{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T01:01:17Z","timestamp":1788483677004,"version":"build-2803163510"},"reference-count":79,"publisher":"Pharmaceutical Society of Japan","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["YAKUGAKU ZASSHI"],"published-print":{"date-parts":[[2020,8,1]]},"DOI":"10.1248\/yakushi.20-00011","type":"journal-article","created":{"date-parts":[[2020,7,31]],"date-time":"2020-07-31T22:15:23Z","timestamp":1596233723000},"page":"1013-1024","source":"Crossref","is-referenced-by-count":1,"title":["Particle Design Strategies for Developing Patient Centric Dosage Form Preparations","\u4eba\u306b\u3084\u3055\u3057\u3044\u88fd\u5264\u8a2d\u8a08\u306e\u305f\u3081\u306e\u7c92\u5b50\u8a2d\u8a08\u6226\u7565"],"prefix":"10.1248","volume":"140","author":[{"given":"Hirofumi","family":"Takeuchi","sequence":"first","affiliation":[{"name":"Laboratory of Pharmaceutical Engineering, Gifu Pharmaceutical University"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"163","reference":[{"key":"1","unstructured":"1) Takeuchi H., Niwa T., Hino C., Kawashima Y., \u201cParticle Design and Pharmaceutical Technology,\u201d ed. by Kawashima Y., Yakugyojihosha, Tokyo, 1993, pp. 21-26."},{"key":"2","doi-asserted-by":"crossref","unstructured":"2) Corrigan O. I., Sabra K., Holohan E. M., <i>Drug Dev. Ind. Pharm.<\/i>, <b>9<\/b>, 1-20 (1983).","DOI":"10.3109\/03639048309048541"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3) Corrigan O. I., Holohan E. M., Sabra K., <i>Int. J. Pharm.<\/i>, <b>18<\/b>, 195-200 (1984).","DOI":"10.1016\/0378-5173(84)90119-4"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4) Takeuchi H., Handa T., Kawashima Y., <i>Chem. Pharm. Bull.<\/i>, <b>35<\/b>, 3800-3806 (1987).","DOI":"10.1248\/cpb.35.3800"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5) Gidwani R., Venkat K., Audhya, T., Goldstein G., <i>Drug Dev. Ind. Pharm.<\/i>, <b>18<\/b>, 385-394 (1992).","DOI":"10.3109\/03639049209043859"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6) Takeuchi H., Nagira S., Yamamoto H., Kawashima Y., <i>Powder Technol.<\/i>, <b>141<\/b>, 187-195 (2004).","DOI":"10.1016\/j.powtec.2004.03.007"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7) Takeuchi H., Nagira S., Yamamoto H., Kawashima Y., <i>Int. J. Pharm.<\/i>, <b>293<\/b>, 155-164 (2005).","DOI":"10.1016\/j.ijpharm.2004.12.019"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8) Takeuchi H., Handa T., Kawashima Y., <i>J. Pharm. Pharmacol.<\/i>, <b>39<\/b>, 769-773 (1987).","DOI":"10.1111\/j.2042-7158.1987.tb05117.x"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9) Takeuchi H., Sasaki H., Niwa T., Hino T., Kawashima Y., Uesugi K., Ozawa H., <i>Drug Dev. Ind. Pharm.<\/i>, <b>18<\/b>, 919-937 (1992).","DOI":"10.3109\/03639049209069307"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10) Takeuchi H., Sasaki H., Niwa T., Hino T., Kawashima Y., Uesugi K., Ozawa H., <i>Chem. Pharm. Bull.