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A., Ciulli A., Winter G. E., <i>Nat. Rev. Cancer<\/i>, <b>25<\/b>, 493\u2013516 (2025).","DOI":"10.1038\/s41568-025-00817-8"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2) Samarasinghe K. T. G., Crews C. M., <i>Cell Chem. Biol.<\/i>, <b>28<\/b>, 934\u2013951 (2021).","DOI":"10.1016\/j.chembiol.2021.04.011"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3) Alabi S. B., Crews C. M., <i>J. Biol. Chem.<\/i>, <b>296<\/b>, 100647 (2021).","DOI":"10.1016\/j.jbc.2021.100647"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4) B\u00e9k\u00e9s M., Langley D. R., Crews C. M., <i>Nat. Rev. Drug Discov.<\/i>, <b>21<\/b>, 181\u2013200 (2022).","DOI":"10.1038\/s41573-021-00371-6"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5) Cai H., Zhang T., Hu Y., <i>Eur. J. Med. Chem.<\/i>, <b>299<\/b>, 118055 (2025).","DOI":"10.1016\/j.ejmech.2025.118055"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6) Sakamoto K. M., Kim K. B., Kumagai A., Mercurio F., Crews C. M., Deshaies R. J., <i>Proc. Natl. Acad. Sci. U.S.A.<\/i>, <b>98<\/b>, 8554\u20138559 (2001).","DOI":"10.1073\/pnas.141230798"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7) Ge J., Li S., Weng G., Wang H., Fang M., Sun H., Deng Y., Hsieh C. Y., Li D., Hou T., <i>Nucleic Acids Res.<\/i>, <b>53<\/b> (D1), D1510\u2013D1515 (2025).","DOI":"10.1093\/nar\/gkae768"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8) Gough S. M., Flanagan J. J., Teh J., <i>et al<\/i>., <i>Clin. Cancer Res.<\/i>, <b>30<\/b>, 3549\u20133563 (2024).","DOI":"10.1158\/1078-0432.CCR-23-3465"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9) Neven P., Han S. N., <i>Nat. Rev. Clin. Oncol.<\/i>, <b>22<\/b>, 709\u2013710 (2025).","DOI":"10.1038\/s41571-025-01062-6"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10) Ma Z., Zhou J., <i>J. Med. Chem.<\/i>, <b>68<\/b>, 14129\u201314136 (2025).","DOI":"10.1021\/acs.jmedchem.5c01818"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11) Kaiho-Soma A., Akizuki Y., Igarashi K., Endo A., Shoda T., Kawase Y., Demizu Y., Naito M., Saeki Y., Tanaka K., Ohtake F., <i>Mol. Cell<\/i>, <b>81<\/b>, 1411\u20131424.e7 (2021).","DOI":"10.1016\/j.molcel.2021.01.023"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12) Mori Y., Akizuki Y., Honda R., Takao M., Tsuchimoto A., Hashimoto S., Iio H., Kato M., Kaiho-Soma A., Saeki Y., Hamazaki J., Murata S., Ushijima T., Hattori N., Ohtake F., <i>Nat. Commun.<\/i>, <b>15<\/b>, 5379 (2024).","DOI":"10.1038\/s41467-024-49519-z"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13) Crowe C., Nakasone M. A., Chandler S., Craigon C., Sathe G., Tatham M. H., Makukhin N., Hay R. T., Ciulli A., <i>Sci. Adv.<\/i>, <b>10<\/b>, eado6492 (2024).","DOI":"10.1126\/sciadv.ado6492"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14) Lipinski C. A., Lombardo F., Dominy B. W., Feeney P. J., <i>Adv. Drug Deliv. Rev.<\/i>, <b>23<\/b>, 3\u201325 (1997).","DOI":"10.1016\/S0169-409X(96)00423-1"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15) Poongavanam V., Atilaw Y., Siegel S., Giese A., Lehmann L., Meibom D., Erdelyi M., Kihlberg J., <i>J. Med. Chem.<\/i>, <b>65<\/b>, 13029\u201313040 (2022).","DOI":"10.1021\/acs.jmedchem.2c00877"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16) Atilaw Y., Poongavanam V., Svensson Nilsson C., Nguyen D., Giese A., Meibom D., Erdelyi M., Kihlberg J., <i>ACS Med. Chem. Lett.<\/i>, <b>12<\/b>, 107\u2013114 (2021).","DOI":"10.1021\/acsmedchemlett.0c00556"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17) Lou K., Wassarman D. R., Yang T., Paung Y., Zhang Z., O\u2019Loughlin T. A., Moore M. K., Egan R. K., Greninger P., Benes C. H., Seeliger M. A., Taunton J., Gilbert L. A., Shokat K. M., <i>Science<\/i>, <b>378<\/b>, 1097\u20131104 (2022).","DOI":"10.1126\/science.abl5829"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18) Zhang D., Ma B., Dragovich P. S., Ma L., Chen S., Chen E. C., Ye X., Liu J., Pizzano J., Bortolon E., Chan E., Zhang X., Chen Y. C., Levy E. S., Yauch R. L., Khojasteh S. C., Hop C., <i>Commun. Med.