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Bull.<\/i>, 72, 36\u201340 (2024).","DOI":"10.1248\/cpb.c23-00635"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17) Uchiyama N., Hosoe J., Kiyota K., <i>et al.<\/i>, <i>J. Pharm. Biomed. Anal. Open<\/i>, 4, 100039 (2024).","DOI":"10.1016\/j.jpbao.2024.100039"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18) Okaru A. O., Brunner T. S., Ackermann S. M., Kuballa T., Walch S. G., Kohl-Himmelseher M., Lachenmeier D. W., <i>J. Anal. Methods Chem.<\/i>, 9206297, 9206297 (2017).","DOI":"10.1155\/2017\/9206297"},{"key":"19","unstructured":"19) The European Network of Forensic Science Institutes (ENFSI), \u201cGuideline for qNMR analysis, Issue 001 (2019).\u201d: \u2039https:\/\/enfsi.eu\/wp-content\/uploads\/2017\/06\/qNMR-Guideline_version001.pdf\u203a, cited 1 February, 2026."},{"key":"20","unstructured":"20) qNMR primary guide working group, \u201cqNMR primary guide. 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