{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T03:40:55Z","timestamp":1760672455141,"version":"build-2065373602"},"reference-count":34,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":["Transl J ACSM"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:sec>\n            <jats:title>Introduction<\/jats:title>\n            <jats:p>Preoperative risk assessment is essential for identifying high-risk patients who may benefit from prehabilitation programs. This preliminary study aimed to examine the impact of preoperative probable sarcopenia (PS) on postoperative outcomes in patients undergoing gastric cancer surgery.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods<\/jats:title>\n            <jats:p>A cross-sectional study was conducted in patients with gastric cancer eligible for major elective surgery at the Instituto Portugu\u00eas de Oncologia, Porto, between December 2018 and July 2019. PS was defined as low muscle strength (&lt; 27 kg for males and &lt; 16 kg for females), assessed using a handgrip strength test. Postoperative outcomes included postoperative complications (POCs), length of hospital stay (LOS), need for admission to the intermediate care unit (ICU), 30-d readmission, 30-d reintervention, and 1-yr mortality. Fisher\u2019s exact test or the Fisher\u2013Freeman\u2013Halton exact test were used to analyze associations between PS and outcomes. A <jats:italic toggle=\"yes\">P<\/jats:italic> value &lt; 0.05 was considered statistically significant.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>Forty-three patients were included (60.5% male; mean age, 64 \u00b1 13 yr). Of those, seven (19.44%) were classified as having PS. The frequency of POCs was significantly higher in the with-PS group compared to the without-PS group (85.7% vs 33.3%; <jats:italic toggle=\"yes\">P<\/jats:italic> = 0.01), including both major (28.6% vs 16.7%; <jats:italic toggle=\"yes\">P<\/jats:italic> = 0.01) and minor (57.1% vs 16.7%; <jats:italic toggle=\"yes\">P<\/jats:italic> = 0.01) complications. Patients with PS also had higher rates of ICU admission (85.7% vs 13.9%; <jats:italic toggle=\"yes\">P<\/jats:italic> &lt; 0.001), prolonged LOS (85.7% vs 38.9%; <jats:italic toggle=\"yes\">P<\/jats:italic> = 0.04), 30-d readmission (57.1% vs 5.6%; <jats:italic toggle=\"yes\">P<\/jats:italic> = 0.004), and 30-d reintervention after discharge (42.9% vs 2.8%; <jats:italic toggle=\"yes\">P<\/jats:italic> = 0.01). No significant difference was observed in 1-yr mortality (<jats:italic toggle=\"yes\">P<\/jats:italic> = 0.30).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion<\/jats:title>\n            <jats:p>These preliminary findings suggest that preoperative PS is associated with poorer postoperative outcomes in gastric cancer patients. Early identification of patients with PS may support timely optimization strategies such as prehabilitation.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1249\/tjx.0000000000000328","type":"journal-article","created":{"date-parts":[[2025,10,14]],"date-time":"2025-10-14T15:26:52Z","timestamp":1760455612000},"update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Preoperative Probable Sarcopenia and Postoperative Outcomes in Gastric Cancer: A Cross-Sectional Preliminary Study"],"prefix":"10.1249","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2938-1623","authenticated-orcid":false,"given":"Clara","family":"Gentil-Daher","sequence":"first","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8156-4470","authenticated-orcid":false,"given":"Carolina","family":"Castro","sequence":"additional","affiliation":[{"name":"Experimental Pathology and Therapeutics Group, Portuguese Oncology Institute of Porto (IPO Porto)\/Porto Comprehensive Cancer Centre (Porto.CCC) & RISE@CI-IPOP (Health Research Network), Porto, PORTUGAL"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9904-5115","authenticated-orcid":false,"given":"Jo\u00e3o","family":"Antunes","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0521-5655","authenticated-orcid":false,"given":"L\u00facio","family":"Lara-Santos","sequence":"additional","affiliation":[{"name":"Experimental Pathology and Therapeutics Group, Portuguese Oncology Institute of Porto (IPO Porto)\/Porto Comprehensive Cancer Centre (Porto.CCC) & RISE@CI-IPOP (Health Research Network), Porto, PORTUGAL"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7404-7405","authenticated-orcid":false,"given":"Daniel","family":"Moreira-Gon\u00e7alves","sequence":"additional","affiliation":[]}],"member":"276","published-online":{"date-parts":[[2025,10]]},"reference":[{"issue":"3","key":"bib1-20251017","first-page":"229","article-title":"Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"74","year":"2024","journal-title":"CA Cancer J Clin"},{"issue":"10272","key":"bib2-20251017","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/S0140-6736(21)00001-5","article-title":"Global variation in postoperative mortality and complications after cancer surgery: a multicentre, prospective cohort study in 82 