{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T02:58:00Z","timestamp":1772852280797,"version":"3.50.1"},"reference-count":32,"publisher":"Japanese Circulation Society","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Circ J"],"published-print":{"date-parts":[[2009]]},"DOI":"10.1253\/circj.cj-08-0614","type":"journal-article","created":{"date-parts":[[2009,1,23]],"date-time":"2009-01-23T05:56:58Z","timestamp":1232690218000},"page":"310-315","source":"Crossref","is-referenced-by-count":38,"title":["Physiological Changes in Human Cardiac Sympathetic Innervation and Activity Assessed by 123I-Metaiodobenzylguanidine (MIBG) Imaging"],"prefix":"10.1253","volume":"73","author":[{"given":"Kazuyuki","family":"Sakata","sequence":"first","affiliation":[{"name":"Division of Cardiology, Shizuoka Cancer Center Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kei","family":"Iida","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Shizuoka Cancer Center Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nao","family":"Mochizuki","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Shizuoka Cancer Center Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michitoshi","family":"Ito","sequence":"additional","affiliation":[{"name":"Division of Diagnostic Radiology, Shizuoka Cancer Center Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshihiro","family":"Nakaya","sequence":"additional","affiliation":[{"name":"Division of Diagnostic Radiology, Shizuoka Cancer Center Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"330","reference":[{"key":"1","unstructured":"1. Remme WJ. The sympathetic nervous system and ischaemic heart disease. Eur Heart J 1998; 19: F62-F71."},{"key":"2","doi-asserted-by":"crossref","unstructured":"2. Kaye D, Esler M. Sympathetic neuronal regulation of the heart in aging and heart failure. Cardiovasc Res 2005; 66: 256-264.","DOI":"10.1016\/j.cardiores.2005.02.012"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1046\/j.1542-474X.2003.08112.x"},{"key":"4","unstructured":"4. Schwartz PJ, La Rovere MT, Vanoli E. Autonomic nervous system and sudden cardiac death: Experimental basis and clinical observations for post-myocardial infarction risk stratification. Circulation 1992; 85(Suppl): I-77-I-91."},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1016\/0002-8703(86)90155-9"},{"key":"6","unstructured":"6. Stokes J 3rd, Kannel WB, Wolf PA, Cupples LA, D' Agostino RB. The relative importance of selected risk factors for various manifestations of cardiovascular disease among women and men from 35-64 years: 30 years of follow-up in the Framingham Study. Circulation 1987; 75: V-65-V-73."},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1038\/261333a0"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8. Kuo TB, Lin T, Yang CC, Li CL, Chen CF, Chou P. Effect of aging on gender differences in neural control of heart rate. Am J Physiol 1999; 277: H2233-H2239.","DOI":"10.1152\/ajpheart.1999.277.6.H2233"},{"key":"9","unstructured":"9. Ramaekers D, Ector H, Aubert AE, Rubens A, Van de Werf F. Heart rate variability and heart rate in healthy volunteers: Is the female autonomic nervous system cardioprotective? Eur Heart J 1998; 19: 1334-1341."},{"key":"10","doi-asserted-by":"crossref","unstructured":"10. Esler MD, Thompson JM, Kaye DM, Turner AG, Jennings GL, Cox HS, et al. Effects of aging on the responsiveness of the human cardiac sympathetic nerves to stressors. Circulation 1995; 91: 351-358.","DOI":"10.1161\/01.CIR.91.2.351"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11. Ng AV, Callister R, Johnson DG, Seals DR. Age and gender influence muscle sympathetic nerve activity at rest in healthy humans. Hypertension 1993; 21: 498-503.","DOI":"10.1161\/01.HYP.21.4.498"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12. Matsukawa T, Sugiyama Y, Watanabe T, Kobayashi F, Mano T. Gender difference in age-related changes in muscle sympathetic nerve activity in healthy subjects. Am J Physiol 1998; 275: R1600-R1604.","DOI":"10.1152\/ajpregu.1998.275.5.R1600"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13. Narkiewicz K, Philips BG, Kato M, Hering D, Bieniaszewski L, Somers VK. Gender-selective interaction between