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T., Hungerford D. A., Nowell P. C., <i>Science<\/i>, <b>144<\/b>, 1229\u20131232 (1964).","DOI":"10.1126\/science.144.3623.1229"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2) Rowley J. D., <i>Nature<\/i> (London), <b>243<\/b>, 290\u2013293 (1973).","DOI":"10.1038\/243290a0"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3) Konopka J. B., Watanabe S. M., Witte O. N., <i>Cell<\/i>, <b>37<\/b>, 1035\u20131042 (1984).","DOI":"10.1016\/0092-8674(84)90438-0"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4) Heisterkamp N., Stam K., Groffen J., de Klein A., Grosveld G., <i>Nature<\/i> (London), <b>315<\/b>, 758\u2013761 (1985).","DOI":"10.1038\/315758a0"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5) Shtivelman E., Lifshitz B., Gale R. P., Canaani E., <i>Nature<\/i> (London), <b>315<\/b>, 550\u2013554 (1985).","DOI":"10.1038\/315550a0"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6) Druker B. J., Tamura S., Buchdunger E., Ohno S., Segal G. M., Fanning S., Zimmermann J., Lydon N. B., <i>Nat. Med.<\/i>, <b>2<\/b>, 561\u2013566 (1996).","DOI":"10.1038\/nm0596-561"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7) Druker B. J., <i>Blood<\/i>, <b>112<\/b>, 4808\u20134817 (2008).","DOI":"10.1182\/blood-2008-07-077958"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8) Hochhaus A., Larson R. A., Guilhot F., Radich J. P., Branford S., Hughes T. P., Baccarani M., Deininger M. W., Cervantes F., Fujihara S., Ortmann C. E., Menssen H. D., Kantarjian H., O\u2019Brien S. G., Druker B. J.; IRIS Investigators, <i>N. Engl. J. Med.<\/i>, <b>376<\/b>, 917\u2013927 (2017).","DOI":"10.1056\/NEJMoa1609324"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9) Shah N. P., Tran C., Lee F. Y., Chen P., Norris D., Sawyers C. L., <i>Science<\/i>, <b>305<\/b>, 399\u2013401 (2004).","DOI":"10.1126\/science.1099480"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10) Weisberg E., Manley P. W., Breitenstein W., Br\u00fcggen J., Cowan-Jacob S. W., Ray A., Huntly B., Fabbro D., Fendrich G., Hall-Meyers E., Kung A. L., Mestan J., Daley G. Q., Callahan L., Catley L., Cavazza C., Mohammed A., Neuberg D., Wright R. D., Gilliland D. G., Griffin J. D., <i>Cancer Cell<\/i>, <b>7<\/b>, 129\u2013141 (2005).","DOI":"10.1016\/j.ccr.2005.01.007"},{"key":"11","unstructured":"11) Golas J. M., Arndt K., Etienne C., Lucas J., Nardin D., Gibbons J., Frost P., Ye F., Boschelli D. H., Boschelli F., <i>Cancer Res.<\/i>, <b>63<\/b>, 375\u2013381 (2003)."},{"key":"12","doi-asserted-by":"crossref","unstructured":"12) O\u2019Hare T., Shakespeare W. C., Zhu X., Eide C. A., Rivera V. M., Wang F., Adrian L. T., Zhou T., Huang W. S., Xu Q., Metcalf C. A. 3rd, Tyner J. W., Loriaux M. M., Corbin A. S., Wardwell S., Ning Y., Keats J. A., Wang Y., Sundaramoorthi R., Thomas M., Zhou D., Snodgrass J., Commodore L., Sawyer T. K., Dalgarno D. C., Deininger M. W., Druker B. J., Clackson T., <i>Cancer Cell<\/i>, <b>16<\/b>, 401\u2013412 (2009).","DOI":"10.1016\/j.ccr.2009.09.028"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13) Gandhi V., Plunkett W., Cortes J. E., <i>Clin. Cancer Res.