{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T22:27:24Z","timestamp":1777415244524,"version":"3.51.4"},"reference-count":36,"publisher":"Japanese Circulation Society","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Circ J"],"published-print":{"date-parts":[[2015]]},"DOI":"10.1253\/circj.cj-15-0050","type":"journal-article","created":{"date-parts":[[2015,5,20]],"date-time":"2015-05-20T22:05:07Z","timestamp":1432159507000},"page":"1841-1845","source":"Crossref","is-referenced-by-count":25,"title":["Impact of Elevated D-Dimer on Diagnosis of Acute Aortic Dissection With Isolated Neurological Symptoms in Ischemic Stroke"],"prefix":"10.1253","volume":"79","author":[{"given":"Tsuyoshi","family":"Yoshimuta","sequence":"first","affiliation":[{"name":"Division of Cardiovascular Medicine, Kanazawa University Graduate School of Medical Science"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroyuki","family":"Yokoyama","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, National Cerebral and Cardiovascular Center"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshiya","family":"Okajima","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Takarazuka City Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, National Cerebral and Cardiovascular Center"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazunori","family":"Toyoda","sequence":"additional","affiliation":[{"name":"Department of Stroke, National Cerebral and Cardiovascular Center"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuyuki","family":"Nagatsuka","sequence":"additional","affiliation":[{"name":"Department of Stroke, National Cerebral and Cardiovascular Center"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masahiro","family":"Higashi","sequence":"additional","affiliation":[{"name":"Department of Radiology, National Cerebral and Cardiovascular Center"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenshi","family":"Hayashi","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine, Kanazawa University Graduate School of Medical Science"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masa-aki","family":"Kawashiri","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine, Kanazawa University Graduate School of Medical Science"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satoshi","family":"Yasuda","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, National Cerebral and Cardiovascular Center"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masakazu","family":"Yamagishi","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine, Kanazawa University Graduate School of Medical Science"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"330","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"1. Hagen PG, Nienaber CA, Isselbacher EM, Bruckman D, Karavite DJ, Russman PL, et al. The international registry of acute aortic dissection. <i>JAMA<\/i> 2000; 283: 897\u2013903.","DOI":"10.1001\/jama.283.7.897"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2. Pacini D, Di Marco L, Fortuna D, Belotti LM, Gabbieri D, Zussa C, et al. Acute aortic dissection: Epidemiology and outcomes. <i>Int J Cardiol<\/i> 2013; 167: 2806\u20132812.","DOI":"10.1016\/j.ijcard.2012.07.008"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3. JCS Joint Working Group. Guidelines for diagnosis and treatment of aortic aneurysm and aortic dissection (JCS 2011): Digest version. <i>Circ J<\/i> 2013; 77: 789\u2013828.","DOI":"10.1253\/circj.CJ-66-0057"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4. Gaul C, Dietrich W, Friedrich I, Sirch J, Erbguth FJ. Neurological symptoms in type A aortic dissections. <i>Stroke<\/i> 2007; 38: 292\u2013297.","DOI":"10.1161\/01.STR.0000254594.33408.b1"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5. M\u00e9sz\u00e1ros I, M\u00f3rocz J, Szl\u00e1vi J, Schmidt J, Torn\u00f3ci L, Nagy L, et al. Epidemiology and clinicopathology of aortic dissection: A population-based longitudinal study over 27 years. <i>Chest<\/i> 2000; 117: 1271\u20131278.","DOI":"10.1378\/chest.117.5.1271"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6. Blanco M, D\u00edez-Tejedor E, Larrea JL, Ram\u00edrez U. Neurologic complications of type I aortic dissection. <i>Acta Neurol Scand<\/i> 1999; 99: 