{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T05:48:51Z","timestamp":1791179331777,"version":"4.1.0"},"reference-count":44,"publisher":"Japanese Circulation Society","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Circ J"],"published-print":{"date-parts":[[2009]]},"DOI":"10.1253\/circj.cj-08-1082","type":"journal-article","created":{"date-parts":[[2009,1,23]],"date-time":"2009-01-23T05:56:58Z","timestamp":1232690218000},"page":"201-207","source":"Crossref","is-referenced-by-count":115,"title":["Novel Aspects of Oxidative Stress in Cardiovascular Diseases"],"prefix":"10.1253","volume":"73","author":[{"given":"Donald D.","family":"Heistad","sequence":"first","affiliation":[{"name":"Departments of Internal Medicine and Pharmacology, University of Iowa Carver College of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshinobu","family":"Wakisaka","sequence":"additional","affiliation":[{"name":"Departments of Internal Medicine and Pharmacology, University of Iowa Carver College of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jordan","family":"Miller","sequence":"additional","affiliation":[{"name":"Departments of Internal Medicine and Pharmacology, University of Iowa Carver College of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Chu","sequence":"additional","affiliation":[{"name":"Departments of Internal Medicine and Pharmacology, University of Iowa Carver College of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricardo","family":"Pena-Silva","sequence":"additional","affiliation":[{"name":"Departments of Internal Medicine and Pharmacology, University of Iowa Carver College of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"330","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000093661.90582.c4"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2. Heistad DD. Oxidative stress and vascular disease. Arterioscler Thromb Vasc Biol 2006; 26: 689-695.","DOI":"10.1161\/01.ATV.0000203525.62147.28"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1016\/S0891-5849(03)00239-9"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4. Dröge W. Free radicals in physiological control of cell function. Physiol Rev 2002; 82: 47-95.","DOI":"10.1152\/physrev.00018.2001"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5. Arimura K, Egashira K, Nakamura R, Ide T, Tsutsui H, Shimokawa H, et al. Increased inactivation of nitric oxide is involved in coronary endothelial dysfunction in heart failure. Am J Physiol Heart 2001; 280: H68-H75.","DOI":"10.1152\/ajpheart.2001.280.1.H68"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6. Morikawa K, Shimokawa H, Matoba T, Kubtoa H, Akaike T, Talukder MAH, et al. Pivotal role of Cu,Zn-superoxide dismutase in endothelium-dependent hyperpolarization. J Clin Invest 2003; 112: 1871-1879.","DOI":"10.1172\/JCI200319351"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.0000163846.51473.09"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8. Zhao X, Sun G, Zhang J, Strong R, Dash PK, Kan YW, et al. Transcription factor Nrf2 protects the brain from damage produced by intracerebral hemorrhage. Stroke 2007; 38: 3280-3286.","DOI":"10.1161\/STROKEAHA.107.486506"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2006.09.024"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10. Faraci FM, Didion SP. Vascular protection: Superoxide dismutase isoforms in the vessel wall. Arterioscler Thromb Vasc Biol 2004; 24: 1367-1373.","DOI":"10.1161\/01.ATV.0000133604.20182.cf"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000105720.28086.6C"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000048966.26216.4C"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13. Rajamannan NM, Bonow RO, Rahimtoola SH. Calcific aortic stenosis: An update. Nat Clin Pract Cardiovasc Med 2007; 4: 