{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T11:54:59Z","timestamp":1785153299237,"version":"3.55.0"},"reference-count":45,"publisher":"Pharmaceutical Society of Japan","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["YAKUGAKU ZASSHI"],"published-print":{"date-parts":[[2019,11,1]]},"DOI":"10.1248\/yakushi.19-00160","type":"journal-article","created":{"date-parts":[[2019,10,31]],"date-time":"2019-10-31T22:44:26Z","timestamp":1572561866000},"page":"1403-1415","source":"Crossref","is-referenced-by-count":1,"title":["Lysophosphatidic Acid Receptor Signaling Underlying Chronic Pain and Neuroprotective Mechanisms through Prothymosin \u03b1","\u6162\u6027\u75bc\u75db\u3092\u62c5\u3046\u9375\u5206\u5b50\u30ea\u30be\u30db\u30b9\u30d5\u30a1\u30c1\u30b8\u30f3\u9178\u3068\u8133\u3092\u5b88\u308b\u9375\u5206\u5b50\u30d7\u30ed\u30b5\u30a4\u30e2\u30b7\u30f3\u03b1\u306b\u95a2\u3059\u308b\u7814\u7a76"],"prefix":"10.1248","volume":"139","author":[{"given":"Hiroshi","family":"Ueda","sequence":"first","affiliation":[{"name":"Department of Pharmacology and Therapeutic Innovation, Nagasaki University, Institute of Biomedical Sciences"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"163","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"1) Takagi H., Shiomi H., Ueda H., Amano H., Nature<\/i>, 282<\/b>, 410-412 (1979).","DOI":"10.1038\/282410a0"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2) Ueda H., Tatsumi K., Shiomi H., Takagi H., Brain Res.<\/i>, 231<\/b>, 222-224 (1982).","DOI":"10.1016\/0006-8993(82)90023-3"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3) Ueda H., Ge M., Hazato T., Katayama T., Takagi H., Life Sci.<\/i>, 36<\/b>, 1865-1871 (1985).","DOI":"10.1016\/0024-3205(85)90160-2"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4) Ueda H., Yoshihara Y., Fukushima N., Shiomi H., Nakamura A., Takagi H., J. Biol. Chem.<\/i>, 262<\/b>, 8165-8173 (1987).","DOI":"10.1016\/S0021-9258(18)47544-8"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5) Tsukahara T., Yamagishi S., Neyama H., Ueda H., Peptides<\/i>, 101<\/b>, 60-68 (2018).","DOI":"10.1016\/j.peptides.2017.12.026"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6) Ueda H., Yoshihara Y., Misawa H., Fukushima N., Katada T., Ui M., Takagi H., Satoh M., J. Biol. Chem.<\/i>, 264<\/b>, 3732-3741 (1989).","DOI":"10.1016\/S0021-9258(19)84911-6"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7) Neyama H., Hamada Y., Tsukahara R., Narita M., Tsukamoto K., Ueda H., Peptides<\/i>, 107<\/b>, 10-16 (2018).","DOI":"10.1016\/j.peptides.2018.06.010"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8) Ueda H., Harada H., Nozaki M., Katada T., Ui M., Satoh M., Takagi H., Proc. Natl. Acad. Sci. USA<\/i>, 85<\/b>, 7013-7017 (1988).","DOI":"10.1073\/pnas.85.18.7013"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9) Evans C. J., Keith D. E. Jr., Morrison H., Magendzo K., Edwards R. H., Science<\/i>, 258<\/b>, 1952-1955 (1992).","DOI":"10.1126\/science.1335167"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10) Kieffer B. L., Befort K., Gaveriaux-Ruff C., Hirth C. G., Proc. Natl. Acad. Sci. USA<\/i>, 89<\/b>, 12048-12052 (1992).","DOI":"10.1073\/pnas.89.24.12048"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11) Inoue M., Kobayashi M., Kozaki S., Zimmer A., Ueda H., Proc. Natl. Acad. Sci. USA<\/i>, 95<\/b>, 10949-10953 (1998).","DOI":"10.1073\/pnas.95.18.10949"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12) Matsumoto M., Xie W., Ma L., Ueda H., Mol. Pain<\/i>, 4<\/b>, 25 (2008).","DOI":"10.1186\/1744-8069-4-25"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13) Uchida H., Ma L., Ueda H., J. Neurosci.