{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T04:08:51Z","timestamp":1789186131177,"version":"build-2803163510"},"reference-count":61,"publisher":"Pharmaceutical Society of Japan","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biological &amp; Pharmaceutical Bulletin","Biol. Pharm. Bull."],"published-print":{"date-parts":[[2026,9,10]]},"DOI":"10.1248\/bpb.b26-00225","type":"journal-article","created":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T22:11:39Z","timestamp":1788991899000},"page":"1452-1462","source":"Crossref","is-referenced-by-count":0,"title":["Realgar Transforming Solution Triggers Ferroptosis-Associated Death in NB4 Leukemia Cells through Disruption of Iron Homeostasis and Suppression of the SLC7A11\/GPX4 Axis"],"prefix":"10.1248","volume":"49","author":[{"given":"Zhaorong","family":"Yue","sequence":"first","affiliation":[{"name":"Institute of Microbiology, School of Life Sciences, Lanzhou University, Lanzhou 730000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qinghong","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Lanzhou University, Lanzhou 730000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanni","family":"Wang","sequence":"additional","affiliation":[{"name":"Institute of Microbiology, School of Life Sciences, Lanzhou University, Lanzhou 730000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruyue","family":"Wang","sequence":"additional","affiliation":[{"name":"Institute of Microbiology, School of Life Sciences, Lanzhou University, Lanzhou 730000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongqing","family":"Li","sequence":"additional","affiliation":[{"name":"Department of General Surgery, The Second Hospital of Lanzhou University &amp; The Second Clinical Medical School, Lanzhou University, Lanzhou 730000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manjie","family":"Xu","sequence":"additional","affiliation":[{"name":"Institute of Microbiology, School of Life Sciences, Lanzhou University, Lanzhou 730000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piao","family":"Luo","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Lanzhou University, Lanzhou 730000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaxuan","family":"Li","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Lanzhou University, Lanzhou 730000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiawen","family":"Xu","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Lanzhou University, Lanzhou 730000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjun","family":"Xu","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Lanzhou University, Lanzhou 730000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weizhong","family":"Zhang","sequence":"additional","affiliation":[{"name":"Institute of Microbiology, School of Life Sciences, Lanzhou University, Lanzhou 730000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianing","family":"He","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Lanzhou University, Lanzhou 730000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiayi","family":"Chen","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Lanzhou University, Lanzhou 730000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shahab","family":"Uddin","sequence":"additional","affiliation":[{"name":"Institute of Microbiology, School of Life