{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T04:18:36Z","timestamp":1791951516977,"version":"4.3.4"},"reference-count":35,"publisher":"Japanese Circulation Society","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Circ J"],"published-print":{"date-parts":[[2010]]},"DOI":"10.1253\/circj.cj-10-0234","type":"journal-article","created":{"date-parts":[[2010,10,15]],"date-time":"2010-10-15T05:20:23Z","timestamp":1287120023000},"page":"2410-2418","source":"Crossref","is-referenced-by-count":41,"title":["Reduced ACTC1 Expression Might Play a Role in the Onset of Congenital Heart Disease by Inducing Cardiomyocyte Apoptosis"],"prefix":"10.1253","volume":"74","author":[{"given":"Hong-Kun","family":"Jiang","sequence":"first","affiliation":[{"name":"Department of Pediatrics, The First Affiliated Hospital of China Medical University"},{"name":"Department of Medical Genetics, China Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guang-Rong","family":"Qiu","sequence":"additional","affiliation":[{"name":"Department of Medical Genetics, China Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jesse","family":"Li-Ling","sequence":"additional","affiliation":[{"name":"Department of Medical Genetics, China Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na","family":"Xin","sequence":"additional","affiliation":[{"name":"Department of Medical Genetics, China Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai-Lai","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Medical Genetics, China Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"330","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1038\/ng0197-30"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2. Gelb BD, Tartaglia M. Noonan syndrome and related disorders: Dysregulated RAS-mitogen activated protein kinase signal transduction. Hum Mol Genet 2006; 15: R220-R226.","DOI":"10.1093\/hmg\/ddl197"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3. Wiseman FK, Alford KA, Tybulewicz VL, Fisher EM. Down syndrome--recent progress and future prospects. Hum Mol Genet 2009; 18: R75-R83.","DOI":"10.1093\/hmg\/ddp010"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4. Wat MJ, Shchelochkov OA, Holder AM, Breman AM, Dagli A, Bacino C, et al. Chromosome 8p23.1 deletions as a cause of complex congenital heart defects and diaphragmatic hernia. Am J Med Genet A 2009; 149A: 1661-1677.","DOI":"10.1002\/ajmg.a.32896"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1038\/nature06801"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1038\/ng1526"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7. Matsson H, Eason J, Bookwalter CS, Klar J, Gustavsson P, Sunnegardh J, et al. Alpha-cardiac actin mutations produce atrial septal defects. Hum Mol Genet 2008; 17: 256-265.","DOI":"10.1093\/hmg\/ddm302"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00001.2007"},{"issue":"11","key":"9","first-page":"2174","volume":"1783","author":"FEDOROVA ELENA","year":"2008","ISSN":"https:\/\/id.crossref.org\/issn\/0005-2728","issn-type":"print"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1126\/science.1168823"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11. McNally E, Dellefave L. Sarcomere mutations in cardiogenesis and ventricular noncompaction. Trends Cardiovasc Med 2009; 19: 17-21.","DOI":"10.1016\/j.tcm.2009.03.003"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12. Abdelwahid E, Pelliniemi LJ, Szucsik JC, Lessard JL, Jokinen E. Cellular disorganization and extensive apoptosis in the developing heart of mice that lack cardiac muscle alpha-actin: Apparent cause of perinatal death. Pediatr Res 2004; 55: 197-204.","DOI":"10.1203\/01.PDR.0000100900.56627.E1"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13. Suurmeijer AJ, Clement S, Francesconi A, Bocchi L, Angelini A, Van Veldhuisen DJ, et al. Alpha-actin isoform distribution in normal and failing human heart: A morphological, morphometric, and biochemical study. J Pathol 2003; 199: 387-397.","DOI":"10.1002\/path.1311"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14. Laing NG. Congenital myopathies. Curr Opin Neurol 2007; 20: 583-589.","DOI":"10.1097\/WCO.0b013e3282ef6e69"},{"key":"15","unstructured":"15. Capek P, Brdicka R. Hypertrophic cardiomyopathy. Cas Lek Cesk 2006; 145: 93-96; Discussion 96-97."