<\/i>, 30<\/b>, 4806-4814 (2010).","DOI":"10.1523\/JNEUROSCI.5541-09.2010"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14) Ueda H., Kurita J. I., Neyama H., Hirao Y., Kouji H., Mishina T., Kasai M., Nakano H., Yoshimori A., Nishimura Y., Bioorg. Med. Chem. Lett.<\/i>, 27<\/b>, 4705-4709 (2017).","DOI":"10.1016\/j.bmcl.2017.09.006"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15) Hecht J. H., Weiner J. A., Post S. R., Chun J., J. Cell Biol.<\/i>, 135<\/b>, 1071-1083 (1996).","DOI":"10.1083\/jcb.135.4.1071"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16) Ma L., Matsumoto M., Xie W., Inoue M., Ueda H., J. Neurochem.<\/i>, 109<\/b>, 603-610 (2009).","DOI":"10.1111\/j.1471-4159.2009.05987.x"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17) Weiner J. A., Fukushima N., Contos J. J., Scherer S. S., Chun J., J. Neurosci.<\/i>, 21<\/b>, 7069-7078 (2001).","DOI":"10.1523\/JNEUROSCI.21-18-07069.2001"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18) Ueda H., Mol. Pain<\/i>, 4<\/b>, 11 (2008).","DOI":"10.1186\/1744-8069-4-11"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19) Ueda H., Pain<\/i>, 158<\/b>, S55-S65 (2017).","DOI":"10.1097\/j.pain.0000000000000813"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20) Inoue M., Yamaguchi A., Kawakami M., Chun J., Ueda H., Mol. Pain<\/i>, 2<\/b>, 25 (2006).","DOI":"10.1186\/1744-8069-2-25"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21) Inoue M., Rashid M. H., Fujita R., Contos J. J., Chun J., Ueda H., Nat. Med.<\/i>, 10<\/b>, 712-718 (2004).","DOI":"10.1038\/nm1060"},{"key":"22","doi-asserted-by":"crossref","unstructured":"22) Nagai J., Uchida H., Matsushita Y., Yano R., Ueda M., Niwa M., Aoki J., Chun J., Ueda H., Mol. Pain<\/i>, 6<\/b>, 78 (2010).","DOI":"10.1186\/1744-8069-6-78"},{"key":"23","doi-asserted-by":"crossref","unstructured":"23) Fujita R., Kiguchi N., Ueda H., Neurochem. Int.<\/i>, 50<\/b>, 351-355 (2007).","DOI":"10.1016\/j.neuint.2006.09.003"},{"key":"24","doi-asserted-by":"crossref","unstructured":"24) Inoue M., Ma L., Aoki J., Ueda H., J. Neurochem.<\/i>, 107<\/b>, 1556-1565 (2008).","DOI":"10.1111\/j.1471-4159.2008.05725.x"},{"key":"25","doi-asserted-by":"crossref","unstructured":"25) Ma L., Uchida H., Nagai J., Inoue M., Chun J., Aoki J., Ueda H., Mol. Pain<\/i>, 5<\/b>, 64 (2009).","DOI":"10.1186\/1744-8069-5-64"},{"key":"26","doi-asserted-by":"crossref","unstructured":"26) Coull J. A., Beggs S., Boudreau D., Boivin D., Tsuda M., Inoue K., Gravel C., Salter M. W., De Koninck Y., Nature<\/i>, 438<\/b>, 1017-1021 (2005).","DOI":"10.1038\/nature04223"},{"key":"27","doi-asserted-by":"crossref","unstructured":"27) Ueda H., Neyama H., Nagai J., Matsushita Y., Tsukahara T., Tsukahara R., Pain<\/i>, 159<\/b>, 2170-2178 (2018).","DOI":"10.1097\/j.pain.0000000000001316"},{"key":"28","doi-asserted-by":"crossref","unstructured":"28) Kim D., You B., Lim H., Lee S. J., Mol. Pain<\/i>, 7<\/b>, 74 (2011).","DOI":"10.1186\/1744-8069-7-74"},{"key":"29","doi-asserted-by":"crossref","unstructured":"29) Uchida H., Nagai J., Ueda H., Mol. Pain<\/i>, 10<\/b>, 71 (2014).","DOI":"10.1186\/1744-8069-10-71"},{"key":"30","doi-asserted-by":"crossref","unstructured":"30) Ueda H., Neyama H., Sasaki K., Miyama C., Iwamoto R., Neurobiol. Pain<\/i>, 5<\/b>, 100020 (2019).","DOI":"10.1016\/j.ynpai.2018.07.001"},{"key":"31","doi-asserted-by":"crossref","unstructured":"31) Ueda H., Neyama H., Neurobiol. Pain<\/i>, 1<\/b>, 16-25 (2017).","DOI":"10.1016\/j.ynpai.2017.04.002"},{"key":"32","doi-asserted-by":"crossref","unstructured":"32) Ueda H., Fujita R., Yoshida A., Matsunaga H., Ueda M., J. Cell Biol.