{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T15:37:19Z","timestamp":1791041839299,"version":"4.1.0"},"reference-count":81,"publisher":"Pharmaceutical Society of Japan","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["YAKUGAKU ZASSHI"],"published-print":{"date-parts":[[2026,9,1]]},"DOI":"10.1248\/yakushi.26-00087","type":"journal-article","created":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T22:22:30Z","timestamp":1788214950000},"page":"741-748","source":"Crossref","is-referenced-by-count":1,"title":["Metabolic Activations and Pharmacokinetics of Drugs Using Data-driven Modeling","\u85ac\u7269\u306e\u4ee3\u8b1d\uff0c\u4f53\u5185\u52d5\u614b\u3068\u85ac\u52b9\u6bd2\u6027\u306b\u95a2\u3059\u308b\u30c7\u30fc\u30bf\u99c6\u52d5\u578b\u7814\u7a76"],"prefix":"10.1248","volume":"146","author":[{"given":"Hiroshi","family":"Yamazaki","sequence":"first","affiliation":[{"name":"Laboratory of Drug Metabolism and Pharmacokinetics, Showa Pharmaceutical University"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"163","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"1) Guengerich F. P., Pharmacol. Rev.<\/i>, 76<\/b>, 1104\u20131132 (2024).","DOI":"10.1124\/pharmrev.124.001173"},{"key":"2","unstructured":"2) Li A. P., Chem. Biol. Interact.<\/i>, 179<\/b>, 1\u20133 (2009)."},{"key":"3","doi-asserted-by":"crossref","unstructured":"3) Guengerich F. P., Drug Metab. Dispos.<\/i>, 52<\/b>, 493\u2013497 (2024).","DOI":"10.1124\/dmd.123.001431"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4) Cashman J. R., Chem. Res. Toxicol.<\/i>, 37<\/b>, 1776\u20131793 (2024).","DOI":"10.1021\/acs.chemrestox.4c00316"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5) Uno Y., Uehara S., Yamazaki H., \u201cPharmacology and Toxicology of Cytochrome P450\u201460th Anniversary,\u201d Chap. 11, ed. by Yamazaki H., Academic Press, 2022, pp. 329\u2013364.","DOI":"10.1016\/bs.apha.2022.05.005"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6) Omura T., Sato R., J. Biol. Chem.<\/i>, 237<\/b>, PC1375\u2013PC1376 (1962).","DOI":"10.1016\/S0021-9258(18)60338-2"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7) Shimada T., Yamazaki H., Mimura M., Inui Y., Guengerich F. P., J. Pharmacol. Exp. Ther.<\/i>, 270<\/b>, 414\u2013423 (1994).","DOI":"10.1016\/S0022-3565(25)22379-5"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8) Yamazaki H., Yakugaku Zasshi<\/i>, 120<\/b>, 1347\u20131357 (2000).","DOI":"10.1248\/yakushi1947.120.12_1347"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9) Guengerich F. P., Chem. Biol. Interact.<\/i>, 106<\/b>, 161\u2013182 (1997).","DOI":"10.1016\/S0009-2797(97)00068-9"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10) Shimada T., Mimura M., Inoue K., Nakamura S., Oda H., Ohmori S., Yamazaki H., Arch. Toxicol.