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Simpson MTW, Beyea JA. Pharyngitis: Approach to diagnosis and treatment. <i>Can. Fam. Physician<\/i>, <b>66<\/b>, 251\u2013257 (2020)."},{"key":"2","doi-asserted-by":"crossref","unstructured":"2) Cots JM, Al\u00f3s JI, B\u00e1rcena M, Boleda X, Ca\u00f1ada JL, G\u00f3mez N, Mendoza A, Vilaseca I, Llor C. Recommendations for management of acute pharyngitis in adults. <i>Acta Otorrinolaringol. Esp.<\/i>, <b>66<\/b>, 159\u2013170 (2015).","DOI":"10.1016\/j.otoeng.2015.05.003"},{"key":"3","unstructured":"3) Jiang QS, Li SY. Clinical observation on the therapeutic effect of Houyanqing Oral Liquid in the treatment of acute pharyngitis. <i>Mod. Med. Health Res<\/i>., <b>7<\/b>, 92\u201395 (2023)."},{"key":"4","doi-asserted-by":"crossref","unstructured":"4) Wei J, Sun J, Zeng J, Ji E, Xu J, Tang C, Huo H, Zhang Y, Li H, Yang H. Precise investigation of the efficacy of multicomponent drugs against pneumonia infected with influenza virus. <i>Front. Pharmacol.<\/i>, <b>12<\/b>, 604009 (2021).","DOI":"10.3389\/fphar.2021.604009"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5) Kobayashi EH, Suzuki T, Funayama R, Nagashima T, Hayashi M, Sekine H, Tanaka N, Moriguchi T, Motohashi H, Nakayama K, Yamamoto M. Nrf2 suppresses macrophage inflammatory response by blocking proinflammatory cytokine transcription. <i>Nat. Commun.<\/i>, <b>7<\/b>, 11624 (2016).","DOI":"10.1038\/ncomms11624"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6) Yu H, Lin L, Zhang Z, Zhang H, Hu H. Targeting NF-\u03baB pathway for the therapy of diseases: mechanism and clinical study. <i>Signal Transduct. Target. Ther.<\/i>, <b>5<\/b>, 209 (2020).","DOI":"10.1038\/s41392-020-00312-6"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7) Bellezza I, Giambanco I, Minelli A, Donato R. Nrf2-Keap1 signaling in oxidative and reductive stress. <i>Biochim. Biophys. Acta Mol. Cell Res.<\/i>, <b>1865<\/b>, 721\u2013733 (2018).","DOI":"10.1016\/j.bbamcr.2018.02.010"},{"key":"8","unstructured":"8) Zhang H, Wang YF, Tang CY, Zhang JQ, Wang XL, Li D, Liu SQ, Tu HY, Li SX, Ouyang W. Mechanism of houyanqing in treating pharyngitis based on network pharmacology and experimental verification. <i>World Sci. Technol.-. Mod. Tradit. Chin. Med. Mater. Med.<\/i>, <b>25<\/b>, 1714\u20131728 (2023)."},{"key":"9","doi-asserted-by":"crossref","unstructured":"9) Xu M, Hu TY, Li DC, Ma L, Zhang H, Fan JT, Fan XM, Zeng XH, Qiu SQ, Liu ZQ, Cheng BH. Yan-Hou-Qing formula attenuates ammonia-induced acute pharyngitis in rats <i>via<\/i> inhibition of NF-\u03baB and COX-2. <i>BMC Complement. Med. Ther.<\/i>, <b>20<\/b>, 280 (2020).","DOI":"10.1186\/s12906-020-03077-1"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10) Kan H, Zhang D, Chen W, Wang S, He Z, Pang S, Qu S, Wang Y. Identification of anti-inflammatory components in <i>Panax ginseng<\/i> of Sijunzi Decoction based on spectrum-effect relationship. <i>Chin. Herb. Med.<\/i>, <b>15<\/b>, 123\u2013131 (2023).","DOI":"10.1016\/j.chmed.2022.04.003"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11) Xu T, Li X, Huang M, Wang Q, Li C, Tian G, Chen Y, Xu R. A Preferable approach for the quality control of Xiaoer Chiqiao Qingre granules based on the combination of chromatographic fingerprints and chemometrics. <i>J. Anal. Methods Chem.