{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T00:36:42Z","timestamp":1787963802917,"version":"build-2784847793"},"reference-count":80,"publisher":"Pharmaceutical Society of Japan","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["YAKUGAKU ZASSHI"],"published-print":{"date-parts":[[2004]]},"DOI":"10.1248\/yakushi.124.791","type":"journal-article","created":{"date-parts":[[2004,11,1]],"date-time":"2004-11-01T06:06:23Z","timestamp":1099289183000},"page":"791-802","source":"Crossref","is-referenced-by-count":9,"title":["The Physiological Function of the Blood-Brain Barrier Transporters as the CNS Supporting and Protecting System","\u4e2d\u67a2\u652f\u63f4\u9632\u5fa1\u30b7\u30b9\u30c6\u30e0\u3068\u3057\u3066\u306e\u8840\u6db2\u8133\u95a2\u9580\u8f38\u9001\u306e\u751f\u7406\u6a5f\u80fd"],"prefix":"10.1248","volume":"124","author":[{"given":"Sumio","family":"OHTSUKI","sequence":"first","affiliation":[{"name":"Graduate School of Pharmaceutical Sciences, Tohoku University"},{"name":"New Industry Creation Hatchery Center, Tohoku University"},{"name":"SORST and CREST, Japan Science and Technology Agency"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"163","reference":[{"issue":"3","key":"1","first-page":"219","volume":"7","author":"Cornford E.M.","year":"1985","journal-title":"Mol. Physiol.","ISSN":"https:\/\/id.crossref.org\/issn\/0166-3178","issn-type":"print"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(94)90212-7"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1016\/0024-3205(92)90537-Y"},{"issue":"5","key":"4","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1038\/jcbfm.1993.106","volume":"13","year":"1993","journal-title":"J. Cereb. Blood Flow Metab.","ISSN":"https:\/\/id.crossref.org\/issn\/0271-678X","issn-type":"print"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.7.3990"},{"key":"6","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.1097\/01.WCB.0000033966.83623.7D","volume":"22","author":"Ohtsuki S., Tachikawa M., Takanaga","year":"2002","journal-title":"J. Cereb. Blood Flow Metab.","ISSN":"https:\/\/id.crossref.org\/issn\/0271-678X","issn-type":"print"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1016\/0026-0495(92)90213-T"},{"key":"8","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1016\/S0022-3476(97)70075-1","volume":"131","author":"Schulze A., Hess T., Wevers R., May","year":"1997","journal-title":"J. Pediatr.","ISSN":"https:\/\/id.crossref.org\/issn\/0022-3476","issn-type":"print"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1016\/0197-4580(94)90152-X"},{"key":"10","first-page":"R698","volume":"277","author":"Dechent P., Pouwels P. J., Wilken B","year":"1999","journal-title":"Am. J. Physiol.","ISSN":"https:\/\/id.crossref.org\/issn\/0002-9505","issn-type":"print"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1016\/S0169-328X(00)00269-2"},{"key":"12","doi-asserted-by":"crossref","first-page":"E27","DOI":"10.1208\/ps020213","volume":"2","author":"Hosoya K., Tetsuka K., Nagase K., T","year":"2000","journal-title":"AAPS Pharm. Sci.","ISSN":"https:\/\/id.crossref.org\/issn\/1346-0706","issn-type":"print"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1016\/S1359-6446(03)02858-7"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1086\/320595"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1002\/ana.79"},{"key":"16","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1152\/physrev.2000.80.3.1107","volume":"80","author":"Wyss M., Kaddurah-Daouk R.","year":"2000","journal-title":"Physiol. Rev.","ISSN":"https:\/\/id.crossref.org\/issn\/0031-9333","issn-type":"print"},{"key":"17","doi-asserted-by":"crossref","first-page":"1232","DOI":"10.1097\/00004647-200110000-00012","volume":"21","author":"Takanaga H., Ohtsuki S., Hosoya K.,","year":"2001","journal-title":"J. Cereb. Blood Flow Metab.","ISSN":"https:\/\/id.crossref.org\/issn\/0271-678X","issn-type":"print"},{"issue":"3","key":"18","first-page":"1550","volume":"277","year":"1996","journal-title":"J. Pharmacol. Exp. Ther.","ISSN":"https:\/\/id.crossref.org\/issn\/0022-3565","issn-type":"print"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.2001.00540.x"},{"key":"20","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1111\/j.1748-1716.1980.tb06526.x","volume":"108","author":"Hardebo J. E., Owman C.","year":"1980","journal-title":"Acta Physiol. Scand.","ISSN":"https:\/\/id.crossref.org\/issn\/0001-6772","issn-type":"print"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(81)90229-8"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-0102(02)00120-7"},{"issue":"2","key":"23","first-page":"413","volume":"294","author":"GANAPATHY