{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T20:39:00Z","timestamp":1792701540410,"version":"4.5.0"},"reference-count":13,"publisher":"Pharmaceutical Society of Japan","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["YAKUGAKU ZASSHI"],"published-print":{"date-parts":[[2018,4,1]]},"DOI":"10.1248\/yakushi.17-00179","type":"journal-article","created":{"date-parts":[[2018,3,31]],"date-time":"2018-03-31T22:21:39Z","timestamp":1522534899000},"page":"443-450","source":"Crossref","is-referenced-by-count":11,"title":["Development of Noninvasive Drug Delivery Systems to the Brain for the Treatment of Brain\/Central Nervous System Diseases","\u975e\u4fb5\u8972\u7684\u306a\u8133\u5185\u3078\u306e\u85ac\u7269\u9001\u9054\u6280\u8853\u306e\u958b\u767a\u3068\u8133\u795e\u7d4c\u75be\u60a3\u6cbb\u7642\u3078\u306e\u5fdc\u7528"],"prefix":"10.1248","volume":"138","author":[{"given":"Takanori","family":"Kanazawa","sequence":"first","affiliation":[{"name":"Laboratory of Pharmaceutical Technology, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"163","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"1) Armulik A., Genov&#x00E9; G., M&#x00E4;e M., Nisancioglu M. H., Wallgard E., Niaudet C., He L., Norlin J., Lindblom P., Strittmatter K., Johansson B. R., Betsholtz C., <i>Nature<\/i>, <b>468<\/b>, 557-561 (2010).","DOI":"10.1038\/nature09522"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2) Pardridge W. M., <i>Drug Discov. Today<\/i>, <b>6<\/b>, 381-383 (2001).","DOI":"10.1016\/S1359-6446(01)01721-4"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3) Illum L., <i>Eur. J. Pharm. Sci.<\/i>, <b>11<\/b>, 1-18 (2000).","DOI":"10.1016\/S0928-0987(00)00087-7"},{"key":"4","unstructured":"4) Frey W. H., <i>Drug Deliv. Technol.<\/i>, <b>2<\/b>, 46-49 (2002)."},{"key":"5","doi-asserted-by":"crossref","unstructured":"5) Lochhead J. J., Thorne G., <i>Adv. Drug Deliv. Rev.<\/i>, <b>64<\/b>, 614-628 (2012).","DOI":"10.1016\/j.addr.2011.11.002"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6) Djupesland P. G., Messina J. C., Mahmoud R. A., <i>Ther. Deliv.<\/i>, <b>5<\/b>, 709-733 (2014).","DOI":"10.4155\/tde.14.41"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7) Kanazawa T., <i>Med. Devices<\/i> (Auckl), <b>8<\/b>, 57-64 (2015).","DOI":"10.2147\/MDER.S70856"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8) Tanaka K., Kanazawa T., Shibata Y., Suda Y., Fukuda T., Takashima Y., Okada H., <i>Int. J. Pharm.<\/i>, <b>396<\/b>, 229-238 (2010).","DOI":"10.1016\/j.ijpharm.2010.06.028"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9) Kanazawa T., Morisaki K., Suzuki S., Takashima Y., <i>Mol. Pharm.<\/i>, <b>11<\/b>, 1471-1478 (2014).","DOI":"10.1021\/mp400644e"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10) Kanazawa T., Taki H., Tanaka K., Takashima Y., Okada H., <i>Pharm. Res.<\/i>, <b>28<\/b>, 2130-2139 (2011).","DOI":"10.1007\/s11095-011-0440-7"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11) Kanazawa T., Akiyama F., Kakizaki S., Takashima Y., Seta Y., <i>Biomaterials<\/i>, <b>34<\/b>, 9220-9226 (2013).","DOI":"10.1016\/j.biomaterials.2013.08.036"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12) in 't Veen J. P., van den Berg M. P., Romeijn S. G., Verhoef J. C., Merkus F. W., <i>Eur. J. Pharm. Biopharm.<\/i>, <b>61<\/b>, 27-31 (2005).","DOI":"10.1016\/j.ejpb.2005.02.015"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13) Kozlovskaya L., Abou-Kaoud M., Stepensky D., <i>J. Control. Release<\/i>, <b>10<\/b>, 133-140 (2014).","DOI":"10.1016\/j.jconrel.2014.06.053"}],"container-title":["YAKUGAKU ZASSHI"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/yakushi\/138\/4\/138_17-00179\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,9,1]],"date-time":"2018-09-01T06:22:53Z","timestamp":1535782973000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/yakushi\/138\/4\/138_17-00179\/_article\/-char\/ja\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,4,1]]},"references-count":13,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2018]]}},"URL":"https:\/\/doi.org\/10.1248\/yakushi.17-00179","relation":{},"ISSN":["0031-6903","1347-5231"],"issn-type":[{"value":"0031-6903","type":"print"},{"value":"1347-5231","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,4,1]]}}}