{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T17:30:25Z","timestamp":1774978225516,"version":"3.50.1"},"reference-count":45,"publisher":"Japanese Circulation Society","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Circ J"],"published-print":{"date-parts":[[2009]]},"DOI":"10.1253\/circj.cj-08-1077","type":"journal-article","created":{"date-parts":[[2009,7,24]],"date-time":"2009-07-24T06:01:22Z","timestamp":1248415282000},"page":"1423-1430","source":"Crossref","is-referenced-by-count":38,"title":["Use of Serum Homocysteine to Predict Stroke, Coronary Heart Disease and Death in Ethnic Chinese  12-Year Prospective Cohort Study"],"prefix":"10.1253","volume":"73","author":[{"given":"Yu","family":"Sun","sequence":"first","affiliation":[{"name":"Department of Neurology, En Chu Kong Hospital"},{"name":"Institute of Preventive Medicine, College of Public Health, National Taiwan University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kuo-Liong","family":"Chien","sequence":"additional","affiliation":[{"name":"Institute of Preventive Medicine, College of Public Health, National Taiwan University"},{"name":"Department of Cardiology, National Taiwan University Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hsiu-Ching","family":"Hsu","sequence":"additional","affiliation":[{"name":"Department of Cardiology, National Taiwan University Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ta-Chen","family":"Su","sequence":"additional","affiliation":[{"name":"Department of Cardiology, National Taiwan University Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ming-Fong","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Cardiology, National Taiwan University Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuan-Teh","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Cardiology, National Taiwan University Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"330","reference":[{"key":"1","unstructured":"1. Christen WG, Ajani UA, Glynn RJ, Hennekens CH. Blood levels of homocysteine and increased risks of cardiovascular disease: Causal or casual? Arch Intern Med 2000; 160: 422-434."},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.288.16.2015"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3. Bostom AG, Rosenberg IH, Silbershatz H, Jacques PF, Selhub J, D'Agostino RB, et al. Nonfasting plasma total homocysteine levels and stroke incidence in elderly persons: The Framingham Study. Ann Intern Med 1999; 131: 352-355.","DOI":"10.7326\/0003-4819-131-5-199909070-00006"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4. Sacco RL, Anand K, Lee HS, Boden-Albala B, Stabler S, Allen R, et al. Homocysteine and the risk of ischemic stroke in a triethnic cohort: The NOrthern MAnhattan Study. Stroke 2004; 35: 2263-2269.","DOI":"10.1161\/01.STR.0000142374.33919.92"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5. Fallon UB, Elwood P, Ben-Shlomo Y, Ubbink JB, Greenwood R, Smith GD. Homocysteine and ischaemic stroke in men: The Caerphilly study. J Epidemiol Community Health 2001; 55: 91-96.","DOI":"10.1136\/jech.55.2.91"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6. Alfthan G, Pekkanen J, Jauhiainen M, Pitkaniemi J, Karvonen M, Tuomilehto J, et al. Relation of serum homocysteine and lipoprotein(a) concentrations to atherosclerotic disease in a prospective Finnish population based study. Atherosclerosis 1994; 106: 9-19.","DOI":"10.1016\/0021-9150(94)90078-7"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7. Folsom AR, Nieto FJ, McGovern PG, Tsai MY, Malinow MR, Eckfeldt JH, et al. Prospective study of coronary heart disease incidence in relation to fasting