{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T22:12:56Z","timestamp":1774390376364,"version":"3.50.1"},"reference-count":34,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,3]]},"abstract":"\n Purpose:<\/jats:title>\n This study investigated the relationship between muscle thickness and raw and derived bioelectrical impedance analysis (BIA) parameters following 12\u2009wk of resistance training (RT) in older women.<\/jats:p>\n <\/jats:sec>\n \n Methods:<\/jats:title>\n \n Fifty-five older women were assigned to a control group (\n n<\/jats:italic>\n = 31) or an RT group (\n n<\/jats:italic>\n = 24). Muscle thickness was assessed using B-mode ultrasound, while BIA parameters, including reactance (Xc), resistance (R), phase angle (PhA), intracellular water, extracellular water (ECW), and total body water, were measured at 50\u2009kHz. Total and appendicular lean soft tissue and fat mass were evaluated via dual-energy X-ray absorptiometry.\n <\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n \n Muscle thickness and total and appendicular lean soft tissue increased in the RT group (2.9%\u20136.2%;\n P<\/jats:italic>\n < 0.001), whereas muscle thickness decreased in the control group (\u22124.1%;\n P<\/jats:italic>\n < 0.001). Xc, PhA, and ECW also increased in the RT group (1.6%\u20135.8%;\n P<\/jats:italic>\n \u2264 0.002) but decreased in the control group (\u22121.1% to \u22125.8%;\n P<\/jats:italic>\n \u2264 0.022). In the RT group, muscle thickness was positively correlated with Xc, PhA, total body water, and ECW (\n r<\/jats:italic>\n rm<\/jats:sub>\n = 0.40\u20130.52;\n P<\/jats:italic>\n \u2264 0.023), whereas in the control group, muscle thickness correlated only with Xc, R, and PhA (\n r<\/jats:italic>\n rm<\/jats:sub>\n = 0.43\u20130.46;\n P<\/jats:italic>\n \u2264 0.015). Linear mixed models showed that muscle thickness was associated with all raw and derived BIA parameters in the RT group but only with PhA in the control group.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions:<\/jats:title>\n Our findings suggest that increases in muscle thickness resulting from a 12-wk RT program are synergistically associated with changes in both raw and derived BIA parameters, which may play a crucial role in enhancing cellular health in older women.<\/jats:p>\n <\/jats:sec>","DOI":"10.1249\/mss.0000000000003884","type":"journal-article","created":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T20:00:50Z","timestamp":1761681650000},"page":"597-605","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Synergistic Relationship between Muscle Thickness and Cellular Health after Resistance Training in Older Women"],"prefix":"10.1249","volume":"58","author":[{"given":"NAT\u00c3","family":"STAVINSKI","sequence":"first","affiliation":[{"name":"Metabolism, Nutrition, and Exercise Laboratory, Physical Education and Sport Center, State University of Londrina, Londrina, BRAZIL"}]},{"given":"GIL B.","family":"ROSA","sequence":"additional","affiliation":[{"name":"Exercise and Health Laboratory, CIPER, Faculdade Motricidade Humana, Universidade de Lisboa, Lisbon, PORTUGAL"}]},{"given":"WITALO","family":"KASSIANO","sequence":"additional","affiliation":[{"name":"Metabolism, Nutrition, and Exercise Laboratory, Physical Education and Sport Center, State University of Londrina, Londrina, BRAZIL"}]},{"given":"VANESSA","family":"SANTOS-MELO","sequence":"additional","affiliation":[{"name":"Metabolism, Nutrition, and Exercise Laboratory, Physical Education and Sport Center, State University of Londrina, Londrina, BRAZIL"}]},{"given":"ALINE","family":"PRADO","sequence":"additional","affiliation":[{"name":"Metabolism, Nutrition, and Exercise Laboratory, Physical Education and Sport Center, State University of Londrina, Londrina, BRAZIL"}]},{"given":"JARLISSON","family":"FRANCSUEL","sequence":"additional","affiliation":[{"name":"Metabolism, Nutrition, and Exercise Laboratory, Physical Education and Sport Center, State University of Londrina, Londrina, BRAZIL"}]},{"given":"FELIPE","family":"LISBOA","sequence":"additional","affiliation":[{"name":"Metabolism, Nutrition, and Exercise Laboratory, Physical Education and Sport Center, State University of Londrina, Londrina, BRAZIL"}]},{"given":"ALEXANDRE M.","family":"CAVALCANTI","sequence":"additional","affiliation":[{"name":"Metabolism, Nutrition, and Exercise Laboratory, Physical