<\/i>, 71<\/b>, 401\u2013408 (1997).","DOI":"10.1007\/s002040050403"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11) Guengerich F. P., Martin M. V., Beaune P. H., Kremers P., Wolff T., Waxman D. J., J. Biol. Chem.<\/i>, 261<\/b>, 5051\u20135060 (1986).","DOI":"10.1016\/S0021-9258(19)89213-X"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12) Guengerich F. P., Shimada T., Yun C. H., Yamazaki H., Raney K. D., Thier R., Coles B., Harris T. M., Environ. Health Perspect.<\/i>, 102<\/b> (Suppl 9), 49\u201353 (1994).","DOI":"10.1289\/ehp.94102s949"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13) Nakajima M., Yamazaki H., Yoshinari K., Kobayashi K., Ishii Y., Nakai D., Kamimura H., Kume T., Saito Y., Maeda K., Kusuhara H., Tamai I., Drug Metab. Dispos.<\/i>, 53<\/b>, 100071 (2025).","DOI":"10.1016\/j.dmd.2025.100071"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14) Uehara S., Higuchi Y., Fukuda S., Shimizu M., Shimoi A., Suemizu H., Yamazaki H., Drug Metab. Dispos.<\/i>, 54<\/b>, 100283 (2026).","DOI":"10.1016\/j.dmd.2026.100283"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15) Kuwagata M., Hasegawa T., Takashima H., Shimizu M., Kitajima S., Yamazaki H., J. Toxicol. Sci.<\/i>, 46<\/b>, 553\u2013560 (2021).","DOI":"10.2131\/jts.46.553"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16) Yamazaki H., Chem. Res. Toxicol.<\/i>, 30<\/b>, 53\u201360 (2017).","DOI":"10.1021\/acs.chemrestox.6b00286"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17) Yamazaki H., Shimizu M., Drug Metab. Dispos.<\/i>, 51<\/b>, 123\u2013129 (2023).","DOI":"10.1124\/dmd.121.000742"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18) Miura T., Uehara S., Shimizu M., Suemizu H., Yamazaki H., J. Toxicol. Sci.<\/i>, 46<\/b>, 311\u2013317 (2021).","DOI":"10.2131\/jts.46.311"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19) Chowdhury G., Murayama N., Okada Y., Uno Y., Shimizu M., Shibata N., Guengerich F. P., Yamazaki H., Chem. Res. Toxicol.<\/i>, 23<\/b>, 1018\u20131024 (2010).","DOI":"10.1021\/tx900367p"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20) Yamazaki H., Suemizu H., Shimizu M., Igaya S., Shibata N., Nakamura M., Chowdhury G., Guengerich F. P., Chem. Res. Toxicol.<\/i>, 25<\/b>, 274\u2013276 (2012).","DOI":"10.1021\/tx300009j"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21) Uehara S., Murayama N., Higuchi Y., Shimizu M., Suemizu H., Guengerich F. P., Yamazaki H., Chem. Res. Toxicol.<\/i>, 37<\/b>, 671\u2013674 (2024).","DOI":"10.1021\/acs.chemrestox.4c00069"},{"key":"22","doi-asserted-by":"crossref","unstructured":"22) Yamazaki H., Suemizu H., Murayama N., Utoh M., Shibata N., Nakamura M., Guengerich F. P., Chem. Res. Toxicol.<\/i>, 26<\/b>, 486\u2013489 (2013).","DOI":"10.1021\/tx400008g"},{"key":"23","doi-asserted-by":"crossref","unstructured":"23) Yamazaki H., Suemizu H., Kazuki Y., Oofusa K., Kuribayashi S., Shimizu M., Ninomiya S., Horie T., Shibata N., Guengerich F. P., Chem. Res. Toxicol.