{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,12,7]],"date-time":"2024-12-07T04:10:35Z","timestamp":1733544635333,"version":"3.30.1"},"reference-count":129,"publisher":"Pharmaceutical Society of Japan","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["YAKUGAKU ZASSHI"],"published-print":{"date-parts":[[2024,12,1]]},"DOI":"10.1248\/yakushi.24-00157","type":"journal-article","created":{"date-parts":[[2024,11,30]],"date-time":"2024-11-30T22:17:43Z","timestamp":1733005063000},"page":"1109-1123","source":"Crossref","is-referenced-by-count":0,"title":["Synthetic Studies on Bioactive Substances: From Research on Water-soluble Compounds to the Field of Lipophilic Ligands","\u751f\u7269\u6d3b\u6027\u7269\u8cea\u306e\u5408\u6210\u7684\u63a2\u7d22\u7814\u7a76\uff1a\u6c34\u6eb6\u6027\u5316\u5408\u7269\u5408\u6210\u304b\u3089\u8102\u6eb6\u6027\u30ea\u30ac\u30f3\u30c9\u7814\u7a76\u3078"],"prefix":"10.1248","volume":"144","author":[{"given":"Atsushi","family":"Kittaka","sequence":"first","affiliation":[{"name":"Faculty of Pharmaceutical Sciences, Teikyo University"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"163","reference":[{"key":"1","unstructured":"1) Nakamura S., Karasawa K., Yonehara H., Tanaka N., Umezawa H., J. Antibiot.<\/i>, 14<\/b>, 103\u2013106 (1961)."},{"key":"2","doi-asserted-by":"crossref","unstructured":"2) Kuroya M., Kikuchi K., Kobayashi N., Matsumoto K., Chiba T., Matsuura S., Hinuma Y., Jpn. J. Microbiol.<\/i>, 1<\/b>, 85\u201390 (1957).","DOI":"10.1111\/j.1348-0421.1957.tb00012.x"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3) Kaneda M., Nakamura S., Iitaka Y., J. Antibiot. (Tokyo)<\/i>, 33<\/b>, 778\u2013780 (1980).","DOI":"10.7164\/antibiotics.33.778"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4) Takita T., Umezawa Y., Saito S., Morishima H., Naganawa H., Umezawa H., Tsuchiya T., Miyake T., Kageyama S., Umezawa S., Muraoka Y., Suzuki M., Otsuka M., Narita M., Kobayashi S., Ohno M., Tetrahedron Lett.<\/i>, 23<\/b>, 521\u2013524 (1982).","DOI":"10.1016\/S0040-4039(00)86878-1"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5) Aoyagi Y., Katano K., Suguna H., Primeau J., Chang L. H., Hecht S. M., J. Am. Chem. Soc.<\/i>, 104<\/b>, 5537\u20135538 (1982).","DOI":"10.1021\/ja00384a067"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6) Otsuka M., Yoshida M., Kobayashi S., Ohno M., Sugiura Y., Takita T., Umezawa H., J. Am. Chem. Soc.<\/i>, 103<\/b>, 6986\u20136988 (1981).","DOI":"10.1021\/ja00413a047"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7) Kittaka A., Sugano Y., Otsuka M., Ohno M., Sugiura Y., Umezawa H., Tetrahedron Lett.<\/i>, 27<\/b>, 3631\u20133634 (1986).","DOI":"10.1016\/S0040-4039(00)84867-4"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8) Sugano Y., Kittaka A., Otsuka M., Ohno M., Sugiura Y., Umezawa H., Tetrahedron Lett.<\/i>, 27<\/b>, 3635\u20133638 (1986).","DOI":"10.1016\/S0040-4039(00)84868-6"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9) Kittaka A., Sugano Y., Otsuka M., Ohno M., Tetrahedron<\/i>, 44<\/b>, 2811\u20132820 (1988).","DOI":"10.1016\/S0040-4020(88)90017-8"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10) Otsuka M., Kittaka A., Ohno M., Suzuki T., Kuwahara J., Sugiura Y., Umezawa H., Tetrahedron Lett.<\/i>, 27<\/b>, 3639\u20133642 (1986).","DOI":"10.1016\/S0040-4039(00)84869-8"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11) Kittaka A., Sugano Y., Otsuka M., Ohno M., Tetrahedron<\/i>, 44<\/b>, 2821\u20132833 (1988).","DOI":"10.1016\/S0040-4020(88)90018-X"},{"key":"12","unstructured":"12) Ohno M., Otsuka M., Kittaka A., Sugano Y., Sugiura Y., Suzuki T., Kuwahara J., Umezawa K., Umezawa H., Int. J. Exp. Clin. Chemotherapy<\/i>, 1<\/b>, 12\u201322 (1988)."},{"key":"13","doi-asserted-by":"crossref","unstructured":"13) M\u00fcller D., Pitsch S., Kittaka A., Wagner E., Wintner C. E., Eschenmoser A., Helv. Chim. Acta<\/i>, 73<\/b>, 1410\u20131468 (1990).","DOI":"10.1002\/hlca.19900730526"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14) Saimoto H., Shigemasa Y., J. Synth. Org. Chem. Jpn.