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Bull."],"published-print":{"date-parts":[[2026,9,1]]},"DOI":"10.1248\/bpb.b26-00318","type":"journal-article","created":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T22:18:35Z","timestamp":1788214715000},"page":"1334-1351","source":"Crossref","is-referenced-by-count":0,"title":["Multifaceted Food Effects on Intestinal Drug Uptake Transporters: Mechanistic Insights from Small Molecules to Macromolecules"],"prefix":"10.1248","volume":"49","author":[{"given":"Ikumi","family":"Tamai","sequence":"first","affiliation":[{"name":"Faculty of Pharmaceutical Sciences, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"163","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"1) Tsuji A, Terasaki T, Takabatake Y, Tenda Y, Tamai I, Yamashima T, Moritani S, Tsuruo T, Yamashita J. P-glycoprotein as the drug efflux pump in primary cultured bovine brain capillary endothelial cells. <i>Life Sci.<\/i>, <b>51<\/b>, 1427\u20131437 (1992).","DOI":"10.1016\/0024-3205(92)90537-Y"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2) Terao T, Hisanaga E, Sai Y, Tamai I, Tsuji A. Active secretion of drugs from the small intestinal epithelium in rats by P-glycoprotein functioning as an absorption barrier. <i>J. Pharm. Pharmacol.<\/i>, <b>48<\/b>, 1083\u20131089 (1996).","DOI":"10.1111\/j.2042-7158.1996.tb05904.x"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3) Galetin A, Brouwer KLR, Tweedie D, <i>et al.<\/i> Membrane transporters in drug development and as determinants of precision medicine. <i>Nat. Rev. Drug Discov.<\/i>, <b>23<\/b>, 255\u2013280 (2024).","DOI":"10.1038\/s41573-023-00877-1"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4) Hosomi A, Nakanishi T, Fujita T, Tamai I. Extra-renal elimination of uric acid <i>via<\/i> intestinal efflux transporter BCRP\/ABCG2. <i>PLoS One<\/i>, <b>7<\/b>, e30456 (2012).","DOI":"10.1371\/journal.pone.0030456"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5) Tsuji A, Tamai I, Hirooka H, Terasaki T. Beta-lactam antibiotics and transport <i>via<\/i> the dipeptide carrier system across the intestinal brush-border membrane. <i>Biochem. Pharmacol.<\/i>, <b>36<\/b>, 565\u2013567 (1987).","DOI":"10.1016\/0006-2952(87)90369-8"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6) Tamai I, Tomizawa N, Kadowaki A, Terasaki T, Nakayama K, Higashida H, Tsuji A. Functional expression of intestinal dipeptide\/beta-lactam antibiotic transporter in <i>Xenopus laevis<\/i> oocytes. <i>Biochem. Pharmacol.<\/i>, <b>48<\/b>, 881\u2013888 (1994).","DOI":"10.1016\/0006-2952(94)90358-1"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7) Tsuji A, Tamai I. Carrier-mediated intestinal transport of drugs. <i>Pharm. Res.<\/i>, <b>13<\/b>, 963\u2013977 (1996).","DOI":"10.1023\/A:1016086003070"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8) Nozawa T, Toyobuku H, Kobayashi D, Kuruma K, Tsuji A, Tamai I. Enhanced intestinal absorption of drugs by activation of peptide transporter PEPT1 using proton-releasing polymer. <i>J. Pharm. Sci.<\/i>, <b>92<\/b>, 2208\u20132216 (2003).","DOI":"10.1002\/jps.10491"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9) Tsuji A, Simanjuntak MT, Tamai I, Terasaki T. pH-dependent intestinal transport of monocarboxylic acids: carrier-mediated and H<sup>+<\/sup>-cotransport mechanism <i>versus<\/i> pH-partition hypothesis. <i>J. Pharm. Sci.