{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T12:35:33Z","timestamp":1793450133311,"version":"4.5.0"},"reference-count":49,"publisher":"Pharmaceutical Society of Japan","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Chem. Pharm. Bull.","CHEMICAL &amp; PHARMACEUTICAL BULLETIN"],"published-print":{"date-parts":[[2025,6,28]]},"DOI":"10.1248\/cpb.c25-00086","type":"journal-article","created":{"date-parts":[[2025,6,27]],"date-time":"2025-06-27T22:07:38Z","timestamp":1751062058000},"page":"559-567","source":"Crossref","is-referenced-by-count":3,"title":["Dynamic Dialysis Method for Characterizing Ammonia-Driven Drug Release from Liposomal Doxorubicin: Applicability and Kinetic Modeling"],"prefix":"10.1248","volume":"73","author":[{"given":"Yoshinori","family":"Maeda","sequence":"first","affiliation":[{"name":"Kitasato University, 5\u20139\u20131 Shirokane, Minato-ku, Tokyo 108\u20138641, Japan"},{"name":"Division of Drugs, National Institute of Health Sciences, 3\u201325\u201326 Tonomachi, Kawasaki-ku, Kawasaki 210\u20139501, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuki","family":"Takechi-Haraya","sequence":"additional","affiliation":[{"name":"Division of Biochemistry, National Institute of Health Sciences, 3\u201325\u201326 Tonomachi, Kawasaki-ku, Kawasaki 210\u20139501, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emi","family":"Kawarai","sequence":"additional","affiliation":[{"name":"Division of Drugs, National Institute of Health Sciences, 3\u201325\u201326 Tonomachi, Kawasaki-ku, Kawasaki 210\u20139501, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuhiro","family":"Abe","sequence":"additional","affiliation":[{"name":"Division of Drugs, National Institute of Health Sciences, 3\u201325\u201326 Tonomachi, Kawasaki-ku, Kawasaki 210\u20139501, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norihito","family":"Shibata","sequence":"additional","affiliation":[{"name":"Division of Biochemistry, National Institute of Health Sciences, 3\u201325\u201326 Tonomachi, Kawasaki-ku, Kawasaki 210\u20139501, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoji","family":"Sato","sequence":"additional","affiliation":[{"name":"Division of Drugs, National Institute of Health Sciences, 3\u201325\u201326 Tonomachi, Kawasaki-ku, Kawasaki 210\u20139501, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kumiko","family":"Sakai-Kato","sequence":"additional","affiliation":[{"name":"Kitasato University, 5\u20139\u20131 Shirokane, Minato-ku, Tokyo 108\u20138641, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"163","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"1) Andra V. V. S. N. L., Pammi S. V. N., Bhatraju L. V. K. P., Ruddaraju L. K., <i>Bionanoscience<\/i>, <b>12<\/b>, 274\u2013291 (2022).","DOI":"10.1007\/s12668-022-00941-x"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2) Barenholz Y., <i>J. Control. Release<\/i>, <b>160<\/b>, 117\u2013134 (2012).","DOI":"10.1016\/j.jconrel.2012.03.020"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3) Germain M., Caputo F., Metcalfe S., Tosi G., Spring K., \u00c5slund A. K. O., Pottier A., Schiffelers R., Ceccaldi A., Schmid R., <i>J. Control. Release<\/i>, <b>326<\/b>, 164\u2013171 (2020).","DOI":"10.1016\/j.jconrel.2020.07.007"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4) Luiz H., Oliveira Pinho J., Gaspar M. M., <i>Biomedicines<\/i>, <b>11<\/b>, 435 (2023).","DOI":"10.3390\/biomedicines11020435"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5) Nsairat