<\/i>, <b>2020<\/b>, 6836981 (2020).","DOI":"10.1155\/2020\/6836981"},{"key":"12","unstructured":"12) Chen Y, Chen M, Wang J, Li Y, Zhang X, Xu F, Xiao W, Wu YJ. Identification of key process parameters of Chinese materia medica production process based on grey relation analysis. <i>Chin. Tradit. Herbal Drugs<\/i>, <b>50<\/b>, 582\u2013587 (2019)."},{"key":"13","doi-asserted-by":"crossref","unstructured":"13) Megha KB, Joseph X, Akhil V, Mohanan PV. Cascade of immune mechanism and consequences of inflammatory disorders. <i>Phytomedicine<\/i>, <b>91<\/b>, 153712 (2021).","DOI":"10.1016\/j.phymed.2021.153712"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14) Fiebich BL, H\u00fcll M, Lieb K, Gyufko K, Berger M, Bauer J. Prostaglandin E<sub>2<\/sub> induces interleukin-6 synthesis in human astrocytoma cells. <i>J. Neurochem.<\/i>, <b>68<\/b>, 704\u2013709 (1997).","DOI":"10.1046\/j.1471-4159.1997.68020704.x"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15) Pang Y, Liu X, Zhao C, Shi X, Zhang J, Zhou T, Xiong H, Gao X, Zhao X, Yang X, Ning G, Zhang X, Feng S, Yao X. LC-MS\/MS-based arachidonic acid metabolomics in acute spinal cord injury reveals the upregulation of 5-LOX and COX-2 products. <i>Free Radic. Biol. Med.<\/i>, <b>193<\/b>, 363\u2013372 (2022).","DOI":"10.1016\/j.freeradbiomed.2022.10.303"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16) Hu Y, Wang P, Han K. Hydrogen attenuated inflammation response and oxidative in hypoxic ischemic encephalopathy <i>via<\/i> Nrf2 mediated the inhibition of NLRP3 and NF-\u03baB. <i>Neuroscience<\/i>, <b>485<\/b>, 23\u201336 (2022).","DOI":"10.1016\/j.neuroscience.2021.12.024"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17) Sivandzade F, Prasad S, Bhalerao A, Cucullo L. NRF2 and NF-\u03baB interplay in cerebrovascular and neurodegenerative disorders: Molecular mechanisms and possible therapeutic approaches. <i>Redox Biol.<\/i>, <b>21<\/b>, 101059 (2019).","DOI":"10.1016\/j.redox.2018.11.017"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18) Yang L, Jiang H, Wang S, Hou AJ, Man WJ, Zhang JX, Guo XY, Yang BY, Kuang HX, Wang QH. Discovering the major antitussive, expectorant, and anti-inflammatory bioactive constituents in <i>Tussilago farfara L<\/i>. based on the spectrum-effect relationship combined with chemometrics. <i>Molecules<\/i>, <b>25<\/b>, 620 (2020).","DOI":"10.3390\/molecules25030620"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19) Rao SW, Duan YY, Pang HQ, Xu SH, Hu SQ, Cheng KG, Liang D, Shi W. Spectrum-effect relationship analysis of bioactive compounds in <i>Zanthoxylum nitidum<\/i> (Roxb.) DC. by ultra-high performance liquid chromatography mass spectrometry coupled with comprehensive filtering approaches. <i>Front. Pharmacol.<\/i>, <b>13<\/b>, 794277 (2022).","DOI":"10.3389\/fphar.2022.794277"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20) Xu N, Li M, Wang P, Wang S, Shi H. Spectrum-effect relationship between antioxidant and anti-inflammatory effects of Banxia Baizhu Tianma Decoction: an identification method of active substances with endothelial cell protective effect. <i>Front. Pharmacol.