V","year":"2000","journal-title":"J. Pharmacol. Exp. Ther.","ISSN":"https:\/\/id.crossref.org\/issn\/0022-3565","issn-type":"print"},{"issue":"4","key":"24","doi-asserted-by":"crossref","first-page":"2195","DOI":"10.1016\/S0021-9258(18)94161-X","volume":"264","year":"1989","journal-title":"J. Biol. Chem.","ISSN":"https:\/\/id.crossref.org\/issn\/0021-9258","issn-type":"print"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.1016\/S0197-0186(02)00055-4"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.1016\/0163-7258(93)90043-D"},{"key":"27","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.1999.0731206.x"},{"key":"28","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.274.45.31891"},{"key":"29","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1152\/physrev.1998.78.4.969","volume":"78","author":"Palacin M., Estevez R., Bertran J.,","year":"1998","journal-title":"Physiol. Rev.","ISSN":"https:\/\/id.crossref.org\/issn\/0031-9333","issn-type":"print"},{"key":"30","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.2003.02063.x"},{"issue":"21","key":"31","doi-asserted-by":"crossref","first-page":"15329","DOI":"10.1016\/S0021-9258(18)82257-8","volume":"268","year":"1993","journal-title":"J. Biol. Chem.","ISSN":"https:\/\/id.crossref.org\/issn\/0021-9258","issn-type":"print"},{"key":"32","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.271.25.14883"},{"key":"33","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1523\/JNEUROSCI.23-02-00550.2003","volume":"23","author":"Sakai K., Shimizu H., Koike T., Fur","year":"2003","journal-title":"J. Neurosci.","ISSN":"https:\/\/id.crossref.org\/issn\/0270-6474","issn-type":"print"},{"issue":"9","key":"34","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1111\/j.2042-7158.1987.tb06973.x","volume":"39","author":"Emanuelsson BM, Paalzow L, Sunzel M","year":"1987","journal-title":"J. Pharm. Pharmacol.","ISSN":"https:\/\/id.crossref.org\/issn\/0022-3573","issn-type":"print"},{"issue":"4","key":"35","doi-asserted-by":"crossref","first-page":"1499","DOI":"10.1111\/j.1471-4159.1992.tb11370.x","volume":"58","year":"1992","journal-title":"J. Neurochem.","ISSN":"https:\/\/id.crossref.org\/issn\/0022-3042","issn-type":"print"},{"key":"36","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.1999.0722135.x"},{"key":"37","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1111\/j.1528-1167.1990.tb06303.x","volume":"31","author":"Giroud M., Dumas R., Dauvergne M.,","year":"1990","journal-title":"Epilepsia","ISSN":"https:\/\/id.crossref.org\/issn\/0013-9580","issn-type":"print"},{"key":"38","first-page":"63","author":"Le Witt P. A., Galloway M. P.","year":"1990","journal-title":"Therapy of Parkinson's Disease","ISSN":"https:\/\/id.crossref.org\/issn\/1475-0708","issn-type":"print"},{"key":"39","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1136\/jnnp.41.7.581","volume":"41","author":"Sullivan P. A., Murnaghan D., Calla","year":"1978","journal-title":"J. Neurol. Neurosurg. Psychiatry","ISSN":"https:\/\/id.crossref.org\/issn\/0022-3050","issn-type":"print"},{"key":"40","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1212\/WNL.29.4.467","volume":"29","author":"Shaywitz B. A., Venes J., Cohen D.","year":"1979","journal-title":"Neurology","ISSN":"https:\/\/id.crossref.org\/issn\/0028-3878","issn-type":"print"},{"key":"41","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1097\/01.WCB.0000050062.57184.75","volume":"23","author":"Mori S., Takanaga H., Ohtsuki S., D","year":"2003","journal-title":"J. Cereb. Blood Flow Metab.","ISSN":"https:\/\/id.crossref.org\/issn\/0271-678X","issn-type":"print"},{"key":"42","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.274.19.13675"},{"issue":"1","key":"43","first-page":"316","volume":"298","author":"SUGIYAMA D","year":"2001","journal-title":"J. Pharmacol. Exp. Ther.","ISSN":"https:\/\/id.crossref.org\/issn\/0022-3565","issn-type":"print"},{"key":"44","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.103.049197"},{"key":"45","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.2002.01108.x"},{"key":"46","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.103.063370"},{"key":"47","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1212\/WNL.27.10.985","volume":"27","author":"Lloyd K. G., Davidson L., Price K.,","year":"1977","journal-title":"Neurology","ISSN":"https:\/\/id.crossref.org\/issn\/0028-3878","issn-type":"print"},{"key":"48","doi-asserted-by":"crossref","first-page":"1450","DOI":"10.1152\/ajplegacy.1973.224.6.1450","volume":"224","author":"Oldendorf