Education and Sport Center, State University of Londrina, Londrina, BRAZIL"}]},{"given":"LET\u00cdCIA T.","family":"CYRINO","sequence":"additional","affiliation":[{"name":"Metabolism, Nutrition, and Exercise Laboratory, Physical Education and Sport Center, State University of Londrina, Londrina, BRAZIL"}]},{"given":"GABRIEL","family":"KUNEVALIKI","sequence":"additional","affiliation":[{"name":"Metabolism, Nutrition, and Exercise Laboratory, Physical Education and Sport Center, State University of Londrina, Londrina, BRAZIL"}]},{"given":"MELISSA","family":"ANTUNES","sequence":"additional","affiliation":[{"name":"Metabolism, Nutrition, and Exercise Laboratory, Physical Education and Sport Center, State University of Londrina, Londrina, BRAZIL"}]},{"given":"RICARDO J.","family":"RODRIGUES","sequence":"additional","affiliation":[{"name":"Metabolism, Nutrition, and Exercise Laboratory, Physical Education and Sport Center, State University of Londrina, Londrina, BRAZIL"}]},{"given":"JO\u00c3O P.","family":"MAGALH\u00c3ES","sequence":"additional","affiliation":[{"name":"Exercise and Health Laboratory, CIPER, Faculdade Motricidade Humana, Universidade de Lisboa, Lisbon, PORTUGAL"}]},{"given":"ANALIZA M.","family":"SILVA","sequence":"additional","affiliation":[{"name":"Exercise and Health Laboratory, CIPER, Faculdade Motricidade Humana, Universidade de Lisboa, Lisbon, PORTUGAL"}]},{"given":"LU\u00cdS B.","family":"SARDINHA","sequence":"additional","affiliation":[{"name":"Exercise and Health Laboratory, CIPER, Faculdade Motricidade Humana, Universidade de Lisboa, Lisbon, PORTUGAL"}]},{"given":"EDILSON S.","family":"CYRINO","sequence":"additional","affiliation":[{"name":"Metabolism, Nutrition, and Exercise Laboratory, Physical Education and Sport Center, State University of Londrina, Londrina, BRAZIL"}]}],"member":"276","published-online":{"date-parts":[[2025,10,27]]},"reference":[{"issue":"3","key":"R1-20260324","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1007\/s11154-022-09775-0","article-title":"Phase angle and cellular health: inflammation and oxidative damage.","volume":"24","author":"da Silva","year":"2023","journal-title":"Rev Endocr Metab Disord"},{"key":"R2-20260324","doi-asserted-by":"crossref","first-page":"111493","DOI":"10.1016\/j.nut.2021.111493","article-title":"Exploring the potential role of phase angle as a marker of oxidative stress: a narrative review.","volume":"93","author":"da Silva","year":"2022","journal-title":"Nutrition"},{"issue":"3","key":"R3-20260324","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1007\/s11154-022-09780-3","article-title":"Bioimpedance basics and phase angle fundamentals.","volume":"24","author":"Ward","year":"2023","journal-title":"Rev Endocr Metab Disord"},{"key":"R4-20260324","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1111\/j.1749-6632.2000.tb06441.x","article-title":"Bioelectrical impedance analysis. What does it measure?","volume":"904","author":"Schoeller","year":"2000","journal-title":"Ann N Y Acad Sci"},{"issue":"5","key":"R5-20260324","doi-asserted-by":"crossref","first-page":"1411","DOI":"10.1016\/j.clnu.2019.07.004","article-title":"Reference values for the phase angle of the electrical bioimpedance: systematic review and meta-analysis involving more than 250,000 subjects.","volume":"39","author":"Mattiello","year":"2020","journal-title":"Clin Nutr"},{"issue":"2","key":"R6-20260324","doi-asserted-by":"crossref","first-page":"afac328","DOI":"10.1093\/ageing\/afac328","article-title":"Inflammaging as a target for healthy ageing.","volume":"52","author":"Dugan","year":"2023","journal-title":"Age Ageing"},{"issue":"3","key":"R7-20260324","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1007\/s11154-022-09747-4","article-title":"Effect of resistance training on bioelectrical phase angle in older adults: a systematic review with meta-analysis of randomized controlled trials.","volume":"24","author":"Campa","year":"2023","journal-title":"Rev Endocr Metab Disord"},{"issue":"3","key":"R8-20260324","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1007\/s11154-023-09791-8","article-title":"Phase angle, muscle tissue, and resistance training.","volume":"24","author":"Sardinha","year":"2023","journal-title":"Rev Endocr Metab Disord"},{"issue":"1","key":"R9-20260324","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1186\/s12970-019-0325-4","article-title":"Changes