{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,21]],"date-time":"2026-03-21T07:15:02Z","timestamp":1774077302994,"version":"3.50.1"},"reference-count":19,"publisher":"Pharmaceutical Society of Japan","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Chem. Pharm. Bull.","CHEMICAL &amp; PHARMACEUTICAL BULLETIN"],"published-print":{"date-parts":[[2026,3,18]]},"DOI":"10.1248\/cpb.c25-00731","type":"journal-article","created":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T22:08:12Z","timestamp":1773785292000},"page":"240-246","source":"Crossref","is-referenced-by-count":0,"title":["Synthesis and Evaluation of a Potential RSK2 Degrader in Human Multiple Myeloma Cell Lines"],"prefix":"10.1248","volume":"74","author":[{"given":"Daisuke","family":"Ide","sequence":"first","affiliation":[{"name":"Division of Hematology and Oncology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 1\u20135 Shimogamohangi-cho, Sakyo-ku, Kyoto 606\u20130823, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hidetomo","family":"Yokoo","sequence":"additional","affiliation":[{"name":"Medical Chemistry, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 465 Kajii-cho, Kamigyo-ku, Kyoto 602\u20138566, Japan"},{"name":"National Institute of Health Sciences, 3\u201325\u201326 Tonomachi, Kawasaki-ku, Kawasaki 210\u20139501, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinsuke","family":"Mizutani","sequence":"additional","affiliation":[{"name":"Division of Hematology and Oncology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 1\u20135 Shimogamohangi-cho, Sakyo-ku, Kyoto 606\u20130823, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Inoue","sequence":"additional","affiliation":[{"name":"Division of Hematology and Oncology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 1\u20135 Shimogamohangi-cho, Sakyo-ku, Kyoto 606\u20130823, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haruya","family":"Okamoto","sequence":"additional","affiliation":[{"name":"Division of Hematology and Oncology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 1\u20135 Shimogamohangi-cho, Sakyo-ku, Kyoto 606\u20130823, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taku","family":"Tsukamoto","sequence":"additional","affiliation":[{"name":"Division of Hematology and Oncology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 1\u20135 Shimogamohangi-cho, Sakyo-ku, Kyoto 606\u20130823, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yosuke","family":"Demizu","sequence":"additional","affiliation":[{"name":"National Institute of Health Sciences, 3\u201325\u201326 Tonomachi, Kawasaki-ku, Kawasaki 210\u20139501, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuji","family":"Shimura","sequence":"additional","affiliation":[{"name":"Division of Hematology and Oncology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 1\u20135 Shimogamohangi-cho, Sakyo-ku, Kyoto 606\u20130823, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Makoto","family":"Oba","sequence":"additional","affiliation":[{"name":"Medical Chemistry, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 465 Kajii-cho, Kamigyo-ku, Kyoto 602\u20138566, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junya","family":"Kuroda","sequence":"additional","affiliation":[{"name":"Division of Hematology and Oncology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 1\u20135 Shimogamohangi-cho, Sakyo-ku, Kyoto 606\u20130823, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"163","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"1) Clark D. E., Errington T. M., Smith J. A., Frierson H. F. Jr., Weber M. J., Lannigan D. A., <i>Cancer Res.<\/i>, <b>65<\/b>, 3108\u20133116 (2005).","DOI":"10.1158\/0008-5472.CAN-04-3151"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2) Sun Y., Tang L., Wu C., Wang J., Wang C., <i>Eur. J. Med. Chem.<\/i>, <b>251<\/b>, 115229 (2023).","DOI":"10.1016\/j.ejmech.2023.115229"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3) Elf S., Blevins D., Jin L., Chung T. W., Williams I. R., Lee B. H., Lin J. X., Leonard W. J., Taunton J., Khoury H. J., Kang S., <i>Blood<\/i>, <b>117<\/b>, 6885\u20136894 (2011).","DOI":"10.1182\/blood-2010-10-315721"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4) Hospital M. A., Jacquel A., Mazed F., <i>et al<\/i>., <i>Leukemia<\/i>, <b>32<\/b>, 597\u2013605 (2018).","DOI":"10.1038\/leu.2017.284"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5) Shimura Y., Kuroda J., Ri M., Nagoshi H., Yamamoto-Sugitani M., Kobayashi T., Kiyota M., Nakayama R., Mizutani S., Chinen Y., Sakamoto N., Matsumoto Y., Horiike S., Shiotsu Y., Iida S., Taniwaki M., <i>Mol. Cancer Ther.