<\/i>, <b>39<\/b>, 3362-3364 (1991).","DOI":"10.1248\/cpb.39.3362"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11) Takeuchi H., Sasaki H., Niwa T., Hino T., Kawashima Y., Uesugi K., Ozawa H., <i>Int. J. Pharm.<\/i>, <b>86<\/b>, 25-33 (1992).","DOI":"10.1016\/0378-5173(92)90027-Y"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12) Crowe J. H., Crowe L. M., Carpenter J. F., Whistrom C. A., <i>Biochem. J.<\/i>, <b>242<\/b>, 1-10 (1987).","DOI":"10.1042\/bj2420001"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13) Payne N. I., Timmins P., Ambrose C. V., Ward M. D., Ridgway F., <i>J. Pharm. Sci.<\/i>, <b>75<\/b>, 325-329 (1986).","DOI":"10.1002\/jps.2600750402"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14) Kawashima Y., Hino T., Takeuchi H., Niwa T., Kawakatsu E., Kayano M., Ida K., Ozawa H., <i>Chem. Pharm. Bull.<\/i>, <b>40<\/b>, 1911-1916 (1992).","DOI":"10.1248\/cpb.40.1911"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15) Kawashima Y., Hino T., Takeuchi H., Niwa T., Kawakatsu E., Kayano M., Ida K., Ozawa H., Sakamoto H., <i>Chem. Pharm. Bull.<\/i>, <b>40<\/b>, 472-478 (1992).","DOI":"10.1248\/cpb.40.472"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16) Kakino Y., Hishikawa Y., Onodera R., Tahara K., Takeuchi H., <i>Chem. Pharm. Bull.<\/i>, <b>65<\/b>, 1035-1044 (2017).","DOI":"10.1248\/cpb.c17-00447"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17) Takeuchi H., Handa T., Kawashima Y., <i>Drug Dev. Ind. Pharm.<\/i>, <b>15<\/b>, 1999-2016 (1989).","DOI":"10.3109\/03639048909052515"},{"key":"18","unstructured":"18) Takeuchi H., Kawashima Y., \u201cAqueous Polymeric Coatings for Pharmaceutical Dosage Forms,\u201d 2nd ed., ed. by McGinity J. W., Marcel Dekker, New York, 1997, pp. 549-569."},{"key":"19","doi-asserted-by":"crossref","unstructured":"19) Takeuchi H., Yasuji T., Yamamoto H., Kawashima Y., <i>Pharm. Dev. Technol.<\/i>, <b>5<\/b>, 355-363 (2000).","DOI":"10.1081\/PDT-100100551"},{"key":"20","unstructured":"20) Takeuchi H., Yasuji T., Yamamoto H., Kawashima Y., <i>S.T.P. Pharma Sciences<\/i>, <b>10<\/b>, 173-179 (2000)."},{"key":"21","doi-asserted-by":"crossref","unstructured":"21) Takeuchi H., Yasuji T., Yamamoto H., Kawashima Y., <i>Pharm. Res.<\/i>, <b>17<\/b>, 94-99 (2000).","DOI":"10.1023\/A:1007530927887"},{"key":"22","doi-asserted-by":"crossref","unstructured":"22) Takeuchi H., Yasuji T., Yamamoto H., Kawashima Y., <i>Chem. Pharm. Bull.<\/i>, <b>48<\/b>, 585-588 (2000).","DOI":"10.1248\/cpb.48.585"},{"key":"23","doi-asserted-by":"crossref","unstructured":"23) Takeuchi H., Nagira S., Yamamoto H., Kawashima Y., <i>Int. J. Pharm.<\/i>, <b>274<\/b>, 131-138 (2004).","DOI":"10.1016\/j.ijpharm.2004.01.008"},{"key":"24","doi-asserted-by":"crossref","unstructured":"24) Takeuchi H., Handa T., Kawashima Y., <i>J. Soc. Powder Technol., Japan<\/i>, <b>23<\/b>, 599-606 (1986).","DOI":"10.4164\/sptj.23.599"},{"key":"25","doi-asserted-by":"crossref","unstructured":"25) Niwa T., Takeuchi H., Hino T., Kunou N. Kawashima Y., <i>J. Control. Release<\/i>, <b>25<\/b>, 89-98 (1993).","DOI":"10.1016\/0168-3659(93)90097-O"},{"key":"26","doi-asserted-by":"crossref","unstructured":"26) Yamamoto H., Takeuchi H., Kawashima Y., <i>Drug Delivery System<\/i>, <b>31<\/b>, 415-420 (2000).","DOI":"10.2745\/dds.15.415"},{"key":"27","unstructured":"27) Yasuji T., Takeuchi H., Yamamoto H., Kawashima Y., <i>Atomization: journal of the ILASS-Japan<\/i>, <b>10<\/b>, 9-18 (2001)."