{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,3,13]],"date-time":"2025-03-13T04:15:19Z","timestamp":1741839319349,"version":"3.38.0"},"reference-count":47,"publisher":"Pharmaceutical Society of Japan","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["YAKUGAKU ZASSHI"],"published-print":{"date-parts":[[2011,10,1]]},"DOI":"10.1248\/yakushi.131.1445","type":"journal-article","created":{"date-parts":[[2011,10,3]],"date-time":"2011-10-03T06:16:43Z","timestamp":1317622603000},"page":"1445-1451","source":"Crossref","is-referenced-by-count":2,"title":["Blood-Brain Barrier Transport of Opioid Analgesics","\u30aa\u30d4\u30aa\u30a4\u30c9\u93ae\u75db\u85ac\u306e\u8840\u6db2\u8133\u95a2\u9580\u8f38\u9001"],"prefix":"10.1248","volume":"131","author":[{"given":"Toyofumi","family":"SUZUKI","sequence":"first","affiliation":[{"name":"Laboratory of Pharmaceutics, School of Pharmacy, Nihon University"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"163","reference":[{"doi-asserted-by":"publisher","unstructured":"1) Redzic Z., Fluids Barriers CNS<\/i>, 8<\/b>, 3 (2011).","key":"1","DOI":"10.1186\/2045-8118-8-3"},{"doi-asserted-by":"crossref","unstructured":"2) Ohtsuki S., Terasaki T., Pharm. Res.<\/i>, 24<\/b>, 1745-1758 (2007).","key":"2","DOI":"10.1007\/s11095-007-9374-5"},{"doi-asserted-by":"crossref","unstructured":"3) Tsuji A., NeuroRx.<\/i>, 2<\/b>, 54-62 (2005).","key":"3","DOI":"10.1602\/neurorx.2.1.54"},{"doi-asserted-by":"crossref","unstructured":"4) Kusuhara H., Sugiyama Y., NeuroRx.<\/i>, 2<\/b>, 73-85 (2005).","key":"4","DOI":"10.1602\/neurorx.2.1.73"},{"doi-asserted-by":"crossref","unstructured":"5) Koepsell H., Lips K., Volk C., Pharm. Res.<\/i>, 24<\/b>, 1227-1251 (2007).","key":"5","DOI":"10.1007\/s11095-007-9254-z"},{"unstructured":"6) Suzuki T., Yakuzaigaku<\/i>, 69<\/b>, 191-197 (2009).","key":"6"},{"doi-asserted-by":"crossref","unstructured":"7) Bickel U., Schumacher O. P., Kang Y. S., Voigt K., J. Pharmacol. Exp. Ther.<\/i>, 278<\/b>, 107-113 (1996).","key":"7","DOI":"10.1016\/S0022-3565(25)20113-6"},{"doi-asserted-by":"publisher","unstructured":"8) Oldendorf W. H., Hyman S., Braun L., Oldendorf S. Z., Science<\/i>, 178<\/b>, 984-986 (1972).","key":"8","DOI":"10.1126\/science.178.4064.984"},{"doi-asserted-by":"crossref","unstructured":"9) Oldendorf W. H., Proc. Soc. Exp. Biol. Med.<\/i>, 147<\/b>, 813-815 (1974).","key":"9","DOI":"10.3181\/00379727-147-38444"},{"doi-asserted-by":"crossref","unstructured":"10) Avdeef A., Barrett D. A., Shaw P. N., Knaggs R. D., Davis S. S., J. Med. Chem.<\/i>, 39<\/b>, 4377-4381 (1996).","key":"10","DOI":"10.1021\/jm960073m"},{"doi-asserted-by":"crossref","unstructured":"11) Hammarlund-Udenaes M., Fridén M., Syvänen S., Gupta A., Pharm. Res.<\/i>, 25<\/b>, 1737-1750 (2008).","key":"11","DOI":"10.1007\/s11095-007-9502-2"},{"doi-asserted-by":"crossref","unstructured":"12) Dagenais C., Graff C. L., Pollack G. M., Biochem. Pharmacol.<\/i>, 67<\/b>, 269-276 (2004).","key":"12","DOI":"10.1016\/j.bcp.2003.08.027"},{"doi-asserted-by":"publisher","unstructured":"13) Thompson S. J., Koszdin K., Bernards C. M., Anesthesiology<\/i>, 92<\/b>, 1392-1399 (2000).","key":"13","DOI":"10.1097\/00000542-200005000-00030"},{"doi-asserted-by":"crossref","unstructured":"14) Letrent S. P., Pollack G. M., Brouwer K. R., Brouwer K. L., Drug Metab. Dispos.<\/i>, 27<\/b>, 827-834 (1999).","key":"14","DOI":"10.1016\/S0090-9556(24)11822-3"},{"doi-asserted-by":"crossref","unstructured":"15) Bouw M. R., Gårdmark M., Hammarlund-Udenaes M., Pharm. Res.