{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T15:59:37Z","timestamp":1787327977691,"version":"build-2736575974"},"reference-count":40,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,10]]},"DOI":"10.1249\/mss.0b013e318217e8b6","type":"journal-article","created":{"date-parts":[[2011,3,29]],"date-time":"2011-03-29T01:57:02Z","timestamp":1301363822000},"page":"1836-1848","source":"Crossref","is-referenced-by-count":25,"title":["Anabolic Steroid Associated to Physical Training Induces Deleterious Cardiac Effects"],"prefix":"10.1249","volume":"43","author":[{"given":"EVERTON CRIVOI","family":"DO CARMO","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"TIAGO","family":"FERNANDES","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"DANIEL","family":"KOIKE","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"NATHAN DANIEL","family":"DA SILVA","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"KATT COELHO","family":"MATTOS","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"KALEIZU TEODORO","family":"ROSA","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"DIEGO","family":"BARRETTI","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ST\u00c9PHANO FREITAS SOARES","family":"MELO","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ROG\u00c9RIO B.","family":"WICHI","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MARIA CLAUDIA COSTA","family":"IRIGOYEN","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"EDILAMAR MENEZES","family":"DE OLIVEIRA","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"issue":"6","key":"R1-4-20210227","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1590\/S0100-879X2005000600007","article-title":"A continuous fluorescent assay for the determination of plasma and tissue angiotensin I-converting enzyme activity.","volume":"38","author":"Alves","year":"2005","journal-title":"Braz J Med Biol Res"},{"issue":"1","key":"R2-4-20210227","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.jsbmb.2004.11.003","article-title":"Effects of chronic anabolic steroid treatment on tonic and reflex cardiovascular control in male rats.","volume":"93","author":"Beutel","year":"2005","journal-title":"J Steroid Biochem Mol Biol"},{"key":"R3-4-20210227","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1016\/S0008-6363(96)88507-5","article-title":"Molecular signalling mechanisms controlling growth and function of cardiac fibroblast.","volume":"30","author":"Booz","year":"1995","journal-title":"Cardiovasc Res"},{"key":"R4-4-20210227","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/0003-2697(76)90527-3","article-title":"A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding.","volume":"72","author":"Bradford","year":"1976","journal-title":"Anal Biochem"},{"key":"R5-4-20210227","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1006\/jmcc.1993.1066","article-title":"Anti-aldosterone treatment and the prevention of myocardial fibrosis in primary and secondary hyperaldosteronism.","volume":"25","author":"Brilla","year":"1993","journal-title":"J Mol Cell Cardiol"},{"key":"R6-4-20210227","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/0003-2697(87)90021-2","article-title":"Single step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction.","volume":"162","author":"Chomczynski","year":"1987","journal-title":"Anal Biochem"},{"key":"R7-4-20210227","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1007\/BF01002772","article-title":"Picrosirius staining plus polarization microscopy, a specific method for collagen detection in tissue sections.","volume":"11","author":"Junqueira","year":"1979","journal-title":"Histochem J"},{"key":"R8-4-20210227","doi-asserted-by":"crossref","first-page":"1244","DOI":"10.1253\/circj.69.1244","article-title":"Valsartan decrease Type I collagen synthesis in patients with hypertrophy cardiomyopathy.","volume":"69","author":"Kawano","year":"2005","journal-title":"Circ J"},{"key":"R9-4-20210227","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1055\/s-2007-964848","article-title":"Cardiac tissue Doppler in steroid users.","volume":"28","author":"Krieg","year":"2007","journal-title":"Int J Sports Med"},{"key":"R10-4-20210227","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1007\/s00109-008-0323-5","article-title":"New insights on signaling cascades induced by cross-talk between angiotensin II and aldosterone.","volume":"86","author":"Lemarie","year":"2008","journal-title":"J Mol Med"},{"key":"R11-4-20210227","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1097\/00005344-199707000-00011","article-title":"Effect of AT1 angiotensin-receptor blockade on structure and function of small arteries in SHR.","volume":"30","author":"Li","year":"1997","journal-title":"J