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Bull.<\/i>, 18<\/b>, 143-146 (1970).","DOI":"10.1248\/cpb.18.143"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12) Kaku T., Kase Y., Nagai M., Yakugaku Zasshi<\/i>, 74<\/b>, 122-128 (1954).","DOI":"10.1248\/yakushi1947.74.2_122"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13) Tateoka Y., Kimura T., Yamazaki F., Watanabe K., Yamamoto I., Yakugaku Zasshi<\/i>, 106<\/b>, 504-510 (1986).","DOI":"10.1248\/yakushi1947.106.6_504"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14) Nadkarni M. V., Jones J. W., J. Am. Pharm. Assoc.<\/i>, 39<\/b>, 297-302 (1950).","DOI":"10.1002\/jps.3030390517"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15) Sandberg F., Acta Physiol. Scand.<\/i>, 24<\/b>, 7-26 (1951).","DOI":"10.1111\/j.1748-1716.1951.tb00823.x"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16) Sandberg F., Acta Physiol. Scand.<\/i>, 24<\/b>, 149-162 (1951).","DOI":"10.1111\/j.1748-1716.1951.tb00834.x"},{"key":"17","unstructured":"17) Harvey S. C., “Goodman and Gilman's the Pharmacological Basis of Therapeutics, 6th Ed.,” eds. by Goodman A. G., Goodman L. S., Gilman A., McMillan Publishing Co., Inc., New York, 1980, pp. 339-375."},{"key":"18","doi-asserted-by":"crossref","unstructured":"18) Wenzel D. G., Keplinger M. L., J. Am. Pharm. Assoc.<\/i>, 44<\/b>, 56-59 (1955).","DOI":"10.1002\/jps.3030440121"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19) Wenzel D. G., J. Am. Pharm. Assoc.<\/i>, 44<\/b>, 550-553 (1955).","DOI":"10.1002\/jps.3030440911"},{"key":"20","unstructured":"20) Brodie B. B., Mark L. C., Papper E. M., Lief P. A., Bernstein E., Rovenstine E. A., J. Pharmacol. Exp. Ther.<\/i>, 98<\/b>, 85-96 (1950)."},{"key":"21","unstructured":"21) Goldbaum L. R., Smith P. K., J. Pharmacol. Exp. Ther.<\/i>, 111<\/b>, 197-209 (1954)."},{"key":"22","doi-asserted-by":"crossref","unstructured":"22) Lee J., J. Am. Chem. Soc.<\/i>, 60<\/b>, 993-996 (1938).","DOI":"10.1021\/ja01272a003"},{"key":"23","unstructured":"23) Yamamoto I., Tateoka Y., Watanabe K., Nabeshima T., Fontenot H. J., Ho I. K., Res. Commun. Chem. Pathol. Pharmacol.<\/i>, 50<\/b>, 209-219 (1985)."},{"key":"24","unstructured":"24) Tateoka Y., Yamamoto I., Watanabe K., Ho I.K., Res. Commun. Chem. Pathol. Pharmacol.<\/i>, 52<\/b>, 17-28 (1986)."},{"key":"25","doi-asserted-by":"crossref","unstructured":"25) Tateoka Y., Kimura T., Watanabe K., Yamamoto I., Ho I. K., Chem. Pharm. Bull.<\/i> (Tokyo), 35<\/b>, 778-784 (1987).","DOI":"10.1248\/cpb.35.778"},{"key":"26","unstructured":"26) Harvey S. C., “The Pharmacological Basis of Therapeutics, 5th Ed.,” eds. by Goodman L. S., Gilman A., McMillan Publishing Co., Inc., New York, 1975, pp. 102-123."},{"key":"27","doi-asserted-by":"crossref","unstructured":"27) Andrews P. R., Jones G. P., Lodge D., Eur. J. Pharmacol.