{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T21:58:38Z","timestamp":1776290318280,"version":"3.50.1"},"reference-count":27,"publisher":"Pharmaceutical Society of Japan","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Chem. Pharm. Bull.","CHEMICAL &amp; PHARMACEUTICAL BULLETIN"],"published-print":{"date-parts":[[2023,9,1]]},"DOI":"10.1248\/cpb.c23-00387","type":"journal-article","created":{"date-parts":[[2023,8,31]],"date-time":"2023-08-31T22:59:20Z","timestamp":1693522760000},"page":"701-716","source":"Crossref","is-referenced-by-count":4,"title":["Synthesis and Evaluation of Novel Triaryl Derivatives with Readthrough-Inducing Activity"],"prefix":"10.1248","volume":"71","author":[{"given":"Shota","family":"Kawai","sequence":"first","affiliation":[{"name":"Drug Discovery Research Department, Kyoto Pharmaceutical Industries, Ltd."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shunsuke","family":"Takashima","sequence":"additional","affiliation":[{"name":"Drug Discovery Research Department, Kyoto Pharmaceutical Industries, Ltd."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masafumi","family":"Ando","sequence":"additional","affiliation":[{"name":"Drug Discovery Research Department, Kyoto Pharmaceutical Industries, Ltd."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sayaka","family":"Shintaku","sequence":"additional","affiliation":[{"name":"Drug Discovery Research Department, Kyoto Pharmaceutical Industries, Ltd."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shigemitsu","family":"Takeda","sequence":"additional","affiliation":[{"name":"Drug Discovery Research Department, Kyoto Pharmaceutical Industries, Ltd."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuya","family":"Otake","sequence":"additional","affiliation":[{"name":"Drug Discovery Research Department, Kyoto Pharmaceutical Industries, Ltd."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuma","family":"Ito","sequence":"additional","affiliation":[{"name":"Drug Discovery Research Department, Kyoto Pharmaceutical Industries, Ltd."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masaki","family":"Fukui","sequence":"additional","affiliation":[{"name":"Drug Discovery Research Department, Kyoto Pharmaceutical Industries, Ltd."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Megumi","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"Drug Discovery Research Department, Kyoto Pharmaceutical Industries, Ltd."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshimichi","family":"Shoji","sequence":"additional","affiliation":[{"name":"Drug Discovery Research Department, Kyoto Pharmaceutical Industries, Ltd."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroaki","family":"Shirahase","sequence":"additional","affiliation":[{"name":"Drug Discovery Research Department, Kyoto Pharmaceutical Industries, Ltd."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatsuya","family":"Kitao","sequence":"additional","affiliation":[{"name":"Drug Discovery Research Department, Kyoto Pharmaceutical Industries, Ltd."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"163","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"1) Mort M., Ivanov D., Cooper D. N., Chuzhanova N. A., <i>Hum. Mutat.<\/i>, <b>29<\/b>, 1037\u20131047 (2008).","DOI":"10.1002\/humu.20763"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2) Korinthenberg R., <i>Dev. Med. Child Neurol.<\/i>, <b>61<\/b>, 292\u2013297 (2019).","DOI":"10.1111\/dmcn.14129"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3) Pranke I., Golec A., Hinzpeter A., Edelman A., Gaudelus I. S., <i>Front. Pharmacol.<\/i>, <b>10<\/b>, 121\u2013141 (2019).","DOI":"10.3389\/fphar.2019.00121"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4) Bunge S., Kleijer W. J., Steglich C., Beck M., Zuther C., Morris C. P., Schwinger E., Hopwood J. J., Scott H. S., Gal A., <i>Hum. Mol. Genet.<\/i>, <b>3<\/b>, 861\u2013866 (1994).","DOI":"10.1093\/hmg\/3.6.861"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5) Kellermayer R., <i>Eur. J. Med. Genet.<\/i>, <b>49<\/b>, 445\u2013450 (2006).","DOI":"10.1016\/j.ejmg.2006.04.003"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6) Dabrowski M., Bieryllo Z. B., Zietkiewicz E., <i>Mol. Med.<\/i>, <b>24<\/b>, 25\u201339 (2018).","DOI":"10.1186\/s10020-018-0024-7"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7) Dias P. M., Rom\u00e3o L., <i>Cell. Mol. Life Sci.<\/i>, <b>78<\/b>, 4677\u20134701 (2021).","DOI":"10.1007\/s00018-021-03809-7"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8) Spelier S., van Doorn E. P. M., van der Ent C. K., Beekman J. M., Koppens M. A. J., <i>Trends Mol. Med.<\/i>, <b>29<\/b>, 297\u2013314 (2023).","DOI":"10.1016\/j.molmed.2023.01.004"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9) Campofelice A., Lentini L., Leonardo A. D., Melfi R., Tutone M., Pace A., Pibiri I., <i>Int. J. Mol. Sci.