<\/i>, 29<\/b>, 1279\u20131281 (2016).","DOI":"10.1021\/acs.chemrestox.6b00210"},{"key":"24","unstructured":"24) Uno Y., Ushirozako G., Murayama N., Yamazaki H., Biochem. Pharmacol.<\/i>, 242<\/b>, 117209 (2025)."},{"key":"25","doi-asserted-by":"crossref","unstructured":"25) Uno Y., Shimizu M., Yamazaki H., Biochem. Pharmacol.<\/i>, 228<\/b>, 116124 (2024).","DOI":"10.1016\/j.bcp.2024.116124"},{"key":"26","doi-asserted-by":"crossref","unstructured":"26) Ushirozako G., Asano A., Otomaru K., Tsukiyama-Kohara K., Yamazaki H., Uno Y., Drug Metab. Dispos.<\/i>, 54<\/b>, 100322 (2026).","DOI":"10.1016\/j.dmd.2026.100322"},{"key":"27","doi-asserted-by":"crossref","unstructured":"27) Uehara S., Uno Y., Yamazaki H., Biochem. Pharmacol.<\/i>, 171<\/b>, 113721 (2020).","DOI":"10.1016\/j.bcp.2019.113721"},{"key":"28","doi-asserted-by":"crossref","unstructured":"28) Uno Y., Uehara S., Yamazaki H., Biochem. Pharmacol.<\/i>, 197<\/b>, 114887 (2022).","DOI":"10.1016\/j.bcp.2021.114887"},{"key":"29","doi-asserted-by":"crossref","unstructured":"29) Uno Y., Uehara S., Yamazaki H., Biochem. Pharmacol.<\/i>, 121<\/b>, 1\u20137 (2016).","DOI":"10.1016\/j.bcp.2016.06.008"},{"key":"30","doi-asserted-by":"crossref","unstructured":"30) Uno Y., Uehara S., Yamazaki H., Biochem. Pharmacol.<\/i>, 153<\/b>, 184\u2013195 (2018).","DOI":"10.1016\/j.bcp.2017.12.015"},{"key":"31","doi-asserted-by":"crossref","unstructured":"31) Yamazaki H., Drug Metab. Dispos.<\/i>, 54<\/b>, 100334 (2026).","DOI":"10.1016\/j.dmd.2026.100334"},{"key":"32","doi-asserted-by":"crossref","unstructured":"32) Cashman J. R., Bi Y. A., Lin J., Youil R., Knight M., Forrest S., Treacy E., Chem. Res. Toxicol.<\/i>, 10<\/b>, 837\u2013841 (1997).","DOI":"10.1021\/tx9700533"},{"key":"33","doi-asserted-by":"crossref","unstructured":"33) Yamazaki H., Shimizu M., Curr. Drug Metab.<\/i>, 8<\/b>, 487\u2013491 (2007).","DOI":"10.2174\/138920007780866825"},{"key":"34","doi-asserted-by":"crossref","unstructured":"34) Humbert J. A., Hammond K. B., Hathaway W. E., Marcoux J. G., O\u2019Brien D., Lancet<\/i>, 296<\/b>, 770\u2013771 (1970).","DOI":"10.1016\/S0140-6736(70)90241-2"},{"key":"35","doi-asserted-by":"crossref","unstructured":"35) Cashman J. R., Akerman B. R., Forrest S. M., Treacy E. P., Drug Metab. Dispos.<\/i>, 28<\/b>, 169\u2013173 (2000).","DOI":"10.1016\/S0090-9556(24)15124-0"},{"key":"36","doi-asserted-by":"crossref","unstructured":"36) Yeung C. K., Adman E. T., Rettie A. E., Arch. Biochem. Biophys.<\/i>, 464<\/b>, 251\u2013259 (2007).","DOI":"10.1016\/j.abb.2007.04.014"},{"key":"37","doi-asserted-by":"crossref","unstructured":"37) Yamazaki H., Shimizu M., Biochem. Pharmacol.