{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T02:58:56Z","timestamp":1773284336141,"version":"3.50.1"},"reference-count":44,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:sec>\n            <jats:title>Introduction<\/jats:title>\n            <jats:p>Platelet-rich plasma (PRP) has been used for arthroscopic rotator cuff repairs (aRCR), but no studies have addressed the impact of platelet concentration. The primary aim was to evaluate whether the PRP cell concentration has an effect on tendon healing after aRCR compared with surgery alone. The secondary aim was to assess the functional and pain outcomes.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Materials and Methods<\/jats:title>\n            <jats:p>A systematic review was performed with searches in the MEDLINE (PubMed), Scopus, Web of Science, and Cochrane (Central) databases according to Preferred Reporting Items for Systematic Reviews and Meta-Analysis guidelines. Metanalytic procedures were performed for randomized controlled trials (RCTs), and a subgroup analysis was used for studies with target (approximately 10<jats:sup>6<\/jats:sup> cells\u00b7\u03bcL<jats:sup>\u22121<\/jats:sup>) or below-target PRP cellular concentrations (app. 5 \u00d7 10<jats:sup>5<\/jats:sup> cells\u00b7\u03bcL<jats:sup>\u22121<\/jats:sup>) regarding the primary outcome of tendon healing.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>This review included 10 studies (8 RCTs) with 342 patients in the aRCR + PRP group and 344 patients with isolated aRCR. The risk of bias was low to intermediate (6\/4, respectively). Meta-analysis of the RCT revealed that the aRCR + high-concentration PRP group had an approximately 3.9-fold higher chance of healing than the non-PRP group (odds ratio, 3.89; 95% confidence interval, 1.78\u20138.44; <jats:italic toggle=\"yes\">P<\/jats:italic> = 0.0007). No significant difference in healing was found between the aRCR + low-concentration PRP and non-PRP groups (odds ratio, 2.21; 95% confidence interval, 0.66\u20137.45; <jats:italic toggle=\"yes\">P<\/jats:italic> = 0.2). The Constant\u2013Murley score and University of California Los Angeles scores were significantly improved in the aRCR + PRP groups with more than 12 months of follow-up, and no significant differences were found consistently for the American Shoulder and Elbow Society and visual analog scale scores.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p>This study highlights that a PRP cell concentration close to the target (10<jats:sup>6<\/jats:sup> cells\u00b7\u03bcL<jats:sup>\u22121<\/jats:sup>) of patients with aRCR may improve their healing and functional outcomes and that dosing may be potentially useful in therapy.<\/jats:p>\n          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Network, MEDCIDS\u2013Department of Community Medicine, Information and Health Decision Sciences, Faculty of Medicine of the University of Porto, Porto, PORTUGAL"}]},{"given":"RAPH\u00c4EL","family":"CANADAS","sequence":"additional","affiliation":[]},{"given":"MANUEL","family":"GUTIERRES","sequence":"additional","affiliation":[]}],"member":"276","published-online":{"date-parts":[[2024,3,14]]},"reference":[{"issue":"4","key":"bib1-20250424","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/j.otsr.2011.01.012","article-title":"Occupational outcome after surgery in patients with a rotator cuff tear due to a work-related injury or occupational disease. a series of 262 cases","volume":"97","year":"2011","journal-title":"Orthop Traumatol Surg Res"},{"issue":"80","key":"bib2-20250424","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3310\/hta19800","article-title":"Clinical effectiveness and cost-effectiveness of open and arthroscopic rotator cuff repair [the UK Rotator 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