{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T02:50:13Z","timestamp":1787021413120,"version":"build-2736575974"},"reference-count":48,"publisher":"Pharmaceutical Society of Japan","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Chem. Pharm. Bull.","CHEMICAL &amp; PHARMACEUTICAL BULLETIN"],"published-print":{"date-parts":[[2002]]},"DOI":"10.1248\/cpb.50.941","type":"journal-article","created":{"date-parts":[[2002,10,11]],"date-time":"2002-10-11T16:47:05Z","timestamp":1034354825000},"page":"941-959","source":"Crossref","is-referenced-by-count":15,"title":["Synthesis and Structure-Activity Relationships of 4-Amino-5-chloro-N-(1,4-dialkylhexahydro-1,4-diazepin-6-yl)-2-methoxybenzamide Derivatives, Novel and Potent Serotonin 5-HT3 and Dopamine D2 Receptors Dual Antagonist."],"prefix":"10.1248","volume":"50","author":[{"given":"Yoshimi","family":"Hirokawa","sequence":"first","affiliation":[{"name":"Medicinal Chemistry Group, Chemistry Research Laboratories, Dainippon Pharmaceutical Co. Ltd."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Harada","sequence":"additional","affiliation":[{"name":"Medicinal Chemistry Group, Chemistry Research Laboratories, Dainippon Pharmaceutical Co. Ltd."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Yoshikawa","sequence":"additional","affiliation":[{"name":"Discovery Pharmacology II Group, Pharmacolgy & Microbiology Research Laboratories, Dainippon Pharmaceutical Co. Ltd."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoyuki","family":"Yoshida","sequence":"additional","affiliation":[{"name":"Discovery Pharmacology II Group, Pharmacolgy & Microbiology Research Laboratories, Dainippon Pharmaceutical Co. Ltd."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiro","family":"Kato","sequence":"additional","affiliation":[{"name":"Medicinal Chemistry Group, Chemistry Research Laboratories, Dainippon Pharmaceutical Co. Ltd."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"163","reference":[{"key":"1","first-page":"631","volume":"47","author":"Briejer M. R., Akkermans L. M. A.,","year":"1995","journal-title":"Pharmcol. Rev."},{"issue":"2","key":"2","doi-asserted-by":"crossref","first-page":"81","DOI":"10.2165\/00003495-197612020-00001","volume":"12","author":"Pinder R. M., Brodgen R. N., Sawyer","year":"1976","journal-title":"Drugs","ISSN":"https:\/\/id.crossref.org\/issn\/0012-6667","issn-type":"print"},{"issue":"5","key":"3","doi-asserted-by":"crossref","first-page":"451","DOI":"10.2165\/00003495-198325050-00002","volume":"25","author":"Harrington R.A., Hamilton C.W., Bro","year":"1983","journal-title":"Drugs","ISSN":"https:\/\/id.crossref.org\/issn\/0012-6667","issn-type":"print"},{"key":"4","unstructured":"4) Imbert T., Dome N., Langlois M., EP 0099789-A1 (1984)."},{"key":"5","first-page":"335","volume":"91","author":"Fake C. S., King F. D., Sanger G. J","year":"1987","journal-title":"Br. J. Pharmacol. (Proc. Suppl.)","ISSN":"https:\/\/id.crossref.org\/issn\/0007-1188","issn-type":"print"},{"issue":"6","key":"6","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1021\/jm00058a004","volume":"36","year":"1993","journal-title":"J. Med. Chem.","ISSN":"https:\/\/id.crossref.org\/issn\/0022-2623","issn-type":"print"},{"issue":"8","key":"7","doi-asserted-by":"crossref","first-page":"1486","DOI":"10.1021\/jm00086a019","volume":"35","year":"1992","journal-title":"J. Med. Chem.","ISSN":"https:\/\/id.crossref.org\/issn\/0022-2623","issn-type":"print"},{"key":"8","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1358\/dof.1993.018.06.209477","volume":"18","author":"Yoshida N., Kato S., Ito T.","year":"1993","journal-title":"Drugs of Future","ISSN":"https:\/\/id.crossref.org\/issn\/0012-6667","issn-type":"print"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098-1128(199901)19:1<25::AID-MED3>3.0.CO;2-E"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1016\/S0968-0896(99)00281-3"},{"key":"11","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.1016\/S0140-6736(87)92159-3","volume":"1","author":"Leibundgut U., Lancranjan I.","year":"1987","journal-title":"Lancet","ISSN":"https:\/\/id.crossref.org\/issn\/0140-6736","issn-type":"print"},{"issue":"8548","key":"12","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.1016\/S0140-6736(87)92208-2","volume":"1","author":"Cunningham P., Pople A., Ford