<\/i>, 55<\/b>, 115-120 (1979).","DOI":"10.1016\/0014-2999(79)90382-0"},{"key":"28","doi-asserted-by":"crossref","unstructured":"28) Andrews P. R., Evans R. H., Johnston G. A. R., Willow M., Experimentia<\/i>, 37<\/b>, 172-175 (1981).","DOI":"10.1007\/BF01963215"},{"key":"29","doi-asserted-by":"crossref","unstructured":"29) Flint B. A., Ho I. K., Prog. Neuropsychopharmacol.<\/i>, 4<\/b>, 233-239 (1980).","DOI":"10.1016\/0364-7722(80)90042-9"},{"key":"30","unstructured":"30) Yamamoto I., Tateoka Y., Kimura T., Yamazaki F., Hamajima K., Watanabe K., Ho I.K., Res. Commun. Chem. Pathol. Pharmacol.<\/i>, 54<\/b>, 191-199 (1986)."},{"key":"31","doi-asserted-by":"crossref","unstructured":"31) Weinswig M. H., Burkman A. M., Jones W. D., Rowe E. J., J. Pharm. Sci.<\/i>, 56<\/b>, 909-911 (1967).","DOI":"10.1002\/jps.2600560729"},{"key":"32","doi-asserted-by":"crossref","unstructured":"32) Shulman A., Proc. Roy. Aust. Chem. Inst.<\/i>, 31<\/b>, 41-63 (1964).","DOI":"10.1111\/j.1748-1716.1964.tb04131.x"},{"key":"33","doi-asserted-by":"publisher","unstructured":"33) Laycock G. M., Shulman A., Nature<\/i>, 200<\/b>, 849-851 (1963).","DOI":"10.1038\/200849a0"},{"key":"34","unstructured":"34) Okano Y., Hitoshi T., Matsuda A., Naka M., Takahama K., Kase Y., Miyata T., “Endogenous Sleep Factors,” eds. by Inoue S., Krueger J.M., SPB Academic Publishing bv, Hague, 1990, pp.165-172."},{"key":"35","doi-asserted-by":"crossref","unstructured":"35) Nosjean O., Ferro M., Coge F., Beauverger P., Henlin K., Lefoulon F., Fauchere J., Delagrange P., Canet E., Boutin J., J. Biol. Chem.<\/i>, 40<\/b>, 31311-31317 (2000).","DOI":"10.1074\/jbc.M005141200"},{"key":"36","unstructured":"36) Krooth R. S., Hsiao W. L., Lam G. F., J. Pharmacol. Exp.Ther.<\/i>, 207<\/b>, 504-514 (1978)."},{"key":"37","unstructured":"37) Honda K., Komoda Y., Inoue S., Rep. Inst. Med. Den. Eng.<\/i>, 18<\/b>, 93-95 (1984)."},{"key":"38","doi-asserted-by":"crossref","unstructured":"38) Yamamoto I., Yakugaku Zasshi<\/i>, 106<\/b>, 537-561 (1986).","DOI":"10.1248\/yakushi1947.106.7_537"},{"key":"39","doi-asserted-by":"crossref","unstructured":"39) Haley T. J., McCormick W. G., Br. J. Pharmacol.<\/i>, 12<\/b>, 12-15 (1957).","DOI":"10.1111\/j.1476-5381.1957.tb01354.x"},{"key":"40","doi-asserted-by":"crossref","unstructured":"40) Yamamoto I., Tateoka Y., Watanabe K., Ho I. K., Life Sci.<\/i>, 40<\/b>, 1439-1442 (1987).","DOI":"10.1016\/0024-3205(87)90335-3"},{"key":"41","unstructured":"41) Tateoka Y., Kimura T., Watanabe K., Yamamoto I., Ho I.K., Res. Commun. Chem. Pathol. Pharmacol.<\/i>, 57<\/b>, 173-185 (1987)."},{"key":"42","doi-asserted-by":"publisher","unstructured":"42) Tateoka Y., Kimura T., Watanabe K., Yamamoto I., Hume A.S., Ho I. 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Res.