{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T23:16:46Z","timestamp":1789600606624,"version":"build-2803163510"},"reference-count":70,"publisher":"Japanese Circulation Society","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Circ J"],"published-print":{"date-parts":[[2009]]},"DOI":"10.1253\/circj.cj-09-0587","type":"journal-article","created":{"date-parts":[[2009,10,23]],"date-time":"2009-10-23T06:00:45Z","timestamp":1256277645000},"page":"1993-1999","source":"Crossref","is-referenced-by-count":108,"title":["LOX-1 The Multifunctional Receptor Underlying Cardiovascular Dysfunction"],"prefix":"10.1253","volume":"73","author":[{"given":"Sayoko","family":"Ogura","sequence":"first","affiliation":[{"name":"Department of Vascular Physiology, National Cardiovascular Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akemi","family":"Kakino","sequence":"additional","affiliation":[{"name":"Department of Vascular Physiology, National Cardiovascular Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuko","family":"Sato","sequence":"additional","affiliation":[{"name":"Department of Vascular Physiology, National Cardiovascular Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiko","family":"Fujita","sequence":"additional","affiliation":[{"name":"Department of Vascular Physiology, National Cardiovascular Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shin","family":"Iwamoto","sequence":"additional","affiliation":[{"name":"Department of Vascular Physiology, National Cardiovascular Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazunori","family":"Otsui","sequence":"additional","affiliation":[{"name":"Department of Vascular Physiology, National Cardiovascular Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryo","family":"Yoshimoto","sequence":"additional","affiliation":[{"name":"Department of Vascular Physiology, National Cardiovascular Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatsuya","family":"Sawamura","sequence":"additional","affiliation":[{"name":"Department of Vascular Physiology, National Cardiovascular Center"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"330","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"1. Ross R. Atherosclerosis--an inflammatory disease. N Engl J Med 1999; 340: 115-126.","DOI":"10.1056\/NEJM199901143400207"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1253\/circj.71.1173"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3. Sawamura T, Kume N, Aoyama T, Moriwaki H, Hoshikawa H, Aiba Y, et al. An endothelial receptor for oxidized low-density lipoprotein. Nature 1997; 386: 73-77.","DOI":"10.1038\/386073a0"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1042\/0264-6021:3390177"},{"issue":"1","key":"5","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1042\/bj3340009","volume":"334","author":"YOSHIDA H","year":"1998","ISSN":"https:\/\/id.crossref.org\/issn\/0264-6021","issn-type":"print"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6. Kataoka H, Kume N, Miyamoto S, Minami M, Morimoto M, Hayashida K, et al. Oxidized LDL modulates Bax\/Bcl-2 through the lectinlike Ox-LDL receptor-1 in vascular smooth muscle cells. Arterioscler Thromb Vasc Biol 2001; 21: 955-960.","DOI":"10.1161\/01.ATV.21.6.955"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.2001.4516"},{"issue":"1-2","key":"8","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1023\/B:MCBI.0000012836.11573.41","volume":"258","author":"SUGANO M","year":"2004","ISSN":"https:\/\/id.crossref.org\/issn\/0300-8177","issn-type":"print"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9. Li L, Roumeliotis N, Sawamura T, Renier