{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T17:54:56Z","timestamp":1791050096737,"version":"4.1.0"},"reference-count":15,"publisher":"Pharmaceutical Society of Japan","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["YAKUGAKU ZASSHI"],"published-print":{"date-parts":[[2010,1,1]]},"DOI":"10.1248\/yakushi.130.63","type":"journal-article","created":{"date-parts":[[2010,1,4]],"date-time":"2010-01-04T05:54:05Z","timestamp":1262584445000},"page":"63-68","source":"Crossref","is-referenced-by-count":7,"title":["Creation of TNFR1-selective Antagonist and Its Therapeutic Effects","I\u578bTNF\u53d7\u5bb9\u4f53\u9078\u629e\u7684\u30a2\u30f3\u30bf\u30b4\u30cb\u30b9\u30c8\u306e\u5275\u51fa\u3068\u305d\u306e\u81ea\u5df1\u514d\u75ab\u75be\u60a3\u6cbb\u7642\u85ac\u3068\u3057\u3066\u306e\u53ef\u80fd\u6027"],"prefix":"10.1248","volume":"130","author":[{"given":"Tetsuya","family":"NOMURA","sequence":"first","affiliation":[{"name":"Graduate School of Pharmaceutical Sciences, Osaka University"},{"name":"Laboratory of Pharmaceutical Proteomics, National Institute of Biomedical Innovation (NiBio)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuhiro","family":"ABE","sequence":"additional","affiliation":[{"name":"Laboratory of Pharmaceutical Proteomics, National Institute of Biomedical Innovation (NiBio)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuo","family":"YOSHIOKA","sequence":"additional","affiliation":[{"name":"Graduate School of Pharmaceutical Sciences, Osaka University"},{"name":"Laboratory of Pharmaceutical Proteomics, National Institute of Biomedical Innovation (NiBio)"},{"name":"The Center for Advanced Medical Engineering and Informatics, Osaka University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinsaku","family":"NAKAGAWA","sequence":"additional","affiliation":[{"name":"Graduate School of Pharmaceutical Sciences, Osaka University"},{"name":"The Center for Advanced Medical Engineering and Informatics, Osaka University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shin-ichi","family":"TSUNODA","sequence":"additional","affiliation":[{"name":"Graduate School of Pharmaceutical Sciences, Osaka University"},{"name":"Laboratory of Pharmaceutical Proteomics, National Institute of Biomedical Innovation (NiBio)"},{"name":"The Center for Advanced Medical Engineering and Informatics, Osaka University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuo","family":"TSUTSUMI","sequence":"additional","affiliation":[{"name":"Graduate School of Pharmaceutical Sciences, Osaka University"},{"name":"Laboratory of Pharmaceutical Proteomics, National Institute of Biomedical Innovation (NiBio)"},{"name":"The Center for Advanced Medical Engineering and Informatics, Osaka University"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"163","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"1) Feldmann M., Maini R. N., <i>Nat. Med.<\/i>, <b>9<\/b>, 1245-1250 (2003).","DOI":"10.1038\/nm939"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2) Wajant H., Pfizenmaier K., Scheurich P., <i>Cell Death Differ.<\/i>, <b>10<\/b>, 45-65 (2003).","DOI":"10.1038\/sj.cdd.4401189"},{"key":"3","doi-asserted-by":"publisher","unstructured":"3) Feldmann M., <i>Nat. Rev. Immunol.<\/i>, <b>2<\/b>, 364-371 (2002).","DOI":"10.1038\/nri802"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4) Brown S. L., Greene M. H., Gershon S. K., Edwards E. T., Braun M. M., <i>Arthritis Rheum.<\/i>, <b>46<\/b>, 3151-3158 (2002).","DOI":"10.1002\/art.10679"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5) Gomez-Reino J. J., Carmona L., Valverde V. R., Mola E. M., Montero M. D., <i>Arthritis Rheum.