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Chem.<\/i>, <b>49<\/b>, 7063\u20137075 (2006).","DOI":"10.1021\/jm060797q"},{"key":"72","doi-asserted-by":"crossref","unstructured":"72) Saito N., Masuda M., Matsunaga T., Saito H., Anzai M., Takenouchi K., Miura D., Ishizuka S., Takimoto-Kamimura M., Kittaka A., <i>Tetrahedron<\/i>, <b>60<\/b>, 7951\u20137961 (2004).","DOI":"10.1016\/j.tet.2004.05.113"},{"key":"73","doi-asserted-by":"crossref","unstructured":"73) Saito N., Masuda M., Saito H., Takenouchi K., Seiichi I., Namekawa N.-i., Takimoto-Kamimura M., Kittaka A., <i>Synthesis<\/i> (Stuttg.), 2533\u20132543 (2005).","DOI":"10.1055\/s-2005-872075"},{"key":"74","doi-asserted-by":"crossref","unstructured":"74) Saito N., Matsunaga T., Saito H., Anzai M., Takenouchi K., Miura D., Ishizuka S., Takayama H., Kittaka A., <i>Heterocycles<\/i>, <b>67<\/b>, 311\u2013336 (2006).","DOI":"10.3987\/COM-05-S(T)32"},{"key":"75","doi-asserted-by":"crossref","unstructured":"75) Saito N., Kittaka A., <i>ChemBioChem<\/i>, <b>7<\/b>, 1478\u20131490 (2006).","DOI":"10.1002\/cbic.200600054"},{"key":"76","doi-asserted-by":"crossref","unstructured":"76) Saito N., <i>Yakugaku Zasshi<\/i>, <b>127<\/b>, 1215\u20131222 (2007).","DOI":"10.1248\/yakushi.127.1215"},{"key":"77","doi-asserted-by":"crossref","unstructured":"77) Saito N., Kittaka A., <i>J. Synth. Org. Chem. Jpn.<\/i>, <b>65<\/b>, 947\u2013958 (2007).","DOI":"10.5059\/yukigoseikyokaishi.65.947"},{"key":"78","unstructured":"78) Kittaka A., Saito N., Takenouchi K., Ishizuka S., <i>Vitamins<\/i>, <b>83<\/b>, 569\u2013579 (2009)."},{"key":"79","doi-asserted-by":"crossref","unstructured":"79) Reddy S. V., <i>J. Cell. Biochem.<\/i>, <b>93<\/b>, 688\u2013696 (2004).","DOI":"10.1002\/jcb.20256"},{"key":"80","doi-asserted-by":"crossref","unstructured":"80) Matsuo M., Hasegawa A., Takano M., Saito H., Kakuda S., Chida T., Takagi K., Ochiai E., Horie K., Harada Y., Takimoto-Kamimura M., Takenouchi K., Sawada D., Kittaka A., <i>ACS Med. Chem. Lett.<\/i>, <b>4<\/b>, 671\u2013674 (2013).","DOI":"10.1021\/ml400098w"},{"key":"81","doi-asserted-by":"crossref","unstructured":"81) Matsuo M., Hasegawa A., Takano M., Saito H., Kakuda S., Takagi K., Ochiai E., Horie K., Takimoto-Kamimura M., Takenouchi K., Sawada D., Kittaka A., <i>J. Steroid Biochem. Mol. Biol.<\/i>, <b>144<\/b> (Pt A), 201\u2013203 (2014).","DOI":"10.1016\/j.jsbmb.2013.09.001"},{"key":"82","doi-asserted-by":"crossref","unstructured":"82) Kittaka A., Takano M., Saitoh H., \u201cVitamins and Hormones,\u201d Vol. <b>100<\/b>, ed. by Litwack G., Elsevier Inc. Academic Press, Burlington, 2016, pp. 379\u2013394.","DOI":"10.1016\/bs.vh.2015.10.010"},{"key":"83","doi-asserted-by":"crossref","unstructured":"83) Takano M., Yasuda K., Tohyama E., Higuchi E., Sakaki T., Kittaka A., <i>J. Steroid Biochem. Mol. Biol.