Sciences, Lanzhou University, Lanzhou 730000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Li","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Lanzhou University, Lanzhou 730000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Lanzhou University, Lanzhou 730000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongyu","family":"Li","sequence":"additional","affiliation":[{"name":"Institute of Microbiology, School of Life Sciences, Lanzhou University, Lanzhou 730000, China"},{"name":"School of Pharmacy, Lanzhou University, Lanzhou 730000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"163","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"1) Wang Z-Y, Chen Z. Acute promyelocytic leukemia: from highly fatal to highly curable. <i>Blood<\/i>, <b>111<\/b>, 2505\u20132515 (2008).","DOI":"10.1182\/blood-2007-07-102798"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2) Callens C, Coulon S, Naudin J, <i>et al<\/i>. Targeting iron homeostasis induces cellular differentiation and synergizes with differentiating agents in acute myeloid leukemia. <i>J. Exp. Med.<\/i>, <b>207<\/b>, 731\u2013750 (2010).","DOI":"10.1084\/jem.20091488"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3) Tang X, Wang Y, Zhu Y, Guo Y, Liu B. Basic mechanisms and novel potential therapeutic targets for ferroptosis in acute myeloid leukemia. <i>Ann. Hematol.<\/i>, <b>102<\/b>, 1985\u20131999 (2023).","DOI":"10.1007\/s00277-023-05293-4"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4) Yu Y, Xie Y, Cao L, Yang L, Yang M, Lotze MT, Zeh HJ, Kang R, Tang D. The ferroptosis inducer erastin enhances sensitivity of acute myeloid leukemia cells to chemotherapeutic agents. <i>Mol. Cell. Oncol.<\/i>, <b>2<\/b>, e1054549 (2015).","DOI":"10.1080\/23723556.2015.1054549"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5) Kumar S, Yedjou CG, Tchounwou PB. Arsenic trioxide induces oxidative stress, DNA damage, and mitochondrial pathway of apoptosis in human leukemia (HL-60) cells. <i>J. Exp. Clin. Cancer Res.<\/i>, <b>33<\/b>, 42 (2014).","DOI":"10.1186\/1756-9966-33-42"},{"key":"6","unstructured":"6) Zhang P, Wang SY, Hu LH, Shi FD, Liu YP. Arsenic trioxide treated 72 cases of acute promyelocytic leukemia. <i>Zhonghua Xue Ye Xue Za Zhi,<\/i> <b>17<\/b>, 58\u201360 (1996)."},{"key":"7","doi-asserted-by":"crossref","unstructured":"7) Lu D-P, Wang Q. Current study of APL treatment in China. <i>Int. J. Hematol.<\/i>, <b>76<\/b> (Suppl 1), 316\u2013318 (2002).","DOI":"10.1007\/BF03165273"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8) Fan L, Zhang Y, Shi D, Xi R, Zhang Z, Wang X. Hypoxia enhances the cytotoxic effect of As<sub>4<\/sub>S<sub>4<\/sub> on rat ventricular H9c2 cells through activation of ubiquitin-proteasome system. <i>J. Trace Elem. Med. Biol.<\/i>, <b>66<\/b>, 1\u20138 (2021).","DOI":"10.1016\/j.jtemb.2021.126720"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9) Liu J, Wei L-X, Wang Q, Lu Y-F, Zhang F, Shi J-Z, Li C, Cherian MG. A review of cinnabar (HgS) and\/or realgar (As<sub>4<\/sub>S<sub>4<\/sub>)-containing traditional medicines. <i>J. Ethnopharmacol.<\/i>, <b>210<\/b>, 340\u2013350 (2018).","DOI":"10.1016\/j.jep.2017.08.037"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10) Zhang X, Xie Q, Wang X, Wang B, Li H-Y. Biological extraction of realgar by <i>Acidithiobacillus ferrooxidans<\/i> and its <i>in vitro<\/i> and <i>in vivo<\/i> antitumor activities. <i>Pharm. Biol.