<\/i>, 50<\/b>, 703\u2013712 (1992).","DOI":"10.5059\/yukigoseikyokaishi.50.703"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15) Sawada S., Okajima S., Aiyama R., Nokata K., Furuta T., Yokokura T., Sugino E., Yamaguchi K., Miyasaka T., Chem. Pharm. Bull.<\/i>, 39<\/b>, 1446\u20131454 (1991).","DOI":"10.1248\/cpb.39.1446"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16) Kittaka A., Tanaka H., Yamada N., Miyasaka T., Tetrahedron Lett.<\/i>, 37<\/b>, 2801\u20132804 (1996).","DOI":"10.1016\/0040-4039(96)00433-9"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17) Kittaka A., Asakura T., Kuze T., Tanaka H., Yamada N., Nakamura K. T., Miyasaka T., J. Org. Chem.<\/i>, 64<\/b>, 7081\u20137093 (1999).","DOI":"10.1021\/jo990611d"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18) Kittaka A., Tsubaki Y., Tanaka H., Nakamura K. T., Miyasaka T., Nucleosides Nucleotides<\/i>, 15<\/b>, 97\u2013107 (1996).","DOI":"10.1080\/07328319608002373"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19) Gimisis T., Chatgilialoglu C., J. Org. Chem.<\/i>, 61<\/b>, 1908\u20131909 (1996).","DOI":"10.1021\/jo952218n"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20) Kittaka A., Tanaka H., Odanaka Y., Ohnuki K., Yamaguchi K., Miyasaka T., J. Org. Chem.<\/i>, 59<\/b>, 3636\u20133641 (1994).","DOI":"10.1021\/jo00092a024"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21) Kittaka A., Tanaka H., Kato H., Nonaka Y., Nakamura K. T., Miyasaka T., Tetrahedron Lett.<\/i>, 38<\/b>, 6421\u20136424 (1997).","DOI":"10.1016\/S0040-4039(97)01486-X"},{"key":"22","doi-asserted-by":"crossref","unstructured":"22) Kittaka A., Kato H., Tanaka H., Nonaka Y., Amano M., Nakamura K. T., Miyasaka T., Tetrahedron<\/i>, 55<\/b>, 5319\u20135344 (1999).","DOI":"10.1016\/S0040-4020(99)00232-X"},{"key":"23","doi-asserted-by":"crossref","unstructured":"23) Gimisis T., Chatgilialoglu C., Castellari C., Chem. Commun. (Camb.)<\/i>, 21<\/b>, 2089\u20132090 (1997).","DOI":"10.1039\/a705742c"},{"key":"24","doi-asserted-by":"crossref","unstructured":"24) Kittaka A., Kuze T., Asakura T., Ito K., Miyasaka T., Inoue J., Bioorg. Med. Chem. Lett.<\/i>, 8<\/b>, 3207\u20133210 (1998).","DOI":"10.1016\/S0960-894X(98)00584-8"},{"key":"25","doi-asserted-by":"crossref","unstructured":"25) Kittaka A., Horii C., Kuze T., Asakura T., Ito K., Nakamura K. T., Miyasaka T., Inoue J., Synlett<\/i>, 1999<\/b> (S1), 869\u2013872 (1999).","DOI":"10.1055\/s-1999-3084"},{"key":"26","doi-asserted-by":"crossref","unstructured":"26) Kittaka A., Kuze T., Amano M., Tanaka H., Miyasaka T., Hirose K., Yoshida T., Sarai A., Yasukawa T., Ishii S., Nucleosides Nucleotides<\/i>, 18<\/b>, 2769\u20132783 (1999).","DOI":"10.1080\/07328319908044640"},{"key":"27","unstructured":"27) Konno K., Maki S., Fujishima T., Liu Z., Miura D., Chokki M., Takayama H., Bioorg. Med. Chem. Lett.<\/i>, 8<\/b>, 151\u2013156 (1998)."},{"key":"28","doi-asserted-by":"crossref","unstructured":"28) Konno K., Fujishima T., Maki S., Liu Z., Miura D., Chokki M., Ishizuka S., Yamaguchi K., Kan Y., Kurihara M., Miyata N., Smith C., DeLuca H. F., Takayama H., J. Med. Chem.<\/i>, 43<\/b>, 4247\u20134265 (2000).","DOI":"10.1021\/jm000261j"},{"key":"29","doi-asserted-by":"crossref","unstructured":"29) Takayama H., Kittaka A., Fujishima T., Suhara Y., \u201cRecent Results in Cancer Research,\u201d Vol. 164, ed. by Reichrath J., Fridrich M., Tilgen W., Springer-Verlag, Berlin Heidelberg, 2003, pp. 289\u2013317.","DOI":"10.1007\/978-3-642-55580-0_21"},{"key":"30","doi-asserted-by":"crossref","unstructured":"30) Suhara Y., Nihei K.-i., Tanigawa H., Fujishima T., Konno K., Nakagawa K., Okano T., Takayama H., Bioorg. Med. Chem. Lett.<\/i>, 10<\/b>, 1129\u20131132 (2000).","DOI":"10.1016\/S0960-894X(00)00189-X"},{"key":"31","doi-asserted-by":"crossref","unstructured":"31) Suhara Y., Nihei K.-i., Kurihara M., Kittaka A., Yamaguchi K., Fujishima T., Konno K., Miyata N., Takayama H., J. Org. Chem.