{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,15]],"date-time":"2025-12-15T19:47:07Z","timestamp":1765828027788,"version":"3.40.4"},"reference-count":51,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"8","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:sec>\n            <jats:title>Purpose<\/jats:title>\n            <jats:p>This study aimed to determine the role of mammalian target of rapamycin (mTORC1) activation and catabolic markers in resistance training\u2019s (RT) antiatrophy effect during cachexia-induced muscle loss.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods<\/jats:title>\n            <jats:p>Myofiber atrophy was induced by injecting Walker 256 tumor cells into rats exposed or not exposed to the RT protocol of ladder climbing. The role of RT-induced anabolic stimulation was investigated in tumor-bearing rats with the mTORC1 inhibitor rapamycin, and cross-sectional areas of skeletal muscle were evaluated to identify atrophy or hypertrophy. Components of the mTORC1 and ubiquitin\u2013proteasome pathways were assessed by real-time polymerase chain reaction or immunoblotting.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>Although RT prevented myofiber atrophy and impaired the strength of tumor-bearing rats, in healthy rats, it promoted activated mTORC1, as demonstrated by p70S6K\u2019s increased phosphorylation and myofiber\u2019s enlarged cross-sectional area. However, RT promoted no changes in the ratio of p70S6K to phospho-p70S6K protein expression while prevented myofiber atrophy in tumor-bearing rats. Beyond that, treatment with rapamycin did not preclude RT\u2019s preventive effect on myofiber atrophy in tumor-bearing rats. Thus, RT\u2019s ability to prevent cancer-induced myofiber atrophy seems to be independent of mTORC1\u2019s and p70S6K\u2019s activation. Indeed, RT\u2019s preventive effect on cancer-induced myofiber atrophy was associated with its capacity to attenuate elevated tumor necrosis factor \u03b1 and interleukin 6 as well as to prevent oxidative damage in muscles and an elevated abundance of atrogin-1.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p>By inducing attenuated myofiber atrophy independent of mTORC1\u2019s signaling activation, RT prevents muscle atrophy during cancer by reducing inflammation, oxidative damage, and atrogin-1 expression.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1249\/mss.0000000000002624","type":"journal-article","created":{"date-parts":[[2021,3,18]],"date-time":"2021-03-18T05:02:42Z","timestamp":1616043762000},"page":"1572-1582","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":15,"title":["Resistance Training\u2019s Ability to Prevent Cancer-induced Muscle Atrophy Extends Anabolic Stimulus"],"prefix":"10.1249","volume":"53","author":[{"given":"CAMILA S.","family":"PADILHA","sequence":"first","affiliation":[]},{"given":"PAOLA S.","family":"CELLA","sequence":"additional","affiliation":[{"name":"Department of Physical Education, State University of Londrina, Londrina, PR, BRAZIL"}]},{"given":"PATR\u00cdCIA","family":"CHIMIN","sequence":"additional","affiliation":[{"name":"Department of Physical Education, State University of Londrina, Londrina, PR, BRAZIL"}]},{"given":"FABR\u00cdCIO A.","family":"VOLTARELLI","sequence":"additional","affiliation":[{"name":"Federal University of Mato Grosso, Graduate Program of Health Sciences, Faculty of Medicine, Cuiab\u00e1, BRAZIL"}]},{"given":"POLIANA C.","family":"MARINELLO","sequence":"additional","affiliation":[]},{"given":"MAYRA TARDELLI DE JESUS","family":"TESTA","sequence":"additional","affiliation":[{"name":"Department of Physical Education, State University of Londrina, Londrina, PR, BRAZIL"}]},{"given":"PHILIPPE B.","family":"GUIRRO","sequence":"additional","affiliation":[{"name":"Department of Physical Education, State University of Londrina, Londrina, PR, BRAZIL"}]},{"given":"JOS\u00c9 A. R.","family":"DUARTE","sequence":"additional","affiliation":[{"name":"University of Porto, CIAFEL, Faculty of Sport, Porto, PORTUGAL"}]},{"given":"RUBENS","family":"CECCHINI","sequence":"additional","affiliation":[{"name":"State University of Londrina, Department of General Pathology, Londrina, PR, BRAZIL"}]},{"given":"FL\u00c1VIA A.","family":"GUARNIER","sequence":"additional","affiliation":[{"name":"State University of Londrina, Department of General Pathology, Londrina, PR, BRAZIL"}]},{"given":"RAFAEL","family":"DEMINICE","sequence":"additional","affiliation":[{"name":"Department of Physical Education, State University of Londrina, Londrina, PR, BRAZIL"}]}],"member":"276","published-online":{"date-parts":[[2021,3,16]]},"reference":[{"key":"bib1-20250424","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1097\/MCO.0b013e328300ecc1","article-title":"Cachexia: prevalence and impact in medicine","volume":"11","year":"2008","journal-title":"Curr Opin Clin Nutr Metab 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