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Magnesium basics. <i>Clin. Kidney J.<\/i>, <b>5<\/b> (Suppl. 1), i3\u2013i14 (2012).","DOI":"10.1093\/ndtplus\/sfr163"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2) de Baaij JHF. The art of magnesium transport. <i>Magnes. Res.<\/i>, <b>28<\/b>, 85\u201391 (2015).","DOI":"10.1684\/mrh.2015.0388"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3) Volpe SL. Magnesium in disease prevention and overall health. <i>Adv. Nutr.<\/i>, <b>4<\/b>, 378S\u2013383S (2013).","DOI":"10.3945\/an.112.003483"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4) Fawcett WJ, Haxby EJ, Male DA. Magnesium: physiology and pharmacology. <i>Br. J. Anaesth.<\/i>, <b>83<\/b>, 302\u2013320 (1999).","DOI":"10.1093\/bja\/83.2.302"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5) Nowak L, Bregestovski P, Ascher P, Herbet A, Prochiantz A. Magnesium gates glutamate-activated channels in mouse central neurones. <i>Nature<\/i>, <b>307<\/b>, 462\u2013465 (1984).","DOI":"10.1038\/307462a0"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6) Mayer ML, Westbrook GL, Guthrie PB. Voltage-dependent block by Mg<sup>2+<\/sup> of NMDA responses in spinal cord neurones. <i>Nature<\/i>, <b>309<\/b>, 261\u2013263 (1984).","DOI":"10.1038\/309261a0"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7) Tsuji H, Venditti FJ Jr, Evans JC, Larson MG, Levy D. The associations of levels of serum potassium and magnesium with ventricular premature complexes (the Framingham Heart Study). <i>Am. J. Cardiol.<\/i>, <b>74<\/b>, 232\u2013235 (1994).","DOI":"10.1016\/0002-9149(94)90362-X"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8) Chakraborti S, Chakraborti T, Mandal M, Mandal A, Das S, Ghosh S. Protective role of magnesium in cardiovascular diseases: a review. <i>Mol. Cell. 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Expression and role of ionotropic glutamate receptors in pancreatic islet cells. <i>FASEB J.<\/i>, <b>9<\/b>, 686\u2013691 (1995).","DOI":"10.1096\/fasebj.9.8.7768362"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12) Moln\u00e1r E, V\u00e1radi A, McIlhinney RA, Ashcroft SJ. Identification of functional ionotropic glutamate receptor proteins in pancreatic beta-cells and in islets of Langerhans. <i>FEBS Lett.<\/i>, <b>371<\/b>, 253\u2013257 (1995).","DOI":"10.1016\/0014-5793(95)00890-L"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13) Bertrand G, Gross R, Puech R, Loubati\u00e8res-Mariani MM, Bockaert J. Evidence for a glutamate receptor of the AMPA subtype which mediates insulin release from rat perfused pancreas. <i>Br. J. Pharmacol.<\/i>, <b>106<\/b>, 354\u2013359 (1992).","DOI":"10.1111\/j.1476-5381.1992.tb14340.x"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14) Inoue S, Ikegaya Y, Matsumoto N, Kashima T. Magnesium deficiency differentially modulates hippocampal and prefrontal oscillations and cardiac rhythms. <i>J. Pharmacol. Sci.<\/i>, <b>160<\/b>, 97\u2013110 (2026).","DOI":"10.1016\/j.jphs.2025.12.002"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15) Kendig MD, Martire SI, Boakes RA, Rooney KB. Comparable metabolic effects of isocaloric sucrose and glucose solutions in rats. <i>Physiol. Behav.<\/i>, <b>229<\/b>, 113239 (2021).","DOI":"10.1016\/j.physbeh.2020.113239"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16) Frandes M, Timar B, Timar R, Lungeanu D. Chaotic time series prediction for glucose dynamics in type 1 diabetes mellitus using regime-switching models. <i>Sci. Rep.<\/i>, <b>7<\/b>, 6232 (2017).","DOI":"10.1038\/s41598-017-06478-4"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17) \u0160terk M, Kri\u017ean\u010di\u0107 Bombek L, Skelin Klemen M, Slak Rupnik M, Marhl M, Sto\u017eer A, Gosak M. NMDA receptor inhibition increases, synchronizes, and stabilizes the collective pancreatic beta cell activity: Insights through multilayer network analysis. <i>PLOS Comput. Biol.<\/i>, <b>17<\/b>, e1009002 (2021).","DOI":"10.1371\/journal.pcbi.1009002"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18) Kushner T, Mosquera-Lopez C, Hilts W, Leitschuh J, Dodier R, Branigan D, Eom J, Howard M, Aby-Daniel D, Wilson LM, Jacobs PG. Identifying and intervening on glucose patterns in multivariate data using block-based recurrence quantification analysis. <i>J. Diabetes Sci. Technol.<\/i>, <b>19<\/b>, 1448\u20131456 (2025).","DOI":"10.1177\/19322968251386058"},{"key":"19","unstructured":"19) Liu H, Li N, Jin M, Miao X, Zhang X, Zhong W. Magnesium supplementation enhances insulin sensitivity and decreases insulin resistance in diabetic rats. <i>Iran. J. Basic Med. 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