<\/i>, 1<\/b>, 243-252 (1984).","DOI":"10.1016\/S0168-0102(84)80003-6"},{"key":"54","doi-asserted-by":"crossref","unstructured":"54) Ueno R., Honda K., Inoue S., Hayaishi O., Proc. Natl. Acad. Sci. U.S.A.<\/i>, 80<\/b>, 1735-1737 (1983).","DOI":"10.1073\/pnas.80.6.1735"},{"key":"55","unstructured":"55) Simon P., Chermat R., Doare L., Bourin M., Farinotti R., J. Pharmacol.<\/i>, 13<\/b>, 241-252 (1982)."},{"key":"56","unstructured":"56) Menez J.-F., Bourin M., Colombel M.-C., Benamou C., Larousse C., Bardou L., Eur. J. Med. Chem.<\/i>, 18<\/b>, 521-529 (1983)."},{"key":"57","unstructured":"57) Bourin M., Menez J.-F., Colombel M.-C., Larousse C., Arzneim.-Forsch.<\/i>, 37<\/b>, 506-509 (1987)."},{"key":"58","doi-asserted-by":"crossref","unstructured":"58) Yamamoto I., Watanabe K., Matsunaga T., Kimura T., Funahashi T., Yoshimura H., J. Toxicol. Toxin Rev.<\/i>, 22<\/b>, 577-589 (2003).","DOI":"10.1081\/TXR-120026915"},{"key":"59","unstructured":"59) Kalyanpur S. G., Naik S. R., Sheth U. K., Arch. Int. Pharmacodyn. Ther.<\/i>, 173<\/b>, 1-10 (1968)."},{"key":"60","doi-asserted-by":"crossref","unstructured":"60) Jori A., Bianchetti A., Prestini P.E., Biochem. Pharmacol.<\/i>, 19<\/b>, 2687-2694 (1970).","DOI":"10.1016\/0006-2952(70)90094-8"},{"key":"61","unstructured":"61) Shah H. C., Lal H., J. Pharmacol. Exp. Ther.<\/i>, 179<\/b>, 404-409 (1971)."},{"key":"62","unstructured":"62) Peters M. A., J. Pharmacol. Exp. Ther.<\/i>, 181<\/b>, 417-424 (1972)."},{"key":"63","doi-asserted-by":"crossref","unstructured":"63) Marzi E., Gambazza K., Piccinelli G., Garattini S., Bartosek I., J. Pharm. Pharmacol.<\/i>, 33<\/b>, 677-679 (1981).","DOI":"10.1111\/j.2042-7158.1981.tb13902.x"},{"key":"64","doi-asserted-by":"crossref","unstructured":"64) Sasaki K., Furusawa S., Takayanagi G., J. Pharmacobio-Dyn.<\/i>, 4<\/b>, 394-401 (1981).","DOI":"10.1248\/bpb1978.4.394"},{"key":"65","doi-asserted-by":"crossref","unstructured":"65) Bhargava H. N., Res. Commun. Chem. Pathol. Pharmacol.<\/i>, 28<\/b>, 267-284 (1980).","DOI":"10.1159\/000131542"},{"key":"66","unstructured":"66) Giarman N. J., Bowers Jr. G. N., Quie P. G., Hampton L. J., Arch. Int. Pharmacodyn. Ther.<\/i>, 97<\/b>, 473-482 (1954)."},{"key":"67","doi-asserted-by":"crossref","unstructured":"67) Chang Y.-F., Hernandez M. F., Myslinski N. R., Life Sci.<\/i>, 28<\/b>, 407-413 (1981).","DOI":"10.1016\/0024-3205(81)90086-2"},{"key":"68","unstructured":"68) Hafely W., “Biochemistry and Pharmacology,” eds. by Biggio G., Costa E., Raven Press, New York, 1983, pp. 73-93."},{"key":"69","doi-asserted-by":"crossref","unstructured":"69) Yamamoto I., Ho I. K., Loh H. H., Life Sci.<\/i>, 20<\/b>, 1353-1362 (1977).","DOI":"10.1016\/0024-3205(77)90361-7"},{"key":"70","unstructured":"70) Brodie B. B., Burns J. J., Mark L. C., Lief P. A., Bernstein E., Papper E. M., J. Pharmacol. Exp. Ther.<\/i>, 109<\/b>, 26-34 (1953)."