<\/i>, 66<\/b>, 8760\u20138771 (2001).","DOI":"10.1021\/jo010375i"},{"key":"32","doi-asserted-by":"crossref","unstructured":"32) Kittaka A., Suhara Y., Takayanagi H., Fujishima T., Kurihara M., Takayama H., Org. Lett.<\/i>, 2<\/b>, 2619\u20132622 (2000).","DOI":"10.1021\/ol006222j"},{"key":"33","unstructured":"33) Honzawa S., Yamamoto Y., Hirasaka K., Takayama H., Kittaka A., Heterocycles<\/i>, 61<\/b>, 327\u2013338 (2003)."},{"key":"34","doi-asserted-by":"crossref","unstructured":"34) Saito N., Suhara Y., Kurihara M., Fujishima T., Honzawa S., Takayanagi H., Kozono T., Matsumoto M., Ohmori M., Miyata N., Takayama H., Kittaka A., J. Org. Chem.<\/i>, 69<\/b>, 7463\u20137471 (2004).","DOI":"10.1021\/jo0491051"},{"key":"35","doi-asserted-by":"crossref","unstructured":"35) Honzawa S., Hirasaka K., Yamamoto Y., Peleg S., Fujishima T., Kurihara M., Saito N., Kishimoto S., Sugiura T., Waku K., Takayama H., Kittaka A., Tetrahedron<\/i>, 61<\/b>, 11253\u201311263 (2005).","DOI":"10.1016\/j.tet.2005.08.116"},{"key":"36","doi-asserted-by":"crossref","unstructured":"36) Kittaka A., Yakugaku Zasshi<\/i>, 128<\/b>, 1235\u20131250 (2008).","DOI":"10.1248\/yakushi.128.1235"},{"key":"37","doi-asserted-by":"crossref","unstructured":"37) Saito N., Honzawa S., Kittaka A., Curr. Top. Med. Chem.<\/i>, 6<\/b>, 1273\u20131288 (2006).","DOI":"10.2174\/156802606777864953"},{"key":"38","doi-asserted-by":"crossref","unstructured":"38) Takahashi E., Nakagawa K., Suhara Y., Kittaka A., Nihei K.-i., Konno K., Takayama H., Ozono K., Okano T., Biol. Pharm. Bull.<\/i>, 29<\/b>, 2246\u20132250 (2006).","DOI":"10.1248\/bpb.29.2246"},{"key":"39","doi-asserted-by":"crossref","unstructured":"39) Kittaka A., Saito N., Honzawa S., Takenouchi K., Ishizuka S., Chen T. C., Peleg S., Kato S., Arai M. A., J. Steroid Biochem. Mol. Biol.<\/i>, 103<\/b>, 269\u2013276 (2007).","DOI":"10.1016\/j.jsbmb.2006.12.002"},{"key":"40","doi-asserted-by":"crossref","unstructured":"40) Suhara Y., Kittaka A., Kishimoto S., Calverley M. J., Fujishima T., Saito N., Sugiura T., Waku K., Takayama H., Bioorg. Med. Chem. Lett.<\/i>, 12<\/b>, 3255\u20133258 (2002).","DOI":"10.1016\/S0960-894X(02)00722-9"},{"key":"41","doi-asserted-by":"crossref","unstructured":"41) Binderup L., Latini S., Binderup E., Bretting C., Calverley M., Hansen K., Biochem. Pharmacol.<\/i>, 42<\/b>, 1569\u20131575 (1991).","DOI":"10.1016\/0006-2952(91)90426-6"},{"key":"42","doi-asserted-by":"crossref","unstructured":"42) Fujishima T., Liu Z., Miura D., Chokki M., Ishizuka S., Konno K., Takayama H., Bioorg. Med. Chem. Lett.<\/i>, 8<\/b>, 2145\u20132148 (1998).","DOI":"10.1016\/S0960-894X(98)00363-1"},{"key":"43","doi-asserted-by":"crossref","unstructured":"43) Honzawa S., Suhara Y., Nihei K.-i., Saito N., Kishimoto S., Fujishima T., Kurihara M., Sugiura T., Waku K., Takayama T., Kittaka A., Bioorg. Med. Chem. Lett.<\/i>, 13<\/b>, 3503\u20133506 (2003).","DOI":"10.1016\/S0960-894X(03)00739-X"},{"key":"44","doi-asserted-by":"crossref","unstructured":"44) Perlman K. L., Sicinski R. R., Schnoes H. K., DeLuca H. F., Tetrahedron Lett.<\/i>, 31<\/b>, 1823\u20131824 (1990).","DOI":"10.1016\/S0040-4039(00)98795-1"},{"key":"45","doi-asserted-by":"crossref","unstructured":"45) Ono K., Yoshida A., Saito N., Fujishima T., Honzawa S., Suhara Y., Kishimoto S., Sugiura T., Waku K., Takayama H., Kittaka A., J. Org. Chem.<\/i>, 68<\/b>, 7407\u20137415 (2003).","DOI":"10.1021\/jo034787y"},{"key":"46","unstructured":"46) Flanagan J. N., Zheng S., Chiang K.-C., Kittaka A., Sakaki T., Nakabayashi S., Spanjaard R. A., Persons K. S., Mathieu J. S., Holick M. F., Chen T. C., Anticancer Res.<\/i>, 29<\/b>, 3547\u20133553 (2009)."},{"key":"47","doi-asserted-by":"crossref","unstructured":"47) Chen T. C., Kittaka A., ISRN Urol.<\/i>, 2011<\/b>, 301490 (2011).","DOI":"10.5402\/2011\/301490"},{"key":"48","doi-asserted-by":"crossref","unstructured":"48) Iglesias-Gato D., Zheng S., Flanagan J. N., Jiang L., Kittaka A., Sakaki T., Yamamoto K., Itoh T., LeBrasseur N. K., Norstedt G., Chen T. C., J. Steroid Biochem. Mol. Biol.