H., Alshaer W., Odeh F., Esawi E., Khater D., Bawab A. A., El-Tanani M., Awidi A., Mubarak M. S., <i>OpenNano<\/i>, <b>11<\/b>, 100132 (2023).","DOI":"10.1016\/j.onano.2023.100132"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6) Nsairat H., Khater D., Sayed U., Odeh F., Al Bawab A., Alshaer W., <i>Heliyon<\/i>, <b>8<\/b>, e09394 (2022).","DOI":"10.1016\/j.heliyon.2022.e09394"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7) Tenchov R., Bird R., Curtze A. E., Zhou Q., <i>ACS Nano<\/i>, <b>15<\/b>, 16982\u201317015 (2021).","DOI":"10.1021\/acsnano.1c04996"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8) Clogston J. D., Foss W., Harris D., Oberoi H., Pan J., Pu E., Guzm\u00e1n E. A. T., Walter K., Brown S., Lim Soo P., <i>J. Pharm. Sci.<\/i>, <b>113<\/b>, 3395\u20133405 (2024).","DOI":"10.1016\/j.xphs.2024.09.005"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9) Alshaer W., Nsairat H., Lafi Z., Hourani O. M., Al-Kadash A., Esawi E., Alkilany A. M., <i>Molecules<\/i>, <b>28<\/b>, 10 (2022).","DOI":"10.3390\/molecules28010010"},{"key":"10","unstructured":"10) D\u2019Souza S., <i>Adv. Pharm.<\/i>, <b>2014<\/b>, 304757 (2014)."},{"key":"11","doi-asserted-by":"crossref","unstructured":"11) Gaspar R. S., Silva-Lima B., Magro F., Alcobia A., da Costa F. L., Feio J., <i>Front. Med.<\/i> (Lausanne), <b>7<\/b>, 590527 (2020).","DOI":"10.3389\/fmed.2020.590527"},{"key":"12","unstructured":"12) Ministry of Health, Labour and Welfare (MHLW), \u201cGuideline for the Development of Liposome Drug Products.\u201d: &lt;https:\/\/www.nihs.go.jp\/drug\/section4\/160328_MHLW_liposome_guideline.pdf&gt;, cited 18 December, 2024."},{"key":"13","doi-asserted-by":"crossref","unstructured":"13) de Vlieger J. S. B., Crommelin D. J. A., Tyner K., Drummond D. C., Jiang W., McNeil S. E., Neervannan S., Crist R. M., Shah V. P., <i>AAPS J.<\/i>, <b>21<\/b>, 56 (2019).","DOI":"10.1208\/s12248-019-0329-7"},{"key":"14","unstructured":"14) FDA, \u201cDraft Guidance on Doxorubicin Hydrochloride.\u201d: &lt;https:\/\/www.accessdata.fda.gov\/drugsatfda_docs\/psg\/PSG_050718.pdf&gt;, cited 18 December, 2024."},{"key":"15","unstructured":"15) FDA, \u201cDrug Products, Including Biological Products, that Contain Nanomaterials Guidance for Industry.\u201d: &lt;https:\/\/www.fda.gov\/media\/157812\/download&gt;, cited 18 December, 2024."},{"key":"16","unstructured":"16) FDA, \u201cLiposome Drug Products Chemistry, Manufacturing, and Controls; Human Pharmacokinetics and Bioavailability; and Labeling Documentation, Guidance for Industry.\u201d: &lt;https:\/\/www.fda.gov\/media\/70837\/download&gt;, cited 18 December, 2024."},{"key":"17","unstructured":"17) EMA, \u201cReflection paper on the data requirements for intravenous liposomal products developed with innovator liposomal product.\u201d: &lt;https:\/\/etp-nanomedicine.eu\/wp-content\/uploads\/2018\/10\/reflection-paper-data-requirements-intravenous-liposomal-products-developed-reference-innovator_en-0.pdf&gt;, cited 18 December, 2024."},{"key":"18","doi-asserted-by":"crossref","unstructured":"18) Jayaraj S., Jiang W., Mudalige T., <i>J. Pharm. Sci.<\/i>, <b>113<\/b>, 1088\u20131093 (2024).","DOI":"10.1016\/j.xphs.2023.12.017"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19) D\u2019Souza S. S., DeLuca P. P., <i>Pharm. Res.<\/i>, <b>23<\/b>, 460\u2013474 (2006).","DOI":"10.1007\/s11095-005-9397-8"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20) Fugit K. D., Anderson B. D., <i>Mol. Pharm.