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Immunol.<\/i>, <b>21<\/b>, 382\u2013393 (2021).","DOI":"10.1038\/s41577-021-00542-x"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6) Mantani N., Andoh T., Kawamata H., Terasawa K., Ochiai H., <i>Antiviral Res.<\/i>, <b>44<\/b>, 193\u2013200 (1999).","DOI":"10.1016\/S0166-3542(99)00067-4"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7) Nabeshima S., Kashiwagi K., Ajisaka K., Masui S., Takeoka H., Ikematsu H., Kashiwagi S., <i>J. Infect. Chemother.<\/i>, <b>18<\/b>, 534\u2013543 (2012).","DOI":"10.1007\/s10156-012-0378-7"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8) Oshima N., Yamashita T., Hyuga S., Hyuga M., Kamakura H., Yoshimura M., Maruyama T., Hakamatsuka T., Amakura Y., Hanawa T., Goda Y., <i>J. Nat. Med.<\/i>, <b>70<\/b>, 554\u2013562 (2016).","DOI":"10.1007\/s11418-016-0977-1"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9) Hyuga S., Hyuga M., Oshima N., Maruyama T., Kamakura H., Yamashita T., Yoshimura M., Amakura Y., Hakamatsuka T., Odaguchi H., Goda Y., Hanawa T., <i>J. Nat. Med.<\/i>, <b>70<\/b>, 571\u2013583 (2016).","DOI":"10.1007\/s11418-016-0979-z"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10) Yoshimura M., Amakura Y., Hyuga S., Hyuga M., Nakamori S., Maruyama T., Oshima N., Uchiyama N., Yang J., Oka H., Ito H., Kobayashi Y., Odaguchi H., Hakamatsuka T., Hanawa T., Goda Y., <i>Chem. Pharm. Bull.<\/i>, <b>68<\/b>, 140\u2013149 (2020).","DOI":"10.1248\/cpb.c19-00761"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11) Uema M., Hyuga M., Yonemitsu K., Hyuga S., Amakura Y., Uchiyama N., Mizoguchi K., Odaguchi H., Goda Y., <i>Microorganisms<\/i>, <b>11<\/b>, 534 (2023).","DOI":"10.3390\/microorganisms11020534"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12) Okada C., Ikeda-Ishizaka E., Ono C., Matsuura Y., Sonoda H., <i>Monoclon. Antib. Immunodiagn. Immunother.<\/i>, <b>41<\/b>, 173\u2013180 (2022).","DOI":"10.1089\/mab.2021.0043"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13) Lan J., Ge J., Yu J., Shan S., Zhou H., Fan S., Zhang Q., Shi X., Wang Q., Zhang L., Wang X., <i>Nature<\/i> (London), <b>581<\/b>, 215\u2013220 (2020).","DOI":"10.1038\/s41586-020-2180-5"},{"key":"14","unstructured":"14) \u201cMolecular Operating Environment (MOE), 2020.0901,\u201d Chemical Computing Group ULC, 1010 Sherbooke St. West, Suite #910, Montreal, QC, Canada, p3A 2R7."},{"key":"15","unstructured":"15) Case D. A., Darden T. A., Case D. A., <i>et al<\/i>., Amber 10, University of California, San Francisco, 2008."},{"key":"16","doi-asserted-by":"crossref","unstructured":"16) Orejola J., Matsuo Y., Saito Y., Tanaka T., <i>Molecules<\/i>, <b>22<\/b>, 1308 (2017).","DOI":"10.3390\/molecules22081308"},{"key":"17","unstructured":"17) Syed A. M., Ciling A., Taha T. Y., <i>et al<\/i>., <i>Proc. Natl. Acad. Sci. U.S.A.<\/i>, <b>119<\/b>, e2200592119 (2022)."},{"key":"18","doi-asserted-by":"crossref","unstructured":"18) Takashita E., Kinoshita N., Yamayoshi S., <i>et al<\/i>., <i>N. Engl. J. Med.<\/i>, <b>386<\/b>, 995\u2013998 (2022).","DOI":"10.1056\/NEJMc2119407"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19) Liu J., Bodnar B. H., Meng F., Khan A. I., Wang X., Saribas S., Wang T., Lohani S. C., Wang P., Wei Z., Luo J., Zhou L., Wu J., Luo G., Li Q., Hu W., Ho W., <i>Cell Biosci.<\/i>, <b>11<\/b>, 168 (2021).","DOI":"10.1186\/s13578-021-00680-8"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20) Ohishi T., Hishiki T., Baig M. S., Rajpoot S., Saqib U., Takasaki T., Hara Y., <i>PLOS ONE<\/i>, <b>17<\/b>, e0271112 (2022).","DOI":"10.1371\/journal.pone.0271112"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21) Sugamoto K., Tanaka Y. L., Saito A., Goto Y., Nakayama T., Okabayashi T., Kunitake H., Morishita K., <i>Biochem. Biophys. Res. Commun.<\/i>, <b>615<\/b>, 56\u201362 (2022).","DOI":"10.1016\/j.bbrc.2022.04.072"},{"key":"22","doi-asserted-by":"crossref","unstructured":"22) Chen H. F., Wang W. J., Chen C. Y., Chang W. C., Hsueh P. R., Peng S. L., Wu C. S., Chen Y., Huang H. Y., Shen W. J., Wang S. C., Hung M. C., <i>eLife<\/i>, <b>12<\/b>, e84899 (2023).","DOI":"10.7554\/eLife.84899"},{"key":"23","doi-asserted-by":"crossref","unstructured":"23) Shoji T., Masumoto S., Moriichi N., Akiyama H., Kanda T., Ohtake Y., Goda Y., <i>J. Agric. Food Chem.<\/i>, <b>54<\/b>, 884\u2013892 (2006).","DOI":"10.1021\/jf052260b"},{"key":"24","doi-asserted-by":"crossref","unstructured":"24) Ou K., Percival S. S., Zou T., Khoo C., Gu L., <i>J. Agric. Food Chem.<\/i>, <b>60<\/b>, 1390\u20131396 (2012).","DOI":"10.1021\/jf2040912"},{"key":"25","doi-asserted-by":"crossref","unstructured":"25) Tuma P., Hubbard A. L., <i>Physiol. Rev.<\/i>, <b>83<\/b>, 871\u2013932 (2003).","DOI":"10.1152\/physrev.00001.2003"},{"key":"26","doi-asserted-by":"crossref","unstructured":"26) Cammisotto P. G., Bendayan M., San\u00e9 A., Dominguez M., Garofalo C., Levy E., <i>Int. J. Cell Biol.<\/i>, <b>2010<\/b>, 928169 (2010).","DOI":"10.1155\/2010\/928169"},{"key":"27","doi-asserted-by":"crossref","unstructured":"27) Sawa Y., Ibaragi S., Okui T., Yamashita J., Ikebe T., Harada H., <i>J. Anat.<\/i>, <b>238<\/b>, 1341\u20131354 (2021).","DOI":"10.1111\/joa.13391"},{"key":"28","unstructured":"28) Huang N., P\u00e9rez P., Kato T., <i>et al<\/i>., <i>Nat. 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