<\/i>, 127<\/b>, 269\u2013275 (2011).","DOI":"10.1016\/j.jsbmb.2011.08.010"},{"key":"49","unstructured":"49) Chen T. C., Sakaki T., Yamamoto K., Kittaka A., Anticancer Res.<\/i>, 32<\/b>, 291\u2013298 (2012)."},{"key":"50","doi-asserted-by":"crossref","unstructured":"50) Chen T. C., Persons K. S., Zheng S., Mathieu J., Holick M. F., Lee Y. F., Bao B., Arai M. A., Kittaka A., J. Steroid Biochem. Mol. Biol.<\/i>, 103<\/b>, 717\u2013720 (2007).","DOI":"10.1016\/j.jsbmb.2006.12.009"},{"key":"51","doi-asserted-by":"crossref","unstructured":"51) Kittaka A., Yoshida A., Chiang K.-C., Takano M., Sawada D., Sakaki T., Chen T. C., Future Med. Chem.<\/i>, 4<\/b>, 2049\u20132065 (2012).","DOI":"10.4155\/fmc.12.130"},{"key":"52","doi-asserted-by":"crossref","unstructured":"52) Chiang K.-C., Yeh C.-N., Chen H.-Y., Lee J.-m., Juang H.-H., Chen M.-F., Takano M., Kittaka A., Chen T. C., Steroids<\/i>, 76<\/b>, 1513\u20131519 (2011).","DOI":"10.1016\/j.steroids.2011.08.006"},{"key":"53","unstructured":"53) Chiang K.-C., Yeh C.-N., Chen S.-C., Shen S.-C., Hsu J.-T., Yeh T.-s., Pang J.-H. S., Su L.-J., Takano M., Kittaka A., Juang H.-H., Chen T. C., Evidence-Based Complementary Alternative Med.<\/i>, 2012<\/b>, 310872 (2012)."},{"key":"54","doi-asserted-by":"crossref","unstructured":"54) Chiang K.-C., Chen S.-C., Yeh C.-N., Pang J.-H. S., Shen S.-C., Hsu J.-T., Liu Y.-Y., Chen L.-W., Kuo S.-F., Takano M., Kittaka A., Sun C.-C., Juang H.-H., Chen T. C., J. Steroid Biochem. Mol. Biol.<\/i>, 139<\/b>, 54\u201360 (2014).","DOI":"10.1016\/j.jsbmb.2013.10.005"},{"key":"55","doi-asserted-by":"crossref","unstructured":"55) Chiang K.-C., Yeh T.-S., Chen S.-C., Pang J.-H. S., Yeh C.-N., Hsu J.-T., Chen L.-W., Kuo S.-F., Takano M., Kittaka A., Chen T. C., Sun C.-C., Juang H.-H., Int. J. Mol. Sci.<\/i>, 17<\/b>, 606\u2013619 (2016).","DOI":"10.3390\/ijms17040606"},{"key":"56","doi-asserted-by":"crossref","unstructured":"56) Chiang K.-C., Yeh C.-N., Yeh T.-S., Juang H.-H., Chen L.-W., Kuo S.-F., Chen M.-H., Chen T. C., Takano M., Kittaka A., Pang J.-H. S., Anticancer Res.<\/i>, 38<\/b>, 3879\u20133887 (2018).","DOI":"10.21873\/anticanres.12672"},{"key":"57","doi-asserted-by":"crossref","unstructured":"57) Chiang K.-C., Yeh C.-N., Hsu J.-T., Yeh T., Jan Y.-y., Wu C.-T., Chen H.-Y., Jwo S.-C., Takano M., Kittaka A., Juang H.-H., Chen T. C., Cell Cycle<\/i>, 12<\/b>, 1316\u20131325 (2013).","DOI":"10.4161\/cc.24445"},{"key":"58","doi-asserted-by":"crossref","unstructured":"58) Chiang K.-C., Yeh C.-N., Hsu J.-T., Jan Y.-Y., Chen L.-W., Kuo S.-F., Takano M., Kittaka A., Chen T. C., Chen W.-T., Pang J.-H. S., Yeh T.-S., Juang H.-H., Cancer Lett.<\/i>, 354<\/b>, 235\u2013244 (2014).","DOI":"10.1016\/j.canlet.2014.08.019"},{"key":"59","doi-asserted-by":"crossref","unstructured":"59) Chiang K.-C., Yeh C.-N., Hsu J.-T., Chen L.-W., Kuo S.-F., Sun C.-C., Huang C.-C., Pang J.-H. S., Flanagan J. N., Takano M., Kittaka A., Juang H.-H., Yang S.-W., Chen T. C., J. Steroid Biochem. Mol. Biol.<\/i>, 138<\/b>, 427\u2013434 (2013).","DOI":"10.1016\/j.jsbmb.2013.09.002"},{"key":"60","unstructured":"60) Yang S.-W., Tsai C.-Y., Pan Y.-C., Yeh C.-N., Pang J.-H. S., Takano M., Kittaka A., Juang H.-H., Chen T. C., Chiang K.-C., Drug Des. Devel. Ther.<\/i>, 10<\/b>, 1995\u20132002 (2016)."},{"key":"61","doi-asserted-by":"crossref","unstructured":"61) Chiang K.-C., Kuo S.-F., Chen C.-H., Ng S., Lin S.-F., Yeh C.-N., Chen L.-W., Takano M., Chen T. C., Juang H.-H., Kittaka A., Lin J.-D., Pang J.-H. S., Cancer Lett.<\/i>, 369<\/b>, 76\u201385 (2015).","DOI":"10.1016\/j.canlet.2015.07.024"},{"key":"62","unstructured":"62) Chiang K.-C., Yeh C.-N., Pang J.-H. S., Hsu J.-T., Yeh T.-S., Chen L.-W., Kuo S.-F., Hsieh P.-J., Pan Y.-C., Takano M., Chen T. C., Feng T.-H., Kittaka A., Juang H.-H., Anticancer Res.<\/i>, 36<\/b>, 3307\u20133313 (2016)."},{"key":"63","unstructured":"63) Chiang K.-C., Yeh C.-N., Pang J.-H. S., Hsu J.-T., Yeh T.-S., Chen L.-W., Kuo S.-F., Takano M., Chen T. C., Kittaka A., Hsieh P.