<\/i>, <b>13<\/b>, 823341 (2022).","DOI":"10.3389\/fphar.2022.823341"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21) Sun D, Han Y, Wang W, Wang Z, Ma X, Hou Y, Bai G. Screening and identification of Caulis Sinomenii bioactive ingredients with dual-target NF-\u03baB inhibition and \u03b2<sub>2<\/sub>- AR agonizing activities. <i>Biomed. Chromatogr.<\/i>, <b>30<\/b>, 1843\u20131853 (2016).","DOI":"10.1002\/bmc.3761"},{"key":"22","doi-asserted-by":"crossref","unstructured":"22) Gao W, Guo L, Yang Y, Wang Y, Xia S, Gong H, Zhang BK, Yan M. Dissecting the crosstalk between Nrf2 and NF-\u03baB response pathways in drug-induced toxicity. <i>Front. Cell Dev. Biol.<\/i>, <b>9<\/b>, 809952 (2022).","DOI":"10.3389\/fcell.2021.809952"},{"key":"23","unstructured":"23) Zhang X, Xie YM, Li GX, Gao Y, Zhao YC, Tang JJ, Yao XY, Li M. Advantages and problems of traditional Chinese medicine in treatment of acute pharyngitis. <i>Zhongguo Zhongyao Zazhi<\/i>, <b>42<\/b>, 3819\u20133825 (2017)."},{"key":"24","unstructured":"24) Li Y, Tao JH, Wang JY, Guo JB. Research progress in the treatment of acute pharyngitis with external therapy of traditional Chinese medicine. <i>Chin. J. Emerg. Tradit. Chin. Med<\/i>., <b>30<\/b>, 2065\u20132068 (2021)."},{"key":"25","unstructured":"25) Ye B, Sun WH. Clinical efficacy and safety of Houyanqing Oral Liquid combined with Kaihoujian Spray in the treatment of pediatric herpangina. <i>Linchuang Heli Yongyao Zazhi<\/i>, <b>21<\/b>, 51\u201354 (2021)."},{"key":"26","unstructured":"26) Xi JY, Wei ZY, Zhang Q, Xie YM. Clinical comprehensive evaluation of Houyanqing Oral Liquid in treatment of acute pharyngitis. <i>Zhongguo Zhongyao Zazhi<\/i>, <b>49<\/b>, 279\u2013284 (2024)."},{"key":"27","doi-asserted-by":"crossref","unstructured":"27) Ahmed SM, Luo L, Namani A, Wang XJ, Tang X. Nrf2 signaling pathway: Pivotal roles in inflammation. <i>Biochim. Biophys. Acta Mol. Basis Dis.<\/i>, <b>1863<\/b>, 585\u2013597 (2017).","DOI":"10.1016\/j.bbadis.2016.11.005"},{"key":"28","doi-asserted-by":"crossref","unstructured":"28) Ricciotti E, FitzGerald GA. Prostaglandins and inflammation. <i>Arterioscler. Thromb. Vasc. Biol.<\/i>, <b>31<\/b>, 986\u20131000 (2011).","DOI":"10.1161\/ATVBAHA.110.207449"},{"key":"29","doi-asserted-by":"crossref","unstructured":"29) Gim\u00e9nez-Bastida JA, Gonz\u00e1lez-Sarr\u00edas A, Esp\u00edn JC, Schneider C. Inhibition of 5-lipoxygenase-derived leukotrienes and hemiketals as a novel anti-inflammatory mechanism of urolithins. <i>Mol. Nutr. Food Res.<\/i>, <b>64<\/b>, 2000129 (2020).","DOI":"10.1002\/mnfr.202000129"},{"key":"30","doi-asserted-by":"crossref","unstructured":"30) Poligone B, Baldwin AS. Positive and negative regulation of NF-kappaB by COX-2: roles of different prostaglandins. <i>J. Biol. Chem.<\/i>, <b>276<\/b>, 38658\u201338664 (2001).","DOI":"10.1074\/jbc.M106599200"},{"key":"31","doi-asserted-by":"crossref","unstructured":"31) Gim\u00e9nez-Bastida JA, Gonz\u00e1lez-Sarr\u00edas A, Laparra-Llopis JM, Schneider C, Esp\u00edn JC. Targeting mammalian 5-lipoxygenase by dietary phenolics as an anti-inflammatory mechanism: a systematic review. <i>Int. J. Mol. Sci.