<\/i>, <b>20<\/b>, 1735\u20131740 (2014).","DOI":"10.1158\/1078-0432.CCR-13-1283"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14) Alvandi F., Kwitkowski V. E., Ko C. W., Rothmann M. D., Ricci S., Saber H., Ghosh D., Brown J., Pfeiler E., Chikhale E., Grillo J., Bullock J., Kane R., Kaminskas E., Farrell A. T., Pazdur R., <i>Oncologist<\/i>, <b>19<\/b>, 94\u201399 (2014).","DOI":"10.1634\/theoncologist.2013-0077"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15) Massimino M., Stella S., Tirro E., Romano C., Pennisi M. S., Puma A., Manzella L., Zanghi A., Stagno F., Di Raimondo F., Vigneri P., <i>Mol. Cancer<\/i>, <b>17<\/b>, 56 (2018).","DOI":"10.1186\/s12943-018-0805-1"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16) Peng C., Brain J., Hu Y., Goodrich A., Kong L., Grayzel D., Pak R., Read M., Li S., <i>Blood<\/i>, <b>110<\/b>, 678\u2013685 (2007).","DOI":"10.1182\/blood-2006-10-054098"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17) Peng C., Li D., Li S., <i>Cell Cycle<\/i>, <b>6<\/b>, 2227\u20132231 (2007).","DOI":"10.4161\/cc.6.18.4722"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18) Itoh Y., Ishikawa M., Naito M., Hashimoto Y., <i>J. Am. Chem. Soc.<\/i>, <b>132<\/b>, 5820\u20135826 (2010).","DOI":"10.1021\/ja100691p"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19) Okuhira K., Ohoka N., Sai K., Nishimaki-Mogami T., Itoh Y., Ishikawa M., Hashimoto Y., Naito M., <i>FEBS Lett.<\/i>, <b>585<\/b>, 1147\u20131152 (2011).","DOI":"10.1016\/j.febslet.2011.03.019"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20) Demizu Y., Okuhira K., Motoi H., Ohno A., Shoda T., Fukuhara K., Okuda H., Naito M., Kurihara M., <i>Bioorg. Med. Chem. Lett.<\/i>, <b>22<\/b>, 1793\u20131796 (2012).","DOI":"10.1016\/j.bmcl.2011.11.086"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21) Itoh Y., Ishikawa M., Kitaguchi R., Okuhira K., Naito M., Hashimoto Y., <i>Bioorg. Med. Chem. Lett.<\/i>, <b>22<\/b>, 4453\u20134457 (2012).","DOI":"10.1016\/j.bmcl.2012.04.134"},{"key":"22","doi-asserted-by":"crossref","unstructured":"22) Okuhira K., Demizu Y., Hattori T., Ohoka N., Shibata N., Nishimaki-Mogami T., Okuda H., Kurihara M., Naito M., <i>Cancer Sci.<\/i>, <b>104<\/b>, 1492\u20131498 (2013).","DOI":"10.1111\/cas.12272"},{"key":"23","doi-asserted-by":"crossref","unstructured":"23) Ohoka N., Nagai K., Hattori T., Okuhira K., Shibata N., Cho N., Naito M., <i>Cell Death Dis.<\/i>, <b>5<\/b>, e1513 (2014).","DOI":"10.1038\/cddis.2014.471"},{"key":"24","doi-asserted-by":"crossref","unstructured":"24) Tomoshige S., Naito M., Hashimoto Y., Ishikawa M., <i>Org. Biomol. Chem.<\/i>, <b>13<\/b>, 9746\u20139750 (2015).","DOI":"10.1039\/C5OB01395J"},{"key":"25","doi-asserted-by":"crossref","unstructured":"25) Demizu Y., Shibata N., Hattori T., Ohoka N., Motoi H., Misawa T., Shoda T., Naito M., Kurihara M., <i>Bioorg. Med. Chem. Lett.