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Bull.<\/i>, <b>56<\/b>, 1395\u20131399 (2008).","DOI":"10.1248\/cpb.56.1395"},{"key":"7","unstructured":"7) Fukuda T., <i>The Journal of Practical Pharmacy<\/i>, <b>62<\/b>, 107\u2013112 (2011)."},{"key":"8","doi-asserted-by":"crossref","unstructured":"8) Katsuragi Y., <i>Journal of Japan Oil Chemists\u2019, Society<\/i>, <b>47<\/b>, 467\u2013474 (1998).","DOI":"10.5650\/jos1996.47.467"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9) Hamasaki A., Akazawa N., Yoshikawa T., Myoenzono K., Tanahashi K., Sawano Y., Nakata Y., Maeda S., <i>Am. J. Clin. Nutr.<\/i>, <b>109<\/b>, 353\u2013360 (2019).","DOI":"10.1093\/ajcn\/nqy235"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10) Kim M. J., Son H. J., Kim Y., Misaka T., Rhyu M. R., <i>Biochem. Biophys. Res. Commun.<\/i>, <b>456<\/b>, 586\u2013590 (2015).","DOI":"10.1016\/j.bbrc.2014.11.114"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11) Glendinning J. I., <i>Physiol. Behav.<\/i>, <b>56<\/b>, 1217\u20131227 (1994).","DOI":"10.1016\/0031-9384(94)90369-7"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12) Nissim I., Dagan-Wiener A., Niv M. Y., <i>IUBMB Life<\/i>, <b>69<\/b>, 938\u2013946 (2017).","DOI":"10.1002\/iub.1694"},{"key":"13","unstructured":"13) \u201cHandbook of olfaction and gustation,\u201d ed. by Miller Jr. I. J., Dekker, New York, 1995."},{"key":"14","doi-asserted-by":"crossref","unstructured":"14) Behrens M., Foerster S., Staehler F., Raguse J. D., Meyerhof W., <i>J. Neurosci.<\/i>, <b>27<\/b>, 12630\u201312640 (2007).","DOI":"10.1523\/JNEUROSCI.1168-07.2007"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15) Adler E., Hoon M. A., Mueller K. L., Chandrashekar J., Ryba N. J., Zuker C. S., <i>Cell<\/i>, <b>100<\/b>, 693\u2013702 (2000).","DOI":"10.1016\/S0092-8674(00)80705-9"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16) Di Pizio A., Levit A., Slutzki M., Behrens M., Karaman R., Niv M. Y., <i>Methods Cell Biol.<\/i>, <b>132<\/b>, 401\u2013427 (2016).","DOI":"10.1016\/bs.mcb.2015.10.005"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17) Behrens M., Meyerhof W., <i>Semin. Cell Dev. Biol.<\/i>, <b>24<\/b>, 215\u2013221 (2013).","DOI":"10.1016\/j.semcdb.2012.08.006"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18) Bufe B., Hofmann T., Krautwurst D., Raguse J. D., Meyerhof W., <i>Nat. Genet.<\/i>, <b>32<\/b>, 397\u2013401 (2002).","DOI":"10.1038\/ng1014"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19) Behrens M., Brockhoff A., Kuhn C., Bufe B., Winnig M., Meyerhof W., <i>Biochem. Biophys. Res. Commun.<\/i>, <b>319<\/b>, 479\u2013485 (2004).","DOI":"10.1016\/j.bbrc.2004.05.019"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20) Brockhoff A., Behrens M., Massarotti A., Appendino G., Meyerhof W., <i>J. Agric. Food Chem.<\/i>, <b>55<\/b>, 6236\u20136243 (2007).","DOI":"10.1021\/jf070503p"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21) Jaggupilli A., Singh N., Jesus V. C., Duan K., Chelikani P., <i>ACS.<\/i> <i>Infect. Dis.<\/i>, <b>4<\/b>, 1146\u20131156 (2018).","DOI":"10.1021\/acsinfecdis.8b00094"},{"key":"22","doi-asserted-by":"crossref","unstructured":"22) Tokuyama E., Shibasaki T., Kawabe H., Mukai J., Okada S., Uchida T., <i>Chem. Pharm. Bull.