<\/i>, <b>48<\/b>, 40\u201347 (2010).","DOI":"10.3109\/13880200903029381"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11) Song P, Chen P, Wang D, Wu Z, Gao Q, Wang A, Zhu R, Wang Y, Wang X, Zhao L, Duan Z, Zhu S, Cui P, Li Y, Li H. Realgar transforming solution displays anticancer potential against human hepatocellular carcinoma HepG2 cells by inducing ROS. <i>Int. J. Oncol.<\/i>, <b>50<\/b>, 660\u2013670 (2017).","DOI":"10.3892\/ijo.2016.3831"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12) Wang X, Zhang X, Xu Z, Wang Z, Yue X, Li H. Reversal effect of arsenic sensitivity in human leukemia cell line K562 and K562\/ADM using realgar transforming solution. <i>Biol. Pharm. Bull.<\/i>, <b>36<\/b>, 641\u2013648 (2013).","DOI":"10.1248\/bpb.b12-01015"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13) Wang X, Chen B, Zhao L, Zhi D, Hai Y, Song P, Li Y, Xie Q, Inam U, Wu Z, Yu L, Li H. Autophagy enhanced antitumor effect in K562 and K562\/ADM cells using realgar transforming solution. <i>Biomed. Pharmacother.<\/i>, <b>98<\/b>, 252\u2013264 (2018).","DOI":"10.1016\/j.biopha.2017.12.038"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14) Hai Y, Wang X, Song P, Li JY, Zhao LH, Xie F, Tan XM, Xie QJ, Yu L, Li Y, Wu ZR, Li HY. Realgar transforming solution-induced differentiation of NB4 cell by the degradation of PML\/RARalpha partially through the ubiquitin-proteasome pathway. <i>Arch. Pharm. Res.<\/i>, <b>42<\/b>, 684\u2013694 (2019).","DOI":"10.1007\/s12272-019-01170-9"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15) Hai Y, Song P, Wang X, Zhao L, Xie Q, Li J, Li Y, Li H. Realgar transforming solution as a novel arsenic agent with a lower risk of cardiotoxicity. <i>J. Pharmacol. Sci.<\/i>, <b>140<\/b>, 162\u2013170 (2019).","DOI":"10.1016\/j.jphs.2019.06.003"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16) Chen X, Yu C, Kang R, Tang D. Iron metabolism in ferroptosis. <i>Front. Cell Dev. Biol.<\/i>, <b>8<\/b>, 590226 (2020).","DOI":"10.3389\/fcell.2020.590226"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17) Chang LC, Chiang SK, Chen SE, Yu YL, Chou RH, Chang WC. Heme oxygenase-1 mediates BAY 11-7085 induced ferroptosis. <i>Cancer Lett.<\/i>, <b>416<\/b>, 124\u2013137 (2018).","DOI":"10.1016\/j.canlet.2017.12.025"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18) Liu Q, Wang M, Hu Y, Xing H, Chen X, Zhang Y, Zhu P. Significance of CD71 expression by flow cytometry in diagnosis of acute leukemia. <i>Leuk. Lymphoma<\/i>, <b>55<\/b>, 892\u2013898 (2014).","DOI":"10.3109\/10428194.2013.819100"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19) Benadiba J, Rosilio C, Nebout M, Heimeroth V, Neffati Z, Popa A, Mary D, Griessinger E, Imbert V, Sirvent N, Peyron JF. Iron chelation: an adjuvant therapy to target metabolism, growth and survival of murine PTEN-deficient T lymphoma and human T lymphoblastic leukemia\/lymphoma. <i>Leuk. Lymphoma<\/i>, <b>58<\/b>, 1433\u20131445 (2017).","DOI":"10.1080\/10428194.2016.1239257"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20) Wang F, Lv H, Zhao B, Zhou L, Wang S, Luo J, Liu J, Shang P. Iron and leukemia: new insights for future treatments. <i>J. Exp. Clin. Cancer Res.