G. C-reactive protein enhances LOX-1 expression in human aortic endothelial cells: Relevance of LOX-1 to C-reactive protein-induced endothelial dysfunction. Circ Res 2004; 95: 877-883.","DOI":"10.1161\/01.RES.0000147309.54227.42"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10. Kume N, Murase T, Moriwaki H, Aoyama T, Sawamura T, Masaki T, et al. Inducible expression of lectin-like oxidized LDL receptor-1 in vascular endothelial cells. Circ Res 1998; 83: 322-327.","DOI":"10.1161\/01.RES.83.3.322"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11. Li D, Singh RM, Liu L, Chen H, Singh BM, Kazzaz N, et al. Oxidized-LDL through LOX-1 increases the expression of angiotensin converting enzyme in human coronary artery endothelial cells. Cardiovasc Res 2003; 57: 238-243.","DOI":"10.1016\/S0008-6363(02)00674-0"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12. Morawietz H, Rueckschloss U, Niemann B, Duerrschmidt N, Galle J, Hakim K, et al. Angiotensin II induces LOX-1, the human endothelial receptor for oxidized low-density lipoprotein. Circulation 1999; 100: 899-902.","DOI":"10.1161\/01.CIR.100.9.899"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13. Murase T, Kume N, Korenaga R, Ando J, Sawamura T, Masaki T, et al. Fluid shear stress transcriptionally induces lectin-like oxidized LDL receptor-1 in vascular endothelial cells. Circ Res 1998; 83: 328-333.","DOI":"10.1161\/01.RES.83.3.328"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.2001.4374"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1997.7176"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.2001.5674"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.2000.3532"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1291\/hypres.26.117"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19. Steinberg D, Parthasarathy S, Carew T, Khoo J, Witztum J. Beyond cholesterol. Modifications of low-density lipoprotein that increase its atherogenicity. N Engl J Med 1989 320: 915-924.","DOI":"10.1056\/NEJM198904063201407"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20. Holvoet P, Vanhaecke J, Janssens S, Van de Werf F, Collen D. Oxidized LDL and malondialdehyde-modified LDL in patients with acute coronary syndromes and stable coronary artery disease. Circulation 1998; 98: 1487-1494.","DOI":"10.1161\/01.CIR.98.15.1487"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21. Yamashita H, Ehara S, Yoshiyama M, Naruko T, Haze K, Shirai N, et al. Elevated plasma levels of oxidized low-density lipoprotein relate to the presence of angiographically detected complex and thrombotic coronary artery lesion morphology in patients with unstable angina. Circ J 2007; 71: 681-687.","DOI":"10.1253\/circj.71.681"},{"key":"22","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1093\/cvr\/cvp177","volume":"84","year":"2009","journal-title":"Cardiovascular Research","ISSN":"https:\/\/id.crossref.org\/issn\/0008-6363","issn-type":"print"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.275.17.12633"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardiores.2004.07.002"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.0000066685.13434.FA"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.1016\/S0008-6363(01)00371-6"},{"key":"27","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.0000229825.98545.5e"},{"key":"28","doi-asserted-by":"crossref","unstructured":"28. Li D, Yang B, Mehta JL. Ox-LDL induces apoptosis in human coronary artery endothelial cells: Role of PKC, PTK, bcl-2, and Fas. Am J Physiol 1998; 275: H568-H576.","DOI":"10.1152\/ajpheart.1998.275.2.H568"},{"key":"29","doi-asserted-by":"crossref","unstructured":"29. Li