Cardiovasc Pharmacol"},{"key":"R12-4-20210227","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1161\/01.RES.71.3.503","article-title":"Immunohistochemical and biochemical evidence for a cardiovascular mineralocorticoid receptor.","volume":"71","author":"Lombes","year":"1992","journal-title":"Circ Res"},{"issue":"1-3","key":"R13-4-20210227","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.jsbmb.2005.02.003","article-title":"11-Hydroxysteroid dehydrogenase in the heart of normotensive and hypertensive rats.","volume":"94","author":"Mazancova","year":"2005","journal-title":"J Steroid Biochem Mol Biol"},{"key":"R14-4-20210227","doi-asserted-by":"crossref","first-page":"1909","DOI":"10.1590\/S0100-879X2004001200018","article-title":"Swimming training increases cardiac vagal activity and induces cardiac hypertrophy in rats.","volume":"37","author":"Medeiros","year":"2004","journal-title":"Braz J Med Biol Res"},{"issue":"9","key":"R15-4-20210227","doi-asserted-by":"crossref","first-page":"1252","DOI":"10.1249\/00005768-199509000-00004","article-title":"Cardiovascular effects of androgenic-anabolic steroids.","volume":"27","author":"Melchert","year":"1995","journal-title":"Med Sci Sports Exerc"},{"issue":"16","key":"R16-4-20210227","doi-asserted-by":"crossref","first-page":"1933","DOI":"10.1161\/01.CIR.0000127112.36796.9B","article-title":"Aldosterone enhances ischemia-induced neovascularization through angiotensin II-dependent pathway.","volume":"109","author":"Michel","year":"2004","journal-title":"Circulation"},{"key":"R17-4-20210227","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1161\/01.RES.0000180753.63183.95","article-title":"Aldosterone and angiotensin II synergistically induce mitogenic response in vascular smooth muscle cells.","volume":"97","author":"Min","year":"2005","journal-title":"Circ Res"},{"key":"R18-4-20210227","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1161\/01.HYP.0000203772.78696.67","article-title":"Mineralocorticoid receptor antagonism attenuates cardiac hypertrophy and failure in low-aldosterone hypertension rats.","volume":"47","author":"Nagata","year":"2006","journal-title":"Hypertension"},{"key":"R19-4-20210227","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.ejphar.2005.07.026","article-title":"Chronic -adrenoceptor stimulation and cardiac hypertrophy with no induction of circulating renin.","volume":"520","author":"Oliveira","year":"2005","journal-title":"Eur J Pharmacol"},{"key":"R20-4-20210227","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1177\/1470320309102304","article-title":"Local renin-angiotensin system regulates LV hypertrophy induced by swimming training independent of circulating renin: a pharmacological study.","volume":"10","author":"Oliveira","year":"2009","journal-title":"J Renin Angiotensin Aldosterone Syst"},{"key":"R21-4-20210227","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.1016\/0002-9149(86)90392-9","article-title":"Left ventricular function in weightlifters.","volume":"58","author":"Pearson","year":"1986","journal-title":"Am J Cardiol"},{"issue":"1","key":"R22-4-20210227","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1007\/BF00877755","article-title":"\"Escape\" zyme inhibitor: implications for therapy.","volume":"9","author":"Pitt","year":"1995","journal-title":"Cardiovasc Drugs Ther"},{"issue":"4","key":"R23-4-20210227","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1176\/ajp.145.4.487","article-title":"Affective and psychotic symptoms associated with anabolic steroid use.","volume":"145","author":"Pope","year":"1988","journal-title":"Am J Psychiatry"},{"key":"R24-4-20210227","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1161\/01.RES.0000080521.15238.E5","article-title":"Transgenic model of aldosterone-driven cardiac hypertrophy and heart failure.","volume":"93","author":"Qin","year":"2003","journal-title":"Circ Res"},{"issue":"9","key":"R25-4-20210227","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.2174\/138955709788922692","article-title":"Pharmacological options for treatment of hyperandrogenic disorders.","volume":"9","author":"Reismann","year":"2009","journal-title":"Mini Rev Med Chem"},{"key":"R26-4-20210227","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1161\/01.HYP.26.6.971","article-title":"Biological determinants of aldosterone-induced cardiac fibrosis in rats.","volume":"26","author":"Robert","year":"1995","journal-title":"Hypertension"},{"key":"R27-4-20210227","doi-asserted-by":"crossref","first-page":"H3575","DOI":"10.1152\/ajpheart.01251.2006","article-title":"Anabolic steroids induce cardiac renin-angiotensin system and impair the beneficial effects of aerobic training in