{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T16:39:48Z","timestamp":1787503188846,"version":"build-2736575974"},"reference-count":44,"publisher":"Pharmaceutical Society of Japan","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Chem. Pharm. Bull.","CHEMICAL &amp; PHARMACEUTICAL BULLETIN"],"published-print":{"date-parts":[[2024,11,7]]},"DOI":"10.1248\/cpb.c24-00570","type":"journal-article","created":{"date-parts":[[2024,11,6]],"date-time":"2024-11-06T17:12:08Z","timestamp":1730913128000},"page":"944-949","source":"Crossref","is-referenced-by-count":4,"title":["Facile Synthesis of 1,2-Disubstituted Benzimidazoles as Potent Cytotoxic Agents"],"prefix":"10.1248","volume":"72","author":[{"given":"Hue Thi Buu","family":"Bui","sequence":"first","affiliation":[{"name":"Department of Chemistry, College of Natural Sciences, Can Tho University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zin Paing","family":"Htoo","sequence":"additional","affiliation":[{"name":"Institute of Natural Medicine, University of Toyama"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quang Vinh","family":"Hong","sequence":"additional","affiliation":[{"name":"Department of Chemistry, College of Natural Sciences, Can Tho University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hieu Trong","family":"Le","sequence":"additional","affiliation":[{"name":"Department of Chemistry, College of Natural Sciences, Can Tho University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"De Quang","family":"Tran","sequence":"additional","affiliation":[{"name":"Department of Chemistry, College of Natural Sciences, Can Tho University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saw Yu Yu","family":"Hnin","sequence":"additional","affiliation":[{"name":"Institute of Natural Medicine, University of Toyama"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiep Minh","family":"Do","sequence":"additional","affiliation":[{"name":"Institute of Natural Medicine, University of Toyama"},{"name":"Faculty of Pharmacy, Nam Can Tho University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroyuki","family":"Morita","sequence":"additional","affiliation":[{"name":"Institute of Natural Medicine, University of Toyama"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"163","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"1) Ebenezer O., Oyetunde-Joshua F., Omotoso O. D., Shapi M., <i>Results Chem.<\/i>, <b>5<\/b>, 100925 (2023).","DOI":"10.1016\/j.rechem.2023.100925"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2) Bansal Y., Silakari O., <i>Bioorg. Med. Chem.<\/i>, <b>20<\/b>, 6208\u20136236 (2012).","DOI":"10.1016\/j.bmc.2012.09.013"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3) Barot K. P., Nikolova S., Ivanov I., Ghate M. D., <i>Mini Rev. Med. Chem.<\/i>, <b>13<\/b>, 1421\u20131447 (2013).","DOI":"10.2174\/13895575113139990072"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4) Yadav G., Ganguly S., <i>Eur. J. Med. Chem.