<\/i>, <b>54<\/b>, 1288\u20131292 (2006).","DOI":"10.1248\/cpb.54.1288"},{"key":"23","doi-asserted-by":"crossref","unstructured":"23) Tokuyama E., Matsunaga C., Yoshida K., Mifsud J. C., Irie T., Yoshida M., Uchida T., <i>Chem. Pharm. Bull.<\/i>, <b>57<\/b>, 382\u2013387 (2009).","DOI":"10.1248\/cpb.57.382"},{"key":"24","doi-asserted-by":"crossref","unstructured":"24) Uchida T., Yoshida M., Hazekawa M., Haraguchi T., Furuno H., Teraoka M., Ikezaki H., <i>J. Pharm. 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T., Boonstra J., Blanchetot C., Ekokoski E., <i>PLOS ONE<\/i>, <b>7<\/b>, e35630 (2012).","DOI":"10.1371\/journal.pone.0035630"},{"key":"33","doi-asserted-by":"crossref","unstructured":"33) Solanki P. R., Arya S. K., Nishimura Y., Iwamoto M., Malhotra B. D., <i>Langmuir<\/i>, <b>23<\/b>, 7398\u20137403 (2007).","DOI":"10.1021\/la700350x"},{"key":"34","doi-asserted-by":"crossref","unstructured":"34) Kurihara K., Katuragi Y., Matsuoka I., Kashiwayanagi M., Kumazawa T., Shoji T., <i>Physiol. Behav.<\/i>, <b>56<\/b>, 1125\u20131132 (1994).","DOI":"10.1016\/0031-9384(94)90356-5"},{"key":"35","doi-asserted-by":"crossref","unstructured":"35) Kumazawa T., Kashiwayanagi M., Kurihara K., <i>Biochim. Biophys. Acta BBAMol. Cell Res.<\/i>, <b>888<\/b>, 62\u201369 (1986).","DOI":"10.1016\/0167-4889(86)90071-6"},{"key":"36","doi-asserted-by":"crossref","unstructured":"36) Uchida T., Shiosaki K., Nakada Y., Fukuda K., Eda Y., Nagareya N., Matsuyama K., <i>Pharm. Res.<\/i>, <b>15<\/b>, 1708\u20131713 (1998).","DOI":"10.1023\/A:1011904627929"},{"key":"37","doi-asserted-by":"crossref","unstructured":"37) Miyanaga Y., Tanigake A., Nakamura T., Kobayashi Y., Ikezaki H., Taniguchi A., Matsuyama K., Uchida T., <i>Int. J. Pharm.<\/i>, <b>248<\/b>, 207\u2013218 (2002).","DOI":"10.1016\/S0378-5173(02)00456-8"},{"key":"38","doi-asserted-by":"crossref","unstructured":"38) Chaudhari N., Roper S. D., <i>J. Cell Biol.<\/i>, <b>190<\/b>, 285\u2013296 (2010).","DOI":"10.1083\/jcb.201003144"},{"key":"39","doi-asserted-by":"crossref","unstructured":"39) Chandrashekar J., Hoon M. A., Ryba N. J., Zuker C. S., <i>Nature<\/i> (London), <b>444<\/b>, 288\u2013294 (2006).","DOI":"10.1038\/nature05401"},{"key":"40","unstructured":"40) Pharmaceutical reference of OPSO.: \u2039https:\/\/pins.japic.or.jp\/pdf\/newPINS\/00049418.pdf\u203a, cited 22 August, 2019"},{"key":"41","unstructured":"41) Maebuchi M., Kishi Y., Koikeda T., Furuya S., <i>Jpn. Pharmacol. Ther.<\/i>, <b>41<\/b>, 67\u201374 (2013)."},{"key":"42","unstructured":"42) Nakamori T., Maebuchi M., Okuda J., Suzuki M., Takeda R., Sawabe A. , <i>Jpn. Pharmacol. Ther.<\/i>, <b>41<\/b>, 457\u2013464 (2013)."},{"key":"43","doi-asserted-by":"crossref","unstructured":"43) Noguchi M., Yamashita M., Arai S., Fujimaki M., <i>J. Food Sci.<\/i>, <b>40<\/b>, 367\u2013369 (1975).","DOI":"10.1111\/j.1365-2621.1975.tb02203.x"},{"key":"44","doi-asserted-by":"crossref","unstructured":"44) Nishimura T., <i>Kagaku To Seibutsu<\/i>, <b>39<\/b>, 177\u2013183 (2001).","DOI":"10.1271\/kagakutoseibutsu1962.39.177"},{"key":"45","unstructured":"45) Ninomiya Y., <i>Stomato-pharyngology<\/i>, <b>31<\/b>, 7\u201313 (2018)."},{"key":"46","unstructured":"46) Tsumoto K., <i>Seibutu-kougaku Kaishi<\/i>, <b>89<\/b>, 391\u2013394 (2011)."},{"key":"47","doi-asserted-by":"crossref","unstructured":"47) Kuhn C., Bufe B., Batram C., Meyerhof W., <i>Chem. 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