<\/i>, <b>26<\/b>, 4865\u20134869 (2016).","DOI":"10.1016\/j.bmcl.2016.09.041"},{"key":"26","doi-asserted-by":"crossref","unstructured":"26) Tomoshige S., Hashimoto Y., Ishikawa M., <i>Bioorg. Med. Chem.<\/i>, <b>24<\/b>, 3144\u20133148 (2016).","DOI":"10.1016\/j.bmc.2016.05.035"},{"key":"27","doi-asserted-by":"crossref","unstructured":"27) Ohoka N., Nagai K., Shibata N., Hattori T., Nara H., Cho N., Naito M., <i>Cancer Sci.<\/i>, <b>108<\/b>, 1032\u20131041 (2017).","DOI":"10.1111\/cas.13198"},{"key":"28","doi-asserted-by":"crossref","unstructured":"28) Ohoka N., Okuhira K., Ito M., Nagai K., Shibata N., Hattori T., Ujikawa O., Shimokawa K., Sano O., Koyama R., Fujita H., Teratani M., Matsumoto H., Imaeda Y., Nara H., Cho N., Naito M., <i>J. Biol. Chem.<\/i>, <b>292<\/b>, 4556\u20134570 (2017).","DOI":"10.1074\/jbc.M116.768853"},{"key":"29","doi-asserted-by":"crossref","unstructured":"29) Okuhira K., Shoda T., Omura R., Ohoka N., Hattori T., Shibata N., Demizu Y., Sugihara R., Ichino A., Kawahara H., Itoh Y., Ishikawa M., Hashimoto Y., Kurihara M., Itoh S., Saito H., Naito M., <i>Mol. Pharmacol.<\/i>, <b>91<\/b>, 159\u2013166 (2017).","DOI":"10.1124\/mol.116.105569"},{"key":"30","doi-asserted-by":"crossref","unstructured":"30) Shibata N., Miyamoto N., Nagai K., Shimokawa K., Sameshima T., Ohoka N., Hattori T., Imaeda Y., Nara H., Cho N., Naito M., <i>Cancer Sci.<\/i>, <b>108<\/b>, 1657\u20131666 (2017).","DOI":"10.1111\/cas.13284"},{"key":"31","doi-asserted-by":"crossref","unstructured":"31) Shimokawa K., Shibata N., Sameshima T., Miyamoto N., Ujikawa O., Nara H., Ohoka N., Hattori T., Cho N., Naito M., <i>ACS Med. Chem. Lett.<\/i>, <b>8<\/b>, 1042\u20131047 (2017).","DOI":"10.1021\/acsmedchemlett.7b00247"},{"key":"32","doi-asserted-by":"crossref","unstructured":"32) Tomoshige S., Nomura S., Ohgane K., Hashimoto Y., Ishikawa M., <i>Angew. Chem. Int. Ed. Engl.<\/i>, <b>56<\/b>, 11530\u201311533 (2017).","DOI":"10.1002\/anie.201706529"},{"key":"33","doi-asserted-by":"crossref","unstructured":"33) Ohoka N., Morita Y., Nagai K., Shimokawa K., Ujikawa O., Fujimori I., Ito M., Hayase Y., Okuhira K., Shibata N., Hattori T., Sameshima T., Sano O., Koyama R., Imaeda Y., Nara H., Cho N., Naito M., <i>J. Biol. Chem.<\/i>, <b>293<\/b>, 6776\u20136790 (2018).","DOI":"10.1074\/jbc.RA117.001091"},{"key":"34","doi-asserted-by":"crossref","unstructured":"34) Shibata N., Nagai K., Morita Y., Ujikawa O., Ohoka N., Hattori T., Koyama R., Sano O., Imaeda Y., Nara H., Cho N., Naito M., <i>J. Med. Chem.<\/i>, <b>61<\/b>, 543\u2013575 (2018).","DOI":"10.1021\/acs.jmedchem.7b00168"},{"key":"35","doi-asserted-by":"crossref","unstructured":"35) Rodriguez-Gonzalez A., Cyrus K., Salcius M., Kim K., Crews C. M., Deshaies R. J., Sakamoto K. M., <i>Oncogene<\/i>, <b>27<\/b>, 7201\u20137211 (2008).","DOI":"10.1038\/onc.2008.320"},{"key":"36","doi-asserted-by":"crossref","unstructured":"36) Schneekloth A. R., Pucheault M., Tae H. S., Crews C. M., <i>Bioorg. Med. Chem. Lett.