rats.","volume":"293","author":"Rocha","year":"2007","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"R28-4-20210227","doi-asserted-by":"crossref","first-page":"H1802","DOI":"10.1152\/ajpheart.01096.2001","article-title":"Aldosterone induces a vascular inflammatory phenotype in rat heart.","volume":"283","author":"Rocha","year":"2002","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"R29-4-20210227","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.1161\/01.CIR.58.6.1072","article-title":"Recommendations regarding quantitation in M-mode echocardiography: results of survey of echocardiographic measurements.","volume":"58","author":"Sahn","year":"1978","journal-title":"Circulation"},{"key":"R30-4-20210227","first-page":"206","article-title":"Aldosterone blockade by spironolactone improves the hypertensive vascular hypertrophy and remodeling in angiotensin II overproducing transgenic mice.","volume":"60","author":"Sakurabayashi-Kitade","year":"2009","journal-title":"Atherosclerosis"},{"key":"R31-4-20210227","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.amjhyper.2003.10.007","article-title":"Mice lacking osteopontin exhibit increased left ventricular dilation and reduced fibrosis after aldosterone infusion.","volume":"17","author":"Sam","year":"2004","journal-title":"Am J Hypertens"},{"key":"R32-4-20210227","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1042\/cs1020381","article-title":"Aldosterone synthase (CYP11B2) expression and myocardial fibrosis in the failing human heart.","volume":"102","author":"Satoh","year":"2002","journal-title":"Clin Sci"},{"key":"R33-4-20210227","doi-asserted-by":"crossref","first-page":"4883","DOI":"10.1074\/jbc.273.9.4883","article-title":"Myocardial production of aldosterone and corticosterone in the rat.","volume":"273","author":"Silvestre","year":"1998","journal-title":"J Biol Chem"},{"key":"R34-4-20210227","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/0002-9149(76)90491-4","article-title":"Problems in echocardiographic volume determinations: echocardiographic angiographic correlations in the presence or absence of asynergy.","volume":"37","author":"Teichholz","year":"1976","journal-title":"Am J Cardiol"},{"issue":"5","key":"R35-4-20210227","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1161\/01.HYP.0000164567.62172.c5","article-title":"Aldosterone receptor blockade prevents the transition to cardiac pump dysfunction induced by -adrenoreceptor activation.","volume":"45","author":"Veliotes","year":"2005","journal-title":"Hypertension"},{"issue":"8","key":"R36-4-20210227","doi-asserted-by":"crossref","first-page":"3321","DOI":"10.1210\/en.2003-0109","article-title":"Regulation of aldosterone synthase gene expression in the rat adrenal gland and central nervous system by sodium and angiotensin II.","volume":"144","author":"Ye","year":"2003","journal-title":"Endocrinology"},{"key":"R37-4-20210227","doi-asserted-by":"crossref","first-page":"3936","DOI":"10.1210\/jcem.87.8.8731","article-title":"Expression of aldosterone synthase gene in failing human heart: quantitative analysis using modified real-time polymerase chain reaction.","volume":"87","author":"Yoshimura","year":"2002","journal-title":"J Clin Endocrinol Metabol"},{"issue":"6","key":"R38-4-20210227","doi-asserted-by":"crossref","first-page":"1849","DOI":"10.1161\/01.CIR.83.6.1849","article-title":"Pathological hypertrophy and cardiac interstitium. Fibrosis and renin-angiotensin-aldosterone system.","volume":"83","author":"Weber","year":"1991","journal-title":"Circulation"},{"key":"R39-4-20210227","first-page":"2192","article-title":"Blockades of angiotensin and aldosterone reduce osteopontin expression and interstitial fibrosis infiltration in rats with myocardial infarction.","volume":"121","author":"Zhang","year":"2008","journal-title":"J Clin Med"},{"key":"R40-4-20210227","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1111\/j.1440-1681.2003.03942.x","article-title":"Role of angiotensin AT1 and AT2 receptors in cardiac hypertrophy and cardiac remodelling.","volume":"30","author":"Zhu","year":"2003","journal-title":"Clin Exp Pharmacol Physiol"}],"container-title":["Medicine &amp; Science in Sports &amp; Exercise"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/00005768-201110000-00004","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T14:54:12Z","timestamp":1787324052000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/00005768-201110000-00004"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,10]]},"references-count":40,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2011]]}},"URL":"https:\/\/doi.org\/10.1249\/mss.0b013e318217e8b6","relation":{},"ISSN":["0195-9131"],"issn-type":[{"value":"0195-9131","type":"print"}],"subject":[],"published":{"date-parts":[[2011,10]]}}}