<\/i>, <b>11<\/b>, 2600\u20132609 (2012).","DOI":"10.1158\/1535-7163.MCT-12-0605"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6) Matsumura-Kimoto Y., Tsukamoto T., Shimura Y., Chinen Y., Tanba K., Kuwahara-Ota S., Fujibayashi Y., Nishiyama D., Isa R., Yamaguchi J., Kawaji-Kanayama Y., Kobayashi T., Horiike S., Taniwaki M., Kuroda J., <i>Cancer Med.<\/i>, <b>9<\/b>, 5185\u20135199 (2020).","DOI":"10.1002\/cam4.3136"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7) Okamoto H., Mizutani S., Tsukamoto T., Katsuragawa-Taminishi Y., Kawaji-Kanayama Y., Mizuhara K., Muramatsu A., Isa R., Fujino T., Shimura Y., Ichikawa K., Kuroda J., <i>Leukemia<\/i>, <b>39<\/b>, 211\u2013221 (2025).","DOI":"10.1038\/s41375-024-02439-9"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8) Wu T., Chen Z., Liu X., Wu X., Wang Z., Guo W., <i>Anticancer. Agents Med. Chem.<\/i>, <b>25<\/b>, 35\u201341 (2025).","DOI":"10.2174\/0118715206329546240830055233"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9) Katsuragawa-Taminishi Y., Mizutani S., Kawaji-Kanayama Y., Onishi A., Okamoto H., Isa R., Mizuhara K., Muramatsu A., Fujino T., Tsukamoto T., Shimura Y., Taniwaki M., Miyagawa-Hayashino A., Konishi E., Kuroda J., <i>Cancer Sci.<\/i>, <b>114<\/b>, 4691\u20134705 (2023).","DOI":"10.1111\/cas.15995"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10) Ushijima M., Shiota M., Matsumoto T., Kashiwagi E., Inokuchi J., Eto M., <i>Cancer Sci.<\/i>, <b>113<\/b>, 1731\u20131738 (2022).","DOI":"10.1111\/cas.15280"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11) Wright E. B., Fukuda S., Li M., Li Y., O\u2019Doherty G. A., Lannigan D. A., <i>J. Enzyme Inhib. Med. Chem.<\/i>, <b>36<\/b>, 1798\u20131809 (2021).","DOI":"10.1080\/14756366.2021.1957862"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12) Jain R., Mathur M., Lan J., Costales A., Atallah G., Ramurthy S., Subramanian S., Setti L., Feucht P., Warne B., Doyle L., Basham S., Jefferson A. B., Lindvall M., Appleton B. A., Shafer C. M., <i>J. Med. Chem.<\/i>, <b>58<\/b>, 6766\u20136783 (2015).","DOI":"10.1021\/acs.jmedchem.5b00450"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13) Zhang S., Liu J., Lu Z. Y., Xue Y. T., Mu X. R., Liu Y., Cao J., Li Z. Y., Li F., Xu K. L., Wu Q. Y., <i>Cell Oncol.<\/i>, <b>45<\/b>, 1005\u20131018 (2022).","DOI":"10.1007\/s13402-022-00703-7"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14) B\u00e9k\u00e9s M., Langley D. R., Crews C. M., <i>Nat. Rev. Drug Discov.<\/i>, <b>21<\/b>, 181\u2013200 (2022).","DOI":"10.1038\/s41573-021-00371-6"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15) Yokoo H., Naganuma M., Oba M., Demizu Y., <i>Chem. Biodivers.<\/i>, <b>19<\/b>, e202200828 (2022).","DOI":"10.1002\/cbdv.202200828"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16) Yokoo H., Naito M., Demizu Y., <i>Expert Opin. Drug Discov.<\/i>, <b>18<\/b>, 357\u2013361 (2023).","DOI":"10.1080\/17460441.2023.2187047"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17) Lai A. C., Crews C. M., <i>Nat. Rev. Drug Discov.<\/i>, <b>16<\/b>, 101\u2013114 (2017).","DOI":"10.1038\/nrd.2016.211"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18) Aronchik I., Appleton B. A., Basham S. E., Crawford K., Del Rosario M., Doyle L. V., Estacio W. F., Lan J., Lindvall M. K., Luu C. A., Ornelas E., Venetsanakos E., Shafer C. M., Jefferson A. B., <i>Mol. Cancer Res.<\/i>, <b>12<\/b>, 803\u2013812 (2014).","DOI":"10.1158\/1541-7786.MCR-13-0595"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19) Steinebach C., Lindner S., Udeshi N. D., Mani D. C., Kehm H., K\u00f6pff S., Carr S. A., G\u00fctschow M., Kr\u00f6nke J., <i>ACS Chem. Biol.<\/i>, <b>13<\/b>, 2771\u20132782 (2018).","DOI":"10.1021\/acschembio.8b00693"}],"container-title":["Chemical and Pharmaceutical Bulletin"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/cpb\/74\/3\/74_c25-00731\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,21]],"date-time":"2026-03-21T03:54:34Z","timestamp":1774065274000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/cpb\/74\/3\/74_c25-00731\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,18]]},"references-count":19,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026]]}},"URL":"https:\/\/doi.org\/10.1248\/cpb.c25-00731","relation":{},"ISSN":["0009-2363","1347-5223"],"issn-type":[{"value":"0009-2363","type":"print"},{"value":"1347-5223","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,18]]},"article-number":"c25-00731"}}