<\/i>, <b>173<\/b>, 75\u201378 (2017).","DOI":"10.1016\/j.jsbmb.2016.11.022"},{"key":"84","doi-asserted-by":"crossref","unstructured":"84) Yasuda K., Tohyama E., Takano M., Kittaka A., Ohta M., Ikushiro S., Sakaki T., <i>J. Steroid Biochem. Mol. Biol.<\/i>, <b>178<\/b>, 333\u2013339 (2018).","DOI":"10.1016\/j.jsbmb.2018.02.001"},{"key":"85","doi-asserted-by":"crossref","unstructured":"85) Nishikawa M., Murose N., Mano H., Yasuda K., Isogai Y., Kittaka A., Takano M., Ikushiro S., Sakaki T., <i>Sci. Rep.<\/i>, <b>12<\/b>, 12517 (2022).","DOI":"10.1038\/s41598-022-16819-7"},{"key":"86","doi-asserted-by":"crossref","unstructured":"86) Honzawa S., Takahashi N., Yamashita A., Sugiura T., Kurihara M., Arai M. A., Kato S., Kittaka A., <i>Tetrahedron<\/i>, <b>65<\/b>, 7135\u20137145 (2009).","DOI":"10.1016\/j.tet.2009.06.029"},{"key":"87","doi-asserted-by":"crossref","unstructured":"87) Takano M., Higuchi E., Higashi K., Hirano K., Takeuchi A., Sawada D., Kittaka A., <i>Heterocycles<\/i>, <b>90<\/b>, 1274\u20131287 (2015).","DOI":"10.3987\/COM-14-S(K)108"},{"key":"88","doi-asserted-by":"crossref","unstructured":"88) Nagata A., Akagi Y., Asano L., Kotake K., Kawagoe F., Mendoza A., Masoud S. S., Usuda K., Yasui K., Takemoto Y., Kittaka A., Nagasawa K., Uesugi U., <i>ACS Chem. Biol.<\/i>, <b>14<\/b>, 2851\u20132858 (2019).","DOI":"10.1021\/acschembio.9b00718"},{"key":"89","doi-asserted-by":"crossref","unstructured":"89) Havinga E., <i>Experientia<\/i>, <b>29<\/b>, 1181\u20131193 (1973).","DOI":"10.1007\/BF01935064"},{"key":"90","doi-asserted-by":"crossref","unstructured":"90) Maynard D. F., Trankle W. G., Norman A. W., Okamura W. H., <i>J. Med. Chem.<\/i>, <b>37<\/b>, 2387\u20132393 (1994).","DOI":"10.1021\/jm00041a017"},{"key":"91","doi-asserted-by":"crossref","unstructured":"91) Sawada D., Katayama T., Tsukuda Y., Saito N., Saito H., Takagi K.-i., Ochiai E., Ishizuka S., Takenouchi K., Kittaka A., <i>Tetrahedron<\/i>, <b>66<\/b>, 5407\u20135423 (2010).","DOI":"10.1016\/j.tet.2010.05.028"},{"key":"92","doi-asserted-by":"crossref","unstructured":"92) Sawada D., Tsukuda Y., Saito H., Takagi K.-i., Ochiai E., Ishizuka S., Takenouchi K., Kittaka A., <i>J. Steroid Biochem. Mol. Biol.<\/i>, <b>121<\/b>, 20\u201324 (2010).","DOI":"10.1016\/j.jsbmb.2010.02.035"},{"key":"93","doi-asserted-by":"crossref","unstructured":"93) Sawada D., Katayama T., Tsukuda Y., Saito N., Takano M., Saito H., Takagi K.-i., Ochiai E., Ishizuka S., Takenouchi K., Kittaka A., <i>Bioorg. Med. Chem. Lett.