<\/i>, <b>38<\/b>, 406 (2019).","DOI":"10.1186\/s13046-019-1397-3"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21) Wermke M, Schmidt A, Middeke JM, Sockel K, von Bonin M, Sch\u00f6nefeldt C, Mair S, Plodeck V, Laniado M, Weiss G, Schetelig J, Ehninger G, Theurl I, Bornh\u00e4user M, Platzbecker U. MRI-based liver iron content predicts for nonrelapse mortality in MDS and AML patients undergoing allogeneic stem cell transplantation. <i>Clin. Cancer Res.<\/i>, <b>18<\/b>, 6460\u20136468 (2012).","DOI":"10.1158\/1078-0432.CCR-12-1683"},{"key":"22","doi-asserted-by":"crossref","unstructured":"22) Tachibana T, Andou T, Tanaka M, <i>et al<\/i>. Clinical significance of serum ferritin at diagnosis in patients with acute myeloid leukemia: a YACHT multicenter retrospective study. <i>Clin. Lymphoma Myeloma Leuk.<\/i>, <b>18<\/b>, 415\u2013421 (2018).","DOI":"10.1016\/j.clml.2018.03.009"},{"key":"23","doi-asserted-by":"crossref","unstructured":"23) Weber S, Parmon A, Kurrle N, Schn\u00fctgen F, Serve H. The clinical significance of iron overload and iron metabolism in myelodysplastic syndrome and acute myeloid leukemia. <i>Front. Immunol.<\/i>, <b>11<\/b>, 627662 (2021).","DOI":"10.3389\/fimmu.2020.627662"},{"key":"24","doi-asserted-by":"crossref","unstructured":"24) Liu X, Hai Y, Dong J, Xu L, Hou W, Su J, Ren W, Liu D. Realgar-induced KRAS mutation lung cancer cell death <i>via<\/i> KRAS\/Raf\/MAPK mediates ferroptosis. <i>Int. J. Oncol.<\/i>, <b>61<\/b>, 157 (2022).","DOI":"10.3892\/ijo.2022.5447"},{"key":"25","unstructured":"25) Commission CP. <i>Chinese Pharmacopoeia<\/i>. China Pharmaceutical Science and Technology Press, Beijing (2020)."},{"key":"26","doi-asserted-by":"crossref","unstructured":"26) Zhang J, Zhang X, Ni Y, Yang X, Li H. Bioleaching of arsenic from medicinal realgar by pure and mixed cultures. <i>Process Biochem.<\/i>, <b>42<\/b>, 1265\u20131271 (2007).","DOI":"10.1016\/j.procbio.2007.05.021"},{"key":"27","doi-asserted-by":"crossref","unstructured":"27) Chen P, Xu R, Yan L, Wu Z, Wei Y, Zhao W, Wang X, Xie Q, Li H. Properties of realgar bioleaching using an extremely acidophilic bacterium and its antitumor mechanism as an anticancer agent. <i>Biol. Res.<\/i>, <b>50<\/b>, 17 (2017).","DOI":"10.1186\/s40659-017-0122-y"},{"key":"28","doi-asserted-by":"crossref","unstructured":"28) Doncheva NT, Morris JH, Gorodkin J, Jensen LJ. Cytoscape StringApp: network analysis and visualization of proteomics data. <i>J. Proteome Res.<\/i>, <b>18<\/b>, 623\u2013632 (2018).","DOI":"10.1021\/acs.jproteome.8b00702"},{"key":"29","doi-asserted-by":"crossref","unstructured":"29) Zhu X, Wang X, Zhu B, Ding S, Shi H, Yang X. Disruption of histamine\/H1R-STAT3-SLC7A11 axis exacerbates doxorubicin-induced cardiac ferroptosis. <i>Free Radic. Biol. Med.<\/i>, <b>192<\/b>, 98\u2013114 (2022).","DOI":"10.1016\/j.freeradbiomed.2022.09.012"},{"key":"30","doi-asserted-by":"crossref","unstructured":"30) Wang Z, Shen N, Wang Z, Yu L, Yang S, Wang Y, Liu Y, Han G, Zhang Q. TRIM3 facilitates ferroptosis in non-small cell lung cancer through promoting SLC7A11\/xCT K11-linked ubiquitination and degradation. <i>Cell Death Differ.<\/i>, <b>31<\/b>, 53\u201364 (2023).","DOI":"10.1038\/s41418-023-01239-5"},{"key":"31","doi-asserted-by":"crossref","unstructured":"31) Zhang Y, Wu W, An P, Yu Z. Kaempferol inhibits ferroptosis in lung epithelial cells in LPS-induced acute lung injury <i>via<\/i> m5C methylation of TFRC. <i>Biol. Pharm. Bull.