<\/i>, <b>79<\/b>, 1123\u20131124 (1990).","DOI":"10.1002\/jps.2600791217"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10) Tamai I, Takanaga H, Maeda H, Ogihara T, Yoneda M, Tsuji A. Proton-cotransport of pravastatin across intestinal brush-border membrane. <i>Pharm. Res.<\/i>, <b>12<\/b>, 1727\u20131732 (1995).","DOI":"10.1023\/A:1016269806840"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11) Tamai I, Takanaga H, Maeda H, Sai Y, Ogihara T, Higashida H, Tsuji A. Participation of a proton-cotransporter, MCT1, in the intestinal transport of monocarboxylic acids. <i>Biochem. Biophys. Res. Commun.<\/i>, <b>214<\/b>, 482\u2013489 (1995).","DOI":"10.1006\/bbrc.1995.2312"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12) Tamai I. How should we handle decreased efficacy caused by DDI on transporters for drug absorption and target-tissue distribution, but not associated with toxicity? <i>Drug Metab. Pharmacokinet.<\/i>, <b>28<\/b>, 451\u2013452 (2013).","DOI":"10.2133\/dmpk.DMPK-13-PF-906"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13) Nakanishi T, Tamai I. Interaction of drug or food with drug transporters in intestine and liver. <i>Curr. 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Interaction of citrus juices with felodipine and nifedipine. <i>Lancet<\/i>, <b>337<\/b>, 268\u2013269 (1991).","DOI":"10.1016\/0140-6736(91)90872-M"},{"key":"17","unstructured":"17) Guo LQ, Yamazoe Y. Inhibition of cytochromes P450 by furanocoumarins in grapefruit juice and herbal medicine. <i>Acta Pharmacol. Sin.<\/i>, <b>25<\/b>, 129\u2013136 (2004)."},{"key":"18","doi-asserted-by":"crossref","unstructured":"18) Bailey DG, Dresser G, Arnold JMO. Grapefruit-medication interactions: Forbidden fruit or avoidable consequences? <i>CMAJ<\/i>, <b>185<\/b>, 309\u2013316 (2013).","DOI":"10.1503\/cmaj.120951"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19) Vincent J, Harris SI, Foulds G, Dogolo LC, Willavize S, Friedman HL. Lack of effect of grapefruit juice on the pharmacokinetics and pharmacodynamics of amlodipine. <i>Br. J. Clin. Pharmacol.<\/i>, <b>50<\/b>, 455\u2013463 (2000).","DOI":"10.1046\/j.1365-2125.2000.00283.x"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20) D\u00fcrr D, Stieger B, Kullak-Ublick GA, Rentsch KM, Steinert HC, Meier PJ, Fattinger K. St John\u2019s Wort induces intestinal P-glycoprotein\/MDR1 and intestinal and hepatic CYP3A4. <i>Clin. Pharmacol. Ther.<\/i>, <b>68<\/b>, 598\u2013604 (2000).","DOI":"10.1067\/mcp.2000.112240"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21) Tian R, Koyabu N, Morimoto S, Shoyama Y, Ohtani H, Sawada Y. Functional induction and de-induction of P-glycoprotein by St. John\u2019s wort and its ingredients in a human colon adenocarcinoma cell line. <i>Drug Metab. Dispos.<\/i>, <b>33<\/b>, 547\u2013554 (2005).","DOI":"10.1124\/dmd.104.002485"},{"key":"22","doi-asserted-by":"crossref","unstructured":"22) Tamai I, Nezu J, Uchino H, Sai Y, Oku A, Shimane M, Tsuji A. Molecular identification and characterization of novel members of the human organic anion transporter (OATP) family. <i>Biochem. Biophys. Res. Commun.<\/i>, <b>273<\/b>, 251\u2013260 (2000).","DOI":"10.1006\/bbrc.2000.2922"},{"key":"23","doi-asserted-by":"crossref","unstructured":"23) Dresser GK, Bailey DG, Leake BF, Schwarz UI, Dawson PA, Freeman DJ, Kim RB. Fruit juices inhibit organic anion transporting polypeptide-mediated drug uptake to decrease the oral availability of fexofenadine. <i>Clin. Pharmacol. Ther.