total homocysteine, related genetic polymorphisms, and B vitamins: The Atherosclerosis Risk in Communities (ARIC) study. Circulation 1998; 98: 204-210.","DOI":"10.1161\/01.CIR.98.3.204"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1001\/jama.281.19.1817"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9. Zylberstein DE, Bengtsson C, Bjorkelund C, Landaas S, Sundh V, Thelle D, et al. Serum homocysteine in relation to mortality and morbidity from coronary heart disease: A 24-year follow-up of the population study of women in Gothenburg. Circulation 2004; 109: 601-606.","DOI":"10.1161\/01.CIR.0000112581.96154.EA"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10. Stehouwer CD, Weijenberg MP, van den Berg M, Jakobs C, Feskens EJ, Kromhout D. Serum homocysteine and risk of coronary heart disease and cerebrovascular disease in elderly men: A 10-year follow-up. Arterioscler Thromb Vasc Biol 1998; 18: 1895-1901.","DOI":"10.1161\/01.ATV.18.12.1895"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11. Rossi GP, Maiolino G, Seccia TM, Burlina A, Zavattiero S, Cesari M, et al. Hyperhomocysteinemia predicts total and cardiovascular mortality in high-risk women. J Hypertens 2006; 24: 851-859.","DOI":"10.1097\/01.hjh.0000222754.75196.5c"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12. Nygard O, Nordrehaug JE, Refsum H, Ueland PM, Farstad M, Vollset SE. Plasma homocysteine levels and mortality in patients with coronary artery disease. N Engl J Med 1997; 337: 230-236.","DOI":"10.1056\/NEJM199707243370403"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13. Ndrepepa G, Kastrati A, Braun S, Koch W, Kolling K, Mehilli J, et al. A prospective cohort study of predictive value of homocysteine in patients with type 2 diabetes and coronary artery disease. Clin Chim Acta 2006; 373: 70-76.","DOI":"10.1016\/j.cca.2006.05.011"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14. Soinio M, Marniemi J, Laakso M, Lehto S, Ronnemaa T. Elevated plasma homocysteine level is an independent predictor of coronary heart disease events in patients with type 2 diabetes mellitus. Ann Intern Med 2004; 140: 94-100.","DOI":"10.7326\/0003-4819-140-2-200401200-00009"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.107.726562"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1253\/circj.CJ-07-1049"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17. Ohsawa M, Okayama A, Okamura T, Itai K, Nakamura M, Tanno K, et al. Mortality risk attributable to atrial fibrillation in middle-aged and elderly people in the Japanese general population: Nineteen-year follow-up in NIPPON DATA80. Circ J 2007; 71: 814-819.","DOI":"10.1253\/circj.71.814"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18. Castanon MM, Lauricella AM, Kordich L, Quintana I. Plasma homocysteine cutoff values for venous thrombosis. Clin Chem Lab Med 2007; 45: 232-236.","DOI":"10.1515\/CCLM.2007.038"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19. Lee Y, Lin RS, Sung FC, Yang C, Chien K, Chen W, et al. Chin-Shan Community Cardiovascular Cohort in Taiwan: Baseline data and five-year follow-up morbidity and mortality. J Clin Epidemiol 2000; 53: 838-846.","DOI":"10.1016\/S0895-4356(00)00198-0"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20. Chien KL, Hsu HC, Sung FC, Su TC, Chen MF, Lee YT. Incidence of hypertension and risk of cardiovascular events among ethnic Chinese: Report from a community-based cohort study in Taiwan. J Hypertens 2007; 25: 1355-1361.","DOI":"10.1097\/HJH.0b013e3280d94313"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21. Chien KL, Chen MF, Hsu HC, Chang WT, Su TC, Lee YT, et al. Plasma