-J., Juang H.-H., Anticancer Res.<\/i>, 37<\/b>, 6215\u20136221 (2017)."},{"key":"64","doi-asserted-by":"crossref","unstructured":"64) Chiang K.-C., Yeh C.-N., Huang C., Yeh T.-S., Pang J.-H. S., Hsu J.-N., Chen L.-W., Kuo S.-F., Kittaka A., Chen T. C., Juang H.-H., Int. J. Mol. Sci.<\/i>, 17<\/b>, 1326 (2016).","DOI":"10.3390\/ijms17081326"},{"key":"65","doi-asserted-by":"crossref","unstructured":"65) Chiang K.-C., Yeh C.-S., Huang C.-C., Chang Y.-C., Juang H.-H., Cheng C.-T., Pang J.-H. S., Hsu J.-T., Takano M., Chen T. C., Kittaka A., Hsiao M., Yeh C.-N., Sci. Rep.<\/i>, 7<\/b>, 43773 (2017).","DOI":"10.1038\/srep43773"},{"key":"66","unstructured":"66) Kittaka A., Vitamins<\/i>, 91<\/b>, 174\u2013181 (2017)."},{"key":"67","doi-asserted-by":"crossref","unstructured":"67) Chiang K.-C., Sun C.-C., Chen M.-H., Huang C.-Y., Hsu J.-T., Yeh T.-S., Chen L.-W., Kuo S.-F., Juang H.-H., Takano M., Kittaka A., Chen T. C., Yeh C.-N., Pang J.-H. S., J. Steroid Biochem. Mol. Biol.<\/i>, 155<\/b>, 26\u201334 (2016).","DOI":"10.1016\/j.jsbmb.2015.09.022"},{"key":"68","doi-asserted-by":"crossref","unstructured":"68) Arai M. A., Takeyama K.-i., Ito S., Kato S., Chen T. C., Kittaka A., Bioconjug. Chem.<\/i>, 18<\/b>, 614\u2013620 (2007).","DOI":"10.1021\/bc0601121"},{"key":"69","doi-asserted-by":"crossref","unstructured":"69) Hourai S., Fujishima T., Kittaka A., Suhara Y., Takayama H., Rochel N., Moras D., J. Med. Chem.<\/i>, 49<\/b>, 5199\u20135205 (2006).","DOI":"10.1021\/jm0604070"},{"key":"70","doi-asserted-by":"crossref","unstructured":"70) Yasuda K., Ikushiro S., Kamakura M., Takano M., Saito N., Kittaka A., Chen T. C., Ohta M., Sakaki T., J. Steroid Biochem. Mol. Biol.<\/i>, 133<\/b>, 84\u201392 (2013).","DOI":"10.1016\/j.jsbmb.2012.09.006"},{"key":"71","doi-asserted-by":"crossref","unstructured":"71) Ishizawa M., Takano M., Kittaka A., Matsumoto T., Makishima M., Biomolecules<\/i>, 14<\/b>, 706 (2024).","DOI":"10.3390\/biom14060706"},{"key":"72","unstructured":"72) Takano M., Ohya S., Yasuda K., Nishikawa M., Takeuchi A., Sawada D., Sakaki T., Kittaka A., Chem. Pharm. Bull.<\/i>, 62<\/b>, 182\u2013184 (2014)."},{"key":"73","doi-asserted-by":"crossref","unstructured":"73) Saito N., Matsunaga T., Fujishima T., Anzai M., Saito H., Takenouchi K., Miura D., Ishizuka S., Takayama H., Kittaka A., Org. Biomol. Chem.<\/i>, 1<\/b>, 4396\u20134402 (2003).","DOI":"10.1039\/B311107E"},{"key":"74","doi-asserted-by":"crossref","unstructured":"74) Saito N., Saito H., Anzai M., Yoshida A., Fujishima T., Takenouchi K., Miura D., Ishizuka S., Takayama H., Kittaka A., Org. Lett.<\/i>, 5<\/b>, 4859\u20134862 (2003).","DOI":"10.1021\/ol035922w"},{"key":"75","doi-asserted-by":"crossref","unstructured":"75) Saito N., Matsunaga T., Saito H., Anzai M., Takenouchi K., Miura D., Namekawa J.-I., Ishizuka S., Kittaka A., J. Med. Chem.<\/i>, 49<\/b>, 7063\u20137075 (2006).","DOI":"10.1021\/jm060797q"},{"key":"76","doi-asserted-by":"crossref","unstructured":"76) Saito N., Kittaka A., ChemBioChem<\/i>, 7<\/b>, 1478\u20131490 (2006).","DOI":"10.1002\/cbic.200600054"},{"key":"77","doi-asserted-by":"crossref","unstructured":"77) Saito N., Masuda M., Matsunaga T., Saito H., Anzai M., Takenouchi K., Miura D., Ishizuka S., Takimoto-Kamimura M., Kittaka A., Tetrahedron<\/i>, 60<\/b>, 7951\u20137961 (2004).","DOI":"10.1016\/j.tet.2004.05.113"},{"key":"78","doi-asserted-by":"crossref","unstructured":"78) Saito N., Masuda M., Saito H., Takenouchi K., Seiichi I., Namekawa N.-i., Takimoto-Kamimura M., Kittaka A., Synthesis (Stuttg.)<\/i>, 2533\u20132543 (2005).","DOI":"10.1055\/s-2005-872075"},{"key":"79","doi-asserted-by":"crossref","unstructured":"79) Saito N., Matsunaga T., Saito H., Anzai M., Takenouchi K., Miura D., Ishizuka S., Takayama H., Kittaka A., Heterocycles<\/i>, 67<\/b>, 311\u2013336 (2006).","DOI":"10.3987\/COM-05-S(T)32"},{"key":"80","doi-asserted-by":"crossref","unstructured":"80) Saito N., Yakugaku Zasshi<\/i>, 127<\/b>, 1215\u20131222 (2007).","DOI":"10.1248\/yakushi.127.1215"},{"key":"81","doi-asserted-by":"crossref","unstructured":"81) Saito N., Kittaka A., J. Synth. Org. Chem. Jpn.