<\/i>, <b>22<\/b>, 7937 (2021).","DOI":"10.3390\/ijms22157937"},{"key":"32","doi-asserted-by":"crossref","unstructured":"32) Liu Y, Liu Q, Chen D, Matsuura A, Xiang L, Qi J. Inokosterone from <i>Gentiana rigescens<\/i> Franch extends the longevity of yeast and mammalian cells <i>via<\/i> antioxidative stress and mitophagy induction. <i>Antioxidants<\/i>, <b>11<\/b>, 214 (2022).","DOI":"10.3390\/antiox11020214"},{"key":"33","doi-asserted-by":"crossref","unstructured":"33) Yan CP, Wang XK, Jiang K, Yin C, Xiang C, Wang Y, Pu C, Chen L, Li YL. \u03b2-Ecdysterone enhanced bone regeneration through the BMP-2\/SMAD\/RUNX2\/Osterix signaling pathway. <i>Front. Cell Dev. Biol.<\/i>, <b>10<\/b>, 883228 (2022).","DOI":"10.3389\/fcell.2022.883228"},{"key":"34","doi-asserted-by":"crossref","unstructured":"34) Sun J, Zhao K, Zhang W, Guo C, Liu H. Ecdysterone improves oxidative damage induced by acute ischemic stroke <i>via<\/i> inhibiting ferroptosis in neurons through ACSL4. <i>J. Ethnopharmacol.<\/i>, <b>331<\/b>, 118204 (2024).","DOI":"10.1016\/j.jep.2024.118204"},{"key":"35","doi-asserted-by":"crossref","unstructured":"35) Todorova V, Ivanova S, Chakarov D, Kraev K, Ivanov K. Ecdysterone and turkesterone-compounds with prominent potential in sport and healthy nutrition. <i>Nutrients<\/i>, <b>16<\/b>, 1382 (2024).","DOI":"10.3390\/nu16091382"},{"key":"36","doi-asserted-by":"crossref","unstructured":"36) Jin Z, Wang B, Ren L, Yang J, Zheng Z, Yao F, Ding R, Wang J, He J, Wang W, Nan G, Lin R. 20-Hydroxyecdysone inhibits inflammation <i>via<\/i> SIRT6-mediated NF-\u03baB signaling in endothelial cells. <i>Biochim. Biophys. Acta Mol. Cell Res.<\/i>, <b>1870<\/b>, 119460 (2023).","DOI":"10.1016\/j.bbamcr.2023.119460"},{"key":"37","doi-asserted-by":"crossref","unstructured":"37) Zhang X, Xu X, Xu T, Qin S. \u03b2-Ecdysterone suppresses interleukin-1\u03b2-induced apoptosis and inflammation in rat chondrocytes <i>via<\/i> inhibition of NF-\u03baB signaling pathway. <i>Drug Dev. Res.<\/i>, <b>75<\/b>, 195\u2013201 (2014).","DOI":"10.1002\/ddr.21170"},{"key":"38","doi-asserted-by":"crossref","unstructured":"38) Rong H, Li X, Yu C, Wang W, Li L, Xu T, Ding Y, Su Y, Wang X. Targeting the Nrf2-dependent mechanism of b-Ecdysterone in attenuating the motor dysfunction in the MPTP\/Pro-induced Parkinson\u2019s disease mice model. <i>Folia Neuropathol.<\/i>, <b>62<\/b>, 83\u201395 (2024).","DOI":"10.5114\/fn.2023.133039"},{"key":"39","doi-asserted-by":"crossref","unstructured":"39) Park C, Lee H, Kwon CY, Kim GY, Jeong JW, Kim SO, Choi SH, Jeong SJ, Noh JS, Choi YH. Loganin inhibits lipopolysaccharide-induced inflammation and oxidative response through the activation of the Nrf2\/HO-1 signaling pathway in RAW264.7 macrophages. <i>Biol. Pharm. Bull.<\/i>, <b>44<\/b>, 875\u2013883 (2021).","DOI":"10.1248\/bpb.b21-00176"},{"key":"40","doi-asserted-by":"crossref","unstructured":"40) Xu J, Xu S, Luo J, Zhang S, Wu D, Yang Q, Fang R, Shi C, Liu Q, Zhao J. Epigallocatechin-3-gallate alleviates ethanol-induced endothelia cells injury partly through alteration of NF-\u03baB translocation and activation of the Nrf2 signaling pathway. <i>Biol. Pharm. 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