in total and segmental bioelectrical resistance are correlated with whole-body and segmental changes in lean soft tissue following a resistance training intervention.","volume":"16","author":"Tinsley","year":"2019","journal-title":"J Int Soc Sports Nutr"},{"issue":"2","key":"R10-20260324","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1002\/jcsm.12941","article-title":"Effects of resistance training intensity on muscle quantity\/quality in middle-aged and older people: a randomized controlled trial.","volume":"13","author":"Otsuka","year":"2022","journal-title":"J Cachexia Sarcopenia Muscle"},{"issue":"10","key":"R11-20260324","doi-asserted-by":"crossref","first-page":"2173","DOI":"10.1111\/sms.13232","article-title":"Correlations between resistance training-induced changes on phase angle and biochemical markers in older women.","volume":"28","author":"Tomeleri","year":"2018","journal-title":"Scand J Med Sci Sports"},{"issue":"3 Suppl","key":"R12-20260324","first-page":"524S","article-title":"Bioelectrical impedance analysis in body composition measurement: National Institutes of Health Technology Assessment Conference.","volume":"64","author":"Yanovski","year":"1996","journal-title":"Am J Clin Nutr"},{"issue":"1","key":"R13-20260324","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/s42358-022-00241-8","article-title":"Official position of the Brazilian Association of Bone Assessment and Metabolism (ABRASSO) on the evaluation of body composition by densitometry: part I (technical aspects)\u2014general concepts, indications, acquisition, and analysis.","volume":"62","author":"Maeda","year":"2022","journal-title":"Adv Rheumatol"},{"issue":"3","key":"R14-20260324","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1249\/MSS.0b013e3181915670","article-title":"American College of Sports Medicine position stand. Progression models in resistance training for healthy adults.","volume":"41","year":"2009","journal-title":"Med Sci Sports Exerc"},{"issue":"3","key":"R15-20260324","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1111\/sms.12961","article-title":"Muscle thickness correlates to muscle cross-sectional area in the assessment of strength training-induced hypertrophy.","volume":"28","author":"Franchi","year":"2018","journal-title":"Scand J Med Sci Sports"},{"issue":"1","key":"R16-20260324","doi-asserted-by":"crossref","first-page":"e14683","DOI":"10.14814\/phy2.14683","article-title":"Methodological considerations for and validation of the ultrasonographic determination of human skeletal muscle hypertrophy and atrophy.","volume":"9","author":"Stokes","year":"2021","journal-title":"Physiol Rep"},{"issue":"1","key":"R17-20260324","doi-asserted-by":"crossref","first-page":"10028","DOI":"10.1038\/s41598-019-46428-w","article-title":"Changes in DXA-derived lean mass and MRI-derived cross-sectional area of the thigh are modestly associated.","volume":"9","author":"Tavoian","year":"2019","journal-title":"Sci Rep"},{"issue":"24","key":"R18-20260324","doi-asserted-by":"crossref","first-page":"2843","DOI":"10.1080\/02640414.2018.1479103","article-title":"Improvement of cellular health indicators and muscle quality in older women with different resistance training volumes.","volume":"36","author":"Cunha","year":"2018","journal-title":"J Sports Sci"},{"issue":"10","key":"R19-20260324","doi-asserted-by":"crossref","first-page":"2996","DOI":"10.1519\/JSC.0000000000002773","article-title":"Resistance training improves a cellular health parameter in obese older women: a randomized controlled trial.","volume":"34","author":"Ribeiro","year":"2020","journal-title":"J Strength Cond Res"},{"issue":"4","key":"R20-20260324","first-page":"537","article-title":"Effects of single set resistance training with different frequencies on a cellular health indicator in older women.","volume":"26","author":"Ribeiro","year":"2018","journal-title":"J Aging Phys Act"},{"issue":"9","key":"R21-20260324","doi-asserted-by":"crossref","first-page":"1546","DOI":"10.1249\/MSS.0000000000002929","article-title":"An evidence-based narrative review of mechanisms of resistance exercise-induced human skeletal muscle hypertrophy.","volume":"54","author":"Lim","year":"2022","journal-title":"Med Sci Sports Exerc"},{"key":"R22-20260324","doi-asserted-by":"crossref","first-page":"816","DOI":"10.3389\/fphys.2020.00816","article-title":"Sarcoplasmic