{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T03:57:34Z","timestamp":1773287854588,"version":"3.50.1"},"reference-count":67,"publisher":"Pharmaceutical Society of Japan","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["YAKUGAKU ZASSHI"],"published-print":{"date-parts":[[2011]]},"DOI":"10.1248\/yakushi.131.285","type":"journal-article","created":{"date-parts":[[2011,2,1]],"date-time":"2011-02-01T06:08:43Z","timestamp":1296540523000},"page":"285-298","source":"Crossref","is-referenced-by-count":8,"title":["Development of Highly Nuclease-resistant Chemically-modified Oligonucleotides","\u30cc\u30af\u30ec\u30a2\u30fc\u30bc\u62b5\u6297\u6027\u5316\u5b66\u4fee\u98fe\u6838\u9178\u306e\u958b\u767a\u7814\u7a76"],"prefix":"10.1248","volume":"131","author":[{"given":"Akira","family":"MATSUDA","sequence":"first","affiliation":[{"name":"Faculty of Pharmaceutical Sciences, Hokkaido University"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"163","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.1863"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2) Yang W., <i>Quart. Rev. Biophys.<\/i>, doi:10.1017\/S0033583510000181 (2010).","DOI":"10.1017\/S0033583510000181"},{"key":"3","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1146\/annurev.pharmtox.010909.105654","volume":"50","author":"Frank Bennett C., Swayze E. E.","year":"2010","journal-title":"Annual Review of Pharmacology and Toxicology","ISSN":"https:\/\/id.crossref.org\/issn\/0362-1642","issn-type":"print"},{"key":"4","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1021\/bc900247s","volume":"21","author":"Jain A. K., Bhattachary S.","year":"2010","journal-title":"Bioconjugate Chemistry","ISSN":"https:\/\/id.crossref.org\/issn\/1043-1802","issn-type":"print"},{"key":"5","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1016\/j.coph.2010.07.002","volume":"10","author":"Mulhbacher J., St-Pierre P., Lafont","year":"2010","journal-title":"Current Opinion in Pharmacology","ISSN":"https:\/\/id.crossref.org\/issn\/1471-4892","issn-type":"print"},{"key":"6","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1146\/annurev.pharmtox.010909.105547","volume":"50","author":"Bouchard P. R., Hutabarat R. M., Th","year":"2010","journal-title":"Annual Review of Pharmacology and Toxicology","ISSN":"https:\/\/id.crossref.org\/issn\/0362-1642","issn-type":"print"},{"key":"7","doi-asserted-by":"crossref","first-page":"1887","DOI":"10.1016\/j.bcp.2010.06.047","volume":"80","author":"Gambari R., Borgatti M., Bezzerri V","year":"2010","journal-title":"Biochemical Pharmacology","ISSN":"https:\/\/id.crossref.org\/issn\/0006-2952","issn-type":"print"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8) Jackson A. L., Linsley P. S., <i>Nat. Rev. Drug Discov.<\/i>, <b>9<\/b>, 57-67 (2010).","DOI":"10.1038\/nrd3010"},{"key":"9","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1021\/bi00725a025","volume":"12","author":"Kropinski A. M. B., Bose R. J., War","year":"1973","journal-title":"Biochemistry","ISSN":"https:\/\/id.crossref.org\/issn\/0006-2960","issn-type":"print"},{"key":"10","unstructured":"10) Matsuda A., Ueno Y., Takenaka A., &ldquo;Frontiers in Nucleosides and Nucleic Acids, Thermal stability and nuclease-resistance properties of oligonucleotides having an aminoalkyl side chain at the nucleobase and sugar moieties,&rdquo; eds. by Schinazi R. F., Liotta D. C., IHL Press, Tucker, 2004, pp. 549-576."