<\/i>, <b>48<\/b>, 1343\u20131350 (2025).","DOI":"10.1248\/bpb.b25-00114"},{"key":"32","doi-asserted-by":"crossref","unstructured":"32) Catanzaro E, Turrini E, Kerre T, Sioen S, Baeyens A, Guerrini A, Bellau MLA, Sacchetti G, Paganetto G, Krysko DV, Fimognari C. Perillaldehyde is a new ferroptosis inducer with a relevant clinical potential for acute myeloid leukemia therapy. <i>Biomed. Pharmacother.<\/i>, <b>154<\/b>, 113662 (2022).","DOI":"10.1016\/j.biopha.2022.113662"},{"key":"33","doi-asserted-by":"crossref","unstructured":"33) Li H-Y, Wei T-T, Zhuang M, Tan C-Y, Xie T-H, Cai J, Yao Y, Zhu L. Iron derived from NCOA4-mediated ferritinophagy causes cellular senescence <i>via<\/i> the cGAS-STING pathway. <i>Cell Death Discov.<\/i>, <b>9<\/b>, 419 (2023).","DOI":"10.1038\/s41420-023-01712-7"},{"key":"34","unstructured":"34) Zhang J, Fan Q, Li H. Pharmacokinetics of bacteria bioleaching solution of realgar in rat. <i>Yao Xue Xue Bao<\/i>, <b>45<\/b>, 1279\u20131284 (2010)."},{"key":"35","doi-asserted-by":"crossref","unstructured":"35) Xie QJ, Cao XL, Bai L, Wu ZR, Ma YP, Li HY. Anti-tumor effects and apoptosis induction by Realgar bioleaching solution in Sarcoma-180 cells <i>in vitro<\/i> and transplanted tumors in mice in vivo. <i>Asian Pac. J. Cancer Prev.<\/i>, <b>15<\/b>, 2883\u20132888 (2014).","DOI":"10.7314\/APJCP.2014.15.6.2883"},{"key":"36","doi-asserted-by":"crossref","unstructured":"36) Han C, Zheng J, Li F, Guo W, Cai C. Novel prognostic signature for acute myeloid leukemia: bioinformatics analysis of combined CNV-driven and ferroptosis-related genes. <i>Front. Genet.<\/i>, <b>13<\/b>, 849437 (2022).","DOI":"10.3389\/fgene.2022.849437"},{"key":"37","doi-asserted-by":"crossref","unstructured":"37) Sun B, Zhang L, Wu B, Luo X. A morpholine derivative N-(4-morpholinomethylene) ethanesulfonamide induces ferroptosis in tumor cells by targeting NRF2. <i>Biol. Pharm. Bull.<\/i>, <b>47<\/b>, 417\u2013426 (2024).","DOI":"10.1248\/bpb.b23-00544"},{"key":"38","doi-asserted-by":"crossref","unstructured":"38) Akagi T, Shih L-Y, Kato M, Kawamata N, Yamamoto G, Sanada M, Okamoto R, Miller CW, Liang D-C, Ogawa S, Koeffler HP. Hidden abnormalities and novel classification of t(15;17) acute promyelocytic leukemia (APL) based on genomic alterations. <i>Blood<\/i>, <b>113<\/b>, 1741\u20131748 (2009).","DOI":"10.1182\/blood-2007-12-130260"},{"key":"39","doi-asserted-by":"crossref","unstructured":"39) Dongiovanni P, Valenti L, Ludovica Fracanzani A, Gatti S, Cairo G, Fargion S. Iron depletion by deferoxamine up-regulates glucose uptake and insulin signaling in hepatoma cells and in rat liver. <i>Am. J. Pathol.<\/i>, <b>172<\/b>, 738\u2013747 (2008).","DOI":"10.2353\/ajpath.2008.070097"},{"key":"40","doi-asserted-by":"crossref","unstructured":"40) Toyokuni S. Role of iron in carcinogenesis: cancer as a ferrotoxic disease. <i>Cancer Sci.<\/i>, <b>100<\/b>, 9\u201316 (2009).","DOI":"10.1111\/j.1349-7006.2008.01001.x"},{"key":"41","doi-asserted-by":"crossref","unstructured":"41) Dixon SJ, Lemberg KM, Lamprecht MR, Skouta R, Zaitsev EM, Gleason CE, Patel DN, Bauer AJ, Cantley AM, Yang WS, Morrison B 3rd, Stockwell BR. Ferroptosis: an iron-dependent form of nonapoptotic cell death. <i>Cell<\/i>, <b>149<\/b>, 1060\u20131072 (2012).","DOI":"10.1016\/j.cell.2012.03.042"},{"key":"42","doi-asserted-by":"crossref","unstructured":"42) Kennedy AE, Kamdar KY, Lupo PJ, Okcu MF, Scheurer ME, Baum MK, Dorak MT. Examination of HFE associations with childhood leukemia risk and extension to other iron regulatory genes. <i>Leuk. Res.