hypertrophy in skeletal muscle: a scientific \u201cunicorn\u201d or resistance training adaptation?","volume":"11","author":"Roberts","year":"2020","journal-title":"Front Physiol"},{"issue":"Pt 3","key":"R23-20260324","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1042\/bj3130697","article-title":"The role of cellular hydration in the regulation of cell function.","volume":"313","author":"H\u00e4ussinger","year":"1996","journal-title":"Biochem J"},{"issue":"2","key":"R24-20260324","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1519\/JSC.0000000000003478","article-title":"Relationship between muscle swelling and hypertrophy induced by resistance training.","volume":"36","author":"Hirono","year":"2022","journal-title":"J Strength Cond Res"},{"issue":"1","key":"R25-20260324","doi-asserted-by":"crossref","first-page":"7","DOI":"10.3390\/sports8010007","article-title":"Skeletal muscle myofibrillar protein abundance is higher in resistance-trained men, and aging in the absence of training may have an opposite effect.","volume":"8","author":"Vann","year":"2020","journal-title":"Sports (Basel)"},{"issue":"3","key":"R26-20260324","first-page":"1","article-title":"The muscle pump: potential mechanisms and applications for enhancing hypertrophic adaptations.","volume":"36","author":"Schoenfeld","year":"2014","journal-title":"Strength Cond J"},{"issue":"3","key":"R27-20260324","doi-asserted-by":"crossref","first-page":"712","DOI":"10.3945\/ajcn.115.116772","article-title":"Phase angle and its determinants in healthy subjects: influence of body composition.","volume":"103","author":"Gonzalez","year":"2016","journal-title":"Am J Clin Nutr"},{"issue":"4","key":"R28-20260324","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1152\/japplphysiol.00768.2022","article-title":"Human skeletal muscle-specific atrophy with aging: a comprehensive review.","volume":"134","author":"Naruse","year":"2023","journal-title":"J Appl Physiol (1985)"},{"issue":"6977","key":"R29-20260324","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1136\/bmj.310.6977.446","article-title":"Calculating correlation coefficients with repeated observations: part 1- correlation within subjects.","volume":"310","author":"Bland","year":"1995","journal-title":"BMJ"},{"issue":"6980","key":"R30-20260324","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1136\/bmj.310.6980.633","article-title":"Calculating correlation coefficients with repeated observations: part 2 - correlation between subjects.","volume":"310","author":"Bland","year":"1995","journal-title":"BMJ"},{"key":"R31-20260324","doi-asserted-by":"crossref","first-page":"456","DOI":"10.3389\/fpsyg.2017.00456","article-title":"Repeated measures correlation.","volume":"8","author":"Bakdash","year":"2017","journal-title":"Front Psychol"},{"key":"R32-20260324","doi-asserted-by":"crossref","first-page":"2","DOI":"10.3389\/fpsyg.2015.00002","article-title":"Linear mixed-effects models for within-participant psychology experiments: an introductory tutorial and free, graphical user interface (LMMgui).","volume":"6","author":"Magezi","year":"2015","journal-title":"Front Psychol"},{"issue":"3","key":"R33-20260324","doi-asserted-by":"crossref","first-page":"669","DOI":"10.3390\/nu11030669","article-title":"Effects of drugs and excipients on hydration status.","volume":"11","author":"Puga","year":"2019","journal-title":"Nutrients"},{"key":"R34-20260324","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.nut.2018.11.028","article-title":"Current technologies in body composition assessment: advantages and disadvantages.","volume":"62","author":"Ceniccola","year":"2019","journal-title":"Nutrition"}],"container-title":["Medicine & Science in Sports & Exercise"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.lww.com\/10.1249\/MSS.0000000000003884","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T20:01:26Z","timestamp":1774382486000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/10.1249\/MSS.0000000000003884"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,27]]},"references-count":34,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026]]}},"URL":"https:\/\/doi.org\/10.1249\/mss.0000000000003884","relation":{},"ISSN":["0195-9131","1530-0315"],"issn-type":[{"value":"0195-9131","type":"print"},{"value":"1530-0315","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,27]]}}}