W. H.","year":"1973","journal-title":"Am. J. Physiol.","ISSN":"https:\/\/id.crossref.org\/issn\/0002-9505","issn-type":"print"},{"key":"49","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2004.02552.x"},{"key":"50","doi-asserted-by":"publisher","DOI":"10.1007\/s002280050339"},{"key":"51","doi-asserted-by":"publisher","DOI":"10.1016\/S0024-3205(99)00637-2"},{"key":"52","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1998.9978"},{"key":"53","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-0173(99)00021-1"},{"key":"54","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.2000.0751907.x"},{"issue":"10","key":"55","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1177\/002215549904701005","volume":"47","author":"GAO B","year":"1999","journal-title":"J. Histochem. Cytochem.","ISSN":"https:\/\/id.crossref.org\/issn\/0022-1554","issn-type":"print"},{"key":"56","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3940(01)01640-8"},{"key":"57","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M306933200"},{"issue":"1","key":"58","first-page":"73","volume":"294","author":"GAO B","year":"2000","journal-title":"J. Pharmacol. Exp. Ther.","ISSN":"https:\/\/id.crossref.org\/issn\/0022-3565","issn-type":"print"},{"key":"59","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2004.02549.x"},{"key":"60","unstructured":"60) Tohyama K., Kusuhara H., Sugiyama Y., <i>Endocrinology<\/i>, (2004)."},{"key":"61","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.2001.4729"},{"key":"62","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1126\/science.211586","volume":"202","author":"Betz A. L., Goldstein G. W.","year":"1978","journal-title":"Science","ISSN":"https:\/\/id.crossref.org\/issn\/0036-8075","issn-type":"print"},{"key":"63","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.270.25.14913"},{"key":"64","doi-asserted-by":"publisher","DOI":"10.1124\/mol.61.6.1289"},{"key":"65","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.275.6.4049"},{"key":"66","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.C000205200"},{"key":"67","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.140152797"},{"key":"68","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M002965200"},{"issue":"1\/2","key":"69","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/S0005-2736(00)00349-7","volume":"1509","author":"SUGAWARA M","year":"2000","journal-title":"Biochim. Biophys. Acta","ISSN":"https:\/\/id.crossref.org\/issn\/0005-2728","issn-type":"print"},{"key":"70","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.2001.00546.x"},{"key":"71","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1007\/BF02069502","volume":"11","author":"Oja S. S., Saransaari P.","year":"1996","journal-title":"Metab. Brain Dis.","ISSN":"https:\/\/id.crossref.org\/issn\/0885-7490","issn-type":"print"},{"key":"72","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2952(95)02046-2"},{"key":"73","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.2002.01223.x"},{"key":"74","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1007\/978-1-4684-7971-3_26","volume":"203","author":"French E. D., Vezzani A., Whetsell","year":"1986","journal-title":"Adv. Exp. Med. Biol.","ISSN":"https:\/\/id.crossref.org\/issn\/0065-2598","issn-type":"print"},{"key":"75","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3940(99)00150-0"},{"issue":"1","key":"76","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1097\/00004647-199601000-00014","volume":"16","year":"1996","journal-title":"J. Cereb. Blood Flow Metab.","ISSN":"https:\/\/id.crossref.org\/issn\/0271-678X","issn-type":"print"},{"key":"77","doi-asserted-by":"publisher","DOI":"10.1006\/mvre.2001.2328"},{"key":"78","first-page":"774","volume":"43","author":"Tomi M., Hosoya K., Takanaga H., Oh","year":"2002","journal-title":"Invest. Ophthalmol. Vis. Sci.","ISSN":"https:\/\/id.crossref.org\/issn\/0146-0404","issn-type":"print"},{"key":"79","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/BF01870891","volume":"89","author":"Bannai S., Tateishi N.","year":"1986","journal-title":"J. Membr. Biol.","ISSN":"https:\/\/id.crossref.org\/issn\/0022-2631","issn-type":"print"},{"key":"80","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.bi.52.070183.003431"}],"container-title":["YAKUGAKU ZASSHI"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.jstage.jst.go.jp\/article\/yakushi\/124\/11\/124_11_791\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,6,27]],"date-time":"2021-06-27T10:18:33Z","timestamp":1624789113000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.jstage.jst.go.jp\/article\/yakushi\/124\/11\/124_11_791\/_article\/-char\/ja\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004]]},"references-count":80,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2004]]}},"URL":"https:\/\/doi.org\/10.1248\/yakushi.124.791","relation":{},"ISSN":["0031-6903","1347-5231"],"issn-type":[{"value":"0031-6903","type":"print"},{"value":"1347-5231","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004]]}}}