<\/i>, 85<\/b>, 1588\u20131593 (2013).","DOI":"10.1016\/j.bcp.2013.03.020"},{"key":"38","doi-asserted-by":"crossref","unstructured":"38) Shimizu M., Makiguchi M., Hishinuma E., Saito S., Hiratsuka M., Yamazaki H., Drug Metab. Pharmacokinet.<\/i>, 55<\/b>, 100539 (2024).","DOI":"10.1016\/j.dmpk.2023.100539"},{"key":"39","doi-asserted-by":"crossref","unstructured":"39) Makiguchi M., Shimizu M., Yokota Y., Shimamura E., Hishinuma E., Saito S., Hiratsuka M., Yamazaki H., Drug Metab. Dispos.<\/i>, 51<\/b>, 884\u2013891 (2023).","DOI":"10.1124\/dmd.123.001310"},{"key":"40","doi-asserted-by":"crossref","unstructured":"40) Shimizu M., Denton T., Kozono M., Cashman J. R., Leeder J. S., Yamazaki H., Br. J. Clin. Pharmacol.<\/i>, 71<\/b>, 585\u2013591 (2011).","DOI":"10.1111\/j.1365-2125.2010.03876.x"},{"key":"41","doi-asserted-by":"crossref","unstructured":"41) Allerston C. K., Shimizu M., Fujieda M., Shephard E. A., Yamazaki H., Phillips I. R., Pharmacogenet. Genomics<\/i>, 17<\/b>, 827\u2013839 (2007).","DOI":"10.1097\/FPC.0b013e328256b198"},{"key":"42","doi-asserted-by":"crossref","unstructured":"42) Shimizu M., Allerston C. K., Shephard E. A., Yamazaki H., Phillips I. R., Br. J. Clin. Pharmacol.<\/i>, 77<\/b>, 839\u2013851 (2014).","DOI":"10.1111\/bcp.12240"},{"key":"43","doi-asserted-by":"crossref","unstructured":"43) Shimizu M., Yamamoto A., Makiguchi M., Shimamura E., Yokota Y., Harano M., Yamazaki H., Drug Metab. Pharmacokinet.<\/i>, 50<\/b>, 100490 (2023).","DOI":"10.1016\/j.dmpk.2023.100490"},{"key":"44","doi-asserted-by":"crossref","unstructured":"44) Shimizu M., Hishinuma E., Igarashi R., Saito S., Makiguchi M., Hiratsuka M., Yamazaki H., Biol. Pharm. Bull.<\/i>, 48<\/b>, 1062\u20131069 (2025).","DOI":"10.1248\/bpb.b25-00359"},{"key":"45","doi-asserted-by":"crossref","unstructured":"45) Taniguchi-Takizawa T., Kato N., Shimizu M., Kume T., Yamazaki H., Drug Metab. Pharmacokinet.<\/i>, 40<\/b>, 100412 (2021).","DOI":"10.1016\/j.dmpk.2021.100412"},{"key":"46","doi-asserted-by":"crossref","unstructured":"46) Taniguchi-Takizawa T., Kato H., Shimizu M., Yamazaki H., Curr. Drug Metab.<\/i>, 22<\/b>, 208\u2013214 (2021).","DOI":"10.2174\/1389200221666201207195758"},{"key":"47","doi-asserted-by":"crossref","unstructured":"47) Uno Y., Shimizu M., Ogawa Y., Makiguchi M., Kawaguchi H., Yamato O., Ishizuka M., Yamazaki H., Biochem. Pharmacol.<\/i>, 202<\/b>, 115125 (2022).","DOI":"10.1016\/j.bcp.2022.115125"},{"key":"48","doi-asserted-by":"crossref","unstructured":"48) Shimizu M., Makiguchi M., Uno Y., Yamazaki H., Drug Metab. Dispos.<\/i>, 52<\/b>, 906\u2013910 (2024).","DOI":"10.1124\/dmd.124.001728"},{"key":"49","doi-asserted-by":"crossref","unstructured":"49) Shimizu M., Nii A., Uno Y., Yamazaki H., Drug Metab. Dispos.<\/i>, 53<\/b>, 100140 (2025).","DOI":"10.1016\/j.dmd.2025.100140"},{"key":"50","doi-asserted-by":"crossref","unstructured":"50) Adachi K., Shimizu M., Shono F., Funatsu K., Yamazaki H., J. Toxicol. Sci.