<\/i>, <b>20<\/b>, 3329\u20133346 (2019).","DOI":"10.3390\/ijms20133329"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10) Keeling K. M., Bedwell D. M., <i>Current Pharmacogenomics<\/i>, <b>3<\/b>, 259\u2013269 (2005).","DOI":"10.2174\/157016005774913149"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11) Burke J. F., Mogg A. E., <i>Nucleic Acids Res.<\/i>, <b>13<\/b>, 6265\u20136272 (1985).","DOI":"10.1093\/nar\/13.17.6265"},{"key":"12","unstructured":"12) Huth M. E., Ricci A. J., Cheng A. G., <i>Int. J. Otolaryngol.<\/i>, <b>2011<\/b>, 937861\u2013937879 (2011)."},{"key":"13","doi-asserted-by":"crossref","unstructured":"13) Mingeot-Leclercq M. P., Tulkens P. M., <i>Antimicrob. Agents Chemother.<\/i>, <b>43<\/b>, 1003\u20131012 (1999).","DOI":"10.1128\/AAC.43.5.1003"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14) Taguchi A., Hamada K., Kotake M., Shiozuka M., Nakaminami H., Pillaiyar T., Takayama K., Yakushiji F., Noguchi N., Usui T., Matsuda R., Hayashi Y., <i>ChemMedChem<\/i>, <b>9<\/b>, 2233\u20132237 (2014).","DOI":"10.1002\/cmdc.201402208"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15) Taguchi A., Hamada K., Shiozuka M., Kobayashi M., Murakami S., Takayama K., Taniguchi A., Usui T., Matsuda R., Hayashi Y., <i>ACS Med. Chem. Lett.<\/i>, <b>8<\/b>, 1060\u20131065 (2017).","DOI":"10.1021\/acsmedchemlett.7b00269"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16) Hamada K., Omura N., Taguchi A., Heravi A. B., Kotake M., Arai M., Takayama K., Taniguchi A., Roberge M., Hayashi Y., <i>ACS Med. Chem. Lett.<\/i>, <b>10<\/b>, 1450\u20131456 (2019).","DOI":"10.1021\/acsmedchemlett.9b00273"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17) Du L., Damoiseaux R., Nahas S., Gao K., Hu H., Pollard J. M., Goldstine J., Jung M. E., Henning S. M., Bertoni C., Gatti R. A., <i>J. Exp. Med.<\/i>, <b>206<\/b>, 2285\u20132297 (2009).","DOI":"10.1084\/jem.20081940"},{"key":"18","unstructured":"18) Welch E. M., Barton E. R., Zhuo J., <i>et al.<\/i>, <i>Nature<\/i> (London), <b>447<\/b>, 87\u201391 (2007)."},{"key":"19","doi-asserted-by":"crossref","unstructured":"19) Bushby K., Finkel R., Wong B., <i>et al.<\/i>, <i>Muscle Nerve<\/i>, <b>50<\/b>, 477\u2013487 (2014).","DOI":"10.1002\/mus.24332"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20) Kerem E., Hirawat S., Armoni S., Yaakov Y., Shoseyov D., Cohen M., Nissim-Rafinia M., Blau H., Rivlin J., Aviram M., Elfring G. L., Northcutt V. J., Miller L. L., Kerem B., Wilschanski M., <i>Lancet<\/i>, <b>372<\/b>, 719\u2013727 (2008).","DOI":"10.1016\/S0140-6736(08)61168-X"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21) Kerem E., Konstan M. W., De Boeck K., <i>et al.<\/i>, <i>Lancet Respir. Med.<\/i>, <b>2<\/b>, 539\u2013547 (2014).","DOI":"10.1016\/S2213-2600(14)70100-6"},{"key":"22","doi-asserted-by":"crossref","unstructured":"22) Oussoren E., Keulemans J., van Diggelen O. P., Oemardien L. F., Timmermans R. G., van der Ploeg A. T., Ruijter G. J., <i>Mol. Genet. Metab.<\/i>, <b>109<\/b>, 377\u2013381 (2013).","DOI":"10.1016\/j.ymgme.2013.05.016"},{"key":"23","doi-asserted-by":"crossref","unstructured":"23) Nudelman I., Sabbah A. R., Cherniavsky M., Belakhov V., Hainrichson M., Chen F., Schacht J., Pilch D. S., Yosef T. B., Baasov T., <i>J. Med. Chem.<\/i>, <b>52<\/b>, 2836\u20132845 (2009).","DOI":"10.1021\/jm801640k"},{"key":"24","unstructured":"24) Jacoby E., Reinhardt J., Schmiedeberg N., Spanka C., WO2014\/091446 (2014)."},{"key":"25","doi-asserted-by":"crossref","unstructured":"25) Meanwell N. A., <i>J. Med. Chem.<\/i>, <b>61<\/b>, 5822\u20135880 (2018).","DOI":"10.1021\/acs.jmedchem.7b01788"},{"key":"26","doi-asserted-by":"crossref","unstructured":"26) Howard M. T., Shirts B. H., Petros L. M., Flanigan K. M., Gesteland R. F., Atkins J. F., <i>Ann. Neurol.<\/i>, <b>48<\/b>, 164\u2013169 (2000).","DOI":"10.1002\/1531-8249(200008)48:2<164::AID-ANA5>3.0.CO;2-B"},{"key":"27","unstructured":"27) Takeda S., Shirahase H., Takashima S., Kitao T., WO2018\/186365 (2018)."}],"container-title":["Chemical and Pharmaceutical Bulletin"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/cpb\/71\/9\/71_c23-00387\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,2]],"date-time":"2023-09-02T03:32:45Z","timestamp":1693625565000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/cpb\/71\/9\/71_c23-00387\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9,1]]},"references-count":27,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2023]]}},"URL":"https:\/\/doi.org\/10.1248\/cpb.c23-00387","relation":{},"ISSN":["0009-2363","1347-5223"],"issn-type":[{"value":"0009-2363","type":"print"},{"value":"1347-5223","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,9,1]]},"article-number":"c23-00387"}}