aging, blood pressure, and sympathetic nerve activity. Hypertension 2005; 45: 522-525.","DOI":"10.1161\/01.HYP.0000160318.46725.46"},{"issue":"10","key":"14","first-page":"1667","volume":"39","author":"SAKATA K","year":"1998","ISSN":"https:\/\/id.crossref.org\/issn\/0161-5505","issn-type":"print"},{"issue":"6","key":"15","first-page":"969","volume":"36","year":"1995","ISSN":"https:\/\/id.crossref.org\/issn\/0161-5505","issn-type":"print"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16. Estorch M, Carrio I, Berna L, Lopez-Pousa J, Torres G. Myocardail iodine-labeled metaiodobenzylguanidine 123 uptake relates to age. J Nucl Cardiol 1995; 2: 126-132","DOI":"10.1016\/S1071-3581(95)80023-9"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(98)00261-7"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1067\/mhj.2001.112783"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19. Tsutamoto T, Tanaka T, Sakai H, Nishiyama K, Fujii M, Yamamoto T, et al. Beneficial effect of perindopril on cardiac sympathetic nerve activity and brain natriuretic peptide in patients with chronic heart failure. Circ J 2008; 72: 740-746.","DOI":"10.1253\/circj.72.740"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20. Arimoto T, Sukekawa H, Harada M, Takayama S, Ikeno E, Nishigi K, et al. Short cardiac iodine-123-metaiodobenzylguanidine imaging protocol in heart failure. Circ J 2008; 72: 1106-1111.","DOI":"10.1253\/circj.72.1106"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21. Austin WG, Edwards JE, Frye RL, Gensini GG, Gott VL, Griffith LS, et al. A reporting system on patients evaluated for coronary artery disease: Report of the Ad Hoc Committee for Grading of Coronary Artery Disease, Council on Cardiovascular Surgery, American Heart Association. Circulation 1975; 51: 7-38.","DOI":"10.1161\/01.CIR.51.4.5"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2680.2001.00221.x"},{"key":"23","doi-asserted-by":"crossref","unstructured":"23. Akamatsu FE, De-Souza RR, Liberti EA. Fall in the number of intracardiac neurons in aging rats. Mech Ageing Dev 1999; 109: 153-161.","DOI":"10.1016\/S0047-6374(99)00023-8"},{"key":"24","unstructured":"24. Goldberg PB, Kreider MS, McLean MR, Roberts J. Effects of aging at the adrenergic cardiac neuroeffector junction. Fed Proc 1986; 45: 45-47."},{"key":"25","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(96)00437-8"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1681.1994.tb02545.x"},{"key":"27","unstructured":"27. Li ST, Holmes C, Kopin IJ, Goldstein DS. Aging-related changes in cardiac sympathetic function in humans, assessed by 6-18F-fluorodopamine PET scanning. J Nucl Med 2003; 44: 1599-1603."},{"key":"28","doi-asserted-by":"crossref","unstructured":"28. Vongpatanasin WV, Tuncel M, Mansour Y, Arbique D, Victor RG. Transdermal estrogen replacement therapy decreases sympathetic activity in postmenopausal women. Circulation 2001; 103: 2903-2908.","DOI":"10.1161\/01.CIR.103.24.2903"},{"key":"29","doi-asserted-by":"crossref","unstructured":"29. Liu CC, Kuo TB, Yang CC. Effects of estrogen on gender-related autonomic differences in humans. Am J Physiol Heart Circ Physiol 2003; 285: H2188-H2193.","DOI":"10.1152\/ajpheart.00256.2003"},{"key":"30","doi-asserted-by":"publisher","DOI":"10.1097\/gme.0b013e318038d333"},{"key":"31","doi-asserted-by":"publisher","DOI":"10.1001\/jama.288.3.321"},{"key":"32","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000048892.83521.58"}],"container-title":["Circulation Journal"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.jstage.jst.go.jp\/article\/circj\/73\/2\/73_CJ-08-0614\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,9]],"date-time":"2024-03-09T11:53:53Z","timestamp":1709985233000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.jstage.jst.go.jp\/article\/circj\/73\/2\/73_CJ-08-0614\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009]]},"references-count":32,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2009]]}},"URL":"https:\/\/doi.org\/10.1253\/circj.cj-08-0614","relation":{},"ISSN":["1346-9843","1347-4820"],"issn-type":[{"value":"1346-9843","type":"print"},{"value":"1347-4820","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009]]}}}