{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T18:14:36Z","timestamp":1780510476342,"version":"3.54.1"},"reference-count":40,"publisher":"Pharmaceutical Society of Japan","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Chem. Pharm. Bull.","CHEMICAL & PHARMACEUTICAL BULLETIN"],"published-print":{"date-parts":[[2023,12,1]]},"DOI":"10.1248\/cpb.c23-00622","type":"journal-article","created":{"date-parts":[[2023,11,30]],"date-time":"2023-11-30T22:29:21Z","timestamp":1701383361000},"page":"897-905","source":"Crossref","is-referenced-by-count":4,"title":["<i>In Silico<\/i> Identification of Inhibitory Compounds for SARS-Cov-2 Papain-Like Protease"],"prefix":"10.1248","volume":"71","author":[{"given":"Kazunori","family":"Miwa","sequence":"first","affiliation":[{"name":"Graduate School of Pharmaceutical Sciences, Chiba University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Guo","sequence":"additional","affiliation":[{"name":"Graduate School of Pharmaceutical Sciences, Chiba University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masayuki","family":"Hata","sequence":"additional","affiliation":[{"name":"College of Pharmaceutical Sciences, Matsuyama University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshinori","family":"Hirano","sequence":"additional","affiliation":[{"name":"Faculty of Science and Technology, Keio University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norio","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"Department of Virology, Division of Host Defense Mechanism, Tokai University School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tyuji","family":"Hoshino","sequence":"additional","affiliation":[{"name":"Graduate School of Pharmaceutical Sciences, Chiba University"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"163","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"1) Shaker B., Ahmad S., Lee J., Jung C., Na D., Comput. Biol. Med.<\/i>, 137<\/b>, 104851 (2021).","DOI":"10.1016\/j.compbiomed.2021.104851"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2) Nakamura Y., Suganami A., Fukuda M., Hasan M.-K., Yokochi T., Takatori A., Satoh S., Hoshino T., Tamura Y., Nakagawara A., Cancer Medicine<\/i>, 3<\/b>, 25\u201335 (2014).","DOI":"10.1002\/cam4.175"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3) Yanagita H., Yamamoto N., Fuji H., Liu X., Ogata M., Yokota M., Takaku H., Hasegawa H., Odagiri T., Tashiro M., Hoshino T., ACS Chem. Biol.<\/i>, 7<\/b>, 552\u2013562 (2012).","DOI":"10.1021\/cb200332k"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4) Miwa K., Guo Y., Hata M., Yamamoto N., Hoshino T., Chem. Pharm. Bull.<\/i>, 71<\/b>, 360\u2013367 (2023).","DOI":"10.1248\/cpb.c23-00035"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5) Trott O., Olson A. J., J. Comput. Chem.<\/i>, 31<\/b>, 455\u2013461 (2010).","DOI":"10.1002\/jcc.21334"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6) Eberhardt J., Santos-Martins D., Tillack A. F., Forli S., J. Chem. Inf. Model.<\/i>, 61<\/b>, 3891\u20133898 (2021).","DOI":"10.1021\/acs.jcim.1c00203"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7) Halgren T. A., Murphy R. B., Friesner R. A., Beard H. S., Frye L. L., Pollard W. T., Banks J. L., J. Med. Chem.<\/i>, 47<\/b>, 1750\u20131759 (2004).","DOI":"10.1021\/jm030644s"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8) Vandyck K., Deval J., Curr. Opin. Virol.