<\/i>, <b>11<\/b>, 1314\u20131325 (2014).","DOI":"10.1021\/mp400765n"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21) Hua S., <i>Int. J. Nanomedicine<\/i>, <b>9<\/b>, 735\u2013744 (2014).","DOI":"10.2147\/IJN.S55805"},{"key":"22","doi-asserted-by":"crossref","unstructured":"22) Joguparthi V., Anderson B. D., <i>J. Pharm. Sci.<\/i>, <b>97<\/b>, 433\u2013454 (2008).","DOI":"10.1002\/jps.21135"},{"key":"23","doi-asserted-by":"crossref","unstructured":"23) Joguparthi V., Xiang T. X., Anderson B. D., <i>J. Pharm. Sci.<\/i>, <b>97<\/b>, 400\u2013420 (2008).","DOI":"10.1002\/jps.21125"},{"key":"24","doi-asserted-by":"crossref","unstructured":"24) Modi S., Anderson B. D., <i>Mol. Pharm.<\/i>, <b>10<\/b>, 3076\u20133089 (2013).","DOI":"10.1021\/mp400154a"},{"key":"25","doi-asserted-by":"crossref","unstructured":"25) Silverman L., Barenholz Y., <i>Nanomedicine<\/i>, <b>11<\/b>, 1841\u20131850 (2015).","DOI":"10.1016\/j.nano.2015.06.007"},{"key":"26","doi-asserted-by":"crossref","unstructured":"26) Saarinen-Savolainen P., J\u00e4rvinen T., Taipale H., Urtti A., <i>Int. J. Pharm.<\/i>, <b>159<\/b>, 27\u201333 (1997).","DOI":"10.1016\/S0378-5173(97)00264-0"},{"key":"27","doi-asserted-by":"crossref","unstructured":"27) Gray V., Cady S., Curran D., DeMuth J., Eradiri O., Hussain M., Kr\u00e4mer J., Shabushnig J., Stippler E., <i>Dissolut. Technol.<\/i>, <b>25<\/b>, 8\u201313 (2018).","DOI":"10.14227\/DT250418P8"},{"key":"28","doi-asserted-by":"crossref","unstructured":"28) D\u2019Arcy D. M., Wacker M. G., Klein S., Shah V., Burke M. D., Hunter G., Xu H., <i>Dissolut. Technol.<\/i>, <b>29<\/b>, 204\u2013218 (2022).","DOI":"10.14227\/DT290422P204"},{"key":"29","doi-asserted-by":"crossref","unstructured":"29) Zambito Y., Pedreschi E., Di Colo G., <i>Int. J. Pharm.<\/i>, <b>434<\/b>, 28\u201334 (2012).","DOI":"10.1016\/j.ijpharm.2012.05.020"},{"key":"30","doi-asserted-by":"crossref","unstructured":"30) Tardi P. G., Boman N. L., Cullis P. R., <i>J. Drug Target.<\/i>, <b>4<\/b>, 129\u2013140 (1996).","DOI":"10.3109\/10611869609015970"},{"key":"31","doi-asserted-by":"crossref","unstructured":"31) Wei X., Shamrakov D., Nudelman S., Peretz-Damari S., Nativ-Roth E., Regev O., Barenholz Y., <i>ACS Omega<\/i>, <b>3<\/b>, 2508\u20132517 (2018).","DOI":"10.1021\/acsomega.7b01235"},{"key":"32","doi-asserted-by":"crossref","unstructured":"32) Chen E., Chen B. M., Su Y. C., Chang Y. C., Cheng T. L., Barenholz Y., Roffler S. R., <i>ACS Nano<\/i>, <b>14<\/b>, 7808\u20137822 (2020).","DOI":"10.1021\/acsnano.9b07218"},{"key":"33","doi-asserted-by":"crossref","unstructured":"33) Fugit K. D., Xiang T. X., Choi D. H., Kangarlou S., Csuhai E., Bummer P. M., Anderson B. D., <i>J. Control. Release<\/i>, <b>217<\/b>, 82\u201391 (2015).","DOI":"10.1016\/j.jconrel.2015.08.024"},{"key":"34","doi-asserted-by":"crossref","unstructured":"34) Charrois G.J. R., Allen T. M., <i>Biochim. Biophys. Acta Biomembr.<\/i>, <b>1663<\/b>, 167\u2013177 (2004).","DOI":"10.1016\/j.bbamem.2004.03.006"},{"key":"35","doi-asserted-by":"crossref","unstructured":"35) Yu M., Yuan W., Li D., Schwendeman A., Schwendeman S. P., <i>J. Control. Release<\/i>, <b>315<\/b>, 23\u201330 (2019).","DOI":"10.1016\/j.jconrel.2019.09.016"},{"key":"36","doi-asserted-by":"crossref","unstructured":"36) Bian J., Girotti J., Fan Y., Levy E. S., Zang N., Sethuraman V., Kou P., Zhang K., Gruenhagen J., Lin J., <i>J. Chromatogr. A<\/i>, <b>1662<\/b>, 462688 (2022).","DOI":"10.1016\/j.chroma.2021.462688"},{"key":"37","doi-asserted-by":"crossref","unstructured":"37) Po H. N., Senozan N. M., <i>J. Chem. Educ.