{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T09:42:38Z","timestamp":1781516558620,"version":"3.54.1"},"reference-count":27,"publisher":"Pharmaceutical Society of Japan","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Chem. Pharm. Bull.","CHEMICAL &amp; PHARMACEUTICAL BULLETIN"],"published-print":{"date-parts":[[2025,2,26]]},"DOI":"10.1248\/cpb.c24-00599","type":"journal-article","created":{"date-parts":[[2025,2,25]],"date-time":"2025-02-25T22:11:49Z","timestamp":1740521509000},"page":"112-120","source":"Crossref","is-referenced-by-count":2,"title":["Design, Synthesis, and Antitumor Activity of Novel Eupatilin Derivatives Based on the Mannich Reaction"],"prefix":"10.1248","volume":"73","author":[{"given":"Yaqi","family":"Meng","sequence":"first","affiliation":[{"name":"Center of Scientific Research (Institute of Nanyang Geoherbs), Nanyang Medical College, Nanyang 473061, China"},{"name":"Key Laboratory of Research on Effective Substances and Quality Control of Traditional Chinese Medicine, Nanyang Medical College, Nanyang 473061, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuqing","family":"Wang","sequence":"additional","affiliation":[{"name":"Center of Scientific Research (Institute of Nanyang Geoherbs), Nanyang Medical College, Nanyang 473061, China"},{"name":"Key Laboratory of Research on Effective Substances and Quality Control of Traditional Chinese Medicine, Nanyang Medical College, Nanyang 473061, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shujiao","family":"Li","sequence":"additional","affiliation":[{"name":"Center of Scientific Research (Institute of Nanyang Geoherbs), Nanyang Medical College, Nanyang 473061, China"},{"name":"Key Laboratory of Research on Effective Substances and Quality Control of Traditional Chinese Medicine, Nanyang Medical College, Nanyang 473061, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiyan","family":"Cai","sequence":"additional","affiliation":[{"name":"Center of Scientific Research (Institute of Nanyang Geoherbs), Nanyang Medical College, Nanyang 473061, China"},{"name":"Key Laboratory of Research on Effective Substances and Quality Control of Traditional Chinese Medicine, Nanyang Medical College, Nanyang 473061, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guo","family":"Zhuang","sequence":"additional","affiliation":[{"name":"Center of Scientific Research (Institute of Nanyang Geoherbs), Nanyang Medical College, Nanyang 473061, China"},{"name":"Key Laboratory of Research on Effective Substances and Quality Control of Traditional Chinese Medicine, Nanyang Medical College, Nanyang 473061, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanli","family":"Yang","sequence":"additional","affiliation":[{"name":"Center of Scientific Research (Institute of Nanyang Geoherbs), Nanyang Medical College, Nanyang 473061, China"},{"name":"Key Laboratory of Research on Effective Substances and Quality Control of Traditional Chinese Medicine, Nanyang Medical College, Nanyang 473061, China"},{"name":"School of Pharmacy, Henan University, Kaifeng 475001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"163","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"1) Sung H., Ferlay J., Siegel R. L., Laversanne M., Soerjomataram I., Jemal A., Bray F., <i>CA Cancer J. Clin.