<\/i>, 65<\/b>, 947\u2013958 (2007).","DOI":"10.5059\/yukigoseikyokaishi.65.947"},{"key":"82","unstructured":"82) Kittaka A., Saito N., Takenouchi K., Ishizuka S., Vitamins<\/i>, 83<\/b>, 569\u2013579 (2009)."},{"key":"83","doi-asserted-by":"crossref","unstructured":"83) Kittaka A., Kurihara M., Peleg S., Suhara Y., Takayama H., Chem. Pharm. Bull.<\/i>, 51<\/b>, 357\u2013358 (2003).","DOI":"10.1248\/cpb.51.357"},{"key":"84","doi-asserted-by":"crossref","unstructured":"84) Honzawa S., Yamamoto Y., Yamashita A., Sugiura T., Kurihara M., Arai M. A., Kato S., Kittaka A., Bioorg. Med. Chem.<\/i>, 16<\/b>, 3002\u20133024 (2008).","DOI":"10.1016\/j.bmc.2007.12.039"},{"key":"85","doi-asserted-by":"crossref","unstructured":"85) Honzawa S., Takahashi N., Yamashita A., Sugiura T., Kurihara M., Arai M. A., Kato S., Kittaka A., Tetrahedron<\/i>, 65<\/b>, 7135\u20137145 (2009).","DOI":"10.1016\/j.tet.2009.06.029"},{"key":"86","doi-asserted-by":"crossref","unstructured":"86) Matsuo M., Hasegawa A., Takano M., Saito H., Kakuda S., Chida T., Takagi K.-i., Ochiai E., Horie K., Harada Y., Takimoto-Kamimura M., Takenouchi K., Sawada D., Kittaka A., ACS Med. Chem. Lett.<\/i>, 4<\/b>, 671\u2013674 (2013).","DOI":"10.1021\/ml400098w"},{"key":"87","doi-asserted-by":"crossref","unstructured":"87) Kittaka A., Takano M., Saitoh H., \u201cVitamins and Hormones,\u201d Vol. 100, ed. by Litwack G., Elsevier Inc. Academic Press, Burlington, 2016, pp. 379\u2013394.","DOI":"10.1016\/bs.vh.2015.10.010"},{"key":"88","doi-asserted-by":"crossref","unstructured":"88) Mano H., Nishikawa M., Yasuda K., Ikushiro S., Saito N., Sawada D., Honzawa S., Takano M., Kittaka A., Sakaki T., J. Steroid Biochem. Mol. Biol.<\/i>, 167<\/b>, 61\u201366 (2017).","DOI":"10.1016\/j.jsbmb.2016.11.008"},{"key":"89","doi-asserted-by":"crossref","unstructured":"89) Nishikawa M., Murose N., Mano H., Yasuda K., Isogai Y., Kittaka A., Takano M., Ikushiro S., Sakaki T., Sci. Rep.<\/i>, 12<\/b>, 12517 (2022).","DOI":"10.1038\/s41598-022-16819-7"},{"key":"90","doi-asserted-by":"crossref","unstructured":"90) Takano M., Yasuda K., Tohyama E., Higuchi E., Sakaki T., Kittaka A., J. Steroid Biochem. Mol. Biol.<\/i>, 173<\/b>, 75\u201378 (2017).","DOI":"10.1016\/j.jsbmb.2016.11.022"},{"key":"91","doi-asserted-by":"crossref","unstructured":"91) Yasuda K., Tohyama E., Takano M., Kittaka A., Ohta M., Ikushiro S., Sakaki T., J. Steroid Biochem. Mol. Biol.<\/i>, 178<\/b>, 333\u2013339 (2018).","DOI":"10.1016\/j.jsbmb.2018.02.001"},{"key":"92","doi-asserted-by":"crossref","unstructured":"92) Maynard D. F., Trankle W. G., Norman A. W., Okamura W. H., J. Med. Chem.<\/i>, 37<\/b>, 2387\u20132393 (1994).","DOI":"10.1021\/jm00041a017"},{"key":"93","doi-asserted-by":"crossref","unstructured":"93) Sawada D., Katayama T., Tsukuda Y., Saito N., Takano M., Saito H., Takagi K.-i., Ochiai E., Ishizuka S., Takenouchi K., Kittaka A., Bioorg. Med. Chem. Lett.<\/i>, 19<\/b>, 5397\u20135400 (2009).","DOI":"10.1016\/j.bmcl.2009.07.112"},{"key":"94","doi-asserted-by":"crossref","unstructured":"94) Sawada D., Tsukuda Y., Saito H., Takagi K.-i., Horie K., Ochiai E., Takenouchi K., Kittaka A., Chem. Pharm. Bull.<\/i>, 57<\/b>, 1431\u20131433 (2009).","DOI":"10.1248\/cpb.57.1431"},{"key":"95","doi-asserted-by":"crossref","unstructured":"95) Sawada D., Tsukuda Y., Saito H., Takagi K.-i., Ochiai E., Ishizuka S., Takenouchi K., Kittaka A., J. Steroid Biochem. Mol. Biol.<\/i>, 121<\/b>, 20\u201324 (2010).","DOI":"10.1016\/j.jsbmb.2010.02.035"},{"key":"96","doi-asserted-by":"crossref","unstructured":"96) Sawada D., Katayama T., Tsukuda Y., Saito N., Saito H., Takagi K-i., Ochiai E., Ishizuka S., Takenouchi K., Kittaka A., Tetrahedron<\/i>, 66<\/b>, 5407\u20135423 (2010).","DOI":"10.1016\/j.tet.2010.05.028"},{"key":"97","doi-asserted-by":"crossref","unstructured":"97) Norman A. W., Mizwicki M. T., Norman D. P. G., Nat. Rev. Drug Discov.