254-262.","DOI":"10.1038\/ncpcardio0827"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14. Otto CM, Kuusisto J, Reichenbach DD, Gown AM, O'Brien KD. Characterization of the early lesion of `degenerative' valvular aortic stenosis: Histological and immunohistochemical studies. Circulation 1994; 90: 844-853.","DOI":"10.1161\/01.CIR.90.2.844"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15. Lindroos M, Kupari M, Valvanne J, Strandberg T, Heikkila J, Tilvis R. Factors associated with calcific aortic valve degeneration in the elderly. Eur Heart J 1994; 15: 865-870.","DOI":"10.1093\/oxfordjournals.eurheartj.a060602"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16. Weiss RM, Ohashi M, Miller JD, Young SG, Heistad DD. Calcific aortic valve stenosis in old hypercholesterolemic mice. Circulation 2006; 114: 2065-2069.","DOI":"10.1161\/CIRCULATIONAHA.106.634139"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17. Miller JD, Chu Y, Brooks RM, Richenbacher WE, Peña-Silva R, Heistad DD. Dysregulation of antioxidant mechanisms contributes to increased oxidative stress in calcific aortic valvular stenosis in humans. J Am Coll Cardiol 2008; 52: 843-850.","DOI":"10.1016\/j.jacc.2008.05.043"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18. Liberman M, Bassi E, Martinatti MK, Lario FC, Wosniak J Jr, Pomerantzeff PM, et al. Oxidant generation predominates around calcifying foci and enhances progression of aortic valve calcification. Arterioscler Thromb Vasc Biol 2008; 28: 463-470.","DOI":"10.1161\/ATVBAHA.107.156745"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.16.9220"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1999.1422"},{"issue":"4","key":"21","doi-asserted-by":"crossref","first-page":"184","DOI":"10.5551\/jat.9.184","volume":"9","author":"KOBAYASHI S","year":"2002","ISSN":"https:\/\/id.crossref.org\/issn\/1340-3478","issn-type":"print"},{"key":"22","doi-asserted-by":"crossref","unstructured":"22. Towler DA. Oxidation, inflammation, and aortic valve calcification: Peroxide paves an osteogenic path. J Am Coll Cardiol 2008; 52: 851-854.","DOI":"10.1016\/j.jacc.2008.05.044"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1016\/S0891-5849(01)00610-4"},{"key":"24","doi-asserted-by":"crossref","unstructured":"24. Shao JS, Aly ZA, Lai CF, Cheng SL, Cai J, Huang E, et al. Vascular Bmp Msx2 Wnt signaling and oxidative stress in arterial calcification. Ann NY Acad Sci 2007; 1117: 40-50.","DOI":"10.1196\/annals.1402.075"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.1172\/JCI119076"},{"key":"26","doi-asserted-by":"crossref","unstructured":"26. Cowell SJ, Newby DE, Prescott RJ, Bloomfield P, Reid J, Northridge DB, et al. A randomized trial of intensive lipid-lowering therapy in calcific aortic stenosis. N Engl J Med 2005; 352: 2389-2397.","DOI":"10.1056\/NEJMoa043876"},{"key":"27","doi-asserted-by":"crossref","unstructured":"27. Rossebø AB, Pedersen TR, Boman K, Brudi P, Chambers JB, Egstrup K, et al. Intensive lipid lowering with simvastatin and ezetimibe in aortic stenosis. N Engl J Med 2008; 359: 1343-1356.","DOI":"10.1056\/NEJMoa0804602"},{"key":"28","doi-asserted-by":"crossref","unstructured":"28. Miller JD, Berry CJ, Serrano KM, Weiss RM, Iyengar NK, Zimmerman KA, et al. Effects of normalizing hyperlipidemia on oxidative stress and disease progression in a mouse model of aortic valve stenosis (abstract). Circulation 2007; 116: II-52.","DOI":"10.1161\/circ.116.suppl_16.II_52-b"},{"key":"29","doi-asserted-by":"crossref","unstructured":"29. Pena-Silva RA, Miller JD, Heistad DD. Serotonin produces MAO dependent oxidative stress in human heart valves (abstract). FASEB J 2008; 22: 747.6.","DOI":"10.1096\/fasebj.22.1_supplement.747.6"},{"key":"30","doi-asserted-by":"crossref","unstructured":"30. Iida S, Baumbach GL, Lavoie JL, Faraci FM, Sigmund