Yu Z, Hu H, Wang Z. Quality assessment and differentiation of <i>Aucklandiae Radix<\/i> and <i>Vladimiriae Radix<\/i> based on GC-MS fingerprint and chemometrics analysis: basis for clinical application. <i>Anal. Bioanal. Chem.<\/i>, <b>412<\/b>, 1535\u20131549 (2020).","DOI":"10.1007\/s00216-019-02380-2"},{"key":"16","unstructured":"16) Pharmacopoeia Commission of People\u2019s Republic of China. Pharmacopoeia of the People\u2019s Republic of China. <i>China Med. Sci. Press<\/i>: Beijing, <b>1<\/b>, 504 (2020)."},{"key":"17","doi-asserted-by":"crossref","unstructured":"17) Wang W, Li Q, Yan X, Chen Z, Xie Y, Hu H, Wang Z. Comparative study of raw and processed Vladimiriae Radix on pharmacokinetic and anti-acute gastritis effect through anti-oxidation and anti-inflammation. <i>Phytomedicine<\/i>, <b>70<\/b>, 153224 (2020).","DOI":"10.1016\/j.phymed.2020.153224"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18) Jia W, He X, Jin W, Gu J, Yu S, He J, Yi Z, Cai B, Gao H, Yang L. <i>Ramulus Cinnamomi<\/i> essential oil exerts an anti-inflammatory effect on RAW264.7 cells through <i>N<\/i>-acylethanolamine acid amidase inhibition. <i>J. Ethnopharmacol.<\/i>, <b>317<\/b>, 116747 (2023).","DOI":"10.1016\/j.jep.2023.116747"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19) Moon PD, Han NR, Lee JS, Kim HY, Hong S, Kim HJ, Yoo MS, Kim HM, Jeong HJ. \u03b2-Eudesmol inhibits thymic stromal lymphopoietin through blockade of caspase-1\/NF-\u03baB signal cascade in allergic rhinitis murine model. <i>Chem. Biol. Interact.<\/i>, <b>294<\/b>, 101\u2013106 (2018).","DOI":"10.1016\/j.cbi.2018.08.026"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20) Wang R, Zhao Y, Zhou L, Lin F, Wan M, Gan A, Wu B, Yan T, Jia Y. Costunolide ameliorates MNNG-induced chronic atrophic gastritis through inhibiting oxidative stress and DNA damage <i>via<\/i> activation of Nrf2. <i>Phytomedicine<\/i>, <b>130<\/b>, 155581 (2024).","DOI":"10.1016\/j.phymed.2024.155581"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21) Xu H, Chen J, Chen P, Li W, Shao J, Hong S, Wang Y, Chen L, Luo W, Liang G. Costunolide covalently targets NACHT domain of NLRP3 to inhibit inflammasome activation and alleviate NLRP3-driven inflammatory diseases. <i>Acta Pharm. Sin. B<\/i>, <b>13<\/b>, 678\u2013693 (2023).","DOI":"10.1016\/j.apsb.2022.09.014"},{"key":"22","doi-asserted-by":"crossref","unstructured":"22) Sun M, Zhan H, Long X, Alsayed AM, Wang Z, Meng F, Wang G, Mao J, Liao Z, Chen M. Dehydrocostus lactone alleviates irinotecan-induced intestinal mucositis by blocking TLR4\/MD2 complex formation. <i>Phytomedicine<\/i>, <b>128<\/b>, 155371 (2024).","DOI":"10.1016\/j.phymed.2024.155371"},{"key":"23","doi-asserted-by":"crossref","unstructured":"23) Yuan Y, Hu Q, Liu L, Xie F, Yang L, Li Y, Zhang C, Chen H, Tang J, Shen X. Dehydrocostus lactone suppresses dextran sulfate sodium-induced colitis by targeting the IKK\u03b1\/\u03b2-NF-\u03baB and keap1-Nrf2 signalling pathways. <i>Front. Pharmacol.<\/i>, <b>13<\/b>, 817596 (2022).","DOI":"10.3389\/fphar.2022.817596"},{"key":"24","doi-asserted-by":"crossref","unstructured":"24) Liu Y, Wu J, Tan L, Li Z, Gao P, He S, Wang Q, Tang D, Wang C, Wang F, Li P, Liu J. (\u2013)-Syringaresinol attenuates ulcerative colitis by improving intestinal epithelial barrier function and inhibiting inflammatory responses. <i>Phytomedicine<\/i>, <b>124<\/b>, 155292 (2024).","DOI":"10.1016\/j.phymed.2023.155292"},{"key":"25","doi-asserted-by":"crossref","unstructured":"25) Dong Z, Yang L, Jiao J, Jiang Y, Li H, Yin G, Yang P, Sun L. Aspirin in combination with gastrodin protects cardiac function and mitigates gastric mucosal injury in response to myocardial ischemia\/reperfusion. <i>Front. Pharmacol.