<\/i>, 17<\/b>, 1220-1227 (2000).","key":"15","DOI":"10.1023\/A:1026414713509"},{"doi-asserted-by":"publisher","unstructured":"16) Tunblad K., Jonsson E. N., Hammarlund-Udenaes M., Pharm. Res.<\/i>, 20<\/b>, 618-623 (2003).","key":"16","DOI":"10.1023\/A:1023250900462"},{"doi-asserted-by":"publisher","unstructured":"17) Christrup L. L., Acta Anaesthesiol. Scand.<\/i>, 41<\/b>, 116-122 (1997).","key":"17","DOI":"10.1111\/j.1399-6576.1997.tb04625.x"},{"doi-asserted-by":"crossref","unstructured":"18) Paul D., Standifer K. M., Inturrisi C. E., Pasternak G. W., J. Pharmacol. Exp. Ther.<\/i>, 251<\/b>, 477-483 (1989).","key":"18","DOI":"10.1016\/S0022-3565(25)20832-1"},{"doi-asserted-by":"crossref","unstructured":"19) Frances B., Gout R., Monsarrat B., Cros J., Zajac J. M., J. Pharmacol. Exp. Ther.<\/i>, 262<\/b>, 25-31 (1992).","key":"19","DOI":"10.1016\/S0022-3565(25)10743-X"},{"doi-asserted-by":"publisher","unstructured":"20) Hanna M. H., Elliott K. M., Fung M., Anesthesiology<\/i>, 102<\/b>, 815-821 (2005).","key":"20","DOI":"10.1097\/00000542-200504000-00018"},{"unstructured":"21) Wu D., Kang Y. S., Bickel U., Pardridge W. M., Drug Metab. Dispos.<\/i>, 25<\/b>, 768-771 (1997).","key":"21"},{"doi-asserted-by":"crossref","unstructured":"22) Bickel U., Schumacher O. P., Kang Y. S., Voigt K., J. Pharmacol. Exp. Ther.<\/i>, 278<\/b>, 107-113 (1996).","key":"22","DOI":"10.1016\/S0022-3565(25)20113-6"},{"doi-asserted-by":"crossref","unstructured":"23) Bouw M. R., Xie R., Tunblad K., Hammarlund-Udenaes M., Br. J. Pharmacol.<\/i>, 134<\/b>, 1796-1804 (2001).","key":"23","DOI":"10.1038\/sj.bjp.0704406"},{"doi-asserted-by":"publisher","unstructured":"24) Tunblad K., Hammarlund-Udenaes M., Jonsson E. N., Eur. J. Pharm. Sci.<\/i>, 24<\/b>, 49-67 (2005).","key":"24","DOI":"10.1016\/j.ejps.2004.09.009"},{"doi-asserted-by":"crossref","unstructured":"25) Lötsch J., Schmidt R., Vetter G., Schmidt H., Niederberger E., Geisslinger G., Tegeder I., J Neurochem.<\/i>, 83<\/b>, 241-248 (2002).","key":"25","DOI":"10.1046\/j.1471-4159.2002.01177.x"},{"unstructured":"26) Huwyler J., Drewe J., Gutmann H., Thöle M., Fricker G., Int. J. Clin. Pharmacol. Ther.<\/i>, 36<\/b>, 69-70 (1998).","key":"26"},{"doi-asserted-by":"crossref","unstructured":"27) Bourasset F., Cisternino S., Temsamani J., Scherrmann J. M., J. Neurochem.<\/i>, 86<\/b>, 1564-1567 (2003).","key":"27","DOI":"10.1046\/j.1471-4159.2003.01990.x"},{"doi-asserted-by":"crossref","unstructured":"28) Xie R., Hammarlund-Udenaes M., de Boer A. G., de Lange E. C., Br. J. Pharmacol.<\/i>, 128<\/b>, 563-568 (1999).","key":"28","DOI":"10.1038\/sj.bjp.0702804"},{"doi-asserted-by":"crossref","unstructured":"29) Xie R., Bouw M. R., Hammarlund-Udenaes M., Br. J. Pharmacol.<\/i>, 131<\/b>, 1784-1792 (2000).","key":"29","DOI":"10.1038\/sj.bjp.0703759"},{"doi-asserted-by":"publisher","unstructured":"30) Boström E., Simonsson U. S., Hammarlund-Udenaes M., Drug Metab. Dispos.<\/i>, 34<\/b>, 1624-1631 (2006).","key":"30","DOI":"10.1124\/dmd.106.009746"},{"doi-asserted-by":"crossref","unstructured":"31) Okura T., Hattori A., Takano Y., Sato T., Hammarlund-Udenaes M., Terasaki T., Deguchi Y., Drug Metab. Dispos.<\/i>, 36<\/b>, 2005-2013 (2008).","key":"31","DOI":"10.1124\/dmd.108.022087"},{"doi-asserted-by":"publisher","unstructured":"32) Boström E., Simonsson U. S., Hammarlund-Udenaes M., J. Pharm. Sci.<\/i>, 94<\/b>, 1060-1066 (2005).","key":"32","DOI":"10.1002\/jps.20327"},{"doi-asserted-by":"crossref","unstructured":"33) Henthorn T. K., Liu Y., Mahapatro M., Ng K. Y., J. Pharmacol. Exp. Ther.