<\/i>, <b>97<\/b>, 419\u2013443 (2015).","DOI":"10.1016\/j.ejmech.2014.11.053"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5) Kim M. K., Shin H., Park K., Kim H., Park J., Kim K., Nam J., Choo H., Chong Y., <i>J. Med. Chem.<\/i>, <b>58<\/b>, 7596\u20137602 (2015).","DOI":"10.1021\/acs.jmedchem.5b01263"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6) Song D., Ma S., <i>ChemMedChem<\/i>, <b>11<\/b>, 646\u2013659 (2016).","DOI":"10.1002\/cmdc.201600041"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7) Pham E. C., Le T. V. T., Truong T. N., <i>RSC Adv.<\/i>, <b>12<\/b>, 21621\u201321646 (2022).","DOI":"10.1039\/D2RA03491C"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8) Francesconi V., Cichero E., Schenone S., Naesens L., Tonelli M., <i>Molecules<\/i>, <b>25<\/b>, 1487 (2020).","DOI":"10.3390\/molecules25071487"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9) Kanwal A., Ahmad M., Aslam S., Naqvi S. A. R., Saif M. J., <i>Pharm. Chem. J.<\/i>, <b>53<\/b>, 179\u2013187 (2019).","DOI":"10.1007\/s11094-019-01976-3"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10) Perin N., Al\u03afc J., Liekens S., Aerschot V. A., Vervaeke P., Gadakh B., Hranjec M., <i>New J. Chem.<\/i>, <b>42<\/b>, 7096\u20137104 (2018).","DOI":"10.1039\/C8NJ00416A"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11) Nakano H., Inoue T., Kawasaki N., Miyataka H., Matsumoto H., Taguchi T., Inagaki N., Nagai H., Satoh T., <i>Chem. Pharm. Bull.<\/i>, <b>47<\/b>, 1573\u20131578 (1999).","DOI":"10.1248\/cpb.47.1573"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12) Welsh A., Rylands L., Arion V., Prince S., Smith G., <i>Dalton Trans.<\/i>, <b>49<\/b>, 1143\u20131156 (2020).","DOI":"10.1039\/C9DT03902C"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13) Zhou S., Huang G., <i>RSC Adv.<\/i>, <b>10<\/b>, 5874\u20135885 (2020).","DOI":"10.1039\/C9RA10659F"},{"key":"14","unstructured":"14) Bui T. B. H., Phuong H. N., Tran Q. D., Mai V. H., Eunji J., Nguyen V. T., Than T. T., Le D. A., Nguyen H. S., Danh L. D. T., Myrielle D.-R., Regis G., Marc P. W., <i>ChemMedChem<\/i>, <b>15<\/b>, 1\u201312 (2020)."},{"key":"15","doi-asserted-by":"crossref","unstructured":"15) Taha M., Mosaddik A., Rahim F., Ali S., Ibrahim M., Almandil N. B., <i>J. King Saud Univ. Sci.<\/i>, <b>32<\/b>, 191\u2013194 (2018).","DOI":"10.1016\/j.jksus.2018.04.003"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16) Kerimov I., Ayhan-Kilcigil G., Can-Eke B., Altanlar N., Iscan M., <i>J. Enzyme Inhib. Med. Chem.<\/i>, <b>22<\/b>, 696\u2013701 (2007).","DOI":"10.1080\/14756360701228558"},{"key":"17","unstructured":"17) Satija G., Sharma B., Madan A., Iqubal A., Shaquiquzzaman M., Akhter M., Parvez S., Khan M. A., Alam M. M., <i>J. Heterocycl. Chem.<\/i>, <b>2021<\/b>, 1\u201345 (2021)."},{"key":"18","unstructured":"18) Sumit T., Sanjiv K., Saloni K., Balasubramanian N., <i>BMC Chem.<\/i>, <b>13<\/b>, 66 (2019)."},{"key":"19","doi-asserted-by":"crossref","unstructured":"19) Shrivastava N., Naim M. J., Alam M. J., Nawaz F., Ahmed S., Alam O., <i>Arch. Pharm.<\/i> (Weinheim), <b>350<\/b>, e201700040 (2017).","DOI":"10.1002\/ardp.201700040"},{"key":"20","unstructured":"20) Sumit T., Sanjiv K., Saloni K., Balasubramanian N., <i>BMC Chem.