uric acid and the risk of type 2 diabetes in a Chinese community. Clin Chem 2008; 54: 310-316.","DOI":"10.1373\/clinchem.2007.095190"},{"key":"22","doi-asserted-by":"crossref","unstructured":"22. Chien KL, Sung FC, Hsu HC, Su TC, Lin RS, Lee YT. Apolipoprotein A-I and B and stroke events in a community-based cohort in Taiwan: Report of the Chin-Shan Community Cardiovascular Study. Stroke 2002; 33: 39-44.","DOI":"10.1161\/hs0102.101626"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2006.07.033"},{"key":"24","doi-asserted-by":"crossref","unstructured":"24. Chien KL, Sung FC, Hsu HC, Su TC, Chang WD, Lee YT. Relative importance of atherosclerotic risk factors for coronary heart disease in Taiwan. Eur J Cardiovasc Prev Rehabil 2005; 12: 95-101.","DOI":"10.1097\/00149831-200504000-00003"},{"key":"25","doi-asserted-by":"crossref","unstructured":"25. Chien KL, Lee YT, Sung FC, Hsu HC, Su TC, Lin RS. Hyperinsulinemia and related atherosclerotic risk factors in the population at cardiovascular risk: A community-based study. Clin Chem 1999; 45: 838-846.","DOI":"10.1093\/clinchem\/45.6.838"},{"key":"26","doi-asserted-by":"crossref","unstructured":"26. Shipchandler MT, Moore EG. Rapid, fully automated measurement of plasma homocyst(e)ine with the Abbott IMx analyzer. Clin Chem 1995; 41: 991-994.","DOI":"10.1093\/clinchem\/41.7.991"},{"key":"27","doi-asserted-by":"crossref","unstructured":"27. Chao CL, Kuo TL, Lee YT. Effects of methionine-induced hyperhomocysteinemia on endothelium-dependent vasodilation and oxidative status in healthy adults. Circulation 2000; 101: 485-490.","DOI":"10.1161\/01.CIR.101.5.485"},{"key":"28","doi-asserted-by":"crossref","unstructured":"28. Refsum H, Ueland PM, Svardal AM. Fully automated fluorescence assay for determining total homocysteine in plasma. Clin Chem 1989; 35: 1921-1927.","DOI":"10.1093\/clinchem\/35.9.1921"},{"key":"29","doi-asserted-by":"crossref","unstructured":"29. Pencina MJ, D'Agostino RB Sr, D'Agostino RB Jr, Vasan RS. Evaluating the added predictive ability of a new marker: From area under the ROC curve to reclassification and beyond. Stat Med 2008; 27: 157-172; discussion 207-212.","DOI":"10.1002\/sim.2929"},{"key":"30","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.107.187998"},{"key":"31","doi-asserted-by":"crossref","unstructured":"31. Bots ML, Launer LJ, Lindemans J, Hoes AW, Hofman A, Witteman JC, et al. Homocysteine and short-term risk of myocardial infarction and stroke in the elderly: The Rotterdam Study. Arch Intern Med 1999; 159: 38-44.","DOI":"10.1001\/archinte.159.1.38"},{"key":"32","doi-asserted-by":"crossref","unstructured":"32. Lindgren A, Brattstrom L, Norrving B, Hultberg B, Andersson A, Johansson BB. Plasma homocysteine in the acute and convalescent phases after stroke. Stroke 1995; 26: 795-800.","DOI":"10.1161\/01.STR.26.5.795"},{"key":"33","doi-asserted-by":"crossref","unstructured":"33. Gatt A, Makris M. Hyperhomocysteinemia and venous thrombosis. Semin Hematol 2007; 44: 70-76.","DOI":"10.1053\/j.seminhematol.2007.01.002"},{"key":"34","doi-asserted-by":"crossref","unstructured":"34. Tanne D, Haim M, Goldbourt U, Boyko V, Doolman R, Adler Y, et al. Prospective study of serum homocysteine and risk of ischemic stroke among patients with preexisting coronary heart disease. Stroke 2003; 34: 632-636.","DOI":"10.1161\/01.STR.0000060203.58958.35"},{"key":"35","doi-asserted-by":"crossref","unstructured":"35. Eikelboom JW, Hankey GJ, Anand SS, Lofthouse E, Staples N, Baker RI. Association between high homocyst(e)ine and ischemic stroke due to large- and small-artery disease but not other etiologic subtypes of ischemic