<\/i>, <b>71<\/b>, 11\u201320 (2002).","DOI":"10.1067\/mcp.2002.121152"},{"key":"24","doi-asserted-by":"crossref","unstructured":"24) Tamai I, Nozawa T, Koshida M, Nezu J, Sai Y, Tsuji A. Functional characterization of human organic anion transporting polypeptide B (OATP-B) in comparison with liver-specific OATP-C. <i>Pharm. Res.<\/i>, <b>18<\/b>, 1262\u20131269 (2001).","DOI":"10.1023\/A:1013077609227"},{"key":"25","doi-asserted-by":"crossref","unstructured":"25) Nozawa T, Nakajima M, Tamai I, Noda K, Nezu J, Sai Y, Tsuji A, Yokoi T. Genetic polymorphisms of human organic anion transporters OATP-C (SLC21A6) and OATP-B (SLC21A9): allele frequencies in the Japanese population and functional analysis. <i>J. Pharmacol. Exp. Ther.<\/i>, <b>302<\/b>, 804\u2013813 (2002).","DOI":"10.1124\/jpet.302.2.804"},{"key":"26","doi-asserted-by":"crossref","unstructured":"26) Kobayashi D, Nozawa T, Imai K, Nezu J, Tsuji A, Tamai I. Involvement of human organic anion transporting polypeptide OATP-B (SLC21A9) in pH-dependent transport across intestinal apical membrane. <i>J. Pharmacol. Exp. Ther.<\/i>, <b>306<\/b>, 703\u2013708 (2003).","DOI":"10.1124\/jpet.103.051300"},{"key":"27","doi-asserted-by":"crossref","unstructured":"27) Nozawa T, Imai K, Nezu J, Tsuji A, Tamai I. Functional characterization of pH-sensitive organic anion transporting polypeptide OATP-B in human. <i>J. Pharmacol. Exp. Ther.<\/i>, <b>308<\/b>, 438\u2013445 (2004).","DOI":"10.1124\/jpet.103.060194"},{"key":"28","doi-asserted-by":"crossref","unstructured":"28) Kikuchi A, Nozawa T, Wakasawa T, Maeda T, Tamai I. Transporter-mediated intestinal absorption of fexofenadine in rats. <i>Drug Metab. Pharmacokinet.<\/i>, <b>21<\/b>, 308\u2013314 (2006).","DOI":"10.2133\/dmpk.21.308"},{"key":"29","doi-asserted-by":"crossref","unstructured":"29) Tamai I. Oral drug delivery utilizing intestinal OATP transporters. <i>Adv. Drug Deliv. Rev.<\/i>, <b>64<\/b>, 508\u2013514 (2012).","DOI":"10.1016\/j.addr.2011.07.007"},{"key":"30","doi-asserted-by":"crossref","unstructured":"30) Nakanishi T, Tamai I. Genetic polymorphisms of OATP transporters and their impact on intestinal absorption and hepatic disposition of drugs. <i>Drug Metab. Pharmacokinet.<\/i>, <b>27<\/b>, 106\u2013121 (2012).","DOI":"10.2133\/dmpk.DMPK-11-RV-099"},{"key":"31","doi-asserted-by":"crossref","unstructured":"31) Imanaga J, Kotegawa T, Imai H, Tsutsumi K, Yoshizato T, Ohyama T, Shirasaka Y, Tamai I, Tateishi T, Ohashi K. The effects of the SLCO2B1 c.1457C\u2009&gt;\u2009T polymorphism and apple juice on the pharmacokinetics of fexofenadine and midazolam in humans. <i>Pharmacogenet. Genomics<\/i>, <b>21<\/b>, 84\u201393 (2011).","DOI":"10.1097\/FPC.0b013e32834300cc"},{"key":"32","doi-asserted-by":"crossref","unstructured":"32) Chen M, Hu S, Li Y, Gibson AA, Fu Q, Baker SD, Sparreboom A. Role of Oatp2b1 in drug absorption and drug\u2013drug interactions. <i>Drug Metab. Dispos.<\/i>, <b>48<\/b>, 419\u2013425 (2020).","DOI":"10.1124\/dmd.119.090316"},{"key":"33","doi-asserted-by":"crossref","unstructured":"33) Medwid S, Li MMJ, Knauer MJ, Lin K, Mansell SE, Schmerk CL, Zhu C, Griffin KE, Yousif MD, Dresser GK, Schwarz UI, Kim RB, Tirona RG. 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