<\/i>, <b>13<\/b>, 66 (2019)."},{"key":"21","doi-asserted-by":"crossref","unstructured":"21) Yoon Y. K., Ali M. A., Wei A. C., Choon T. S., Osman H., Parang K., Shirazi A. N., <i>Bioorg. Med. Chem.<\/i>, <b>22<\/b>, 703\u2013710 (2014).","DOI":"10.1016\/j.bmc.2013.12.029"},{"key":"22","doi-asserted-by":"crossref","unstructured":"22) Yoon Y. K., Ali M. A., Wei A. C., Shirazi A. N., Parang K., Choon T. S., <i>Eur. J. Med. Chem.<\/i>, <b>83<\/b>, 448\u2013454 (2014).","DOI":"10.1016\/j.ejmech.2014.06.060"},{"key":"23","doi-asserted-by":"crossref","unstructured":"23) Pardeshi V. A. S., Chundawat N. S., Pathan S. I., Sukhwal P., Chundawat T. P. S., Singh G. P., <i>Synth. Commun.<\/i>, <b>51<\/b>, 485\u2013513 (2021).","DOI":"10.1080\/00397911.2020.1841239"},{"key":"24","doi-asserted-by":"crossref","unstructured":"24) Nardi M., Cano N. C. H., Simeonov S., Bence R., Kurutos A., Scarpelli R., Wunderlin D., Procopio A., <i>Catalysts<\/i>, <b>13<\/b>, 392 (2023).","DOI":"10.3390\/catal13020392"},{"key":"25","doi-asserted-by":"crossref","unstructured":"25) Kumar M., Pandey S. K., Chaudhary N., Mishra A., Gupta D., <i>Results Chem.<\/i>, <b>4<\/b>, 100403 (2022).","DOI":"10.1016\/j.rechem.2022.100403"},{"key":"26","doi-asserted-by":"crossref","unstructured":"26) Faheem M., Rathaur A., Pandey A., Singh V. K., Tiwari A. K., <i>ChemistrySelect<\/i>, <b>5<\/b>, 3981\u20133994 (2020).","DOI":"10.1002\/slct.201904832"},{"key":"27","doi-asserted-by":"crossref","unstructured":"27) Naresh G., Kant R., Narender T., <i>J. Org. Chem.<\/i>, <b>79<\/b>, 3821\u20133829 (2014).","DOI":"10.1021\/jo5000797"},{"key":"28","doi-asserted-by":"crossref","unstructured":"28) Tangella Y., Manasa K. L., Sathish M., Alarifi A., Kamal A., <i>ChemistrySelect<\/i>, <b>1<\/b>, 2895\u20132899 (2016).","DOI":"10.1002\/slct.201600772"},{"key":"29","doi-asserted-by":"crossref","unstructured":"29) Bui H. T. B., Do K. M., Hong Q. V., Le H. T., Hnin S. Y. Y., Tran D. Q., Mai H. V., Morita H., <i>Tetrahedron<\/i>, <b>156<\/b>, 133940 (2024).","DOI":"10.1016\/j.tet.2024.133940"},{"key":"30","doi-asserted-by":"crossref","unstructured":"30) Gursoy S., Ersan R. H., <i>J. Mol. Struct.<\/i>, <b>1308<\/b>, 137960 (2024).","DOI":"10.1016\/j.molstruc.2024.137960"},{"key":"31","doi-asserted-by":"crossref","unstructured":"31) Be\u010d A., Mio\u010d M., Berto\u0161a B., Kos M., Debogovi\u0107 P., Kralj M., Star\u010devi\u0107 K., Hranjec M., <i>J. Enzyme Inhib. Med. Chem.<\/i>, <b>37<\/b>, 1327\u20131339 (2022).","DOI":"10.1080\/14756366.2022.2070910"},{"key":"32","doi-asserted-by":"crossref","unstructured":"32) Perin N., Hok L., Be\u010d A., Persoons L., Vanstreels E., Daelemans D., Vianello R., Hranjec M., <i>Eur. J. Med. Chem.<\/i>, <b>211<\/b>, 113003 (2021).","DOI":"10.1016\/j.ejmech.2020.113003"},{"key":"33","unstructured":"33) Nguyen P. Q., Bui T. B. H., Kiep M. D., Ha T. K. Q., Tran Q. D., Tran T. B. P., Pham C. T., Nguyen C. Q., Morita H., <i>Chem. Pharm. Bull.<\/i>, <b>70<\/b>, 448\u2013453 (2022)."