<\/i>, <b>78<\/b>, 1499\u20131503 (2001).","DOI":"10.1021\/ed078p1499"},{"key":"38","doi-asserted-by":"crossref","unstructured":"38) Lande M. B., Donovan J. M., Zeidel M. L., <i>J. Gen. Physiol.<\/i>, <b>106<\/b>, 67\u201384 (1995).","DOI":"10.1085\/jgp.106.1.67"},{"key":"39","doi-asserted-by":"crossref","unstructured":"39) Venable R. M., Kr\u00e4mer A., Pastor R. W., <i>Chem. Rev.<\/i>, <b>119<\/b>, 5954\u20135997 (2019).","DOI":"10.1021\/acs.chemrev.8b00486"},{"key":"40","doi-asserted-by":"crossref","unstructured":"40) Su\u0142kowski W. W., Pentak D., Nowak K., Su\u0142kowska A., <i>J. Mol. Struct.<\/i>, <b>744\u2013747<\/b>, 737\u2013747 (2005).","DOI":"10.1016\/j.molstruc.2004.11.075"},{"key":"41","doi-asserted-by":"crossref","unstructured":"41) Kitayama H., Takechi Y., Tamai N., Matsuki H., Yomota C., Saito H., <i>Chem. Pharm. Bull.<\/i>, <b>62<\/b>, 58\u201363 (2014).","DOI":"10.1248\/cpb.c13-00587"},{"key":"42","doi-asserted-by":"crossref","unstructured":"42) La Verde V., Dominici P., Astegno A., <i>Bio Protoc.<\/i>, <b>7<\/b>, e2230 (2017).","DOI":"10.21769\/BioProtoc.2230"},{"key":"43","doi-asserted-by":"crossref","unstructured":"43) Takechi-Haraya Y., Sakai-Kato K., Goda Y., <i>AAPS PharmSciTech<\/i>, <b>18<\/b>, 1887\u20131893 (2017).","DOI":"10.1208\/s12249-016-0624-x"},{"key":"44","doi-asserted-by":"crossref","unstructured":"44) Konermann L., <i>J. Am. Soc. Mass Spectrom.<\/i>, <b>28<\/b>, 1827\u20131835 (2017).","DOI":"10.1007\/s13361-017-1739-3"},{"key":"45","doi-asserted-by":"crossref","unstructured":"45) Csuhai E., Kangarlou S., Xiang T. X., Ponta A., Bummer P., Choi D., Anderson B. D., <i>J. Pharm. Sci.<\/i>, <b>104<\/b>, 1087\u20131098 (2015).","DOI":"10.1002\/jps.24307"},{"key":"46","doi-asserted-by":"crossref","unstructured":"46) Ryzhkina I., Murtazina L., Kostina L., Dokuchaeva I., Sergeeva S., Meleshenko K., Shevelev M., Petrov A., <i>Front Chem.<\/i>, <b>10<\/b>, 1063278 (2022).","DOI":"10.3389\/fchem.2022.1063278"},{"key":"47","unstructured":"47) International Council for Harmonisation of Technical Requirements for Pharmaceuticals for Human Use (ICH), \u201cICH Harmonised Guideline: Validation of Analytical Procedures Q2(R2).\u201d: &lt;https:\/\/www.pmda.go.jp\/files\/000265998.pdf&gt;, cited 18 December, 2024."},{"key":"48","doi-asserted-by":"crossref","unstructured":"48) Falck E., Patra M., Karttunen M., Hyv\u00f6nen M. T., Vattulainen I., <i>Biophys. J.<\/i>, <b>87<\/b>, 1076\u20131091 (2004).","DOI":"10.1529\/biophysj.104.041368"},{"key":"49","unstructured":"49) Mathews J. H., Fink K. K., \u201cNumerical Methods Using MATLAB,\u201d 3rd ed., Pearson plc, London, 1998, pp. 466\u2013471."}],"container-title":["Chemical and Pharmaceutical Bulletin"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/cpb\/73\/6\/73_c25-00086\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,28]],"date-time":"2025-06-28T03:27:48Z","timestamp":1751081268000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/cpb\/73\/6\/73_c25-00086\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,28]]},"references-count":49,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.1248\/cpb.c25-00086","relation":{},"ISSN":["0009-2363","1347-5223"],"issn-type":[{"value":"0009-2363","type":"print"},{"value":"1347-5223","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6,28]]},"article-number":"c25-00086"}}