},{"key":"28","doi-asserted-by":"crossref","unstructured":"28) Kawashima Y., \u201cSpherical Crystallization as a New Platform for Particle Design Engineering,\u201d Springer, Singapore, 2019, pp. 1-118.","DOI":"10.1007\/978-981-13-6786-1_1"},{"key":"29","doi-asserted-by":"crossref","unstructured":"29) Sunamoto J., Iwamoto K., Takada M., Yuzuriha T., Katayama K., \u201cRecent Advances in Drug Delivery Systems,\u201d ed. by Anderson J. M., Kim S. W., Springer, Berlin, 1984, pp. 153-162.","DOI":"10.1007\/978-1-4613-2745-5_10"},{"key":"30","doi-asserted-by":"crossref","unstructured":"30) Elferink M. G. L., de Wit J. G., In &apos;t Veld G., Reichert A., Driessen A. J. M., Ringsdorf H., Konings W. N., <i>Biochim. Biophys. Acta<\/i>, <b>1106<\/b>, 23-30 (1992).","DOI":"10.1016\/0005-2736(92)90217-A"},{"key":"31","unstructured":"31) Takeuchi H., Kawashima Y., <i>Hyomen<\/i>, <b>32<\/b>, 423-429 (1994)."},{"key":"32","doi-asserted-by":"crossref","unstructured":"32) Takeuchi H., Yamamoto H., Toyoda T., Toyobuku H., Hino T., Kawashima Y., <i>Int. J. Pharm.<\/i>, <b>164<\/b>, 103-111 (1998).","DOI":"10.1016\/S0378-5173(97)00404-3"},{"key":"33","unstructured":"33) Senior J. H., <i>Crit. Rev. Ther. Drug Carrier Syst.<\/i>, <b>3<\/b>, 123-193 (1987)."},{"key":"34","doi-asserted-by":"crossref","unstructured":"34) Allen T. M., Hansen C., Rutledge J., <i>Biochim. Biophys. Acta<\/i>, <b>981<\/b>, 27-35 (1989).","DOI":"10.1016\/0005-2736(89)90078-3"},{"key":"35","doi-asserted-by":"crossref","unstructured":"35) Allen T. M., Hansen C., Martin F., Redemann C., Yau-Young A., <i>Biochim. Biophys. Acta<\/i>, <b>1066<\/b>, 29-36 (1991).","DOI":"10.1016\/0005-2736(91)90246-5"},{"key":"36","doi-asserted-by":"crossref","unstructured":"36) Papahadjopoulos D., Allen T. M., Gabizon A., Mayhew E., Matthay K., Huang S. K., Lee K. D., Woodle M. C., Lasic D. D., Redemann C., Martin F. J., <i>Proc. Natl. Acad. Sci. USA<\/i>, <b>88<\/b>, 11460-11464 (1991).","DOI":"10.1073\/pnas.88.24.11460"},{"key":"37","doi-asserted-by":"crossref","unstructured":"37) Takeuchi H., Kojima H., Toyoda T., Yamamoto H., Hino T., Kawashima Y., <i>Eur. J. Pharm.<\/i>, <b>48<\/b>, 123-129 (1999).","DOI":"10.1016\/S0939-6411(99)00029-6"},{"key":"38","doi-asserted-by":"crossref","unstructured":"38) Takeuchi H., Kojima H., Yamamoto H., Kawashima Y., <i>J. Control. Release<\/i>, <b>68<\/b>, 195-205 (2000).","DOI":"10.1016\/S0168-3659(00)00260-1"},{"key":"39","doi-asserted-by":"crossref","unstructured":"39) Takeuchi H., Kojima H., Yamamoto H., Kawashima Y., <i>J. Control. Release<\/i>, <b>75<\/b>, 83-91 (2001).","DOI":"10.1016\/S0168-3659(01)00368-6"},{"key":"40","doi-asserted-by":"crossref","unstructured":"40) Takeuchi H., Kojima H., Yamamoto H., Kawashima Y., <i>Pharm. Pharmacol. Commun.