<\/i>, 176<\/b>, 853-862 (2007).","DOI":"10.1083\/jcb.200608022"},{"key":"33","doi-asserted-by":"crossref","unstructured":"33) Ueda H., Pharmacol. Ther.<\/i>, 123<\/b>, 323-333 (2009).","DOI":"10.1016\/j.pharmthera.2009.05.007"},{"key":"34","doi-asserted-by":"crossref","unstructured":"34) Fujita R., Ueda M., Fujiwara K., Ueda H., Cell Death Differ.<\/i>, 16<\/b>, 349-358 (2009).","DOI":"10.1038\/cdd.2008.159"},{"key":"35","doi-asserted-by":"crossref","unstructured":"35) Halder S. K., Matsunaga H., Ishii K., Ueda H., J. Neurochem.<\/i>, 135<\/b>, 1161-1177 (2015).","DOI":"10.1111\/jnc.13356"},{"key":"36","doi-asserted-by":"crossref","unstructured":"36) Omotuyi O., Matsunaga H., Ueda H., Expert Opin. Biol. Ther.<\/i>, 15<\/b>, S223-S229 (2015).","DOI":"10.1517\/14712598.2015.1005597"},{"key":"37","doi-asserted-by":"crossref","unstructured":"37) Ueda H., Matsunaga H., Matsushita Y., Maeda S., Iwamoto R., Yokoyama S., Shirouzu M., Expert Opin. Biol. Ther.<\/i>, 18<\/b>, 89-94 (2018).","DOI":"10.1080\/14712598.2018.1454427"},{"key":"38","doi-asserted-by":"crossref","unstructured":"38) Matsunaga H., Ueda H., Cell Death Differ.<\/i>, 17<\/b>, 1760-1772 (2010).","DOI":"10.1038\/cdd.2010.52"},{"key":"39","doi-asserted-by":"crossref","unstructured":"39) Matsunaga H., Ueda H., Neurochem. Int.<\/i>, 49<\/b>, 294-303 (2006).","DOI":"10.1016\/j.neuint.2006.01.017"},{"key":"40","doi-asserted-by":"crossref","unstructured":"40) Matsunaga H., Ueda H., Cell Death Differ.<\/i>, 17<\/b>, 1760-1772 (2010).","DOI":"10.1038\/cdd.2010.52"},{"key":"41","doi-asserted-by":"crossref","unstructured":"41) Fujita R., Ueda M., Fujiwara K., Ueda H., Cell Death Differ.<\/i>, 16<\/b>, 349-358 (2009).","DOI":"10.1038\/cdd.2008.159"},{"key":"42","doi-asserted-by":"crossref","unstructured":"42) Ueda H., Sasaki K., Halder S. K., Deguchi Y., Takao K., Miyakawa T., Tajima A., J. Neurochem.<\/i>, 141<\/b>, 124-136 (2017).","DOI":"10.1111\/jnc.13963"},{"key":"43","doi-asserted-by":"crossref","unstructured":"43) Halder S. K., Matsunaga H., Yamaguchi H., Ueda H., J. Neurochem.<\/i>, 125<\/b>, 713-723 (2013).","DOI":"10.1111\/jnc.12132"},{"key":"44","doi-asserted-by":"crossref","unstructured":"44) Ueda H., Halder S. K., Matsunaga H., Sasaki K., Maeda S., Neuroscience<\/i>, 318<\/b>, 206-218 (2016).","DOI":"10.1016\/j.neuroscience.2016.01.007"},{"key":"45","doi-asserted-by":"crossref","unstructured":"45) Kitahata S., Tanaka Y., Hori K., Kime C., Sugita S., Ueda H., Takahashi M., Sci. Rep.<\/i>, 9<\/b>, 2891 (2019).","DOI":"10.1038\/s41598-018-38065-6"}],"container-title":["YAKUGAKU ZASSHI"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/yakushi\/139\/11\/139_19-00160\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,1,26]],"date-time":"2021-01-26T15:06:57Z","timestamp":1611673617000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/yakushi\/139\/11\/139_19-00160\/_article\/-char\/ja\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,11,1]]},"references-count":45,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2019]]}},"URL":"https:\/\/doi.org\/10.1248\/yakushi.19-00160","relation":{},"ISSN":["0031-6903","1347-5231"],"issn-type":[{"value":"0031-6903","type":"print"},{"value":"1347-5231","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,11,1]]}}}