<\/i>, <b>18<\/b>, 5904\u20135908 (2008).","DOI":"10.1016\/j.bmcl.2008.07.114"},{"key":"37","doi-asserted-by":"crossref","unstructured":"37) Bondeson D. P., Mares A., Smith I. E., Ko E., Campos S., Miah A. H., Mulholland K. E., Routly N., Buckley D. L., Gustafson J. L., Zinn N., Grandi P., Shimamura S., Bergamini G., Faelth-Savitski M., Bantscheff M., Cox C., Gordon D. A., Willard R. R., Flanagan J. J., Casillas L. N., Votta B. J., den Besten W., Famm K., Kruidenier L., Carter P. S., Harling J. D., Churcher I., Crews C. M., <i>Nat. Chem. Biol.<\/i>, <b>11<\/b>, 611\u2013617 (2015).","DOI":"10.1038\/nchembio.1858"},{"key":"38","doi-asserted-by":"crossref","unstructured":"38) Lu J., Qian Y., Altieri M., Dong H., Wang J., Raina K., Hines J., Winkler J. D., Crew A. P., Coleman K., Crews C. M., <i>Chem. Biol.<\/i>, <b>22<\/b>, 755\u2013763 (2015).","DOI":"10.1016\/j.chembiol.2015.05.009"},{"key":"39","doi-asserted-by":"crossref","unstructured":"39) Winter G. E., Buckley D. L., Paulk J., Roberts J. M., Souza A., Dhe-Paganon S., Bradner J. E., <i>Science<\/i>, <b>348<\/b>, 1376\u20131381 (2015).","DOI":"10.1126\/science.aab1433"},{"key":"40","doi-asserted-by":"crossref","unstructured":"40) Lai A. C., Toure M., Hellerschmied D., Salami J., Jaime-Figueroa S., Ko E., Hines J., Crews C. M., <i>Angew. Chem. Int. Ed. Engl.<\/i>, <b>55<\/b>, 807\u2013810 (2016).","DOI":"10.1002\/anie.201507634"},{"key":"41","doi-asserted-by":"crossref","unstructured":"41) Raina K., Lu J., Qian Y., Altieri M., Gordon D., Rossi A. M., Wang J., Chen X., Dong H., Siu K., Winkler J. D., Crew A. P., Crews C. M., Coleman K. G., <i>Proc. Natl. Acad. Sci. U.S.A.<\/i>, <b>113<\/b>, 7124\u20137129 (2016).","DOI":"10.1073\/pnas.1521738113"},{"key":"42","doi-asserted-by":"crossref","unstructured":"42) Remillard D., Buckley D. L., Paulk J., Brien G. L., Sonnett M., Seo H. S., Dastjerdi S., Wuhr M., Dhe-Paganon S., Armstrong S. A., Bradner J. E., <i>Angew. Chem. Int. Ed. Engl.<\/i>, <b>56<\/b>, 5738\u20135743 (2017).","DOI":"10.1002\/anie.201611281"},{"key":"43","doi-asserted-by":"crossref","unstructured":"43) Winter G. E., Mayer A., Buckley D. L., Erb M. A., Roderick J. E., Vittori S., Reyes J. M., di Iulio J., Souza A., Ott C. J., Roberts J. M., Zeid R., Scott T. G., Paulk J., Lachance K., Olson C. M., Dastjerdi S., Bauer S., Lin C. Y., Gray N. S., Kelliher M. A., Churchman L. S., Bradner J. E., <i>Mol. Cell<\/i>, <b>67<\/b>, 5\u201318.e19 (2017).","DOI":"10.1016\/j.molcel.2017.06.004"},{"key":"44","doi-asserted-by":"crossref","unstructured":"44) Bondeson D. P., Smith B. E., Burslem G. M., Buhimschi A. D., Hines J., Jaime-Figueroa S., Wang J., Hamman B. D., Ishchenko A., Crews C. M., <i>Cell. Chem. Biol.<\/i>, <b>25<\/b>, 78\u201387.e5 (2018).","DOI":"10.1016\/j.chembiol.2017.09.010"},{"key":"45","doi-asserted-by":"crossref","unstructured":"45) Buhimschi A. D., Armstrong H. A., Toure M., Jaime-Figueroa S., Chen T. L., Lehman A. M., Woyach J. A., Johnson A. J., Byrd J. C., Crews C. M., <i>Biochemistry<\/i>, <b>57<\/b>, 3564\u20133575 (2018).","DOI":"10.1021\/acs.biochem.8b00391"},{"key":"46","doi-asserted-by":"crossref","unstructured":"46) Burslem G. M., Smith B. E., Lai A. C., Jaime-Figueroa S., McQuaid D. C., Bondeson D. P., Toure M., Dong H., Qian Y., Wang J., Crew A. P., Hines J., Crews C. M., <i>Cell. Chem. Biol.