<\/i>, 49<\/b>, 127\u2013137 (2024).","DOI":"10.2131\/jts.49.127"},{"key":"51","doi-asserted-by":"crossref","unstructured":"51) Adachi K., Sasaki T., Arai A., Shimizu M., Yamazaki H., J. Toxicol. Sci.<\/i>, 49<\/b>, 459\u2013466 (2024).","DOI":"10.2131\/jts.49.459"},{"key":"52","doi-asserted-by":"crossref","unstructured":"52) Yamazaki H., Shimizu M., Chem. Res. Toxicol.<\/i>, 38<\/b>, 1157\u20131166 (2025).","DOI":"10.1021\/acs.chemrestox.5c00157"},{"key":"53","doi-asserted-by":"crossref","unstructured":"53) Tanaka Y., Shimizu M., Saito Y., Yamazaki H., Drug Metab. Pharmacokinet.<\/i>, 64<\/b>, 101496 (2025).","DOI":"10.1016\/j.dmpk.2025.101496"},{"key":"54","doi-asserted-by":"crossref","unstructured":"54) Adachi K., Ohyama K., Tanaka Y., Murayama N., Shimizu M., Saito Y., Yamazaki H., Biol. Pharm. Bull.<\/i>, 47<\/b>, 1028\u20131032 (2024).","DOI":"10.1248\/bpb.b24-00145"},{"key":"55","doi-asserted-by":"crossref","unstructured":"55) Adachi K., Ohyama K., Tanaka Y., Saito Y., Shimizu M., Yamazaki H., Biol. Pharm. Bull.<\/i>, 47<\/b>, 635\u2013640 (2024).","DOI":"10.1248\/bpb.b24-00012"},{"key":"56","doi-asserted-by":"crossref","unstructured":"56) Adachi K., Ohyama K., Shimura Y., Tanaka Y., Shimizu M., Saito Y., Yamazaki H., Biol. Pharm. Bull.<\/i>, 48<\/b>, 1271\u20131276 (2025).","DOI":"10.1248\/bpb.b25-00423"},{"key":"57","unstructured":"57) Shimizu M., Adachi K., Shimura Y., Ohyama K., Tanaka Y., Saito Y., Yamazaki H., J. Toxicol. Sci.<\/i>, in press (2026)."},{"key":"58","doi-asserted-by":"crossref","unstructured":"58) Adachi K., Ohyama K., Tanaka Y., Nakano H., Sato T., Murayama N., Shimizu M., Saito Y., Yamazaki H., Biol. Pharm. Bull.<\/i>, 46<\/b>, 856\u2013863 (2023).","DOI":"10.1248\/bpb.b23-00189"},{"key":"59","doi-asserted-by":"crossref","unstructured":"59) Miura T., Uehara S., Shimizu M., Murayama N., Utoh M., Suemizu H., Yamazaki H., Chem. Res. Toxicol.<\/i>, 33<\/b>, 634\u2013639 (2020).","DOI":"10.1021\/acs.chemrestox.9b00446"},{"key":"60","doi-asserted-by":"crossref","unstructured":"60) Shimizu M., Uehara S., Ohyama K., Nishimura H., Tanaka Y., Saito Y., Suemizu H., Yoshida S., Yamazaki H., Drug Metab. Dispos.<\/i>, 52<\/b>, 35\u201343 (2024).","DOI":"10.1124\/dmd.123.001481"},{"key":"61","doi-asserted-by":"crossref","unstructured":"61) Jamei M., Marciniak S., Feng K., Barnett A., Tucker G., Rostami-Hodjegan A., Exp. Opin. Drug Metab. Toxicol.<\/i>, 5<\/b>, 211\u2013223 (2009).","DOI":"10.1517\/17425250802691074"},{"key":"62","doi-asserted-by":"crossref","unstructured":"62) Kamiya Y., Otsuka S., Miura T., Takaku H., Yamada R., Nakazato M., Nakamura H., Mizuno S., Shono F., Funatsu K., Yamazaki H., Chem. Res. Toxicol.