},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehm239"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.107.746164"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18. Erdogan F, Ullmann R, Chen W, Schubert M, Adolph S, Hultschig C, et al. Characterization of a 5.3Mb deletion in 15q14 by comparative genomic hybridization using a whole genome \"tiling path\" BAC array in a girl with heart defect, cleft palate, and developmental delay. Am J Med Genet A 2007; 143: 172-178.","DOI":"10.1002\/ajmg.a.31541"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2007.08.022"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1038\/nature01282"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21. Auman HJ, Coleman H, Riley HE, Olale F, Tsai HJ, Yelon D. Functional modulation of cardiac form through regionally confined cell shape changes. PLoS Biol 2007; 5: e53.","DOI":"10.1371\/journal.pbio.0050053"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1038\/nature06254"},{"key":"23","doi-asserted-by":"crossref","unstructured":"23. van den Hoff MJ, van den Eijnde SM, Viragh S, Moorman AF. Programmed cell death in the developing heart. Cardiovasc Res 2000; 45: 603-620.","DOI":"10.1016\/S0008-6363(99)00401-0"},{"key":"24","doi-asserted-by":"crossref","unstructured":"24. Abdelwahid E, Pelliniemi LJ, Jokinen E. Cell death and differentiation in the development of the endocardial cushion of the embryonic heart. Microsc Res Tech 2002; 58: 395-403.","DOI":"10.1002\/jemt.10159"},{"key":"25","doi-asserted-by":"crossref","unstructured":"25. Poelmann RE, Gittenberger-de Groot AC. Apoptosis as an instrument in cardiovascular development. Birth Defects Res C Embryo Today 2005; 75: 305-313.","DOI":"10.1002\/bdrc.20058"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20080320"},{"key":"27","doi-asserted-by":"publisher","DOI":"10.1253\/circj.CJ-09-0573"},{"key":"28","doi-asserted-by":"crossref","unstructured":"28. Hosoda T, Kajstura J, Leri A, Anversa P. Mechanisms of myocardial regeneration. Circ J 2010; 74: 13-17.","DOI":"10.1253\/circj.CJ-09-0665"},{"key":"29","doi-asserted-by":"publisher","DOI":"10.1253\/circj.CJ-09-0284"},{"key":"30","doi-asserted-by":"publisher","DOI":"10.1006\/excr.2000.4970"},{"key":"31","doi-asserted-by":"crossref","unstructured":"31. White SR, Williams P, Wojcik KR, Sun S, Hiemstra PS, Rabe KF, et al. Initiation of apoptosis by actin cytoskeletal derangement in human airway epithelial cells. Am J Respir Cell Mol Biol 2001; 24: 282-294.","DOI":"10.1165\/ajrcmb.24.3.3995"},{"key":"32","doi-asserted-by":"crossref","unstructured":"32. Odaka C, Sanders ML, Crews P. Jasplakinolide induces apoptosis in various transformed cell lines by a caspase-3-like protease-dependent pathway. Clin Diagn Lab Immunol 2000; 7: 947-952.","DOI":"10.1128\/CDLI.7.6.947-952.2000"},{"key":"33","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.21.19.6529-6536.2001"},{"key":"34","doi-asserted-by":"crossref","unstructured":"34. Nishida K, Otsu K. Cell death in heart failure. Circ J 2008; 72(Suppl A): A-17-A-21.","DOI":"10.1253\/circj.CJ-08-0669"},{"key":"35","doi-asserted-by":"publisher","DOI":"10.1253\/circj.CJ-09-0074"}],"container-title":["Circulation Journal"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.jstage.jst.go.jp\/article\/circj\/74\/11\/74_CJ-10-0234\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,3,25]],"date-time":"2021-03-25T03:53:34Z","timestamp":1616644414000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.jstage.jst.go.jp\/article\/circj\/74\/11\/74_CJ-10-0234\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010]]},"references-count":35,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2010]]}},"URL":"https:\/\/doi.org\/10.1253\/circj.cj-10-0234","relation":{},"ISSN":["1346-9843","1347-4820"],"issn-type":[{"value":"1346-9843","type":"print"},{"value":"1347-4820","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010]]}}}