<\/i>, <b>19<\/b>, 5397\u20135400 (2009).","DOI":"10.1016\/j.bmcl.2009.07.112"},{"key":"94","doi-asserted-by":"crossref","unstructured":"94) Sawada D., Tsukuda Y., Saito H., Kakuda S., Takimoto-Kamimura M., Ochiai E., Takenouchi K., Kittaka A., <i>J. Am. Chem. Soc.<\/i>, <b>133<\/b>, 7215\u20137221 (2011).","DOI":"10.1021\/ja201481j"},{"key":"95","doi-asserted-by":"crossref","unstructured":"95) Sawada D., Kittaka A., <i>Curr. Top. Med. Chem.<\/i>, <b>14<\/b>, 2454\u20132459 (2014).","DOI":"10.2174\/1568026615666141208103741"},{"key":"96","doi-asserted-by":"crossref","unstructured":"96) Sawada D., Kakuda S., Takeuchi A., Kawagoe F., Takimoto-Kamimura M., Kittaka A., <i>Org. Biomol. Chem.<\/i>, <b>16<\/b>, 2448\u20132455 (2018).","DOI":"10.1039\/C8OB00158H"},{"key":"97","doi-asserted-by":"crossref","unstructured":"97) Sawada D., Tsukuda Y., Saito H., Takagi K., Kakuda S., Takimoto-Kamimura M., Ochiai E., Takenouchi K., Kittaka A., <i>J. Steroid Biochem. Mol. Biol.<\/i>, <b>136<\/b>, 27\u201329 (2013).","DOI":"10.1016\/j.jsbmb.2012.11.014"},{"key":"98","doi-asserted-by":"crossref","unstructured":"98) Sawada D., Kakuda S., Kamimura-Takimoto M., Takeuchi A., Matsumoto Y., Kittaka A., <i>Tetrahedron<\/i>, <b>72<\/b>, 2838\u20132848 (2016).","DOI":"10.1016\/j.tet.2016.03.081"},{"key":"99","unstructured":"99) Kittaka A., <i>Vitamins<\/i>, <b>94<\/b>, 155\u2013161 (2020)."},{"key":"100","doi-asserted-by":"crossref","unstructured":"100) Shindo K., Kumagai G., Takano M., Sawada D., Saito N., Saito H., Kakuda S., Takagi K.-i., Ochiai E., Horie K., Takimoto-Kamimura M., Ishizuka S., Takenouchi K., Kittaka A., <i>Org. Lett.<\/i>, <b>13<\/b>, 2852\u20132855 (2011).","DOI":"10.1021\/ol200828s"},{"key":"101","unstructured":"101) Kumagai G., Takano M., Shindo K., Sawada D., Saito N., Saito H., Kakuda S., Takagi K.-i., Takimoto-Kamimura M., Takenouchi K., Chen T. C., Kittaka A., <i>Anticancer Res.<\/i>, <b>32<\/b>, 311\u2013318 (2012)."},{"key":"102","doi-asserted-by":"crossref","unstructured":"102) Asano L., Watanabe M., Ryoden Y., Usuda K., Yamaguchi T., Khambu B., Takashima M., Sato S., Sakai J., Nagasawa K., Uesugi M., <i>Cell Chem. Biol.<\/i>, <b>24<\/b>, 207\u2013217 (2017).","DOI":"10.1016\/j.chembiol.2016.12.017"},{"key":"103","doi-asserted-by":"crossref","unstructured":"103) Kawagoe F., Mendoza A., Hayata Y., Asano L., Kotake K., Mototani S., Kawamura S., Kurosaki S., Akagi Y., Takemoto Y., Nagasawa K., Nakagawa H., Uesugi M., Kittaka A., <i>J. Med. Chem.<\/i>, <b>64<\/b>, 5689\u20135709 (2021).","DOI":"10.1021\/acs.jmedchem.0c02179"},{"key":"104","unstructured":"104) Uesugi M., Takemoto Y., Nagasawa K., Kittaka A., Kawagoe F., Nakagawa H., Patent No. U.S. 11,932,595 B2. Date of Patent: Mar. 19, 2024."