<\/i>, <b>38<\/b>, 1055\u20131060 (2014).","DOI":"10.1016\/j.leukres.2014.06.016"},{"key":"43","doi-asserted-by":"crossref","unstructured":"43) Chen J, Jin Z, Zhang S, Zhang X, Li P, Yang H, Ma Y. Arsenic trioxide elicits prophylactic and therapeutic immune responses against solid tumors by inducing necroptosis and ferroptosis. <i>Cell. Mol. Immunol.<\/i>, <b>20<\/b>, 51\u201364 (2023).","DOI":"10.1038\/s41423-022-00956-0"},{"key":"44","doi-asserted-by":"crossref","unstructured":"44) Liang S, Huang G, Fu M, Shi Y, Tu X, Lin W, Tian J, Zhai X, Cheng B. Arsenic trioxide enhances the inhibitory effect of lenvatinib on hepatocellular carcinoma through HMOX1-mediated ferroptosis. <i>Int. Immunopharmacol.<\/i>, <b>167<\/b>, 115656 (2025).","DOI":"10.1016\/j.intimp.2025.115656"},{"key":"45","doi-asserted-by":"crossref","unstructured":"45) Song P, Hai Y, Wang X, Zhao L, Chen B, Cui P, Xie Q, Yu L, Li Y, Wu Z, Li H. Realgar transforming solution suppresses angiogenesis and tumor growth by inhibiting VEGF receptor 2 signaling in vein endothelial cells. <i>Arch. Pharm. Res.<\/i>, <b>41<\/b>, 467\u2013480 (2018).","DOI":"10.1007\/s12272-018-1014-6"},{"key":"46","doi-asserted-by":"crossref","unstructured":"46) Zhi DJ, Feng N, Liu DL, Hou RL, Wang MZ, Ding XX, Li HY. Realgar bioleaching solution suppress ras excessive activation by increasing ROS in Caenorhabditis elegans. <i>Arch. Pharm. Res.<\/i>, <b>37<\/b>, 390\u2013398 (2014).","DOI":"10.1007\/s12272-013-0182-7"},{"key":"47","doi-asserted-by":"crossref","unstructured":"47) Tang D, Chen X, Kang R, Kroemer G. Ferroptosis: molecular mechanisms and health implications. <i>Cell Res.<\/i>, <b>31<\/b>, 107\u2013125 (2021).","DOI":"10.1038\/s41422-020-00441-1"},{"key":"48","doi-asserted-by":"crossref","unstructured":"48) Zukor H, Song W, Liberman A, Mui J, Vali H, Fillebeen C, Pantopoulos K, Wu TD, Guerquin-Kern JL, Schipper HM. HO-1-mediated macroautophagy: a mechanism for unregulated iron deposition in aging and degenerating neural tissues. <i>J. Neurochem.<\/i>, <b>109<\/b>, 776\u2013791 (2009).","DOI":"10.1111\/j.1471-4159.2009.06007.x"},{"key":"49","doi-asserted-by":"crossref","unstructured":"49) Lanceta L, Li C, Choi AM, Eaton JW. Haem oxygenase-1 overexpression alters intracellular iron distribution. <i>Biochem. J.<\/i>, <b>449<\/b>, 189\u2013194 (2013).","DOI":"10.1042\/BJ20120936"},{"key":"50","doi-asserted-by":"crossref","unstructured":"50) Moog-Lutz C, Peterson EJ, Lutz PG, Eliason S, Cav\u00e9-Riant F, Singer A, Di Gioia Y, Dmowski S, Kamens J, Cayre YE, Koretzky G. PRAM-1 is a novel adaptor protein regulated by retinoic acid (RA) and promyelocytic leukemia (PML)-RA receptor \u03b1 in acute promyelocytic leukemia cells. <i>J. Biol. Chem.