<\/i>, <b>13<\/b>, 995102 (2022).","DOI":"10.3389\/fphar.2022.995102"},{"key":"26","doi-asserted-by":"crossref","unstructured":"26) Ahmadi M, Bekeschus S, Weltmann KD, von Woedtke T, Wende K. Non-steroidal anti-inflammatory drugs: recent advances in the use of synthetic COX-2 inhibitors. <i>RSC Med. Chem.<\/i>, <b>13<\/b>, 471\u2013496 (2022).","DOI":"10.1039\/D1MD00280E"},{"key":"27","doi-asserted-by":"crossref","unstructured":"27) El-Sayed SF, Mahmoud SM, Samy W, Wahid RM, Talaat A, Seada SG. Vitamin D<sub>3<\/sub> mitigates aspirin-induced gastric injury by modulating gastrokines, E-cadherin, and inhibiting NLRP3 and NF-\u03baB\/MMP-9 signaling pathway. <i>Tissue Cell<\/i>, <b>93<\/b>, 102724 (2025).","DOI":"10.1016\/j.tice.2025.102724"},{"key":"28","doi-asserted-by":"crossref","unstructured":"28) Matsui H, Nagano Y, Shimokawa O, Kaneko T, Rai K, Udo J, Hirayama A, Nakamura Y, Indo HP, Majima HJ, Hyodo I. Gastric acid induces mitochondrial superoxide production and lipid peroxidation in gastric epithelial cells. <i>J. Gastroenterol.<\/i>, <b>46<\/b>, 1167\u20131176 (2011).","DOI":"10.1007\/s00535-011-0434-6"},{"key":"29","doi-asserted-by":"crossref","unstructured":"29) Ali DE, El-Shiekh RA, El Sawy M, Khalifa AA, Elblehi SS, Elsokkary NH, Ali MA. <i>In vivo<\/i> anti-gastric ulcer activity of <i>7<\/i>-<i>O<\/i>-methyl aromadendrin and sakuranetin <i>via<\/i> mitigating inflammatory and oxidative stress trails. <i>J. Ethnopharmacol.<\/i>, <b>335<\/b>, 118617 (2024).","DOI":"10.1016\/j.jep.2024.118617"},{"key":"30","doi-asserted-by":"crossref","unstructured":"30) Mahmoud YI, Abd El-Ghffar EA. Spirulina ameliorates aspirin-induced gastric ulcer in albino mice by alleviating oxidative stress and inflammation. <i>Biomed. Pharmacother.<\/i>, <b>109<\/b>, 314\u2013321 (2019).","DOI":"10.1016\/j.biopha.2018.10.118"},{"key":"31","doi-asserted-by":"crossref","unstructured":"31) Batty M, Bennett MR, Yu E. The role of oxidative stress in atherosclerosis. <i>Cells<\/i>, <b>11<\/b>, 3843 (2022).","DOI":"10.3390\/cells11233843"},{"key":"32","doi-asserted-by":"crossref","unstructured":"32) Yoo J, Jo J, Ha S, Kwak J, Kim M, Kim J, Lee H, Kim D, Kim BM, Kim J, Yun H, Koh M, Chung KW. NRF2 activation by AR-20007 preserves renal tubular epithelial cells from antimycin A-induced cell death <i>via<\/i> glutathione metabolism regulation. <i>Biol. Pharm. Bull.<\/i>, <b>47<\/b>, 1557\u20131564 (2024).","DOI":"10.1248\/bpb.b24-00295"},{"key":"33","doi-asserted-by":"crossref","unstructured":"33) Eggler AL, Small E, Hannink M, Mesecar AD. Cul3-mediated Nrf2 ubiquitination and antioxidant response element (ARE) activation are dependent on the partial molar volume at position 151 of Keap1. <i>Biochem. J.<\/i>, <b>422<\/b>, 171\u2013180 (2009).","DOI":"10.1042\/BJ20090471"},{"key":"34","doi-asserted-by":"crossref","unstructured":"34) Xu J, Zhu K, Wang Y, Chen J. The dual role and mutual dependence of heme\/HO-1\/Bach1 axis in the carcinogenic and anti-carcinogenic intersection. <i>J. Cancer Res. Clin. Oncol.