<\/i>, 49<\/b>, 36\u201340 (2021).","DOI":"10.1016\/j.coviro.2021.04.006"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9) Herlah B., Hoivi A., Jam\u0161ek L., Valjave K., Yamamoto N., Hoshino T., Kranjc K., Perdi A., Pharmaceuticals<\/i>, 15<\/b>, 539 (2022).","DOI":"10.3390\/ph15050539"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10) Yamamoto N., Matsuyama S., Hoshino T., Yamamoto N. Nelfinavir inhibits replication of severe acute respiratory syndrome coronavirus 2 in vitro. bioRxiv<\/i>, 2020<\/b>, doi: https:\/\/doi.org\/10.1101\/2020.04.06.026476","DOI":"10.1101\/2020.04.06.026476"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11) Shiraki K., Daikoku T., Pharm. Therapeutics<\/i>, 209<\/b>, 107512 (2020).","DOI":"10.1016\/j.pharmthera.2020.107512"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12) Enoki Y., Igarashi Y., Watabe Y., Honma K., Suzuki Y., Hayashi Y., Hiraoka K., Taguchi K., Matsumoto K., J. Glob. Antimicrob. Resist.<\/i>, 24<\/b>, 81\u201382 (2021).","DOI":"10.1016\/j.jgar.2020.11.022"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13) Syed Y. Y., Drugs<\/i>, 82<\/b>, 455\u2013460 (2022).","DOI":"10.1007\/s40265-022-01684-5"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14) Unoh Y., Uehara S., Nakahara K., et al.<\/i>, J. Med. Chem.<\/i>, 65<\/b>, 6499\u20136512 (2022).","DOI":"10.1021\/acs.jmedchem.2c00117"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15) Xie Y., Choi T., Al-Aly Z., JAMA Intern. Med.<\/i>, 183<\/b>, 554\u2013564 (2023).","DOI":"10.1001\/jamainternmed.2023.0743"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16) Shin D., Mukherjee R., Grewe D., et al.<\/i>, Nature<\/i> (London), 587<\/b>, 657\u2013662 (2020).","DOI":"10.1038\/s41586-020-2601-5"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17) Ratia K., Pegan S., Takayama J., Sleeman K., Coughlin M., Baliji S., Chaudhuri R., Fu W., Prabhakar B. S., Johnson M. E., Baker S. C., Ghosh A. K., Mesecar A. D., Proc. Natl. Acad. Sci. U.S.A.<\/i>, 105<\/b>, 16119\u201316124 (2008).","DOI":"10.1073\/pnas.0805240105"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18) Freitas B. T., Durie I. A., Murray J., Longo J. E., Miller H. C., Crich D., Hogan R. J., Tripp R. A., Pegan S. D., ACS Infect. Dis.<\/i>, 6<\/b>, 2099\u20132109 (2020).","DOI":"10.1021\/acsinfecdis.0c00168"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19) Shan H., Liu J., Shen J., Dai J., Xu G., Lu K., Han C., Wang Y., Xu X., Tong Y., Xiang H., Ai Z., Zhuang G., Hu J., Zhang Z., Li Y., Pan L., Tan L., Cell Chem. Biol.<\/i>, 28<\/b>, 855\u2013865.e9 (2021).","DOI":"10.1016\/j.chembiol.2021.04.020"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20) Shen Z., Ratia K., Cooper L., Kong D., Lee H., Kwon Y., Li Y., Alqarni S., Huang F., Dubrovskyi O., Rong L., Thatcher G. R. J., Xiong R., J. Med. Chem.<\/i>, 65<\/b>, 2940\u20132955 (2022).","DOI":"10.1021\/acs.jmedchem.1c01307"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21) Ma C., Sacco M. D., Xia Z., Lambrinidis G., Townsend J. A., Hu Y., Meng X., Szeto T., Ba M., Zhang X., Gongora M., Zhang F., Marty M. T., Xiang Y., Kolocouris A., Chen Y., Wang J., ACS Cent. Sci.<\/i>, 7<\/b>, 1245\u20131260 (2021).","DOI":"10.1021\/acscentsci.1c00519"},{"key":"22","doi-asserted-by":"crossref","unstructured":"22) Zhao Y., Du X., Duan Y., et al.<\/i>, Protein Cell.<\/i>, 12<\/b>, 877\u2013888 (2021).","DOI":"10.1007\/s13238-021-00836-9"},{"key":"23","doi-asserted-by":"crossref","unstructured":"23) Napolitano V., Dabrowska A., Schorpp K., et al.<\/i>, Cell Chem. Biol.<\/i>, 29<\/b>, 774\u2013784.e8 (2022).","DOI":"10.1016\/j.chembiol.2021.11.006"},{"key":"24","doi-asserted-by":"crossref","unstructured":"24) Ewert W., G\u00fcnther S., Miglioli F., Falke S., Reinke P. Y. A., Niebling S., G\u00fcnther C., Han H., Srinivasan V., Brognaro H., Lieske J., Lorenzen K., Garcia-Alai M. M., Betzel C., Carcelli M., Hinrichs W., Rogolino D., Meents A., Front. Chem.<\/i>, 10<\/b>, 832431 (2022).","DOI":"10.3389\/fchem.2022.832431"},{"key":"25","doi-asserted-by":"crossref","unstructured":"25) Calleja D. J., Kuchel N., Lu B. G. C., et al.<\/i>, Front. Chem.<\/i>, 10<\/b>, 861209 (2022).","DOI":"10.3389\/fchem.2022.876212"},{"key":"26","doi-asserted-by":"crossref","unstructured":"26) Zev S., Raz K., Schwartz R., Tarabeh R., Gupta P. K., Major D. T., J. Chem. Inf. Model.