},{"key":"34","doi-asserted-by":"crossref","unstructured":"34) Meeniga I., Gokanapalli A., Peddiahgari V. G. R., <i>Sustain. Chem. Pharm.<\/i>, <b>30<\/b>, 100874 (2022).","DOI":"10.1016\/j.scp.2022.100874"},{"key":"35","doi-asserted-by":"crossref","unstructured":"35) Akko\u00e7 S., <i>J. Phys. Org. Chem.<\/i>, <b>34<\/b>, e4125 (2021).","DOI":"10.1002\/poc.4125"},{"key":"36","doi-asserted-by":"crossref","unstructured":"36) Nardi M., Bonacci S., Herrera Cano N., Olivero M., Procipio A., <i>Molecules<\/i>, <b>27<\/b>, 1751 (2022).","DOI":"10.3390\/molecules27051751"},{"key":"37","doi-asserted-by":"crossref","unstructured":"37) Gokanapalli A., Motakatla V., Peddiahgari V. G. R., <i>Appl. Organomet. Chem.<\/i>, <b>34<\/b>, e5869 (2020).","DOI":"10.1002\/aoc.5869"},{"key":"38","doi-asserted-by":"crossref","unstructured":"38) Putta R. R., Chun S., Lee B. L., Oh D.-C., Hong S., <i>Front Chem.<\/i>, <b>8<\/b>, 429 (2020).","DOI":"10.3389\/fchem.2020.00429"},{"key":"39","doi-asserted-by":"crossref","unstructured":"39) Taha M., Khan A. A., Rahim F., Imran S., Salahuddin M., Uddin N., Khan K. M., Shah S. A. A., Zafar A., Zakaria Z. A., <i>Arab. J. Chem.<\/i>, <b>15<\/b>, 103505 (2022).","DOI":"10.1016\/j.arabjc.2021.103505"},{"key":"40","doi-asserted-by":"crossref","unstructured":"40) Dokla E. M. E., Abutaleb N. S., Milik S. N., Li D., El-Baz K., Shalaby M.-A. W., Al-Karaki R., Nasr M., Klein C. D., Abouzid K. A. M., Seleem M. N., <i>Eur. J. Med. Chem.<\/i>, <b>186<\/b>, 111850 (2020).","DOI":"10.1016\/j.ejmech.2019.111850"},{"key":"41","doi-asserted-by":"crossref","unstructured":"41) Xie C., Han X., Gong J., Li D., Ma C., <i>Org. Biomol. Chem.<\/i>, <b>15<\/b>, 5811\u20135819 (2017).","DOI":"10.1039\/C7OB00945C"},{"key":"42","doi-asserted-by":"crossref","unstructured":"42) Kumar B., Smita K., Kumar B., Cumbal L., <i>J. Chem. Sci.<\/i>, <b>126<\/b>, 1831\u20131840 (2014).","DOI":"10.1007\/s12039-014-0662-4"},{"key":"43","doi-asserted-by":"crossref","unstructured":"43) Bonacci S., Iriti G., Mancuso S., Novelli P., Paonessa R., Tallarico S., Nardi M., <i>Catalysts<\/i>, <b>10<\/b>, 845 (2020).","DOI":"10.3390\/catal10080845"},{"key":"44","doi-asserted-by":"crossref","unstructured":"44) Mosmann T., Immunol J., <i>Methods<\/i>, <b>65<\/b>, 55\u201363 (1983).","DOI":"10.1016\/0022-1759(83)90303-4"}],"container-title":["Chemical and Pharmaceutical Bulletin"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/cpb\/72\/11\/72_c24-00570\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,8]],"date-time":"2024-11-08T22:34:26Z","timestamp":1731105266000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/cpb\/72\/11\/72_c24-00570\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,7]]},"references-count":44,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2024]]}},"URL":"https:\/\/doi.org\/10.1248\/cpb.c24-00570","relation":{},"ISSN":["0009-2363","1347-5223"],"issn-type":[{"value":"0009-2363","type":"print"},{"value":"1347-5223","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,11,7]]},"article-number":"c24-00570"}}