H. T.","year":"1987","journal-title":"Lancet","ISSN":"https:\/\/id.crossref.org\/issn\/0140-6736","issn-type":"print"},{"key":"13","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1016\/0165-6147(88)90106-X","volume":"9","author":"Andrew P. L. R., Rapeport W. G., Sa","year":"1988","journal-title":"Trends Pharmcol. Sci.","ISSN":"https:\/\/id.crossref.org\/issn\/0015-749X","issn-type":"print"},{"key":"14","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1093\/jnci\/83.9.613","volume":"83","author":"Hesketh P. J., Gandara D. R.","year":"1991","journal-title":"J. Natl. Cancer Inst.","ISSN":"https:\/\/id.crossref.org\/issn\/0027-8874","issn-type":"print"},{"key":"15","doi-asserted-by":"crossref","first-page":"948","DOI":"10.1056\/NEJM198110153051609","volume":"305","author":"Laszlo J., Lucas V. S., Jr.","year":"1981","journal-title":"Engl. J. Med.","ISSN":"https:\/\/id.crossref.org\/issn\/0025-7850","issn-type":"print"},{"issue":"2","key":"16","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1038\/sj.bjp.0704078","volume":"133","author":"YOSHIKAWA T","year":"2001","journal-title":"Br. J. Pharmacol.","ISSN":"https:\/\/id.crossref.org\/issn\/0007-1188","issn-type":"print"},{"issue":"5","key":"17","doi-asserted-by":"crossref","first-page":"360","DOI":"10.2165\/00003495-198224050-00002","volume":"24","author":"Brogden R.N., Carmine A.A., Heel R.","year":"1982","journal-title":"Drugs","ISSN":"https:\/\/id.crossref.org\/issn\/0012-6667","issn-type":"print"},{"key":"18","doi-asserted-by":"crossref","first-page":"1505","DOI":"10.1007\/BF01535938","volume":"33","author":"Davis R. H., Clench M. H., Mathiae","year":"1988","journal-title":"Dig. Dis. Sci.","ISSN":"https:\/\/id.crossref.org\/issn\/0163-2116","issn-type":"print"},{"issue":"1","key":"19","doi-asserted-by":"crossref","first-page":"136","DOI":"10.2165\/00003495-198734010-00005","volume":"34","author":"Triozzi P.L., Laszlo J.","year":"1987","journal-title":"Drugs","ISSN":"https:\/\/id.crossref.org\/issn\/0012-6667","issn-type":"print"},{"issue":"8","key":"20","doi-asserted-by":"crossref","first-page":"1364","DOI":"10.1248\/cpb.43.1364","volume":"43","author":"HARADA H","year":"1995","journal-title":"Chem. Pharm. Bull.","ISSN":"https:\/\/id.crossref.org\/issn\/0009-2363","issn-type":"print"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-894X(98)00258-3"},{"issue":"12","key":"22","doi-asserted-by":"crossref","first-page":"2205","DOI":"10.1248\/cpb.44.2205","volume":"44","author":"HARADA H","year":"1996","journal-title":"Chem. Pharm. Bull.","ISSN":"https:\/\/id.crossref.org\/issn\/0009-2363","issn-type":"print"},{"key":"23","first-page":"363","volume":"41","author":"Harada H., Hirokawa Y., Morie T., K","year":"1994","journal-title":"Heterocycles","ISSN":"https:\/\/id.crossref.org\/issn\/0385-5414","issn-type":"print"},{"issue":"23","key":"24","doi-asserted-by":"crossref","first-page":"3453","DOI":"10.1021\/jo00911a038","volume":"40","author":"Marchini P., Liso G., Reho A.","year":"1975","journal-title":"J. Org. Chem.","ISSN":"https:\/\/id.crossref.org\/issn\/0022-3263","issn-type":"print"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.1016\/S0957-4166(97)00248-6"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.1039\/c39900001275"},{"key":"27","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-894X(96)00497-0"},{"issue":"2","key":"28","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1021\/jm00106a023","volume":"34","year":"1991","journal-title":"J. Med. Chem.","ISSN":"https:\/\/id.crossref.org\/issn\/0022-2623","issn-type":"print"},{"issue":"1","key":"29","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1248\/cpb.46.42","volume":"46","author":"KAKIGAMI T","year":"1998","journal-title":"Chem. Pharm. Bull.","ISSN":"https:\/\/id.crossref.org\/issn\/0009-2363","issn-type":"print"},{"issue":"10","key":"30","doi-asserted-by":"crossref","first-page":"1224","DOI":"10.1021\/jm00142a019","volume":"24","author":"Iwanami S., Takashima M., Hirata Y.","year":"1981","journal-title":"J. Med. Chem.","ISSN":"https:\/\/id.crossref.org\/issn\/0022-2623","issn-type":"print"},{"issue":"19","key":"31","doi-asserted-by":"crossref","first-page":"4549","DOI":"10.1021\/jo00280a020","volume":"54","author":"Bengtsson S., H&ouml;gberg