<\/i>, 3<\/b>, 27\u201341 (2004).","DOI":"10.1038\/nrd1283"},{"key":"98","doi-asserted-by":"crossref","unstructured":"98) Sawada D., Tsukuda Y., Saito H., Kakuda S., Takimoto-Kamimura M., Ochiai E., Takenouchi K., Kittaka A., J. Am. Chem. Soc.<\/i>, 133<\/b>, 7215\u20137221 (2011).","DOI":"10.1021\/ja201481j"},{"key":"99","doi-asserted-by":"crossref","unstructured":"99) Sawada D., Kakuda S., Takeuchi A., Kawagoe F., Takimoto-Kamimura M., Kittaka A., Org. Biomol. Chem.<\/i>, 16<\/b>, 2448\u20132455 (2018).","DOI":"10.1039\/C8OB00158H"},{"key":"100","unstructured":"100) Kittaka A., Vitamins<\/i>, 94<\/b>, 155\u2013161 (2020)."},{"key":"101","doi-asserted-by":"crossref","unstructured":"101) Sawada D., Kittaka A., Curr. Top. Med. Chem.<\/i>, 14<\/b>, 2454\u20132459 (2014).","DOI":"10.2174\/1568026615666141208103741"},{"key":"102","doi-asserted-by":"crossref","unstructured":"102) Sawada D., Kakuda S., Kamimura-Takimoto M., Takeuchi A., Matsumoto Y., Kittaka A., Tetrahedron<\/i>, 72<\/b>, 2838\u20132848 (2016).","DOI":"10.1016\/j.tet.2016.03.081"},{"key":"103","doi-asserted-by":"crossref","unstructured":"103) Shindo K., Kumagai G., Takano M., Sawada D., Saito N., Saito H., Kakuda S., Takagi K.-i., Ochiai E., Horie K., Takimoto-Kamimura M., Ishizuka S., Takenouchi K., Kittaka A., Org. Lett.<\/i>, 13<\/b>, 2852\u20132855 (2011).","DOI":"10.1021\/ol200828s"},{"key":"104","unstructured":"104) Kumagai G., Takano M., Shindo K., Sawada D., Saito N., Saito H., Kakuda S., Takagi K.-i., Takimoto-Kamimura M., Takenouchi K., Chen T. C., Kittaka A., Anticancer Res.<\/i>, 32<\/b>, 311\u2013318 (2012)."},{"key":"105","doi-asserted-by":"crossref","unstructured":"105) Asano L., Watanabe M., Ryoden Y., Usuda K., Yamaguchi T., Khambu B., Takashima M., Sato S.-I., Sakai J., Nagasawa K., Uesugi M., Cell Chem. Biol.<\/i>, 24<\/b>, 207\u2013217 (2017).","DOI":"10.1016\/j.chembiol.2016.12.017"},{"key":"106","doi-asserted-by":"crossref","unstructured":"106) Kawagoe F., Mendoza A., Hayata Y., Asano L., Kotake K., Mototani S., Kawamura S., Kurosaki S., Akagi Y., Takemoto Y., Nagasawa K., Nakagawa H., Uesugi M., Kittaka A., J. Med. Chem.<\/i>, 64<\/b>, 5689\u20135709 (2021).","DOI":"10.1021\/acs.jmedchem.0c02179"},{"key":"107","doi-asserted-by":"crossref","unstructured":"107) Kawagoe F., Mototani S., Takemoto Y., Uesugi M., Kittaka A., Synthesis (Stuttg.)<\/i>, 56<\/b>, 1460\u20131464 (2024).","DOI":"10.1055\/a-2236-0413"},{"key":"108","doi-asserted-by":"crossref","unstructured":"108) Kawagoe F., Mototani S., Mendoza A., Takemoto Y., Uesugi M., Kittaka A., RSC Med. Chem.<\/i>, 14<\/b>, 2030\u20132034 (2023).","DOI":"10.1039\/D3MD00352C"},{"key":"109","unstructured":"109) Uesugi M., Takemoto Y., Nagasawa K., Kittaka A., Kawagoe F., Nakagawa H., Patent No. US 11,932,595 B2. Date of Patent: Mar. 19, 2024."},{"key":"110","doi-asserted-by":"crossref","unstructured":"110) Kawagoe F., Mototani S., Kittaka A., Int. J. Mol. Sci.<\/i>, 22<\/b>, 8191 (2021).","DOI":"10.3390\/ijms22158191"},{"key":"111","doi-asserted-by":"crossref","unstructured":"111) Fujishima T., Fujii S., Harayama T., Curr. Org. Chem.<\/i>, 14<\/b>, 962\u2013976 (2010).","DOI":"10.2174\/138527210791111786"},{"key":"112","unstructured":"112) Kawagoe F., Kittaka A., Vitamins<\/i>, 96<\/b>, 296\u2013304 (2022)."},{"key":"113","doi-asserted-by":"crossref","unstructured":"113) Kawagoe F., Sugiyama T., Uesugi M., Kittaka A., J. Steroid Biochem. Mol. Biol.<\/i>, 177<\/b>, 250\u2013254 (2018).","DOI":"10.1016\/j.jsbmb.2017.07.008"},{"key":"114","doi-asserted-by":"crossref","unstructured":"114) Kawagoe F., Mototani S., Yasuda K., Mano H., Takeuchi A., Saitoh H., Sakaki T., Kittaka A., Chem. Pharm. Bull.<\/i>, 71<\/b>, 717\u2013723 (2023).","DOI":"10.1248\/cpb.c23-00395"},{"key":"115","doi-asserted-by":"crossref","unstructured":"115) Kawagoe F., Mototani S., Yasuda K., Nagasawa K., Uesugi M., Sakaki T., Kittaka A., J. Steroid Biochem. Mol. Biol.<\/i>, 195<\/b>, 105477 (2019).","DOI":"10.1016\/j.jsbmb.2019.105477"},{"key":"116","doi-asserted-by":"crossref","unstructured":"116) Kawagoe F., Mototani S., Yasuda K., Mano H., Sakaki T., Kittaka A., Int. J. Mol. Sci.