D, Mehta JL. Antisense to LOX-1 inhibits oxidized LDL-mediated upregulation of monocyte chemoattractant protein-1 and monocyte adhesion to human coronary artery endothelial cells. Circulation 2000; 101: 2889-2895.","DOI":"10.1161\/01.CIR.101.25.2889"},{"key":"30","doi-asserted-by":"publisher","DOI":"10.1097\/01.fjc.0000166243.43616.8b"},{"key":"31","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000174286.73200.d4"},{"key":"32","doi-asserted-by":"crossref","unstructured":"32. Mehta JL, Sanada N, Hu CP, Chen J, Dandapat A, Sugawara F, et al. Deletion of LOX-1 reduces atherogenesis in LDLR knockout mice fed high cholesterol diet. Circ Res 2007; 100: 1634-1642.","DOI":"10.1161\/CIRCRESAHA.107.149724"},{"key":"33","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardiores.2005.08.013"},{"key":"34","doi-asserted-by":"crossref","unstructured":"34. Yao EH, Fukuda N, Ueno T, Matsuda H, Matsumoto K, Nagase H, et al. Novel gene silencer pyrrole-imidazole polyamide targeting lectin-like oxidized low-density lipoprotein receptor-1 attenuates restenosis of the artery after injury. Hypertension 2008; 52: 86-92.","DOI":"10.1161\/HYPERTENSIONAHA.108.112797"},{"key":"35","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2007.09.072"},{"key":"36","doi-asserted-by":"crossref","unstructured":"36. Fichtlscherer S, Rosenberger G, Walter DH, Breuer S, Dimmeler S, Zeiher AM. Elevated C-reactive protein levels and impaired endothelial vasoreactivity in patients with coronary artery disease. Circulation 2000; 102: 1000-1006.","DOI":"10.1161\/01.CIR.102.9.1000"},{"key":"37","doi-asserted-by":"publisher","DOI":"10.1042\/CS20000013"},{"key":"38","doi-asserted-by":"crossref","unstructured":"38. Tomai F, Crea F, Gaspardone A, Versaci F, Ghini AS, Chiariello L, et al. Unstable angina and elevated c-reactive protein levels predict enhanced vasoreactivity of the culprit lesion. Circulation 2001; 104: 1471-1476.","DOI":"10.1161\/hc3801.096354"},{"key":"39","doi-asserted-by":"crossref","unstructured":"39. Teoh H, Quan A, Lovren F, Wang G, Tirgari S, Szmitko PE, et al. Impaired endothelial function in C-reactive protein overexpressing mice. Atherosclerosis 2008; 201: 318-325.","DOI":"10.1016\/j.atherosclerosis.2008.02.034"},{"key":"40","doi-asserted-by":"crossref","unstructured":"40. Schwartz R, Osborne-Lawrence S, Hahner L, Gibson LL, Gormley AK, Vongpatanasin W, et al. C-reactive protein downregulates endothelial NO synthase and attenuates reendothelialization in vivo in mice. Circ Res 2007; 100: 1452-1459.","DOI":"10.1161\/01.RES.0000267745.03488.47"},{"key":"41","doi-asserted-by":"crossref","unstructured":"41. Fujita Y, Kakino A, Nishimichi N, Yamaguchi S, Sato Y, Machida S, et al. Oxidized LDL receptor LOX-1 binds to C-reactive protein and mediates its vascular effects. Clin Chem 2009; 55: 285-294.","DOI":"10.1373\/clinchem.2008.119750"},{"key":"42","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.16.9535"},{"key":"43","doi-asserted-by":"crossref","unstructured":"43. Shimaoka T, Kume N, Minami M, Hayashida K, Sawamura T, Kita T, et al. LOX-1 supports adhesion of Gram-positive and Gram-negative bacteria. J Immunol 2001; 166: 5108-5114.","DOI":"10.4049\/jimmunol.166.8.5108"},{"key":"44","doi-asserted-by":"crossref","unstructured":"44. Moriwaki H, Kume N, Sawamura T, Aoyama T, Hoshikawa H, Ochi H, et al. Ligand specificity of LOX-1, a novel endothelial receptor for oxidized low density lipoprotein. Arterioscler Thromb Vasc Biol 1998; 18: 1541-1547.","DOI":"10.1161\/01.ATV.18.10.1541"},{"key":"45","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.R400025200"},{"key":"46","doi-asserted-by":"crossref","unstructured":"46. Shih