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S., Medrano-Relinque J., Navarr\u00f3n C. M., Navarrete F., Manzanares J., <i>Acta Pharmacol. Sin.<\/i>, <b>40<\/b>, 358\u2013364 (2019).","DOI":"10.1038\/s41401-018-0032-8"},{"key":"25","doi-asserted-by":"crossref","unstructured":"25) Gray R. A., Heal D. J., Maguire D. R., Gerak L. R., Javors M. A., Smith S., France C. P., <i>J. Pharmacol. Exp. Ther.<\/i>, <b>382<\/b>, 54\u201365 (2022).","DOI":"10.1124\/jpet.121.000988"},{"key":"26","doi-asserted-by":"crossref","unstructured":"26) Mustafa M. A., Poklis J. L., Karin K. N., Elmer J. A., Porter J. H., Parra V., Lu D., Schlosburg J. E., Lichtman A. H., <i>Cannabis Cannabinoid Res.<\/i>, <b>9<\/b>, 581\u2013590 (2024).","DOI":"10.1089\/can.2022.0198"},{"key":"27","doi-asserted-by":"crossref","unstructured":"27) Babalonis S., Haney M., Malcolm R. J., Lofwall M. R., Votaw V. R., Sparenborg S., Walsh S. 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A., O\u2019Carrol C., Atakan Z., Zuardi A. W., McGuire P. K., <i>Arch. Gen. Psychiatry<\/i>, <b>66<\/b>, 95\u2013105 (2009).","DOI":"10.1001\/archgenpsychiatry.2008.519"},{"key":"45","doi-asserted-by":"crossref","unstructured":"45) Winton-Brown T. T., Allen P., Bhattacharyya S., Borgwardt S. J., Fusar-Poli P., Crippa J. A., Seal M. L., Martin-Santos R., Ffytche D., Zuardi A. W., Atakan Z., McGuire P. K., <i>Neuropsychopharmacology<\/i>, <b>36<\/b>, 1340\u20131348 (2011).","DOI":"10.1038\/npp.2011.17"},{"key":"46","doi-asserted-by":"crossref","unstructured":"46) Heal D. J., Gosden J., Smith S. L., <i>Front. Psychiatry<\/i>, <b>15<\/b>, 1322434 (2024).","DOI":"10.3389\/fpsyt.2024.1322434"},{"key":"47","doi-asserted-by":"crossref","unstructured":"47) Britch S. C., Babalonis S., Walsh S. 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