},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-894X(01)80145-1"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1021\/bc970021r"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkl821"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/25.19.3777"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkg374"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/25.14.2784"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-894X(97)10096-8"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1021\/bc9701508"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1021\/bc00031a005"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-894X(96)00520-3"},{"issue":"1\/3","key":"21","first-page":"283","volume":"17","year":"1998","journal-title":"Nucleosides Nucleotides","ISSN":"https:\/\/id.crossref.org\/issn\/0732-8311","issn-type":"print"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-894X(96)00519-7"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1016\/0040-4039(96)01432-3"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.1021\/jo971703a"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.1021\/jo9720492"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.1021\/ja9934706"},{"key":"27","doi-asserted-by":"crossref","unstructured":"27) Ikemoto N., Kim H.-S., Kanazaki M., Ueno Y., Shuto S., Matsuda A., Wataya Y., <i>Nucleic Acids Sympo. Ser.<\/i>, <b>42<\/b>, 89-90 (1999).","DOI":"10.1093\/nass\/42.1.89"},{"key":"28","doi-asserted-by":"publisher","DOI":"10.1016\/S0040-4020(00)00705-5"},{"key":"29","doi-asserted-by":"crossref","first-page":"2933","DOI":"10.1016\/S0968-0896(02)00141-4","volume":"10","author":"Atsumi N., Ueno Y., Kanazaki M., Sh","year":"2002","journal-title":"Bioorg. Med. Chem.","ISSN":"https:\/\/id.crossref.org\/issn\/0968-0896","issn-type":"print"},{"key":"30","doi-asserted-by":"publisher","DOI":"10.1021\/bi0496283"},{"key":"31","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1021\/bc0000684","volume":"11","author":"Ueno Y., Karino N., Matsuda A.","year":"2000","journal-title":"Bioconjugate Chem.","ISSN":"https:\/\/id.crossref.org\/issn\/1043-1802","issn-type":"print"},{"key":"32","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-894X(01)81240-3"},{"key":"33","doi-asserted-by":"publisher","DOI":"10.1021\/bc00024a012"},{"issue":"9","key":"34","doi-asserted-by":"crossref","first-page":"890","DOI":"10.5059\/yukigoseikyokaishi.61.890","volume":"61","author":"UENO YOSHIHITO","year":"2003","journal-title":"Yuki Gosei Kagaku Kyokai Shi","ISSN":"https:\/\/id.crossref.org\/issn\/0037-9980","issn-type":"print"},{"key":"35","doi-asserted-by":"crossref","unstructured":"35) Shuto S., Kanazaki M., Sugimoto I., Ichikawa S., Nagasawa Y., Ueno Y., Abe H., Minakawa N., Sukeda M., Kodama T., Nomura M., Matsuda A., &ldquo;Recent Advances in Nucleosides: Chemistry and Chemotherapy, Development of new radical reactions with a vinylsilyl group and their application to the synthesis of branched-chain sugar nucleosides,&rdquo; ed. by Chu C. K., Elsevier Science B. V., Amsterdam, 2002, pp. 21-55.","DOI":"10.1016\/B978-044450951-2\/50002-3"},{"issue":"4","key":"36","first-page":"293","volume":"38","author":"MATSUDA AKIRA","year":"2002","journal-title":"Farumashia","ISSN":"https:\/\/id.crossref.org\/issn\/0014-8601","issn-type":"print"},{"key":"37","doi-asserted-by":"publisher","DOI":"10.1021\/jo970867o"},{"issue":"11","key":"38","doi-asserted-by":"crossref","first-page":"1766","DOI":"10.1055\/s-1999-2949","author":"SUGIMOTO I","year":"1999","journal-title":"Synlett","ISSN":"https:\/\/id.crossref.org\/issn\/0936-5214","issn-type":"print"},{"key":"39","doi-asserted-by":"publisher","DOI":"10.1021\/ja993239s"},{"key":"40","doi-asserted-by":"publisher","DOI":"10.1021\/jo990787f"},{"key":"41","doi-asserted-by":"publisher","DOI":"10.1021\/jo000967l"},{"key":"42","doi-asserted-by":"publisher","DOI":"10.1002\/1521-3765(20010601)7:11<2332::AID-CHEM23320>3.0.CO;2-W"},{"key":"43","doi-asserted-by":"crossref","unstructured":"43) Sukeda M., Ichikawa S., Matsuda A., Shuto S., <i>Angew. Chem., Int. Ed. Engl.