<\/i>, <b>71<\/b>, 209\u2013249 (2021).","DOI":"10.3322\/caac.21660"},{"key":"2","unstructured":"2) Wang X., Zhang H. Y., Chen X. Z., <i>Cancer Drug Resist.<\/i>, <b>2<\/b>, 141\u2013160 (2019)."},{"key":"3","doi-asserted-by":"crossref","unstructured":"3) Behranvand N., Nasri F., Zolfaghari Emameh R., Khani P., Hosseini A., Garssen J., Falak R., <i>Cancer Immunol. Immunother.<\/i>, <b>71<\/b>, 507\u2013526 (2022).","DOI":"10.1007\/s00262-021-03013-3"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4) He N. N., Wang J. A., Huang D., Sun X. L., Ding F., Zhao L., Zhang Y. X., Li H. M., Wu C. Z., <i>Chem. Pharm. Bull.<\/i>, <b>71<\/b>, 798\u2013803 (2023).","DOI":"10.1248\/cpb.c23-00215"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5) Nakayama A., <i>Chem. Pharm. Bull.<\/i>, <b>72<\/b>, 422\u2013431 (2024).","DOI":"10.1248\/cpb.c24-00056"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6) Cragg G. M., Pezzuto J. M., <i>Med. Princ. Pract.<\/i>, <b>25<\/b> (Suppl. 2), 41\u201359 (2016).","DOI":"10.1159\/000443404"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7) Butler M. S., Robertson A. A., Cooper M. A., <i>Nat. Prod. Rep.<\/i>, <b>31<\/b>, 1612\u20131661 (2014).","DOI":"10.1039\/C4NP00064A"},{"key":"8","unstructured":"8) Atanasov A. G., Zotchev S. B., Dirsch V. M., Supuran C. T., <i>Nat. Rev. Drug Discov.<\/i>, <b>20<\/b>, 200\u2013216 (2021)."},{"key":"9","doi-asserted-by":"crossref","unstructured":"9) Aldrich L. N., Burdette J. E., Carcache de Blanco E. C., Coss C. C., Eustaquio A. S., Fuchs J. R., Kinghorn A. D., Macfarlane A., Mize B. K., Oberlies N. H., <i>J. Nat. Prod.<\/i>, <b>85<\/b>, 702\u2013719 (2022).","DOI":"10.1021\/acs.jnatprod.2c00036"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10) Wada K., Goto M., Lee K. H., Yamashita H., <i>Chem. Pharm. Bull.<\/i>, <b>71<\/b>, 52\u201357 (2023).","DOI":"10.1248\/cpb.c22-00585"},{"key":"11","unstructured":"11) Nageen B., Sarfraz I., Rasul A., Hussain G., Rukhsar F., Irshad S., Riaz A., Selamoglu Z., Ali M., <i>J. Asian Nat. Prod. Res.<\/i>, <b>22<\/b>, 1\u201316 (2020)."},{"key":"12","doi-asserted-by":"crossref","unstructured":"12) Bai D., Sun T. X., Lu F., Shen Y. C., Zhang Y., Zhang B., Yu G. L., Li H. H., Hao J. J., <i>Int. J. Mol. Sci.<\/i>, <b>23<\/b>, 1582\u20131594 (2022).","DOI":"10.3390\/ijms23031582"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13) Jung Y., Kim J. C., Park N. J., Bong S. K., Lee S., Jegal H., Jin L. T., Kim S. M., Kim Y. K., Kim S. N., <i>Biochem. Biophys. Res. Commun.<\/i>, <b>496<\/b>, 508\u2013514 (2018).","DOI":"10.1016\/j.bbrc.2018.01.098"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14) Wu Z., Zou B. Y., Zhang X., Peng X., <i>Cell Biochem. Funct.<\/i>, <b>38<\/b>, 428\u2013435 (2020).","DOI":"10.1002\/cbf.3493"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15) Fei X. W., Wang J., Chen C., Ding B. Y., Fu X. J., Chen W. J., Wang C. W., Xu R. X., <i>Cancer Manag. Res.<\/i>, <b>11<\/b>, 4781\u20134796 (2019).","DOI":"10.2147\/CMAR.S207257"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16) Zhong W. F., Wu Z. M., Chen N. H., Zhong K. H., Lin Y. F., Jiang H. M., Wan P., Lu S. M., Yang L. W., Liu S. P., <i>BioMed Res. Int.