},{"key":"105","doi-asserted-by":"crossref","unstructured":"105) Kawagoe F., Mototani S., Takemoto Y., Uesugi M., Kittaka A., <i>Synthesis<\/i> (Stuttg.), <b>56<\/b>, 1460\u20131464 (2024).","DOI":"10.1055\/a-2236-0413"},{"key":"106","doi-asserted-by":"crossref","unstructured":"106) Kawagoe F., Mototani S., Mendoza A., Takemoto Y., Uesugi M., Kittaka A., <i>RSC Med. Chem.<\/i>, <b>14<\/b>, 2030\u20132034 (2023).","DOI":"10.1039\/D3MD00352C"},{"key":"107","doi-asserted-by":"crossref","unstructured":"107) Kawagoe F., Mototani S., Kittaka A., <i>Int. J. Mol. Sci.<\/i>, <b>22<\/b>, 8191 (2021).","DOI":"10.3390\/ijms22158191"},{"key":"108","doi-asserted-by":"crossref","unstructured":"108) Fujishima T., Fujii S., Harayama T., <i>Curr. Org. Chem.<\/i>, <b>14<\/b>, 962\u2013976 (2010).","DOI":"10.2174\/138527210791111786"},{"key":"109","unstructured":"109) Kawagoe F., Kittaka A., <i>Vitamins<\/i>, <b>96<\/b>, 296\u2013304 (2022)."},{"key":"110","doi-asserted-by":"crossref","unstructured":"110) Kawagoe F., Mototani S., Yasuda K., Takeuchi A., Mano H., Kakuda S., Saitoh H., Sakaki T., Kittaka A., <i>J. Org. Chem.<\/i>, <b>88<\/b>, 12394\u201312408 (2023).","DOI":"10.1021\/acs.joc.3c01134"},{"key":"111","doi-asserted-by":"crossref","unstructured":"111) Kawagoe F., Yasuda K., Mototani S., Sugiyama T., Uesugi M., Sakaki T., Kittaka A., <i>ACS Omega<\/i>, <b>4<\/b>, 11332\u201311337 (2019).","DOI":"10.1021\/acsomega.9b01500"},{"key":"112","doi-asserted-by":"crossref","unstructured":"112) Mototani S., Kawagoe F., Yasuda K., Mano H., Sakaki T., Kittaka A., <i>Molecules<\/i>, <b>27<\/b>, 5352 (2022).","DOI":"10.3390\/molecules27165352"},{"key":"113","doi-asserted-by":"crossref","unstructured":"113) Kawagoe F., Mototani S., Kittaka A., <i>Biomolecules<\/i>, <b>14<\/b>, 37 (2024).","DOI":"10.3390\/biom14010037"},{"key":"114","doi-asserted-by":"crossref","unstructured":"114) Kawagoe F., Mototani S., Yasuda K., Mano H., Sakaki T., Kittaka A., <i>Int. J. Mol. Sci.<\/i>, <b>22<\/b>, 11863 (2021).","DOI":"10.3390\/ijms222111863"},{"key":"115","doi-asserted-by":"crossref","unstructured":"115) Kawagoe F., Mototani S., Yasuda K., Nagasawa K., Uesugi M., Sakaki T., Kittaka A., <i>J. Steroid Biochem. Mol. Biol.<\/i>, <b>195<\/b>, 105477 (2019).","DOI":"10.1016\/j.jsbmb.2019.105477"},{"key":"116","doi-asserted-by":"crossref","unstructured":"116) Kawagoe F., Mototani S., Yasuda K., Mano H., Takeuchi A., Saitoh H., Sakaki T., Kittaka A., <i>Chem. Pharm. Bull.<\/i>, <b>71<\/b>, 717\u2013723 (2023).","DOI":"10.1248\/cpb.c23-00395"},{"key":"117","doi-asserted-by":"crossref","unstructured":"117) Kawagoe F., Sugiyama T., Uesugi M., Kittaka A., <i>J. Steroid Biochem. Mol. 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