<\/i>, <b>276<\/b>, 22375\u201322381 (2001).","DOI":"10.1074\/jbc.M011683200"},{"key":"51","doi-asserted-by":"crossref","unstructured":"51) Stockwell BR. Ferroptosis turns 10: emerging mechanisms, physiological functions, and therapeutic applications. <i>Cell<\/i>, <b>185<\/b>, 2401\u20132421 (2022).","DOI":"10.1016\/j.cell.2022.06.003"},{"key":"52","doi-asserted-by":"crossref","unstructured":"52) Hassannia B, Vandenabeele P, Vanden Berghe T. Targeting ferroptosis to iron out cancer. <i>Cancer Cell<\/i>, <b>35<\/b>, 830\u2013849 (2019).","DOI":"10.1016\/j.ccell.2019.04.002"},{"key":"53","doi-asserted-by":"crossref","unstructured":"53) Huang P, Feng L, Oldham EA, Keating MJ, Plunkett W. Superoxide dismutase as a target for the selective killing of cancer cells. <i>Nature<\/i>, <b>407<\/b>, 390\u2013395 (2000).","DOI":"10.1038\/35030140"},{"key":"54","doi-asserted-by":"crossref","unstructured":"54) Badgley MA, Kremer DM, Maurer CH, <i>et al<\/i>. Cysteine depletion induces pancreatic tumor ferroptosis in mice. <i>Science<\/i>, <b>368<\/b>, 85\u201389 (2020).","DOI":"10.1126\/science.aaw9872"},{"key":"55","doi-asserted-by":"crossref","unstructured":"55) Li H, Liu W, Zhang X, Wu F, Sun D, Wang Z. Ketamine suppresses proliferation and induces ferroptosis and apoptosis of breast cancer cells by targeting KAT5\/GPX4 axis. <i>Biochem. Biophys. Res. Commun.<\/i>, <b>585<\/b>, 111\u2013116 (2021).","DOI":"10.1016\/j.bbrc.2021.11.029"},{"key":"56","doi-asserted-by":"crossref","unstructured":"56) Gong D, Chen M, Wang Y, Shi J, Hou Y. Role of ferroptosis on tumor progression and immunotherapy. <i>Cell Death Discov.<\/i>, <b>8<\/b>, 427 (2022).","DOI":"10.1038\/s41420-022-01218-8"},{"key":"57","doi-asserted-by":"crossref","unstructured":"57) Liu W, Wang L, Liu C, Dai Z, Li T, Tang B. Edaravone ameliorates cerebral ischemia-reperfusion injury by downregulating ferroptosis via the Nrf2\/FPN pathway in rats. <i>Biol. Pharm. Bull.<\/i>, <b>45<\/b>, 1269\u20131275 (2022).","DOI":"10.1248\/bpb.b22-00186"},{"key":"58","doi-asserted-by":"crossref","unstructured":"58) Sun X, Ou Z, Chen R, Niu X, Chen D, Kang R, Tang D. Activation of the p62-Keap1-NRF2 pathway protects against ferroptosis in hepatocellular carcinoma cells. <i>Hepatology<\/i>, <b>63<\/b>, 173\u2013184 (2016).","DOI":"10.1002\/hep.28251"},{"key":"59","doi-asserted-by":"crossref","unstructured":"59) Arosio P, Carmona F, Gozzelino R, Maccarinelli F, Poli M. The importance of eukaryotic ferritins in iron handling and cytoprotection. <i>Biochem. J.<\/i>, <b>472<\/b>, 1\u201315 (2015).","DOI":"10.1042\/BJ20150787"},{"key":"60","doi-asserted-by":"crossref","unstructured":"60) Bogdan AR, Miyazawa M, Hashimoto K, Tsuji Y. Regulators of iron homeostasis: new players in metabolism, cell death, and disease. <i>Trends Biochem. Sci.<\/i>, <b>41<\/b>, 274\u2013286 (2016).","DOI":"10.1016\/j.tibs.2015.11.012"},{"key":"61","doi-asserted-by":"crossref","unstructured":"61) Drakesmith H, Nemeth E, Ganz T. Ironing out ferroportin. <i>Cell Metab.<\/i>, <b>22<\/b>, 777\u2013787 (2015).","DOI":"10.1016\/j.cmet.2015.09.006"}],"container-title":["Biological and Pharmaceutical Bulletin"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/bpb\/49\/9\/49_b26-00225\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T03:26:40Z","timestamp":1789183600000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/bpb\/49\/9\/49_b26-00225\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,10]]},"references-count":61,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2026]]}},"URL":"https:\/\/doi.org\/10.1248\/bpb.b26-00225","relation":{},"ISSN":["0918-6158","1347-5215"],"issn-type":[{"value":"0918-6158","type":"print"},{"value":"1347-5215","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,10]]},"article-number":"b26-00225"}}