<\/i>, <b>2019<\/b>, 1\u201311 (2019).","DOI":"10.1155\/2019\/5016483"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17) Kim M. J., Kim D. H., Na H. K., Oh T. Y., Shin C. Y., Surh Y. J., <i>J. Environ. Pathol. Toxicol. Oncol.<\/i>, <b>24<\/b>, 261\u2013270 (2005).","DOI":"10.1615\/JEnvironPatholToxicolOncol.v24.i4.30"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18) Nogales C., Mamdouh Z. M., List M., Kiel C., Casas A. I., Schmidt H. H. H. W., <i>Trends Pharmacol. Sci.<\/i>, <b>43<\/b>, 136\u2013150 (2022).","DOI":"10.1016\/j.tips.2021.11.004"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19) Yuan H. D., Ma Q. Q., Cui H. Y., Liu G. C., Zhao X. Y., Li W., Piao G. C., <i>Molecules<\/i>, <b>22<\/b>, 1135\u20131153 (2017).","DOI":"10.3390\/molecules22071135"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20) Shang L., Wang Y. C., Li J. X., Zhou F. Y., Xiao K. M., Liu Y. H., Zhang M. Q., Wang S. H., Yang S. L., <i>J. Ethnopharmacol.<\/i>, <b>302<\/b> (Pt. A), 115876 (2023).","DOI":"10.1016\/j.jep.2022.115876"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21) Wang Y., Yuan Y., Wang W. T., He Y., Zhong H., Zhou X. X., Chen Y., Cai X. J., Liu L. Q., <i>Comput. Biol. Med.<\/i>, <b>145<\/b>, 105454\u2013105473 (2022).","DOI":"10.1016\/j.compbiomed.2022.105454"},{"key":"22","unstructured":"22) Wu J. S., Zhang F. Q., Li Z. Z., Jin W. Y., Shi Y., <i>J. Tradit. Chin. Med.<\/i>, <b>42<\/b>, 479\u2013486 (2022)."},{"key":"23","doi-asserted-by":"crossref","unstructured":"23) Ferreira L. G., Dos Santos R. N., Oliva G., Andricopulo A. D., <i>Molecules<\/i>, <b>20<\/b>, 13384\u201313421 (2015).","DOI":"10.3390\/molecules200713384"},{"key":"24","doi-asserted-by":"crossref","unstructured":"24) Pinzi L., Rastelli G., <i>Int. J. Mol. Sci.<\/i>, <b>20<\/b>, 4331\u20134353 (2019).","DOI":"10.3390\/ijms20184331"},{"key":"25","doi-asserted-by":"crossref","unstructured":"25) Liang X. Q., Chen R. X., Wang C. D., Wang Y. X., Zhang J. F., <i>J. Med. Chem.<\/i>, <b>67<\/b>, 15968\u201315995 (2024).","DOI":"10.1021\/acs.jmedchem.4c00966"},{"key":"26","doi-asserted-by":"crossref","unstructured":"26) Wang Z. Y., Fan L. F., Xu H., Qin Z. Q., Zhu Z. Y., Wu D., Zhang Y. G., Liu R. Y., Wei J. Z., Qian Z., Yang P. P., Xie B., Yuan M., Qian J. Y., <i>Transl. Oncol.<\/i>, <b>50<\/b>, 102148 (2024).","DOI":"10.1016\/j.tranon.2024.102148"},{"key":"27","doi-asserted-by":"crossref","unstructured":"27) Zuehlke A. D., Beebe K., Neckers L., Prince T., <i>Gene<\/i>, <b>570<\/b>, 8\u201316 (2015).","DOI":"10.1016\/j.gene.2015.06.018"}],"container-title":["Chemical and Pharmaceutical Bulletin"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/cpb\/73\/2\/73_c24-00599\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T03:35:49Z","timestamp":1740800149000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/cpb\/73\/2\/73_c24-00599\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,26]]},"references-count":27,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.1248\/cpb.c24-00599","relation":{},"ISSN":["0009-2363","1347-5223"],"issn-type":[{"value":"0009-2363","type":"print"},{"value":"1347-5223","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,2,26]]},"article-number":"c24-00599"}}