<\/i>, <b>5<\/b>, 445-448 (1999).","DOI":"10.1211\/146080899128735144"},{"key":"41","doi-asserted-by":"crossref","unstructured":"41) Takeuchi H., Kojima H., Yamamoto H., Kawashima Y., <i>Biol. Pharm. Bull.<\/i>, <b>24<\/b>, 795-799 (2001).","DOI":"10.1248\/bpb.24.795"},{"key":"42","unstructured":"42) Takeuchi H., Kojima H., Yamamoto H., Kawashima Y., <i>S.T.P. Pharma. Sciences<\/i>, <b>11<\/b>, 271-274 (2001)."},{"key":"43","doi-asserted-by":"crossref","unstructured":"43) Patel H. M., Ryman B. E., <i>FEBS Lett.<\/i>, <b>62<\/b>, 60-63 (1976).","DOI":"10.1016\/0014-5793(76)80016-6"},{"key":"44","doi-asserted-by":"crossref","unstructured":"44) Dapergolas G., Gregoriadis G., <i>Lancet<\/i>, <b>308<\/b>, 824-827 (1976).","DOI":"10.1016\/S0140-6736(76)91209-5"},{"key":"45","doi-asserted-by":"crossref","unstructured":"45) Shenfield M., Hill J., <i>Clin. Exp. Pharmacol. Physiol.<\/i>, <b>9<\/b>, 355-361 (1982).","DOI":"10.1111\/j.1440-1681.1982.tb00819.x"},{"key":"46","doi-asserted-by":"crossref","unstructured":"46) Takeuchi H., Yamamoto H., Niwa T., Hino T., Kawashima Y., <i>Chem. Pharm. Bull.<\/i>, <b>42<\/b>, 1954-1956 (1994).","DOI":"10.1248\/cpb.42.1954"},{"key":"47","doi-asserted-by":"crossref","unstructured":"47) Takeuchi H., Yamamoto H., Niwa T., Hino T., Kawashima Y., <i>Pharm. Res.<\/i>, <b>13<\/b>, 896-901 (1996).","DOI":"10.1023\/A:1016009313548"},{"key":"48","doi-asserted-by":"crossref","unstructured":"48) Takeuchi H., Matsui Y., Yamamoto H., Kawashima Y., <i>J. Control. Release<\/i>, <b>86<\/b>, 235-242 (2003).","DOI":"10.1016\/S0168-3659(02)00411-X"},{"key":"49","doi-asserted-by":"crossref","unstructured":"49) Takeuchi H., Yamamoto H., Kawashima Y., <i>Adv. Drug Deliv. Rev.<\/i>, <b>47<\/b>, 39-54 (2001).","DOI":"10.1016\/S0169-409X(00)00120-4"},{"key":"50","doi-asserted-by":"crossref","unstructured":"50) Takeuchi H., Matsui Y., Sugihara H., Yamamoto H., Kawashima Y., <i>Int. J. Pharm.<\/i>, <b>303<\/b>, 160-170 (2005).","DOI":"10.1016\/j.ijpharm.2005.06.028"},{"key":"51","doi-asserted-by":"crossref","unstructured":"51) Thongborisute J., Takeuchi H., Yamamoto H., Kawashima Y., <i>J. Liposome Res.<\/i>, <b>16<\/b>, 127-141 (2006).","DOI":"10.1080\/08982100600680816"},{"key":"52","doi-asserted-by":"crossref","unstructured":"52) Werle M., Takeuchi H., <i>Int. J. Pharm.<\/i>, <b>370<\/b>, 26-32 (2009).","DOI":"10.1016\/j.ijpharm.2008.11.013"},{"key":"53","doi-asserted-by":"crossref","unstructured":"53) Werle M., Takeuchi H., Bernkop-Schn\u00fcrch A., <i>J. Pharm. Sci.<\/i>, <b>98<\/b>, 1643-1656 (2009).","DOI":"10.1002\/jps.21550"},{"key":"54","doi-asserted-by":"crossref","unstructured":"54) Werle M., Makhlof A., Takeuchi H., <i>Chem. Pharm. Bull.