countries","volume":"397","year":"2021","journal-title":"Lancet"},{"issue":"2","key":"bib3-20251017","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1097\/SLA.0000000000000378","article-title":"Postoperative complications reduce adjuvant chemotherapy use in resectable pancreatic cancer","volume":"260","year":"2014","journal-title":"Ann Surg"},{"issue":"4","key":"bib4-20251017","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1016\/j.ejso.2018.10.063","article-title":"Is preoperative physical activity level of patients undergoing cancer surgery associated with postoperative outcomes? A systematic review and meta-analysis","volume":"45","year":"2019","journal-title":"Eur J Surg Oncol"},{"issue":"5","key":"bib5-20251017","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1016\/j.jamcollsurg.2004.05.280","article-title":"Functional independence after major abdominal surgery in the elderly","volume":"199","year":"2004","journal-title":"J Am Coll Surg"},{"issue":"42","key":"bib6-20251017","doi-asserted-by":"crossref","first-page":"4660","DOI":"10.3748\/wjg.v17.i42.4660","article-title":"Systematic review of health-related quality of life after esophagectomy for esophageal cancer","volume":"17","year":"2011","journal-title":"World J Gastroenterol"},{"issue":"9","key":"bib7-20251017","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1308\/rcsann.2021.0082","article-title":"Sarcopenia as a predictor of postoperative risk of complications, mortality and length of stay following gastrointestinal oncological surgery","volume":"103","year":"2021","journal-title":"Ann R Coll Surg Engl"},{"issue":"3","key":"bib8-20251017","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1007\/s00464-023-10638-1","article-title":"Effect of sarcopenia on short-term and long-term outcomes of older patients with locally advanced gastric cancer: a multicenter study","volume":"38","year":"2024","journal-title":"Surg Endosc"},{"issue":"11","key":"bib9-20251017","doi-asserted-by":"crossref","first-page":"1890","DOI":"10.1007\/s11605-018-3856-0","article-title":"Predictive value of preoperative sarcopenia in patients with gastric cancer: a meta-analysis and systematic review","volume":"22","year":"2018","journal-title":"J Gastrointest Surg"},{"issue":"1","key":"bib10-20251017","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1093\/ageing\/afy169","article-title":"Sarcopenia: revised European consensus on definition and diagnosis","volume":"48","year":"2019","journal-title":"Age Ageing"},{"issue":"7\u20138","key":"bib11-20251017","first-page":"157","article-title":"Sarcopenia","volume":"169","year":"2019","journal-title":"Wien Med Wochenschr"},{"issue":"12","key":"bib12-20251017","doi-asserted-by":"crossref","first-page":"1500","DOI":"10.1016\/j.ijsu.2014.07.014","article-title":"Strengthening the Reporting of Observational Studies in Epidemiology (STROBE): explanation and elaboration","volume":"12","year":"2014","journal-title":"Int J Surg"},{"issue":"6","key":"bib13-20251017","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1080\/07357907.2024.2363879","article-title":"Prognostic effects of sarcopenia on patients with bladder cancer: a systematic review and meta-analysis","volume":"42","year":"2024","journal-title":"Cancer Invest"},{"issue":"1","key":"bib14-20251017","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1002\/jcsm.13126","article-title":"The prognostic value of sarcopenia in oesophageal cancer: a systematic review and meta-analysis","volume":"14","year":"2023","journal-title":"J Cachexia Sarcopenia Muscle"},{"issue":"1","key":"bib15-20251017","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1186\/s12885-023-11073-0","article-title":"The impact of sarcopenia on the outcome of patients with left-sided colon and rectal cancer after curative surgery","volume":"23","year":"2023","journal-title":"BMC Cancer"},{"issue":"5","key":"bib16-20251017","doi-asserted-by":"crossref","first-page":"e311","DOI":"10.1097\/SLA.0000000000005452","article-title":"Sarcopenia determined by skeletal muscle index predicts overall survival, disease-free survival, and postoperative complications in resectable esophageal cancer: a systematic review and meta-analysis","volume":"276","year":"2022","journal-title":"Ann Surg"},{"issue":"2","key":"bib17-20251017","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1177\/00369330241234690","article-title":"Impact of sarcopenia on outcomes of bladder cancer undergoing radical cystectomy: a systematic review and meta-analysis","volume":"69","year":"2024","journal-title":"Scott Med J"},{"issue":"12","key":"bib18-20251017","doi-asserted-by":"crossref","first-page":"1448","DOI":"10.1002\/bjs.9893","article-title":"Systematic review of sarcopenia in patients operated on for gastrointestinal and hepatopancreatobiliary malignancies","volume":"102","year":"2015","journal-title":"Br J Surg"},{"issue":"4","key":"bib19-20251017","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1016\/j.ejso.2021.10.018","article-title":"Sarcopenia assessed by skeletal muscle mass volume is a prognostic factor for oncological outcomes of rectal cancer patients undergoing neoadjuvant chemoradiotherapy followed by surgery","volume":"48","year":"2022","journal-title":"Eur