T.","year":"1989","journal-title":"J. Org. Chem.","ISSN":"https:\/\/id.crossref.org\/issn\/0022-3263","issn-type":"print"},{"key":"32","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(77)90232-1"},{"issue":"3","key":"33","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1111\/j.1476-5381.1993.tb13617.x","volume":"109","year":"1993","ISSN":"https:\/\/id.crossref.org\/issn\/0007-1188","issn-type":"print"},{"issue":"2","key":"34","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/0223-5234(89)90110-4","volume":"24","author":"Collin S., El Tayer N., Van de Wate","year":"1989","journal-title":"Eur. J. Med. Chem.","ISSN":"https:\/\/id.crossref.org\/issn\/0223-5234","issn-type":"print"},{"key":"35","first-page":"59","author":"Gozlan H., Langlois M.","year":"1992","journal-title":"Central and Peripheral 5-HT<sub>3<\/sub> Receptors"},{"key":"36","doi-asserted-by":"publisher","DOI":"10.1016\/0960-894X(95)00115-A"},{"issue":"2","key":"37","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1002\/jhet.5570320244","volume":"32","year":"1995","journal-title":"J. Heterocyclic Chem.","ISSN":"https:\/\/id.crossref.org\/issn\/0022-152X","issn-type":"print"},{"issue":"10","key":"38","doi-asserted-by":"crossref","first-page":"2027","DOI":"10.1021\/jm00118a031","volume":"31","author":"de Paulis T., Janowsky A., Kessler","year":"1988","journal-title":"J. Med. Chem.","ISSN":"https:\/\/id.crossref.org\/issn\/0022-2623","issn-type":"print"},{"issue":"11","key":"39","doi-asserted-by":"crossref","first-page":"1280","DOI":"10.1021\/jm00353a003","volume":"25","author":"Florvall L., &Ouml;gren S.-O.","year":"1982","journal-title":"J. Med. Chem.","ISSN":"https:\/\/id.crossref.org\/issn\/0022-2623","issn-type":"print"},{"key":"40","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1002\/hlca.19570400215","volume":"40","author":"Goldstein H., Schaaf E.","year":"1957","journal-title":"Helv. Chim. Acta","ISSN":"https:\/\/id.crossref.org\/issn\/0018-019X","issn-type":"print"},{"issue":"1","key":"41","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1021\/jm00151a010","volume":"29","author":"de Paulis T., Kumar Y., Johansson L","year":"1986","journal-title":"J. Med. Chem.","ISSN":"https:\/\/id.crossref.org\/issn\/0022-2623","issn-type":"print"},{"key":"42","doi-asserted-by":"crossref","unstructured":"42) Kaplan J. P., Najer H., Obitz D. C. L., Ger. Offen. DE 2907377 6 Sep (1979) [<i>Chem. Abstr.<\/i>, <b>91<\/b>, 211261 (1985)].","DOI":"10.15288\/jsa.1979.40.499"},{"key":"43","unstructured":"43) Renfag S. A. Fr. 2,163,301 [<i>Chem. Abstr.<\/i>, <b>80<\/b>, 3269<i>g<\/i> (1974)]."},{"issue":"4","key":"44","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1021\/jm00124a024","volume":"32","author":"Harrold M. W., Wallace R. A., Faroo","year":"1989","journal-title":"J. Med. Chem.","ISSN":"https:\/\/id.crossref.org\/issn\/0022-2623","issn-type":"print"},{"issue":"11","key":"45","doi-asserted-by":"crossref","first-page":"2081","DOI":"10.1021\/jo00185a072","volume":"49","author":"Olofson R.A., Martz J.T.","year":"1984","journal-title":"J. Org. Chem.","ISSN":"https:\/\/id.crossref.org\/issn\/0022-3263","issn-type":"print"},{"key":"46","doi-asserted-by":"crossref","first-page":"1715","DOI":"10.1351\/pac198860111715","volume":"60","author":"Olofson R. A.","year":"1988","journal-title":"Pure &amp; Appl. Chem."},{"key":"47","doi-asserted-by":"publisher","DOI":"10.1021\/op010068e"},{"issue":"5","key":"48","doi-asserted-by":"crossref","first-page":"1406","DOI":"10.1021\/jm00167a020","volume":"33","year":"1990","journal-title":"J. Med. Chem.","ISSN":"https:\/\/id.crossref.org\/issn\/0022-2623","issn-type":"print"}],"container-title":["Chemical and Pharmaceutical Bulletin"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.jstage.jst.go.jp\/article\/cpb\/50\/7\/50_7_941\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,3,17]],"date-time":"2021-03-17T22:41:44Z","timestamp":1616020904000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.jstage.jst.go.jp\/article\/cpb\/50\/7\/50_7_941\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002]]},"references-count":48,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2002]]}},"URL":"https:\/\/doi.org\/10.1248\/cpb.50.941","relation":{},"ISSN":["0009-2363","1347-5223"],"issn-type":[{"value":"0009-2363","type":"print"},{"value":"1347-5223","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002]]}}}