<\/i>, <b>58<\/b>, 432-434 (2010).","DOI":"10.1248\/cpb.58.432"},{"key":"55","doi-asserted-by":"crossref","unstructured":"55) Makhlof A., Werle M., Tozuka Y., Takeuchi H., <i>J. Control. Release<\/i>, <b>149<\/b>, 81-88 (2011).","DOI":"10.1016\/j.jconrel.2010.02.001"},{"key":"56","doi-asserted-by":"crossref","unstructured":"56) Makhlof A., Fujimoto S., Tozuka Y., Takeuchi H., <i>Eur. J. Pharm. Biopharm.<\/i>, <b>77<\/b>, 216-224 (2011).","DOI":"10.1016\/j.ejpb.2010.12.008"},{"key":"57","doi-asserted-by":"crossref","unstructured":"57) Sriamornsak P., Thongborisute J., Takeuchi H., \u201cOral Delivery of Macromolecular Drugs: Barriers, strategies and future trends,\u201d ed. by Bernkop-Schn\u00fcrch A., Springer, Berlin, 2009, pp. 169-193.","DOI":"10.1007\/978-1-4419-0200-9_10"},{"key":"58","doi-asserted-by":"crossref","unstructured":"58) Takeuchi H., Thongborisute J., Matsui Y., Sugihara H., Yamamoto H., Kawashima Y., <i>Adv. Drug Deliv. Rev.<\/i>, <b>57<\/b>, 1583-1594 (2005).","DOI":"10.1016\/j.addr.2005.07.008"},{"key":"59","doi-asserted-by":"crossref","unstructured":"59) Sugihara H., Yamamoto H., Kawashima Y., Takeuchi H., <i>J. Liposome Res.<\/i>, <b>22<\/b>, 72-79 (2012).","DOI":"10.3109\/08982104.2011.621128"},{"key":"60","doi-asserted-by":"crossref","unstructured":"60) Murata M., Nakano K., Tahara K., Tozuka Y., Takeuchi H., <i>Eur. J. Pharm. Biopharm.<\/i>, <b>80<\/b>, 340-346 (2012).","DOI":"10.1016\/j.ejpb.2011.10.011"},{"key":"61","doi-asserted-by":"crossref","unstructured":"61) Murata M., Tahara K., Takeuchi H., <i>Eur. J. Pharm. Biopharm.<\/i>, <b>86<\/b>, 115-119 (2014).","DOI":"10.1016\/j.ejpb.2013.09.006"},{"key":"62","doi-asserted-by":"crossref","unstructured":"62) Hironaka K., Inokuchi Y., Tozuka Y., Shimazawa M., Hara H., Takeuchi H., <i>J. Control. Release<\/i>, <b>136<\/b>, 247-253 (2009).","DOI":"10.1016\/j.jconrel.2009.02.020"},{"key":"63","doi-asserted-by":"crossref","unstructured":"63) Hironaka K., Inokuchi, Y., Fujisawa T., Shimazaki H., Akane M., Tozuka Y., Tsuruma K., Shimazawa M., Hara H., Takeuchi H., <i>Eur. J. Pharm. Biopharm.<\/i>, <b>79<\/b>, 119-125 (2011).","DOI":"10.1016\/j.ejpb.2011.01.019"},{"key":"64","doi-asserted-by":"crossref","unstructured":"64) Fujisawa T., Miyai H., Hironaka K., Tsukamoto T., Tahara K., Tozuka Y., Ito M., Takeuchi H., <i>Int. J. Pharm.<\/i>, <b>436<\/b>, 564-567 (2012).","DOI":"10.1016\/j.ijpharm.2012.07.024"},{"key":"65","doi-asserted-by":"crossref","unstructured":"65) Sasaki H., Karasawa K., Hironaka K., Tahara K., Tozuka Y., Takeuchi H., <i>Eur. J. Pharm. Biopharm.<\/i>, <b>83<\/b>, 364-369 (2013).","DOI":"10.1016\/j.ejpb.2012.10.014"},{"key":"66","unstructured":"66) \u201cStrategy and Novel Technology on Pharmaceutical Preparations,\u201d ed. by Takeuchi H., CMC Publishing CO., LTD., Tokyo, 2007."},{"key":"67","unstructured":"67) \u201cKoukunai Houkai-Jou Handbook,\u201d ed. by PLCM, Jiho, Tokyo, 2012."},{"key":"68","unstructured":"68) Takeuchi H., Fuji Sylysia Chemical Ltd., Jpn. Patent No. 5026675 (2012)."},{"key":"69","unstructured":"69) Tanimura S., Takeuchi H., Yamamoto H., Kawashima Y., The Proceeding of 22nd Symposium on Particulate Preparation and Design, Hamamatsu, October 2005, pp. 273-276."