<\/i>, <b>41<\/b>, 4748-4750 (2002).","DOI":"10.1002\/anie.200290037"},{"key":"44","doi-asserted-by":"publisher","DOI":"10.1021\/jo0206667"},{"key":"45","doi-asserted-by":"publisher","DOI":"10.1016\/j.tet.2005.06.021"},{"key":"46","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-894X(99)00010-4"},{"issue":"1","key":"47","doi-asserted-by":"crossref","first-page":"50","DOI":"10.5059\/yukigoseikyokaishi.66.50","volume":"66","author":"Shuto Satoshi","year":"2008","journal-title":"Yuki Gosei Kagaku Kyokai Shi","ISSN":"https:\/\/id.crossref.org\/issn\/0037-9980","issn-type":"print"},{"key":"48","doi-asserted-by":"publisher","DOI":"10.1016\/S0040-4039(99)01026-6"},{"key":"49","doi-asserted-by":"publisher","DOI":"10.1016\/S0040-4039(00)00556-6"},{"key":"50","doi-asserted-by":"publisher","DOI":"10.1021\/jo0002339"},{"key":"51","doi-asserted-by":"publisher","DOI":"10.1016\/j.tetlet.2005.07.087"},{"key":"52","doi-asserted-by":"publisher","DOI":"10.1016\/j.tet.2005.02.025"},{"key":"53","doi-asserted-by":"crossref","first-page":"1900","DOI":"10.1021\/jm051039n","volume":"49","author":"Terauchi M., Abe H., Tovey S. C., D","year":"2006","journal-title":"J. Med. Chem.","ISSN":"https:\/\/id.crossref.org\/issn\/0022-2623","issn-type":"print"},{"key":"54","doi-asserted-by":"crossref","first-page":"79","DOI":"10.2174\/1574090054484252","volume":"1","author":"Minakawa N., Hoshika S., Inoue N.,","year":"2005","journal-title":"Frontiers in Organic Chemistry","ISSN":"https:\/\/id.crossref.org\/issn\/1574-0900","issn-type":"print"},{"key":"55","doi-asserted-by":"publisher","DOI":"10.1016\/S0040-4039(99)01287-3"},{"key":"56","doi-asserted-by":"crossref","unstructured":"56) Minakawa N., Kaga D., Kato Y., Kobayashi K., Tanaka M., Sasaki T., Matsuda A., <i>J. Chem. Soc., Perkin Trans. 1<\/i>, 2182-2189 (2002).","DOI":"10.1039\/B204993G"},{"key":"57","doi-asserted-by":"publisher","DOI":"10.1021\/ja000541o"},{"key":"58","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkh705"},{"key":"59","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gki578"},{"key":"60","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkn1088"},{"key":"61","doi-asserted-by":"publisher","DOI":"10.1021\/jo051248f"},{"key":"62","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkl491"},{"key":"63","doi-asserted-by":"publisher","DOI":"10.1021\/ja075953c"},{"key":"64","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkn011"},{"key":"65","doi-asserted-by":"crossref","first-page":"9450","DOI":"10.1016\/j.bmc.2008.09.048","volume":"16","author":"Minakawa N., Sanji M., Kato Y., Mat","year":"2008","journal-title":"Bioorg. Med. Chem.","ISSN":"https:\/\/id.crossref.org\/issn\/0968-0896","issn-type":"print"},{"key":"66","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2005.04.073"},{"key":"67","doi-asserted-by":"crossref","first-page":"2133","DOI":"10.1002\/cbic.200700342","volume":"8","author":"Hoshika S., Minakawa N., Shionoya A","year":"2007","journal-title":"ChemBioChem","ISSN":"https:\/\/id.crossref.org\/issn\/1439-4227","issn-type":"print"}],"container-title":["YAKUGAKU ZASSHI"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.jstage.jst.go.jp\/article\/yakushi\/131\/2\/131_2_285\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,3,19]],"date-time":"2021-03-19T02:02:33Z","timestamp":1616119353000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.jstage.jst.go.jp\/article\/yakushi\/131\/2\/131_2_285\/_article\/-char\/ja\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011]]},"references-count":67,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2011]]}},"URL":"https:\/\/doi.org\/10.1248\/yakushi.131.285","relation":{},"ISSN":["0031-6903","1347-5231"],"issn-type":[{"value":"0031-6903","type":"print"},{"value":"1347-5231","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011]]}}}