<\/i>, 32<\/b>, 211\u2013218 (2019).","DOI":"10.1021\/acs.chemrestox.8b00307"},{"key":"63","doi-asserted-by":"crossref","unstructured":"63) Kamiya Y., Otsuka S., Miura T., Yoshizawa M., Nakano A., Iwasaki M., Kobayashi Y., Shimizu M., Kitajima M., Shono F., Funatsu K., Yamazaki H., Chem. Res. Toxicol.<\/i>, 33<\/b>, 1736\u20131751 (2020).","DOI":"10.1021\/acs.chemrestox.0c00009"},{"key":"64","doi-asserted-by":"crossref","unstructured":"64) Kamiya Y., Handa K., Miura T., Yanagi M., Shigeta K., Hina S., Shimizu M., Kitajima M., Shono F., Funatsu K., Yamazaki H., Chem. Res. Toxicol.<\/i>, 34<\/b>, 507\u2013513 (2021).","DOI":"10.1021\/acs.chemrestox.0c00336"},{"key":"65","doi-asserted-by":"crossref","unstructured":"65) Kamiya Y., Handa K., Miura T., Ohori J., Shimizu M., Kitajima M., Shono F., Funatsu K., Yamazaki H., Chem. Res. Toxicol.<\/i>, 34<\/b>, 2180\u20132183 (2021).","DOI":"10.1021\/acs.chemrestox.1c00249"},{"key":"66","doi-asserted-by":"crossref","unstructured":"66) Padilla Mercado G., Cook C., Adkins N., Albrecht L., Cary G., Edwards B., Haggard D. E., Hanley N. M., Hughes M. F., Jarnagin A., Kodavanti T. D., Korol-Bexell E., Kreutz A., Ngo M., Patullo C., Rowan E. G., Huse L. M., Correa V. A., Kesic B., Casey W., Aboabdo J., Wolf K., Sayre R., Sharma B., Wall J. T., Yamazaki H., Wambaugh J. F., Ring C. L., J. Pharmacokinet. Pharmacodyn.<\/i>, 52<\/b>, 30 (2025).","DOI":"10.1007\/s10928-025-09977-4"},{"key":"67","doi-asserted-by":"crossref","unstructured":"67) Adachi K., Shimizu M., Yamazaki H., J. Toxicol. Sci.<\/i>, 47<\/b>, 453\u2013456 (2022).","DOI":"10.2131\/jts.47.453"},{"key":"68","doi-asserted-by":"crossref","unstructured":"68) Adachi K., Shimizu M., Yamazaki H., Biol. Pharm. Bull.<\/i>, 45<\/b>, 1812\u20131817 (2022).","DOI":"10.1248\/bpb.b22-00502"},{"key":"69","doi-asserted-by":"crossref","unstructured":"69) Adachi K., Nakano H., Sato T., Shimizu M., Yamazaki H., Biol. Pharm. Bull.<\/i>, 46<\/b>, 1133\u20131140 (2023).","DOI":"10.1248\/bpb.b23-00358"},{"key":"70","doi-asserted-by":"crossref","unstructured":"70) Adachi K., Hosoi M., Shimura Y., Shimizu M., Yamazaki H., J. Toxicol. Sci.<\/i>, 50<\/b>, 205\u2013213 (2025).","DOI":"10.2131\/jts.50.205"},{"key":"71","unstructured":"71) Organisation for Economic Co-operation and Development. \u201cAnnex 4. Cases studies to Guidance Document on the Characterisation, Validation and Reporting of PBK Models for Regulatory Purpose, OECD Environment, Health and Safety Publications Series on Testing and Assessment no. 331.\u201d: \u3008https:\/\/one.oecd.org\/document\/ENV\/CBC\/MONO(2021)1\/ann4\/en\/pdf\u3009, cited 4 February 2021."},{"key":"72","doi-asserted-by":"crossref","unstructured":"72) Yamazaki H., \u201cFifty Years of Cytochrome P450 Research,\u201d Chapter 17, Springer Tokyo, 2014, pp. 293\u2013305.","DOI":"10.1007\/978-4-431-54992-5_17"},{"key":"73","doi-asserted-by":"crossref","unstructured":"73) Yamazaki H., \u201cFifty Years of Cytochrome P450 Research,\u201d ed. by Yamazaki H., Springer Tokyo, 2014, pp. v\u2013vi.","DOI":"10.1007\/978-4-431-54992-5"},{"key":"74","doi-asserted-by":"crossref","unstructured":"74) Shimizu M., Shimura Y., Yamazaki H., Biol. Pharm. Bull.