HH, Zhang S, Cao W, Hahn A, Wang J, Paulsen JE, et al. CRP is a novel ligand for the oxidized LDL receptor LOX-1. Am J Physiol Heart Circ Physiol 2009; 296: H1643-H1650.","DOI":"10.1152\/ajpheart.00938.2008"},{"key":"47","doi-asserted-by":"crossref","unstructured":"47. Pasceri V, Willerson JT, Yeh ET. Direct proinflammatory effect of C-reactive protein on human endothelial cells. Circulation 2000; 102: 2165-2168.","DOI":"10.1161\/01.CIR.102.18.2165"},{"key":"48","doi-asserted-by":"crossref","unstructured":"48. Pasceri V, Cheng JS, Willerson JT, Yeh ET. Modulation of C-reactive protein-mediated monocyte chemoattractant protein-1 induction in human endothelial cells by anti-atherosclerosis drugs. Circulation 2001; 103: 2531-2534.","DOI":"10.1161\/01.CIR.103.21.2531"},{"key":"49","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-291X(02)02905-4"},{"key":"50","doi-asserted-by":"crossref","unstructured":"50. Li D, Williams V, Liu L, Chen H, Sawamura T, Antakli T, et al. LOX-1 inhibition in myocardial ischemia-reperfusion injury: Modulation of MMP-1 and inflammation. Am J Physiol Heart Circ Physiol 2002; 283: H1795-H1801.","DOI":"10.1152\/ajpheart.00382.2002"},{"key":"51","doi-asserted-by":"crossref","unstructured":"51. Hu C, Dandapat A, Chen J, Fujita Y, Inoue N, Kawase Y, et al. LOX-1 deletion alters signals of myocardial remodeling immediately after ischemia-reperfusion. Cardiovasc Res 2007; 76: 292-302.","DOI":"10.1016\/j.cardiores.2007.07.003"},{"key":"52","doi-asserted-by":"crossref","unstructured":"52. Kelly KJ, Wu P, Patterson CE, Temm C, Dominguez JH. LOX-1 and inflammation: A new mechanism for renal injury in obesity and diabetes. Am J Physiol Renal Physiol 2008; 294: F1136-F1145.","DOI":"10.1152\/ajprenal.00396.2007"},{"key":"53","doi-asserted-by":"crossref","unstructured":"53. Dominguez JH, Mehta JL, Li D, Wu P, Kelly KJ, Packer CS, et al. Anti-LOX-1 therapy in rats with diabetes and dyslipidemia: Ablation of renal vascular and epithelial manifestations. Am J Physiol Renal Physiol 2008; 294: F110-F119.","DOI":"10.1152\/ajprenal.00013.2007"},{"key":"54","doi-asserted-by":"crossref","unstructured":"54. Hu C, Kang B, Megyesi J, Kaushal GP, Safirstein RL, Mehta JL. Deletion of LOX-1 attenuates renal injury following angiotensin II infusion. Kidney Int 2009; 76: 521-527.","DOI":"10.1038\/ki.2009.234"},{"key":"55","doi-asserted-by":"crossref","unstructured":"55. Mango R, Clementi F, Borgiani P, Forleo GB, Federici M, Contino G, et al. Association of single nucleotide polymorphisms in the oxidised LDL receptor 1 (OLR1) gene in patients with acute myocardial infarction. J Med Genet 2003; 40: 933-936.","DOI":"10.1136\/jmg.40.12.933"},{"key":"56","doi-asserted-by":"crossref","unstructured":"56. Chen Q, Reis SE, Kammerer C, Craig WY, LaPierre SE, Zimmer EL, et al. Genetic variation in lectin-like oxidized low-density lipoprotein receptor 1 (LOX1) gene and the risk of coronary artery disease. Circulation 2003; 107: 3146-3151.","DOI":"10.1161\/01.CIR.0000074207.85796.36"},{"key":"57","doi-asserted-by":"crossref","unstructured":"57. Mango R, Biocca S, del Vecchio F, Clementi F, Sangiuolo F, Amati F, et al. In vivo and in vitro studies support that a new splicing isoform of OLR1 gene is protective against acute myocardial infarction. Circ Res 2005; 97: 152-158.","DOI":"10.1161\/01.RES.0000174563.62625.8e"},{"key":"58","doi-asserted-by":"crossref","unstructured":"58. Tatsuguchi M, Furutani M, Hinagata J, Tanaka T, Furutani Y, Imamura S, et al. Oxidized LDL receptor gene (OLR1) is