<\/i>, <b>25<\/b>, 67\u201377.e3 (2018).","DOI":"10.1016\/j.chembiol.2017.09.009"},{"key":"47","doi-asserted-by":"crossref","unstructured":"47) Gechijian L. N., Buckley D. L., Lawlor M. A., Reyes J. M., Paulk J., Ott C. J., Winter G. E., Erb M. A., Scott T. G., Xu M., Seo H. S., Dhe-Paganon S., Kwiatkowski N. P., Perry J. A., Qi J., Gray N. S., Bradner J. E., <i>Nat. Chem. Biol.<\/i>, <b>14<\/b>, 405\u2013412 (2018).","DOI":"10.1038\/s41589-018-0010-y"},{"key":"48","doi-asserted-by":"crossref","unstructured":"48) Huang H. T., Dobrovolsky D., Paulk J., Yang G., Weisberg E. L., Doctor Z. M., Buckley D. L., Cho J. H., Ko E., Jang J., Shi K., Choi H. G., Griffin J. D., Li Y., Treon S. P., Fischer E. S., Bradner J. E., Tan L., Gray N. S., <i>Cell. Chem. Biol.<\/i>, <b>25<\/b>, 88\u201399.e6 (2018).","DOI":"10.1016\/j.chembiol.2017.10.005"},{"key":"49","doi-asserted-by":"crossref","unstructured":"49) Lu M., Liu T., Jiao Q., Ji J., Tao M., Liu Y., You Q., Jiang Z., <i>Eur. J. Med. Chem.<\/i>, <b>146<\/b>, 251\u2013259 (2018).","DOI":"10.1016\/j.ejmech.2018.01.063"},{"key":"50","doi-asserted-by":"crossref","unstructured":"50) Olson C. M., Jiang B., Erb M. A., Liang Y., Doctor Z. M., Zhang Z., Zhang T., Kwiatkowski N., Boukhali M., Green J. L., Haas W., Nomanbhoy T., Fischer E. S., Young R. A., Bradner J. E., Winter G. E., Gray N. S., <i>Nat. Chem. Biol.<\/i>, <b>14<\/b>, 163\u2013170 (2018).","DOI":"10.1038\/nchembio.2538"},{"key":"51","doi-asserted-by":"crossref","unstructured":"51) Powell C. E., Gao Y., Tan L., Donovan K. A., Nowak R. P., Loehr A., Bahcall M., Fischer E. S., Janne P. A., George R. E., Gray N. S., <i>J. Med. Chem.<\/i>, <b>61<\/b>, 4249\u20134255 (2018).","DOI":"10.1021\/acs.jmedchem.7b01655"},{"key":"52","doi-asserted-by":"crossref","unstructured":"52) Zhang C., Han X. R., Yang X., Jiang B., Liu J., Xiong Y., Jin J., <i>Eur. J. Med. Chem.<\/i>, <b>151<\/b>, 304\u2013314 (2018).","DOI":"10.1016\/j.ejmech.2018.03.071"},{"key":"53","doi-asserted-by":"crossref","unstructured":"53) Zhou B., Hu J., Xu F., Chen Z., Bai L., Fernandez-Salas E., Lin M., Liu L., Yang C.-Y., Zhao Y., McEachern D., Przybranowski S., Wen B., Sun D., Wang S., <i>J. Med. Chem.<\/i>, <b>61<\/b>, 462\u2013481 (2018).","DOI":"10.1021\/acs.jmedchem.6b01816"},{"key":"54","doi-asserted-by":"crossref","unstructured":"54) Zorba A., Nguyen C., Xu Y., Starr J., Borzilleri K., Smith J., Zhu H., Farley K. A., Ding W., Schiemer J., Feng X., Chang J. S., Uccello D. P., Young J. A., Garcia-Irrizary C. N., Czabaniuk L., Schuff B., Oliver R., Montgomery J., Hayward M. M., Coe J., Chen J., Niosi M., Luthra S., Shah J. C., El-Kattan A., Qiu X., West G. M., Noe M. C., Shanmugasundaram V., Gilbert A. M., Brown M. F., Calabrese M. F., <i>Proc. Natl. Acad. Sci. U.S.A.<\/i>, <b>115<\/b>, E7285\u2013E7292 (2018).","DOI":"10.1073\/pnas.1803662115"},{"key":"55","doi-asserted-by":"crossref","unstructured":"55) Sekine K., Takubo K., Kikuchi R., Nishimoto M., Kitagawa M., Abe F., Nishikawa K., Tsuruo T., Naito M., <i>J. Biol. Chem.