CD, Heistad DD. Spontaneous stroke in a genetic model of hypertension in mice. Stroke 2005; 36: 1253-1258.","DOI":"10.1161\/01.str.0000167694.58419.a2"},{"key":"31","doi-asserted-by":"crossref","unstructured":"31. Wakisaka Y, Miller JD, Chu Y, Baumbach GL, Wilson S, Faraci FM, et al. Oxidative stress through activation of NAD(P)H oxidase in hypertensive mice with spontaneous intracranial hemorrhage. J Cereb Blood Flow Metab 2008; 28: 1175-1185.","DOI":"10.1038\/jcbfm.2008.7"},{"key":"32","doi-asserted-by":"crossref","unstructured":"32. Yu F, Kamada H, Niizuma K, Endo H, Chan PH. Induction of MMP-9 expression and endothelial injury by oxidative stress after spinal cord injury. J Neurotrauma 2008; 25: 184-195.","DOI":"10.1089\/neu.2007.0438"},{"key":"33","doi-asserted-by":"crossref","unstructured":"33. Zimmerman MC, Lazartigues E, Sharma RV, Davisson RL. Hypertension caused by angiotensin II infusion involves increased superoxide production in the central nervous system. Circ Res 2004; 95: 210-215.","DOI":"10.1161\/01.RES.0000135483.12297.e4"},{"key":"34","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2005.03292.x"},{"issue":"3","key":"35","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1042\/bj2220649","volume":"222","year":"1984","ISSN":"https:\/\/id.crossref.org\/issn\/0264-6021","issn-type":"print"},{"key":"36","unstructured":"36. Oury TD, Day BJ, Crapo JD. Extracellular superoxide dismutase: A regulator of nitric oxide bioavailability. Lab Invest 1996; 75: 617-636."},{"key":"37","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000057755.02845.F9"},{"key":"38","doi-asserted-by":"crossref","unstructured":"38. Iida S, Chu Y, Weiss RM, Kang YM, Faraci FM, Heistad DD. Vascular effects of a common gene variant of extracellular superoxide dismutase in heart failure. Am J Physiol Heart 2006; 291: H914-H920.","DOI":"10.1152\/ajpheart.00080.2006"},{"key":"39","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.0000234921.88489.5c"},{"key":"40","doi-asserted-by":"crossref","unstructured":"40. Folz RJ, Peno-Green L, Crapo JD. Identification of a homozygous missense mutation (Arg to Gly) in the critical binding region of human EC-SOD gene (SOD3) and its association with dramatically increased serum enzyme levels. Hum Mol Genet 1994; 3: 2251-2254.","DOI":"10.1093\/hmg\/3.12.2251"},{"key":"41","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.104.531251"},{"key":"42","doi-asserted-by":"crossref","unstructured":"42. Lund DD, Chu Y, Brooks RM, Faraci FM, Heistad DD. Effects of a common human gene variant of ECSOD on endothelial function after endotoxin in mice. J Physiol (London) 2007; 584.2: 583-590.","DOI":"10.1113\/jphysiol.2007.140830"},{"key":"43","doi-asserted-by":"publisher","DOI":"10.1159\/000045580"},{"key":"44","doi-asserted-by":"crossref","unstructured":"44. Dahl M, Bowler RP, Juul K, Crapo JD, Levy S, Nordestgaard BG. Superoxide dismutase 3 polymorphism associated with reduced lung function in two large populations. Am J Respir Crit Care Med 2008; 178: 906-912.","DOI":"10.1164\/rccm.200804-549OC"}],"container-title":["Circulation Journal"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.jstage.jst.go.jp\/article\/circj\/73\/2\/73_CJ-08-1082\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,30]],"date-time":"2021-09-30T12:42:27Z","timestamp":1633005747000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.jstage.jst.go.jp\/article\/circj\/73\/2\/73_CJ-08-1082\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009]]},"references-count":44,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2009]]}},"URL":"https:\/\/doi.org\/10.1253\/circj.cj-08-1082","relation":{},"ISSN":["1346-9843","1347-4820"],"issn-type":[{"value":"1346-9843","type":"print"},{"value":"1347-4820","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009]]}}}