associated with the risk of myocardial infarction. Biochem Biophys Res Commun 2003 28: 247-250.","DOI":"10.1016\/S0006-291X(03)00326-7"},{"key":"59","doi-asserted-by":"crossref","unstructured":"59. Knowles J, Assimes T, Boerwinkle E, Fortmann S, Go A, Grove M, et al. Failure to replicate an association of SNPs in the oxidized LDL receptor gene (OLR1) with CAD. BMC Med Genet 2008; 9: 23.","DOI":"10.1186\/1471-2350-9-23"},{"key":"60","doi-asserted-by":"crossref","unstructured":"60. Biocca S, Falconi M, Filesi I, Baldini F, Vecchione L, Mango R, et al. Functional analysis and molecular dynamics simulation of LOX-1 K167N polymorphism reveal alteration of receptor activity. PLoS One 2009; 4: e4648.","DOI":"10.1371\/journal.pone.0004648"},{"key":"61","doi-asserted-by":"crossref","unstructured":"61. Murase T, Kume N, Kataoka H, Minami M, Sawamura T, Masaki T, et al. Identification of soluble forms of lectin-like oxidized LDL receptor-1. Arterioscler Thromb Vasc Biol 2000; 20: 715-720.","DOI":"10.1161\/01.ATV.20.3.715"},{"key":"62","doi-asserted-by":"crossref","unstructured":"62. Mitsuoka H, Kume N, Hayashida K, Inui-Hayashiada A, Aramaki Y, Toyohara M, et al. Interleukin 18 stimulates release of soluble lectin-like oxidized LDL receptor-1 (sLOX-1). Atherosclerosis 2009; 202: 176-182.","DOI":"10.1016\/j.atherosclerosis.2008.04.002"},{"key":"63","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.104.468397"},{"key":"64","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.2001.4508"},{"key":"65","doi-asserted-by":"crossref","unstructured":"65. Sato Y, Nishimichi N, Nakano A, Takikawa K, Inoue N, Matsuda H, et al. Determination of LOX-1-ligand activity in mouse plasma with a chicken monoclonal antibody for ApoB. Atherosclerosis 2008; 200: 303-309.","DOI":"10.1016\/j.atherosclerosis.2008.02.001"},{"key":"66","doi-asserted-by":"crossref","unstructured":"66. Oka K, Yasuhara M, Suzumura K, Tanaka K, Sawamura T. Antioxidants suppress plasma levels of lectinlike oxidized low-density lipoprotein receptor-ligands and reduce atherosclerosis in watanabe heritable hyperlipidemic rabbits. J Cardiovasc Pharmacol 2006; 48: 177-183.","DOI":"10.1097\/01.fjc.0000245989.89771.1b"},{"key":"67","doi-asserted-by":"publisher","DOI":"10.1001\/jama.299.19.2287"},{"key":"68","doi-asserted-by":"publisher","DOI":"10.1001\/jama.281.18.1718"},{"key":"69","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa043175"},{"key":"70","doi-asserted-by":"crossref","unstructured":"70. Ishino S, Mukai T, Kuge Y, Kume N, Ogawa M, Takai N, et al. Targeting of lectinlike oxidized low-density lipoprotein receptor 1 (LOX-1) with 99 mTc-labeled anti-LOX-1 antibody: Potential agent for imaging of vulnerable plaque. J Nucl Med 2008; 49: 1677-1685.","DOI":"10.2967\/jnumed.107.049536"}],"container-title":["Circulation Journal"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.jstage.jst.go.jp\/article\/circj\/73\/11\/73_CJ-09-0587\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,10,12]],"date-time":"2021-10-12T19:21:26Z","timestamp":1634066486000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.jstage.jst.go.jp\/article\/circj\/73\/11\/73_CJ-09-0587\/_article"}},"subtitle":["The Multifunctional Receptor Underlying Cardiovascular Dysfunction"],"short-title":[],"issued":{"date-parts":[[2009]]},"references-count":70,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2009]]}},"URL":"https:\/\/doi.org\/10.1253\/circj.cj-09-0587","relation":{},"ISSN":["1346-9843","1347-4820"],"issn-type":[{"value":"1346-9843","type":"print"},{"value":"1347-4820","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009]]}}}