<\/i>, 289<\/b>, 1084-1089 (1999).","key":"33","DOI":"10.1016\/S0022-3565(24)38239-4"},{"doi-asserted-by":"publisher","unstructured":"34) Elkiweri I. A., Zhang Y. L., Christians U., Ng K.Y., Tissot van Patot M. C., Henthorn T. K., Anesth. Analg.<\/i>, 108<\/b>, 149-159 (2009).","key":"34","DOI":"10.1213\/ane.0b013e31818e0bd1"},{"doi-asserted-by":"crossref","unstructured":"35) Xie R., Hammarlund-Udenaes M., Pharm. Res.<\/i>, 15<\/b>, 570-575 (1998).","key":"35","DOI":"10.1023\/A:1011929910782"},{"doi-asserted-by":"crossref","unstructured":"36) Fischer W., Bernhagen J., Neubert R. H., Brandsch M., Eur. J. Pharm. Sci.<\/i>, 41<\/b>, 31-42 (2010).","key":"36","DOI":"10.1016\/j.ejps.2010.05.010"},{"doi-asserted-by":"crossref","unstructured":"37) Suzuki T., Oshimi M., Hanano M., Biol. Pharm. Bull.<\/i>, 20<\/b>, 997-1001 (1997).","key":"37","DOI":"10.1248\/bpb.20.997"},{"doi-asserted-by":"crossref","unstructured":"38) Suzuki T., Suganuma T., Nishino J., Hanano M., Biol. Pharm. Bull.<\/i>, 20<\/b>, 1193-1198 (1997).","key":"38","DOI":"10.1248\/bpb.20.1193"},{"doi-asserted-by":"crossref","unstructured":"39) Suzuki T., Shimizu R., Suganuma T., Nishino J., Tomono K., Hanano M., Watanabe J., Biol. Pharm. Bull.<\/i>, 23<\/b>, 1504-1510 (2000).","key":"39","DOI":"10.1248\/bpb.23.1504"},{"doi-asserted-by":"crossref","unstructured":"40) Suzuki T., Oshimi M., Tomono K., Hanano M., Watanabe J., J. Pharm. Sci.<\/i>, 91<\/b>, 2346-2353 (2002).","key":"40","DOI":"10.1002\/jps.10224"},{"doi-asserted-by":"crossref","unstructured":"41) Suzuki T., Moriki Y., Goto H., Tomono K., Hanano M., Watanabe J., Biol. Pharm. Bull.<\/i>, 25<\/b>, 1351-1355 (2002).","key":"41","DOI":"10.1248\/bpb.25.1351"},{"doi-asserted-by":"crossref","unstructured":"42) Nakazawa Y., Okura T., Shimomura K., Terasaki T., Deguchi Y., J. Pharm. Sci.<\/i>, 99<\/b>, 467-474 (2010).","key":"42","DOI":"10.1002\/jps.21807"},{"doi-asserted-by":"publisher","unstructured":"43) Moriki Y., Suzuki T., Furuishi T., Fukami T., Tomono K., Watanabe J., J. Drug Target.<\/i>, 13<\/b>, 53-59 (2005).","key":"43","DOI":"10.1080\/10611860400024110"},{"doi-asserted-by":"publisher","unstructured":"44) Suzuki T., Zaima C., Moriki Y., Fukami T., Tomono K., J. Drug Target.<\/i>, 15<\/b>, 67-74 (2007).","key":"44","DOI":"10.1080\/10611860601141606"},{"doi-asserted-by":"crossref","unstructured":"45) Moriki Y., Suzuki T., Fukami T., Hanano M., Tomono K., Watanabe J., Biol. Pharm. Bull.<\/i>, 27<\/b>, 932-935 (2004).","key":"45","DOI":"10.1248\/bpb.27.932"},{"doi-asserted-by":"crossref","unstructured":"46) Suzuki T., Miyata M., Zaima C., Furuishi T., Fukami T., Kugawa F., Tomono K., J. Pharm. Sci.<\/i>, 99<\/b>, 413-421 (2010).","key":"46","DOI":"10.1002\/jps.21819"},{"doi-asserted-by":"crossref","unstructured":"47) Suzuki T., Ohmuro A., Miyata M., Furuishi T., Hidaka S., Kugawa F., Fukami T., Tomono K., Biopharm. Drug Dispos.<\/i>, 31<\/b>, 243-252 (2010).","key":"47","DOI":"10.1002\/bdd.707"}],"container-title":["YAKUGAKU ZASSHI"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/yakushi\/131\/10\/131_10_1445\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,12]],"date-time":"2025-03-12T10:24:28Z","timestamp":1741775068000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/yakushi\/131\/10\/131_10_1445\/_article\/-char\/ja\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,10,1]]},"references-count":47,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2011]]}},"URL":"https:\/\/doi.org\/10.1248\/yakushi.131.1445","relation":{},"ISSN":["0031-6903","1347-5231"],"issn-type":[{"type":"print","value":"0031-6903"},{"type":"electronic","value":"1347-5231"}],"subject":[],"published":{"date-parts":[[2011,10,1]]}}}