{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T20:45:29Z","timestamp":1773434729313,"version":"3.50.1"},"reference-count":15,"publisher":"Pharmaceutical Society of Japan","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["YAKUGAKU ZASSHI"],"published-print":{"date-parts":[[2008,2,1]]},"DOI":"10.1248\/yakushi.128.255","type":"journal-article","created":{"date-parts":[[2008,2,1]],"date-time":"2008-02-01T00:51:35Z","timestamp":1201827095000},"page":"255-261","source":"Crossref","is-referenced-by-count":6,"title":["A Strategy for Development of NSAIDs with Lower Risk for Side Effects","\u526f\u4f5c\u7528\u306e\u5c11\u306a\u3044\u975e\u30b9\u30c6\u30ed\u30a4\u30c9\u7cfb\u6297\u708e\u75c7\u85ac\u306e\u958b\u767a\u3078\u306e\u6226\u7565"],"prefix":"10.1248","volume":"128","author":[{"given":"Tohru","family":"MIZUSHIMA","sequence":"first","affiliation":[{"name":"Graduate School of Medical and Pharmaceutical Sciences, Research Institute for Drug Discovery, Kumamoto University"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"163","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"1) Smalley W. E., Ray W. A., Daugherty J. R., Griffin M. R., <i>Am. J. Epidemiol.<\/i>, <b>141<\/b>, 539-545 (1995).","DOI":"10.1093\/oxfordjournals.aje.a117469"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2) Singh G., <i>Am. J. Med.<\/i>, <b>105<\/b>, 31S-38S (1998).","DOI":"10.1016\/S0002-9343(98)00072-2"},{"key":"3","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1038\/367215a0","volume":"367","year":"1994","unstructured":"3) Vane J., <i>Nature<\/i>, <b>367<\/b>, 215-216 (1994).","journal-title":"Nature Cell Biology","ISSN":"https:\/\/id.crossref.org\/issn\/0028-0836","issn-type":"print"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4) Smith C. J., Zhang Y., Koboldt C. M., Muhammad J., Zweifel B. S., Shaffer A., Talley J. J., Masferrer J. L., Seibert K., Isakson P. C., <i>Proc. Natl. Acad. Sci. U.S.A.<\/i>, <b>95<\/b>, 13313-13318 (1998).","DOI":"10.1073\/pnas.95.22.13313"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5) Tomisato W., Tsutsumi S., Rokutan K., Tsuchiya T., Mizushima T., <i>Am. J. Physiol. Gastrointest. Liver Physiol.<\/i>, <b>281<\/b>, G1092-1100 (2001).","DOI":"10.1152\/ajpgi.2001.281.4.G1092"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6) Tomisato W., Tsutsumi S., Hoshino T., Hwang H. J., Mio M., Tsuchiya T., Mizushima T., <i>Biochem. Pharmacol<\/i>, <b>67<\/b>, 575-585 (2004).","DOI":"10.1016\/j.bcp.2003.09.020"},{"key":"7","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1038\/sj.onc.1209139","volume":"25","year":"2006","unstructured":"7) Tsutsumi S., Namba T., Tanaka K. I., Arai Y., Ishihara T., Aburaya M., Mima S., Hoshino T., Mizushima T., <i>Oncogene<\/i>, <b>25<\/b>, 1018-1029 (2006).","journal-title":"Oncogene","ISSN":"https:\/\/id.crossref.org\/issn\/0950-9232","issn-type":"print"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8) Namba T., Hoshino T., Tanaka K., Tsutsumi S., Ishihara T., Mima S., Suzuki K., Ogawa S., Mizushima T., <i>Mol. Pharmacol.<\/i>, <b>71<\/b>, 860-870 (2007).","DOI":"10.1124\/mol.106.027698"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9) Tomisato W., Tanaka K., Katsu T., Kakuta H., Sasaki K., Tsutsumi S., Hoshino T., Aburaya M., Li D., Tsuchiya T., Suzuki K., Yokomizo K., Mizushima T., <i>Biochem. Biophys. Res. Commun.<\/i>, <b>323<\/b>, 1032-1039 (2004).","DOI":"10.1016\/j.bbrc.2004.08.205"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10) Tanaka K., Tomisato W., Hoshino T., Ishihara T., Namba T., Aburaya M., Katsu T., Suzuki K., Tsutsumi S., Mizushima T., <i>J. Biol. Chem.<\/i>, <b>280<\/b>, 31059-31067 (2005).","DOI":"10.1074\/jbc.M502956200"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11) Lichtenberger L. M., Wang Z. M., Romero J. J., Ulloa C., Perez J. C., Giraud M. N., Barreto J. C., <i>Nat. Med.<\/i>, <b>1<\/b>, 154-158 (1995).","DOI":"10.1038\/nm0295-154"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12) Mima S., Tsutsumi S., Ushijima H., Takeda M., Fukuda I., Yokomizo K., Suzuki K., Sano K., Nakanishi T., Tomisato W., Tsuchiya T., Mizushima T., <i>Cancer Res.<\/i>, <b>65<\/b>, 1868-1876 (2005).","DOI":"10.1158\/0008-5472.CAN-04-2770"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13) Tsutsumi S., Gotoh T., Tomisato W., Mima S., Hoshino T., Hwang H. J., Takenaka H., Tsuchiya T., Mori M., Mizushima T., <i>Cell Death Differ.<\/i>, <b>11<\/b>, 1009-1016 (2004).","DOI":"10.1038\/sj.cdd.4401436"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14) Aburaya M., Tanaka K., Hoshino T., Tsutsumi S., Suzuki K., Makise M., Akagi R., Mizushima T., <i>J. Biol. Chem.<\/i>, <b>281<\/b>, 33422-33432 (2006).","DOI":"10.1074\/jbc.M602074200"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15) Tanaka K., Tsutsumi S., Arai Y., Hoshino T., Suzuki K., Takaki E., Ito T., Takeuchi K., Nakai A., Mizushima T., <i>Mol. Pharmacol.<\/i>, <b>71<\/b>, 985-993 (2007).","DOI":"10.1124\/mol.106.033282"}],"container-title":["YAKUGAKU ZASSHI"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/yakushi\/128\/2\/128_2_255\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,9,8]],"date-time":"2018-09-08T05:29:06Z","timestamp":1536384546000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/yakushi\/128\/2\/128_2_255\/_article\/-char\/ja\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,2,1]]},"references-count":15,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2008]]}},"URL":"https:\/\/doi.org\/10.1248\/yakushi.128.255","relation":{},"ISSN":["0031-6903","1347-5231"],"issn-type":[{"value":"0031-6903","type":"print"},{"value":"1347-5231","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,2,1]]}}}