},{"key":"71","unstructured":"71) Kuntzman R., Ikeda M., Jacobson M., Conney A. H., J. Pharmacol. Exp. Ther.<\/i>, 157<\/b>, 220-226 (1967)."},{"key":"72","unstructured":"72) Valerino D. M., Vasell E. S., Aurori K. C., Johnson A. O., Drug Metab. Dispos.<\/i>, 2<\/b>, 448-457 (1974)."},{"key":"73","doi-asserted-by":"crossref","unstructured":"73) Abbritti G., De Matteis F., Chem.-Biol. Interact.<\/i>, 4<\/b>, 281-286 (1972).","DOI":"10.1016\/0009-2797(72)90022-1"},{"key":"74","doi-asserted-by":"publisher","unstructured":"74) Levin W., Sernatinger E., Jacobson M., Kuntzman R., Science<\/i>, 176<\/b>, 1341-1343 (1972).","DOI":"10.1126\/science.176.4041.1341"},{"key":"75","unstructured":"75) Levin W., Jacobson M., Sernatinger E., Kuntzman R., Drug Metab. Dispos.<\/i>, 1<\/b>, 275-285 (1973)."},{"key":"76","doi-asserted-by":"crossref","unstructured":"76) Dixon R. L., Fouts J. R., Biochem. 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Pharmacol.<\/i>, 27<\/b>, 343-347 (1975).","DOI":"10.1111\/j.2042-7158.1975.tb09452.x"},{"key":"83","doi-asserted-by":"crossref","first-page":"289","DOI":"10.3109\/00498257909038732","volume":"9","year":"1979","unstructured":"83) Vermeulen N. P., Bakker B. H., Schultink J., van der Gen A., Breimer D. D., Xenobiotica<\/i>, 9<\/b>, 289-299 (1979).","journal-title":"Xenobiotica","ISSN":"https:\/\/id.crossref.org\/issn\/0049-8254","issn-type":"print"},{"key":"84","doi-asserted-by":"crossref","unstructured":"84) Yamamoto I., Yakugaku Zasshi<\/i>, 106<\/b>, 537-561 (1986).","DOI":"10.1248\/yakushi1947.106.7_537"},{"key":"85","doi-asserted-by":"crossref","unstructured":"85) Yamamoto I., Watanabe K., Matsunaga T., Kimura T., Funahashi T., Yoshimura H., J. Toxicol. Toxin. Rev.<\/i>, 22<\/b>, 577-589 (2003).","DOI":"10.1081\/TXR-120026915"},{"key":"86","doi-asserted-by":"crossref","unstructured":"86) Hansch C., Anderson S. M., J. Med. Chem.<\/i>, 10<\/b>, 745-753 (1967).","DOI":"10.1021\/jm00317a001"},{"key":"87","doi-asserted-by":"crossref","unstructured":"87) Miller K. W., Yu S. -C., Br. J. Pharmacol.<\/i>, 61<\/b>, 57-63 (1977).","DOI":"10.1111\/j.1476-5381.1977.tb09739.x"},{"key":"88","doi-asserted-by":"crossref","unstructured":"88) Tateoka Y., Kimura T., Watanabe K., Yamamoto I., Ho I.K., Chem. Pharm. Bull<\/i>. (Tokyo) , 35<\/b>, 4928-4934 (1987).","DOI":"10.1248\/cpb.35.4928"},{"key":"89","doi-asserted-by":"publisher","unstructured":"89) Kyogoku Y., Lord R. C., Rich A., Nature<\/i>, 217<\/b>, 69-72 (1968).","DOI":"10.1038\/217069a0"},{"key":"90","doi-asserted-by":"crossref","unstructured":"90) Kim S. H., Rich A., Proc. Natl. Acad. Sci. U.S.A.<\/i>, 60<\/b>, 402-408 (1968).","DOI":"10.1073\/pnas.60.2.402"},{"key":"91","unstructured":"91) Fontenot H. J., Wilson R. D., Nabeshima T., Yamamoto I., Loh H. H., Ho I. K., Res. Commun. Subst. 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