<\/i>, <b>149<\/b>, 483\u2013501 (2023).","DOI":"10.1007\/s00432-022-04447-7"},{"key":"35","doi-asserted-by":"crossref","unstructured":"35) Ross D, Siegel D. The diverse functionality of NQO1 and its roles in redox control. <i>Redox Biol.<\/i>, <b>41<\/b>, 101950 (2021).","DOI":"10.1016\/j.redox.2021.101950"},{"key":"36","doi-asserted-by":"crossref","unstructured":"36) Salem MB, Elzallat M, Mohammed DM, Samir S, Hammam OA, Abdel-Wareth M. <i>Cornu aspersum<\/i> mucin attenuates indomethacins-induced gastric ulcers in mice <i>via<\/i> alleviating oxidative stress and inflammation. <i>Heliyon<\/i>, <b>9<\/b>, e15677 (2023).","DOI":"10.1016\/j.heliyon.2023.e15677"},{"key":"37","doi-asserted-by":"crossref","unstructured":"37) Aziz RS, Siddiqua A, Shahzad M, Shabbir A, Naseem N. Oxyresveratrol ameliorates ethanol-induced gastric ulcer <i>via<\/i> downregulation of IL-6, TNF-\u03b1, NF-\u03baB, and COX-2 levels, and upregulation of TFF-2 levels. <i>Biomed. Pharmacother.<\/i>, <b>110<\/b>, 554\u2013560 (2019).","DOI":"10.1016\/j.biopha.2018.12.002"},{"key":"38","doi-asserted-by":"crossref","unstructured":"38) Vandenabeele P, Galluzzi L, Vanden BT, Kroemer G. Molecular mechanisms of necroptosis: an ordered cellular explosion. <i>Nat. Rev. Mol. Cell Biol.<\/i>, <b>11<\/b>, 700\u2013714 (2010).","DOI":"10.1038\/nrm2970"},{"key":"39","doi-asserted-by":"crossref","unstructured":"39) Pasparakis M, Vandenabeele P. Necroptosis and its role in inflammation. <i>Nature<\/i>, <b>517<\/b>, 311\u2013320 (2015).","DOI":"10.1038\/nature14191"},{"key":"40","doi-asserted-by":"crossref","unstructured":"40) Marunouchi T, Onda S, Kurasawa M, Tanonaka K. Angiotensin II is involved in MLKL activation during the development of heart failure following myocardial infarction in rats. <i>Biol. Pharm. Bull.<\/i>, <b>47<\/b>, 809\u2013817 (2024).","DOI":"10.1248\/bpb.b23-00741"},{"key":"41","doi-asserted-by":"crossref","unstructured":"41) Remijsen Q, Goossens V, Grootjans S, Van den Haute C, Vanlangenakker N, Dondelinger Y, Roelandt R, Bruggeman I, Goncalves A, Bertrand MJ, Baekelandt V, Takahashi N, Berghe TV, Vandenabeele P. Depletion of RIPK3 or MLKL blocks TNF-driven necroptosis and switches towards a delayed RIPK1 kinase-dependent apoptosis. <i>Cell Death Dis.<\/i>, <b>5<\/b>, e1004 (2014).","DOI":"10.1038\/cddis.2013.531"},{"key":"42","doi-asserted-by":"crossref","unstructured":"42) Xiao Y, Zhang Y, Xie K, Huang X, Liu X, Luo J, Tan S. Mitochondrial dysfunction by FADDosome promotes gastric mucosal injury in portal hypertensive gastropathy. <i>Int. J. Biol. Sci.<\/i>, <b>20<\/b>, 2658\u20132685 (2024).","DOI":"10.7150\/ijbs.90835"}],"container-title":["Biological and Pharmaceutical Bulletin"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/bpb\/49\/7\/49_b25-00808\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T03:23:03Z","timestamp":1784344983000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/bpb\/49\/7\/49_b25-00808\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,15]]},"references-count":42,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2026]]}},"URL":"https:\/\/doi.org\/10.1248\/bpb.b25-00808","relation":{},"ISSN":["0918-6158","1347-5215"],"issn-type":[{"value":"0918-6158","type":"print"},{"value":"1347-5215","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,15]]},"article-number":"b25-00808"}}