{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T05:09:53Z","timestamp":1777439393776,"version":"3.51.4"},"reference-count":49,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:sec>\n            <jats:title>Purpose<\/jats:title>\n            <jats:p>To examine the effectiveness of a supervised exercise training program (SETP) on health-related quality of life (HRQoL) and functional capacity in women with breast cancer (BC) undergoing chemotherapy.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods<\/jats:title>\n            <jats:p>Ninety-three women with early-stage BC were randomly allocated to a SETP plus usual care (exercise, <jats:italic toggle=\"yes\">n<\/jats:italic> = 47) or usual care alone (UC, <jats:italic toggle=\"yes\">n<\/jats:italic> = 46). The SETP included three sessions per week, combining aerobic and resistance training, conducted concurrently over the chemotherapy. The EORTC Cancer Quality-of-Life-Questionnaire-Core-30 (QLQ-C30) and the BC-specific module (QLQ-BR23) were used to assess HRQoL. Functional capacity was analyzed by maximum voluntary handgrip strength (MVHS) and by the 30-s chair sit-to-stand test (30-s CST). These endpoints were assessed at baseline (t0); middle (t1; after 8 or 12 wk of t0); and at the end of chemotherapy (t2; after 20 wk of t0). Mean changes from baseline were assessed by an intention-to-treat approach.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>Mixed linear model analyses showed that Exercise group experienced less deterioration in several domains of QLQ-C30 at t2, including in global health status\/QoL (\u0394 = 9.39 units; <jats:italic toggle=\"yes\">P<\/jats:italic> = 0.034), QLQ-C30 summary score (\u0394 = 8.08 units; <jats:italic toggle=\"yes\">P<\/jats:italic> &lt; 0.001), physical (\u0394 = 15.14 units; <jats:italic toggle=\"yes\">P<\/jats:italic> &lt; 0.001), role <jats:italic toggle=\"yes\">(<\/jats:italic>\u0394 = 21.81 units; <jats:italic toggle=\"yes\">P<\/jats:italic> &lt; 0.001), cognitive (\u0394 = 9.16 units; <jats:italic toggle=\"yes\">P<\/jats:italic> = 0.032) and social functioning (\u0394 = 11.67 units; <jats:italic toggle=\"yes\">P<\/jats:italic> = 0.038), compared with the UC group. Similarly, Exercise group exhibited significant lower levels of fatigue (\u0394 = \u221220.19 units; <jats:italic toggle=\"yes\">P<\/jats:italic> &lt; 0.001) and appetite loss (\u0394 = \u221213.69 units; <jats:italic toggle=\"yes\">P<\/jats:italic> = 0.034), compared with the UC group. Significant between-group differences were observed on MVHS of the tumor\/surgery upper limb side (\u0394 = 2.64 kg; <jats:italic toggle=\"yes\">P<\/jats:italic> &lt; 0.001) and contralateral limb (\u0394 = 2.22 kg; <jats:italic toggle=\"yes\">P<\/jats:italic> &lt; 0.001), and on the 30-s CST score (\u0394 = 3.56repetitions; <jats:italic toggle=\"yes\">P<\/jats:italic> &lt; 0.001), favoring the Exercise group. No differences were observed on QLQ-BR23 domains.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p>Exercise training was an effective complementary therapy to prevent the deterioration of HRQoL and functional capacity during chemotherapy in women with early-stage BC.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1249\/mss.0000000000003341","type":"journal-article","created":{"date-parts":[[2023,12,5]],"date-time":"2023-12-05T15:00:39Z","timestamp":1701788439000},"page":"600-611","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":25,"title":["Exercise Training Benefits Health-Related Quality of Life and Functional Capacity during Breast Cancer Chemotherapy: A Randomized Controlled Trial"],"prefix":"10.1249","volume":"56","author":[{"given":"PEDRO","family":"ANTUNES","sequence":"first","affiliation":[]},{"given":"ANA","family":"JOAQUIM","sequence":"additional","affiliation":[]},{"given":"FRANCISCO","family":"SAMPAIO","sequence":"additional","affiliation":[]},{"given":"C\u00c9LIA","family":"NUNES","sequence":"additional","affiliation":[{"name":"Department of Mathematics and Center of Mathematics and Applications, University of Beira Interior, Covilh\u00e3, PORTUGAL"}]},{"given":"ANT\u00d3NIO","family":"ASCENS\u00c3O","sequence":"additional","affiliation":[{"name":"Laboratory of Metabolism and Exercise (LaMetEx), Research Centre in Physical Activity, Health and Leisure (CIAFEL), Laboratory for Integrative and Translational Research in Population Health (ITR), Faculty of Sports, University of Porto, Porto, PORTUGAL"}]},{"given":"EDUARDO","family":"VILELA","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Centro Hospitalar de Vila Nova de Gaia\/Espinho, Vila Nova de Gaia, PORTUGAL"}]},{"given":"MADALENA","family":"TEIXEIRA","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Centro Hospitalar de Vila Nova de Gaia\/Espinho, Vila Nova de Gaia, PORTUGAL"}]},{"given":"JORGE","family":"OLIVEIRA","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Centro Hospitalar de Vila Nova de Gaia\/Espinho, Vila Nova de Gaia, PORTUGAL"}]},{"given":"ANDREIA","family":"CAPELA","sequence":"additional","affiliation":[]},{"given":"ANABELA","family":"AMARELO","sequence":"additional","affiliation":[]},{"given":"IN\u00caS","family":"LE\u00c3O","sequence":"additional","affiliation":[]},{"given":"CRISTIANA","family":"MARQUES","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Centro Hospitalar de Vila Nova de Gaia\/Espinho, Vila Nova de Gaia, PORTUGAL"}]},{"given":"SOFIA","family":"VIAMONTE","sequence":"additional","affiliation":[]},{"given":"ALBERTO","family":"ALVES","sequence":"additional","affiliation":[]},{"given":"DULCE","family":"ESTEVES","sequence":"additional","affiliation":[{"name":"Research Center in Sport Sciences, Health and Human Development (CIDESD), Sport Sciences Department, University of Beira Interior, PORTUGAL"}]}],"member":"276","published-online":{"date-parts":[[2023,11,27]]},"reference":[{"issue":"8","key":"bib1-20250424","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.1093\/annonc\/mdz173","article-title":"Early breast cancer: ESMO clinical practice guidelines for diagnosis, treatment and follow-up","volume":"30","year":"2019","journal-title":"Ann Oncol"},{"issue":"9814","key":"bib2-20250424","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1016\/S0140-6736(11)61625-5","article-title":"Comparisons between different polychemotherapy regimens for early breast cancer: meta-analyses of 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