<\/i>, <b>4<\/b>, 87 (2024).","DOI":"10.1038\/s43856-024-00505-y"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19) Wang Z., Pan B. S., Manne R. K., Chen J., Lv D., Wang M., Tran P., Weldemichael T., Yan W., Zhou H., Martinez G. M., Shao J., Hsu C. C., Hromas R., Zhou D., Qin Z., Lin H. K., Li H. Y., <i>Cell<\/i>, <b>188<\/b>, 3219\u20133237.e18 (2025).","DOI":"10.1016\/j.cell.2025.03.036"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20) Shiraiwa K., Cheng R., Nonaka H., Tamura T., Hamachi I., <i>Cell Chem. Biol.<\/i>, <b>27<\/b>, 970\u2013985 (2020).","DOI":"10.1016\/j.chembiol.2020.06.016"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21) Dragovich P. S., <i>Chem. Soc. Rev.<\/i>, <b>51<\/b>, 3886\u20133897 (2022).","DOI":"10.1039\/D2CS00141A"},{"key":"22","doi-asserted-by":"crossref","unstructured":"22) Huang Y., Yokoe H., Kaiho-Soma A., Takahashi K., Hirasawa Y., Morita H., Ohtake F., Kanoh N., <i>Bioconjug. Chem.<\/i>, <b>33<\/b>, 142\u2013151 (2022).","DOI":"10.1021\/acs.bioconjchem.1c00490"},{"key":"23","doi-asserted-by":"crossref","unstructured":"23) Zengerle M., Chan K. H., Ciulli A., <i>ACS Chem. Biol.<\/i>, <b>10<\/b>, 1770\u20131777 (2015).","DOI":"10.1021\/acschembio.5b00216"},{"key":"24","doi-asserted-by":"crossref","unstructured":"24) Gadd M. S., Testa A., Lucas X., Chan K. H., Chen W., Lamont D. J., Zengerle M., Ciulli A., <i>Nat. Chem. Biol.<\/i>, <b>13<\/b>, 514\u2013521 (2017).","DOI":"10.1038\/nchembio.2329"},{"key":"25","doi-asserted-by":"crossref","unstructured":"25) Roy M. J., Winkler S., Hughes S. J., Whitworth C., Galant M., Farnaby W., Rumpel K., Ciulli A., <i>ACS Chem. Biol.<\/i>, <b>14<\/b>, 361\u2013368 (2019).","DOI":"10.1021\/acschembio.9b00092"},{"key":"26","doi-asserted-by":"crossref","unstructured":"26) Kounde C. S., Shchepinova M. M., Saunders C. N., Muelbaier M., Rackham M. D., Harling J. D., Tate E. W., <i>Chem. Commun.<\/i>, <b>56<\/b>, 5532\u20135535 (2020).","DOI":"10.1039\/D0CC00523A"},{"key":"27","doi-asserted-by":"crossref","unstructured":"27) Maneiro M. A., Forte N., Shchepinova M. M., Kounde C. S., Chudasama V., Baker J. R., Tate E. W., <i>ACS Chem. Biol.<\/i>, <b>15<\/b>, 1306\u20131312 (2020).","DOI":"10.1021\/acschembio.0c00285"},{"key":"28","doi-asserted-by":"crossref","unstructured":"28) Gao J., Hou B., Zhu Q., Yang L., Jiang X., Zou Z., Li X., Xu T., Zheng M., Chen Y. H., Xu Z., Xu H., Yu H., <i>Nat. Commun.<\/i>, <b>13<\/b>, 4318 (2022).","DOI":"10.1038\/s41467-022-32050-4"},{"key":"29","doi-asserted-by":"crossref","unstructured":"29) Bi T., Liang P., Zhou Y., Wang H., Huang R., Sun Q., Shen H., Yang S., Ren W., Liu Z., <i>J. Med. Chem.<\/i>, <b>66<\/b>, 14843\u201314852 (2023).","DOI":"10.1021\/acs.jmedchem.3c01423"},{"key":"30","doi-asserted-by":"crossref","unstructured":"30) Raina K., Lu J., Qian Y., Altieri M., Gordon D., Rossi A. M., Wang J., Chen X., Dong H., Siu K., Winkler J. D., Crew A. P., Crews C. M., Coleman K. G., <i>Proc. Natl. Acad. Sci. U.S.A.<\/i>, <b>113<\/b>, 7124\u20137129 (2016).","DOI":"10.1073\/pnas.1521738113"},{"key":"31","doi-asserted-by":"crossref","unstructured":"31) Douglass E. F. Jr., Miller C. J., Sparer G., Shapiro H., Spiegel D. A., <i>J. Am. Chem. Soc.<\/i>, <b>135<\/b>, 6092\u20136099 (2013).","DOI":"10.1021\/ja311795d"},{"key":"32","doi-asserted-by":"crossref","unstructured":"32) Diehl C. J., Ciulli A., <i>Chem. Soc. Rev.<\/i>, <b>51<\/b>, 8216\u20138257 (2022).","DOI":"10.1039\/D2CS00387B"},{"key":"33","doi-asserted-by":"crossref","unstructured":"33) Hu J., Hu B., Wang M., Xu F., Miao B., Yang C. Y., Wang M., Liu Z., Hayes D. F., Chinnaswamy K., Delproposto J., Stuckey J., Wang S., <i>J. Med. Chem.<\/i>, <b>62<\/b>, 1420\u20131442 (2019).","DOI":"10.1021\/acs.jmedchem.8b01572"},{"key":"34","doi-asserted-by":"crossref","unstructured":"34) Ishikawa M., Tomoshige S., Sato S., <i>J. Med. 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