J Surg Oncol"},{"issue":"7","key":"bib20-20251017","doi-asserted-by":"crossref","first-page":"1484","DOI":"10.3390\/nu14071484","article-title":"Poor physical performance is associated with postoperative complications and mortality in preoperative patients with colorectal cancer","volume":"14","year":"2022","journal-title":"Nutrients"},{"issue":"9","key":"bib21-20251017","doi-asserted-by":"crossref","first-page":"3173","DOI":"10.1245\/s10434-020-08520-8","article-title":"Handgrip strength predicts postoperative pneumonia after thoracoscopic\u2013laparoscopic esophagectomy for patients with esophageal cancer","volume":"27","year":"2020","journal-title":"Ann Surg Oncol"},{"issue":"6","key":"bib22-20251017","first-page":"370","article-title":"Is the ECOG-PS similar to the sarcopenia status for predicting mortality in older adults with cancer? A prospective cohort study","volume":"31","year":"2023","journal-title":"Support Care Cancer"},{"issue":"10","key":"bib23-20251017","doi-asserted-by":"crossref","first-page":"1148","DOI":"10.1007\/s12603-018-1139-9","article-title":"International clinical practice guidelines for sarcopenia (ICFSR): screening, diagnosis and management","volume":"22","year":"2018","journal-title":"J Nutr Health Aging"},{"key":"bib24-20251017","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.maturitas.2020.12.009","article-title":"Exercise, nutrition, and combined exercise and nutrition in older adults with sarcopenia: a systematic review and network meta-analysis","volume":"145","year":"2021","journal-title":"Maturitas"},{"issue":"1","key":"bib25-20251017","first-page":"23","article-title":"Optimizing functional exercise capacity in the elderly surgical population","volume":"8","year":"2005","journal-title":"Curr Opin Clin Nutr Metab Care"},{"issue":"3","key":"bib26-20251017","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1016\/j.bja.2021.12.007","article-title":"Prehabilitation, enhanced recovery after surgery, or both? A narrative review","volume":"128","year":"2022","journal-title":"Br J Anaesth"},{"issue":"2","key":"bib27-20251017","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.suronc.2018.05.010","article-title":"Prehabilitation for radical prostatectomy: a multicentre randomized controlled trial","volume":"27","year":"2018","journal-title":"Surg Oncol"},{"issue":"9","key":"bib28-20251017","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1007\/s10151-020-02262-1","article-title":"Does prehabilitation modify muscle mass in patients with rectal cancer undergoing neoadjuvant therapy? A subanalysis from the REx randomised controlled trial","volume":"24","year":"2020","journal-title":"Tech Coloproctol"},{"issue":"3","key":"bib29-20251017","doi-asserted-by":"crossref","first-page":"1839","DOI":"10.1245\/s10434-021-11002-0","article-title":"Multimodal prehabilitation during neoadjuvant therapy prior to esophagogastric cancer resection: effect on cardiopulmonary exercise test performance, muscle mass and quality of life\u2014a pilot randomized clinical trial","volume":"29","year":"2022","journal-title":"Ann Surg Oncol"},{"issue":"1","key":"bib30-20251017","first-page":"39","article-title":"The impact of prehabilitation in upper gastrointestinal cancer underwent major surgery","volume":"78","year":"2023","journal-title":"Med J Malaysia"},{"issue":"10191","key":"bib31-20251017","doi-asserted-by":"crossref","first-page":"2636","DOI":"10.1016\/S0140-6736(19)31138-9","article-title":"Sarcopenia","volume":"393","year":"2019","journal-title":"Lancet"},{"issue":"9","key":"bib32-20251017","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/j.bjae.2020.04.006","article-title":"Anaesthesia, analgesia, and the surgical stress response","volume":"20","year":"2020","journal-title":"BJA Educ"},{"issue":"6","key":"bib33-20251017","doi-asserted-by":"crossref","first-page":"1370","DOI":"10.3349\/ymj.2013.54.6.1370","article-title":"Perioperative nutritional status changes in gastrointestinal cancer patients","volume":"54","year":"2013","journal-title":"Yonsei Med J"},{"issue":"3","key":"bib34-20251017","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1002\/ags3.12430","article-title":"Current status of function-preserving gastrectomy for gastric cancer","volume":"5","year":"2021","journal-title":"Ann Gastroenterol Surg"}],"container-title":["Translational Journal of the American College of Sports Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.lww.com\/10.1249\/TJX.0000000000000328","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T03:02:02Z","timestamp":1760670122000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/10.1249\/TJX.0000000000000328"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10]]},"references-count":34,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.1249\/tjx.0000000000000328","relation":{},"ISSN":["2379-2868"],"issn-type":[{"type":"electronic","value":"2379-2868"}],"subject":[],"published":{"date-parts":[[2025,10]]},"assertion":[{"value":"2025-04-16","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-08-19","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}