<\/i>, 61<\/b>, 2957\u20132966 (2021).","DOI":"10.1021\/acs.jcim.1c00263"},{"key":"27","doi-asserted-by":"crossref","unstructured":"27) Kamo T., Kuroda K., Kondo S., Hayashi U., Fudo S., Yoneda T., Takaya A., Nukaga M., Hoshino T., Chem. Pharm. Bull.<\/i>, 69<\/b>, 1179\u20131183 (2021).","DOI":"10.1248\/cpb.c21-00611"},{"key":"28","doi-asserted-by":"crossref","unstructured":"28) Qu L., Fudo S., Matsuzaki K., Hoshino T., Chem. Pharm. Bull.<\/i>, 67<\/b>, 959\u2013965 (2019).","DOI":"10.1248\/cpb.c19-00171"},{"key":"29","doi-asserted-by":"crossref","unstructured":"29) Qu L., Qiao X., Qi F., Nishida N., Hoshino T., J. Chem. Inf. Model.<\/i>, 61<\/b>, 2396\u20132406 (2021).","DOI":"10.1021\/acs.jcim.1c00167"},{"key":"30","doi-asserted-by":"crossref","unstructured":"30) Qiao X., Qu L., Guo Y., Hoshino T., J. Phys. Chem.<\/i>, 125<\/b>, 11374\u201311385 (2021).","DOI":"10.1021\/acs.jpcb.1c05997"},{"key":"31","doi-asserted-by":"crossref","unstructured":"31) Fuji H., Qi F., Qu L., Takaesu Y., Hoshino T., Chem. Pharm. Bull.<\/i>, 65<\/b>, 461\u2013468 (2017).","DOI":"10.1248\/cpb.c16-00913"},{"key":"32","doi-asserted-by":"crossref","unstructured":"32) Rut W., Lv Z., Zmudzinski M., Patchett S., Nayak D., Snipas S. J., El Oualid F., Huang T. T., Bekes M., Drag M., Olsen S. K., Sci. Adv.<\/i>, 6<\/b>, eabd4596 (2020).","DOI":"10.1126\/sciadv.abd4596"},{"key":"33","doi-asserted-by":"crossref","unstructured":"33) Maier J. A., Martinez C., Kasavajhala K., Wickstrom L., Hauser K. E., Simmerling C., J. Chem. Theory Comput.<\/i>, 11<\/b>, 3696\u20133713 (2015).","DOI":"10.1021\/acs.jctc.5b00255"},{"key":"34","doi-asserted-by":"crossref","unstructured":"34) Daczkowski C. M., Dzimianski J. V., Clasman J. R., Goodwin O., Andrew D., Mesecar A. D., Pegan S. D., J. Mol. Biol.<\/i>, 429<\/b>, 1661\u20131683 (2017).","DOI":"10.1016\/j.jmb.2017.04.011"},{"key":"35","doi-asserted-by":"crossref","unstructured":"35) Barretto N., Jukneliene D., Ratia K., Chen Z., Mesecar A. D., Baker S. C., J. Virol.<\/i>, 79<\/b>, 15189\u201315198 (2005).","DOI":"10.1128\/JVI.79.24.15189-15198.2005"},{"key":"36","doi-asserted-by":"crossref","unstructured":"36) Cho C. C., Li S. G., Lalonde T. J., Yang K. S., Yu G., Qiao Y., Xu S., Ray Liu W., ChemMedChem<\/i>, 17<\/b>, e202100455 (2022).","DOI":"10.1002\/cmdc.202200053"},{"key":"37","doi-asserted-by":"crossref","unstructured":"37) Sencanski M., Perovic V., Milicevic J., Todorovic T., Prodanovic R., Veljkovic V., Paessler S., Glisic S., ChemistryOpen<\/i>, 11<\/b>, e202100248 (2022).","DOI":"10.1002\/open.202100248"},{"key":"38","doi-asserted-by":"crossref","unstructured":"38) Kouznetsova V. L., Zhang A., Tatineni M., Miller M. A., Tsigelny I. F., Peer J.<\/i>, 8<\/b>, e9965 (2020).","DOI":"10.7717\/peerj.9965"},{"key":"39","doi-asserted-by":"crossref","unstructured":"39) Konno S., Kobayashi K., Senda M., et al.<\/i>, J. Med. Chem.<\/i>, 65<\/b>, 2926\u20132939 (2022).","DOI":"10.1021\/acs.jmedchem.1c00665"},{"key":"40","doi-asserted-by":"crossref","unstructured":"40) Osipiuk J., Azizi S. A., Dvorkin S., et al.<\/i>, Nat. Commun.<\/i>, 12<\/b>, 743 (2021).","DOI":"10.1038\/s41467-021-21060-3"}],"container-title":["Chemical and Pharmaceutical Bulletin"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/cpb\/71\/12\/71_c23-00622\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,2]],"date-time":"2023-12-02T03:34:43Z","timestamp":1701488083000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/cpb\/71\/12\/71_c23-00622\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12,1]]},"references-count":40,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2023]]}},"URL":"https:\/\/doi.org\/10.1248\/cpb.c23-00622","relation":{},"ISSN":["0009-2363","1347-5223"],"issn-type":[{"value":"0009-2363","type":"print"},{"value":"1347-5223","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,12,1]]},"article-number":"c23-00622"}}