<\/i>, <b>48<\/b>, 2122-2127 (2003).","DOI":"10.1002\/art.11137"},{"key":"6","doi-asserted-by":"publisher","unstructured":"6) Chun E. S., Packer M., Lo K. H., Fasanmade A. A., Willerson J. T., <i>Circulation<\/i>, <b>107<\/b>, 3133-3140 (2003).","DOI":"10.1161\/01.CIR.0000077913.60364.D2"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7) Mori L., Iselin S., De Libero G., Lesslauer W., <i>J. Immunol.<\/i>, <b>157<\/b>, 3178-3182 (1996).","DOI":"10.4049\/jimmunol.157.7.3178"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8) Kassiotis G., Kollias G., <i>J. Exp. Med.<\/i>, <b>193<\/b>, 427-434 (2001).","DOI":"10.1084\/jem.193.4.427"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9) Liu J., Marino M. W., Wong G., Grail D., Dunn A., Bettadapura J., Slavin A. J., Old L., Bernard C. C., <i>Nat. Med.<\/i>, <b>4<\/b>, 78-83 (1998).","DOI":"10.1038\/nm0198-078"},{"key":"10","unstructured":"10) Yamamoto Y., Tsutsumi Y., Yoshioka Y., Nishibata K., Kobayashi K., Okamoto T., Mukai Y., Shimizu T., Nakagawa S., Nagata S., Mayumi T., <i>Nat. Biotechnol.<\/i>, <b>100<\/b>, 4831-4836 (2003)."},{"key":"11","doi-asserted-by":"crossref","unstructured":"11) Shibata H., Yoshioka Y., Ohkawa A., Minowa K., Mukai Y., Abe Y., Taniai M., Nomura T., Kayamuro H., Nabeshi H., Sugita T., Imai S., Nagano K., Yoshikawa T., Fujita T., Nakagawa S., Yamamoto A., Ohta T., Hayakawa T., Mayumi T., Vandenabeele P., Aggarwal B. B., Nakamura T., Yamagata Y., Tsunoda S., Kamada H., Tsutsumi Y., <i>J. Biol. Chem.<\/i>, <b>283<\/b>, 998-1007 (2008).","DOI":"10.1074\/jbc.M707933200"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12) Mukai Y., Shibata H., Nakamura Y., Yoshioka Y., Abe Y., Nomura T., Taniai M., Ohta T., Ikemizu S., Nakagawa S., Tsunoda S., Kamada H., Yamagata Y., Tsutsumi Y., <i>J. Mol. Biol.<\/i>, <b>385<\/b>, 1221-1229 (2009).","DOI":"10.1016\/j.jmb.2008.11.053"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13) Nomura T., Abe Y., Kamada H., Inoue M., Kawara T., Arita S., Furuya T., Minowa K., Yoshioka Y., Shibata H., Kayamuro H., Yamashita T., Nagano K., Yoshikawa T., Mukai Y., Nakagawa S., Taniai M., Ohta T., Tsunoda S., Tsutsumi Y., <i>Biochem. Biophys. Res. Commun.<\/i>, <b>388<\/b>, 667-71 (2009).","DOI":"10.1016\/j.bbrc.2009.08.052"},{"key":"14","unstructured":"14) Nomura T., Abe Y., Kamada H., Inoue M., Kawara T., Arita S., Furuya T., Minowa K., Yoshioka Y., Shibata H., Kayamuro H., Yamashita T., Nagano K., Yoshikawa T., Mukai Y., Nakagawa S., Tsunoda S., Tsutsumi Y., <i>Pharmazie<\/i>. (in press)"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15) Chan F. K., Shisler J., Bixby J. G., Felices M., Zheng L., Appel M., Orenstein J., Moss B., Lenardo M. J., <i>J. Biol. Chem.<\/i>, <b>278<\/b>, 51613-51621 (2003).","DOI":"10.1074\/jbc.M305633200"}],"container-title":["YAKUGAKU ZASSHI"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/yakushi\/130\/1\/130_1_63\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,29]],"date-time":"2023-05-29T10:06:47Z","timestamp":1685354807000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/yakushi\/130\/1\/130_1_63\/_article\/-char\/ja\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,1,1]]},"references-count":15,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2010]]}},"URL":"https:\/\/doi.org\/10.1248\/yakushi.130.63","relation":{},"ISSN":["0031-6903","1347-5231"],"issn-type":[{"value":"0031-6903","type":"print"},{"value":"1347-5231","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,1,1]]}}}