},{"key":"70","doi-asserted-by":"crossref","unstructured":"70) Tanimura S., Tahara K., Takeuchi H., <i>Powder Technol.<\/i>, <b>286<\/b>, 444-450 (2015).","DOI":"10.1016\/j.powtec.2015.08.011"},{"key":"71","doi-asserted-by":"crossref","unstructured":"71) Katsuno E., Tahara K., Takeuchi Y., Takeuchi H., <i>Powder Technol.<\/i>, <b>241<\/b>, 60-66 (2013).","DOI":"10.1016\/j.powtec.2013.03.008"},{"key":"72","doi-asserted-by":"crossref","unstructured":"72) Tanimura S., Kawazoe H., Yamamoto H., Takeuchi H., <i>J. Soc. Powder Technol. Japan<\/i>, <b>43<\/b>, 648-652 (2006).","DOI":"10.4164\/sptj.43.648"},{"key":"73","doi-asserted-by":"crossref","unstructured":"73) Takeuchi Y., Tomita T., Kuroda J., Kageyu A., Yonekura C., Hiramura Y., Tahara K., Takeuchi H., <i>Int. J. Pharm.<\/i>, <b>547<\/b>, 106-113 (2018).","DOI":"10.1016\/j.ijpharm.2018.05.061"},{"key":"74","doi-asserted-by":"crossref","unstructured":"74) Osamura T., Takeuchi Y., Onodera R., Kitamura M., Takahashi Y., Tahara K., Takeuchi H., <i>Int. J. Pharm.<\/i>, <b>510<\/b>, 195-202 (2016).","DOI":"10.1016\/j.ijpharm.2016.05.024"},{"key":"75","doi-asserted-by":"crossref","unstructured":"75) Takeuchi H., Yamakawa R., Nishimatsu T., Takeuchi Y., Hayakawa K., Maruyama N., <i>J. Drug Deliv. Sci. Technol.<\/i>, <b>23<\/b>, 471-475 (2013).","DOI":"10.1016\/S1773-2247(13)50068-2"},{"key":"76","doi-asserted-by":"crossref","unstructured":"76) Takeuchi Y., Umemura K., Tahara K., Takeuchi H., <i>J. Drug Deliv. Sci. Technol.<\/i>, <b>46<\/b>, 93-100 (2018).","DOI":"10.1016\/j.jddst.2018.05.002"},{"key":"77","doi-asserted-by":"crossref","unstructured":"77) Takeuchi Y., Usui R., Ikezaki H., Tahara K., Takeuchi H., <i>Int. J. Pharm.<\/i>, <b>531<\/b>, 179-190 (2017).","DOI":"10.1016\/j.ijpharm.2017.07.073"},{"key":"78","doi-asserted-by":"crossref","unstructured":"78) Takeuchi Y., Usui R., Ikezaki H., Tahara K., Takeuchi H., <i>J. Drug Deliv. Sci. Technol.<\/i>, <b>39<\/b>, 104-112 (2017).","DOI":"10.1016\/j.jddst.2017.03.010"},{"key":"79","doi-asserted-by":"crossref","unstructured":"79) Takeuchi Y., Kawamoto M., Tahara K., Takeuchi H., <i>Int. J. Pharm.<\/i>, <b>553<\/b>, 281-289 (2018).","DOI":"10.1016\/j.ijpharm.2018.10.049"}],"container-title":["YAKUGAKU ZASSHI"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/yakushi\/140\/8\/140_20-00011\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,11,5]],"date-time":"2022-11-05T10:53:54Z","timestamp":1667645634000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/yakushi\/140\/8\/140_20-00011\/_article\/-char\/ja\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8,1]]},"references-count":79,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2020]]}},"URL":"https:\/\/doi.org\/10.1248\/yakushi.20-00011","relation":{},"ISSN":["0031-6903","1347-5231"],"issn-type":[{"value":"0031-6903","type":"print"},{"value":"1347-5231","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,8,1]]}}}