<\/i>, 22<\/b>, 11863 (2021).","DOI":"10.3390\/ijms222111863"},{"key":"117","doi-asserted-by":"crossref","unstructured":"117) Kawagoe F., Mototani S., Kittaka A., Biomolecules<\/i>, 14<\/b>, 37 (2024).","DOI":"10.3390\/biom14010037"},{"key":"118","doi-asserted-by":"crossref","unstructured":"118) Mototani S., Kawagoe F., Yasuda K., Mano H., Sakaki T., Kittaka A., Molecules<\/i>, 27<\/b>, 5352 (2022).","DOI":"10.3390\/molecules27165352"},{"key":"119","doi-asserted-by":"crossref","unstructured":"119) Kawagoe F., Yasuda K., Mototani S., Sugiyama T., Uesugi M., Sakaki T., Kittaka A., ACS Omega<\/i>, 4<\/b>, 11332\u201311337 (2019).","DOI":"10.1021\/acsomega.9b01500"},{"key":"120","doi-asserted-by":"crossref","unstructured":"120) Kawagoe F., Mototani S., Yasuda K., Takeuchi A., Mano H., Kakuda S., Saitoh H., Sakaki T., Kittaka A., J. Org. Chem.<\/i>, 88<\/b>, 12394\u201312408 (2023).","DOI":"10.1021\/acs.joc.3c01134"},{"key":"121","unstructured":"121) Kittaka A., Kawagoe F., Sakaki T., Yasuda K., TOKKYO KOKAI<\/i> P2023061920 (2023)."},{"key":"122","doi-asserted-by":"crossref","unstructured":"122) Sakaki T., Yasuda K., Kittaka A., Yamamoto K., Chen T. C., Anticancer. Agents Med. Chem.<\/i>, 14<\/b>, 97\u2013108 (2014).","DOI":"10.2174\/18715206113139990307"},{"key":"123","doi-asserted-by":"crossref","unstructured":"123) Takada K., Hagiwara Y., Togashi M., Kittaka A., Kawagoe F., Uesugi M., Nishimoto-Kusunose S., Higashi T., J. Steroid Biochem. Mol. Biol.<\/i>, 223<\/b>, 106133 (2022).","DOI":"10.1016\/j.jsbmb.2022.106133"},{"key":"124","doi-asserted-by":"crossref","unstructured":"124) Kawagoe F., Sugiyama T., Yasuda K., Uesugi M., Sakaki T., Kittaka A., J. Steroid Biochem. Mol. Biol.<\/i>, 186<\/b>, 161\u2013168 (2019).","DOI":"10.1016\/j.jsbmb.2018.10.010"},{"key":"125","doi-asserted-by":"crossref","unstructured":"125) Wang Z., Lin Y. S., Zheng X. E., Senn T., Hashizume T., Scian M., Dickmann L. J., Nelson S. D., Baillie T. A., Hebert M. F., Blough D., Davis C. L., Thummel K. E., Mol. Pharmacol.<\/i>, 81<\/b>, 498\u2013509 (2012).","DOI":"10.1124\/mol.111.076356"},{"key":"126","doi-asserted-by":"crossref","unstructured":"126) Wang Z., Lin Y. S., Dickmann L. J., Poulton E. J., Eaton D. L., Lampe J. W., Shen D. D., Davis C. L., Shuhart M. C., Thummel K. E., J. Bone Miner. Res.<\/i>, 28<\/b>, 1101\u20131116 (2013).","DOI":"10.1002\/jbmr.1839"},{"key":"127","doi-asserted-by":"crossref","unstructured":"127) Sawada D., Tsukuda Y., Yasuda K., Sakaki T., Saito H., Takagi K., Takenouchi K., Chen T. C., Reddy G. S., Kittaka A., Chem. Pharm. Bull.<\/i>, 60<\/b>, 1343\u20131346 (2012).","DOI":"10.1248\/cpb.c12-00526"},{"key":"128","doi-asserted-by":"crossref","unstructured":"128) Takano M., Sawada D., Yasuda K., Nishikawa M., Takeuchi A., Takagi K., Horie K., Reddy G. S., Chen T. C., Sakaki T., Kittaka A., J. Steroid Biochem. Mol. Biol.<\/i>, 148<\/b>, 34\u201337 (2015).","DOI":"10.1016\/j.jsbmb.2014.09.021"},{"key":"129","doi-asserted-by":"crossref","unstructured":"129) Peluso-Iltis C., Pierrat N., Rovito D., Osz J., Sawada D., Kittaka A., Laverny G., Rochel N., Biomolecules<\/i>, 14<\/b>, 551 (2024).","DOI":"10.3390\/biom14050551"}],"container-title":["YAKUGAKU ZASSHI"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/yakushi\/144\/12\/144_24-00157\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,7]],"date-time":"2024-12-07T03:35:08Z","timestamp":1733542508000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/yakushi\/144\/12\/144_24-00157\/_article\/-char\/ja\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,1]]},"references-count":129,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2024]]}},"URL":"https:\/\/doi.org\/10.1248\/yakushi.24-00157","relation":{},"ISSN":["0031-6903","1347-5231"],"issn-type":[{"type":"print","value":"0031-6903"},{"type":"electronic","value":"1347-5231"}],"subject":[],"published":{"date-parts":[[2024,12,1]]},"article-number":"24-00157"}}