stroke. Stroke 2000; 31: 1069-1075.","DOI":"10.1161\/01.STR.31.5.1069"},{"key":"36","doi-asserted-by":"publisher","DOI":"10.1159\/000047739"},{"key":"37","doi-asserted-by":"crossref","unstructured":"37. Bautista LE, Arenas IA, Penuela A, Martinez LX. Total plasma homocysteine level and risk of cardiovascular disease: A meta-analysis of prospective cohort studies. J Clin Epidemiol 2002; 55: 882-887.","DOI":"10.1016\/S0895-4356(02)00434-1"},{"key":"38","doi-asserted-by":"crossref","unstructured":"38. Nagai Y, Tasaki H, Miyamoto M, Nihei S, Kobayashi K, Yamashita K, et al. Plasma level of homocysteine is inversely-associated with the development of collateral circulation in patients with single-vessel coronary artery disease. Circ J 2002; 66: 158-162.","DOI":"10.1253\/circj.66.158"},{"key":"39","doi-asserted-by":"crossref","unstructured":"39. Sayar N, Terzi S, Bilsel T, Yilmaz HY, Orhan L, Cakmak N, et al. Plasma homocysteine concentration in patients with poor or good coronary collaterals. Circ J 2007; 71: 266-270.","DOI":"10.1253\/circj.71.266"},{"key":"40","doi-asserted-by":"crossref","unstructured":"40. Clarke R, Daly L, Robinson K, Naughten E, Cahalane S, Fowler B, et al. Hyperhomocysteinemia: An independent risk factor for vascular disease. N Engl J Med 1991; 324: 1149-1155.","DOI":"10.1056\/NEJM199104253241701"},{"key":"41","doi-asserted-by":"crossref","unstructured":"41. Wald NJ, Watt HC, Law MR, Weir DG, McPartlin J, Scott JM. Homocysteine and ischemic heart disease: Results of a prospective study with implications regarding prevention. Arch Intern Med 1998; 158: 862-867.","DOI":"10.1001\/archinte.158.8.862"},{"key":"42","doi-asserted-by":"crossref","unstructured":"42. Malinow MR, Bostom AG, Krauss RM. Homocyst(e)ine, diet, and cardiovascular diseases: A statement for healthcare professionals from the Nutrition Committee, American Heart Association. Circulation 1999; 99: 178-182.","DOI":"10.1161\/01.CIR.99.1.178"},{"key":"43","doi-asserted-by":"crossref","unstructured":"43. Leeflang MM, Moons KG, Reitsma JB, Zwinderman AH. Bias in sensitivity and specificity caused by data-driven selection of optimal cutoff values: Mechanisms, magnitude, and solutions. Clin Chem 2008; 54: 729-737.","DOI":"10.1373\/clinchem.2007.096032"},{"key":"44","doi-asserted-by":"crossref","unstructured":"44. Clarke R, Lewington S, Donald A, Johnston C, Refsum H, Stratton I, et al. Underestimation of the importance of homocysteine as a risk factor for cardiovascular disease in epidemiological studies. J Cardiovasc Risk 2001; 8: 363-369.","DOI":"10.1177\/174182670100800605"},{"key":"45","doi-asserted-by":"crossref","unstructured":"45. Pezzini A, Del Zotto E, Padovani A. Homocysteine and cerebral ischemia: Pathogenic and therapeutical implications. Curr Med Chem 2007; 14: 249-263.","DOI":"10.2174\/092986707779941140"}],"container-title":["Circulation Journal"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.jstage.jst.go.jp\/article\/circj\/73\/8\/73_CJ-08-1077\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,3,25]],"date-time":"2021-03-25T03:48:22Z","timestamp":1616644102000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.jstage.jst.go.jp\/article\/circj\/73\/8\/73_CJ-08-1077\/_article"}},"subtitle":["12-Year Prospective Cohort Study"],"short-title":[],"issued":{"date-parts":[[2009]]},"references-count":45,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2009]]}},"URL":"https:\/\/doi.org\/10.1253\/circj.cj-08-1077","relation":{},"ISSN":["1346-9843","1347-4820"],"issn-type":[{"value":"1346-9843","type":"print"},{"value":"1347-4820","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009]]}}}