<\/i>, <b>283<\/b>, 8961\u20138968 (2008).","DOI":"10.1074\/jbc.M709525200"},{"key":"56","doi-asserted-by":"crossref","unstructured":"56) Cohen P., Tcherpakov M., <i>Cell<\/i>, <b>143<\/b>, 686\u2013693 (2010).","DOI":"10.1016\/j.cell.2010.11.016"},{"key":"57","doi-asserted-by":"crossref","unstructured":"57) Fulda S., Vucic D., <i>Nat. Rev. Drug Discov.<\/i>, <b>11<\/b>, 109\u2013124 (2012).","DOI":"10.1038\/nrd3627"},{"key":"58","doi-asserted-by":"crossref","unstructured":"58) Toure M., Crews C. M., <i>Angew. Chem. Int. Ed. Engl.<\/i>, <b>55<\/b>, 1966\u20131973 (2016).","DOI":"10.1002\/anie.201507978"},{"key":"59","doi-asserted-by":"crossref","unstructured":"59) Cromm P. M., Crews C. M., <i>Cell. Chem. Biol.<\/i>, <b>24<\/b>, 1181\u20131190 (2017).","DOI":"10.1016\/j.chembiol.2017.05.024"},{"key":"60","doi-asserted-by":"crossref","unstructured":"60) Lai A. C., Crews C. M., <i>Nat. Rev. Drug Discov.<\/i>, <b>16<\/b>, 101\u2013114 (2017).","DOI":"10.1038\/nrd.2016.211"},{"key":"61","doi-asserted-by":"crossref","unstructured":"61) Salami J., Crews C. M., <i>Science<\/i>, <b>355<\/b>, 1163\u20131167 (2017).","DOI":"10.1126\/science.aam7340"},{"key":"62","doi-asserted-by":"crossref","unstructured":"62) Hantschel O., Warsch W., Eckelhart E., Kaupe I., Grebien F., Wagner K. U., Superti-Furga G., Sexl V., <i>Nat. Chem. Biol.<\/i>, <b>8<\/b>, 285\u2013293 (2012).","DOI":"10.1038\/nchembio.775"},{"key":"63","doi-asserted-by":"crossref","unstructured":"63) Quint\u00e1s-Cardama A., Cortes J., <i>Blood<\/i>, <b>113<\/b>, 1619\u20131630 (2009).","DOI":"10.1182\/blood-2008-03-144790"},{"key":"64","doi-asserted-by":"crossref","unstructured":"64) Shibata N., Shimokawa K., Nagai K., Ohoka N., Hattori T., Miyamoto N., Ujikawa O., Sameshima T., Nara H., Cho N., Naito M., <i>Sci. Rep.<\/i>, <b>8<\/b>, 13549 (2018).","DOI":"10.1038\/s41598-018-31913-5"},{"key":"65","doi-asserted-by":"crossref","unstructured":"65) Weisberg E., Choi H. G., Ray A., Barrett R., Zhang J., Sim T., Zhou W., Seeliger M., Cameron M., Azam M., Fletcher J. A., Debiec-Rychter M., Mayeda M., Moreno D., Kung A. L., Janne P. A., Khosravi-Far R., Melo J. V., Manley P. W., Adamia S., Wu C., Gray N., Griffin J. D., <i>Blood<\/i>, <b>115<\/b>, 4206\u20134216 (2010).","DOI":"10.1182\/blood-2009-11-251751"}],"container-title":["Chemical and Pharmaceutical Bulletin"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/cpb\/67\/3\/67_c18-00703\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,11,19]],"date-time":"2019-11-19T19:03:47Z","timestamp":1574190227000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/cpb\/67\/3\/67_c18-00703\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,3,1]]},"references-count":65,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2019]]}},"URL":"https:\/\/doi.org\/10.1248\/cpb.c18-00703","relation":{},"ISSN":["0009-2363","1347-5223"],"issn-type":[{"value":"0009-2363","type":"print"},{"value":"1347-5223","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,3,1]]}}}