<\/i>, 48<\/b>, 1727\u20131731 (2025).","DOI":"10.1248\/bpb.b25-00526"},{"key":"75","doi-asserted-by":"crossref","unstructured":"75) Adachi K., Utsumi M., Sato T., Nakano H., Shimizu M., Yamazaki H., Biol. Pharm. Bull.<\/i>, 46<\/b>, 1316\u20131323 (2023).","DOI":"10.1248\/bpb.b23-00371"},{"key":"76","doi-asserted-by":"crossref","unstructured":"76) Shimizu M., Hayasaka R., Kamiya Y., Yamazaki H., Biol. Pharm. Bull.<\/i>, 45<\/b>, 1142\u20131157 (2022).","DOI":"10.1248\/bpb.b22-00221"},{"key":"77","doi-asserted-by":"crossref","unstructured":"77) Kamiya Y., Handa K., Miura T., Ohori J., Kato A., Shimizu M., Kitajima M., Yamazaki H., Biol. Pharm. Bull.<\/i>, 45<\/b>, 124\u2013128 (2022).","DOI":"10.1248\/bpb.b21-00769"},{"key":"78","doi-asserted-by":"crossref","unstructured":"78) Miura T., Kamiya Y., Murayama N., Shimizu M., Yamazaki H., Biol. Pharm. Bull.<\/i>, 44<\/b>, 1775\u20131780 (2021).","DOI":"10.1248\/bpb.b21-00589"},{"key":"79","doi-asserted-by":"crossref","unstructured":"79) Uno Y., Fukunaga K., Ushirozako G., Murayama N., Mizukami K., Aoi T., Tomiyasu H., Honnami M., Tsujimoto H., Sakaguchi M., Hisasue M., Mushiroda T., Momozawa Y., Yamazaki H., Drug Metab. Dispos.<\/i>, 53<\/b>, 100189 (2025).","DOI":"10.1016\/j.dmd.2025.100189"},{"key":"80","doi-asserted-by":"crossref","unstructured":"80) Uno Y., Fukunaga K., Shimizu M., Ushirozako G., Mizukami K., Aoi T., Tomiyasu H., Honnami M., Tsujimoto H., Sakaguchi M., Hisasue M., Mushiroda T., Momozawa Y., Yamazaki H., Biochem. Pharmacol.<\/i>, 247<\/b>, 117790 (2026).","DOI":"10.1016\/j.bcp.2026.117790"},{"key":"81","doi-asserted-by":"crossref","unstructured":"81) Uno Y., Fukunaga K., Ushirozako G., Murayama N., Mizukami K., Aoi T., Tomiyasu H., Honnami M., Tsujimoto H., Sakaguchi M., Hisasue M., Mushiroda T., Momozawa Y., Yamazaki H., Biochem. Pharmacol.<\/i>, 242<\/b>, 117394 (2025).","DOI":"10.1016\/j.bcp.2025.117394"}],"container-title":["YAKUGAKU ZASSHI"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/yakushi\/146\/9\/146_26-00087\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T03:36:11Z","timestamp":1788579371000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/yakushi\/146\/9\/146_26-00087\/_article\/-char\/ja\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,1]]},"references-count":81,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2026]]}},"URL":"https:\/\/doi.org\/10.1248\/yakushi.26-00087","relation":{},"ISSN":["0031-6903","1347-5231"],"issn-type":[{"value":"0031-6903","type":"print"},{"value":"1347-5231","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,1]]},"article-number":"26-00087"}}