232\u2013235.","DOI":"10.1111\/j.1600-0404.1999.tb07352.x"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7. Bossone E, Corteville DC, Harris KM, Suzuki T, Fattori R, Hutchison S, et al. Stroke and outcome in patients with acute type A aortic dissection. <i>Circulation<\/i> 2013; 128(Suppl 1): S175\u2013S179.","DOI":"10.1161\/CIRCULATIONAHA.112.000327"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8. Tokuda Y, Miyata H, Motomura N, Oshima H, Usui A, Takamoto S; Japan adult cardiovascular database organization. Brain protection during ascending aortic repair for Stanford type A acute aortic dissection surgery: Nationwide analysis in Japan. <i>Circ J<\/i> 2014; 78: 2431\u20132438.","DOI":"10.1253\/circj.CJ-14-0565"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9. Eggebrecht H, Naber CK, Bruch C, Kr\u00f6ger K, von Birgelen C, Schmermund A, et al. Value of plasma fibrin D-dimers for detection of acute aortic dissection. <i>J Am Coll Cardiol<\/i> 2004; 44: 804\u2013809.","DOI":"10.1016\/j.jacc.2004.04.053"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10. Weber T, H\u00f6gler S, Auer J, Berent R, Lassnig E, Kvas E, et al. D-Dimer in acute aortic dissection. <i>Chest<\/i> 2003; 123: 1375\u20131378.","DOI":"10.1378\/chest.123.5.1375"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11. Suzuki T, Distante A, Zizza A, Trimarchi S, Villani M, Salerno Uriarte JA, et al. Diagnosis of acute aortic dissection by D-dimer: The International Registry of Acute Aortic Dissection Substudy on Biomarkers (IRAD-Bio) experience. <i>Circulation<\/i> 2009; 119: 2702\u20132707.","DOI":"10.1161\/CIRCULATIONAHA.108.833004"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12. Takano K, Yamaguchi T, Kato H, Omae T. Activation of coagulation in acute cardioembolic stroke. <i>Stroke<\/i> 1991; 22: 12\u201316.","DOI":"10.1161\/01.STR.22.1.12"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13. Ono N, Koyama T, Suehiro A, Oku K, Fujikake K, Kakishita E. Clinical significance of new coagulation and fibrinolytic markers in ischemic stroke patients. <i>Stroke<\/i> 1991; 22: 1369\u20131373.","DOI":"10.1161\/01.STR.22.11.1369"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14. Adams HP Jr, Bendixen BH, Kappelle LJ, Biller J, Love BB, Gordon DL, et al. Classification of subtype of acute ischemic stroke: Definitions for use in a multicenter clinical trial: TOAST Trial of Org 10172 in Acute Stroke Treatment. <i>Stroke<\/i> 1993; 24: 35\u201341.","DOI":"10.1161\/01.STR.24.1.35"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15. Dailey PO, Trueblood H, Stinson EB, Wuerflein RD, Shumway NE. Management of acute aortic dissection. <i>Ann Thorac Surg<\/i> 1970; 10: 237\u2013247.","DOI":"10.1016\/S0003-4975(10)65594-4"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16. The National Institute of Neurological Disorders and Stroke rt-PA Stroke Study Group. Tissue plasminogen activator for acute ischemic stroke. <i>N Engl J Med<\/i> 1995; 333: 1581\u20131587.","DOI":"10.1056\/NEJM199512143332401"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17. Sandercock P, Wardlaw JM, Lindley RI, Dennis M, Cohen G, Murray G, et al. The benefit and harms of intravenous thrombolysis with recombinant tissue plasminogen activator within 6 h of acute ischaemic stroke (the Third International Stroke Trial [IST-3]): A randomised controlled trial. <i>Lancet<\/i> 2012; 379: 2352\u20132363.","DOI":"10.1016\/S0140-6736(12)60768-5"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18. Flemming KD, Brown RD Jr. Acute cerebral infarction caused by aortic dissection: Caution in the thrombolytic era. <i>Stroke<\/i> 1999; 30: 477\u2013478.","DOI":"10.1161\/01.STR.30.2.477"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19. Fessler AJ, Alberts MJ. Stroke treatment with tissue plasminogen activator in the setting of aortic dissection. <i>Neurology<\/i> 2000; 54: 1010.","DOI":"10.1212\/WNL.54.4.1010"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20. Ageno W, Finazzi S, Steidl L, Biotti MG, Mera V, Melzi D\u2019Eril G, et al. Plasma measurement of D-dimer levels for the early diagnosis of ischemic stroke subtype. <i>Arch Intern Med<\/i> 2002; 162: 2589\u20132593.","DOI":"10.1001\/archinte.162.22.2589"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21. Wannamethee SG, Whincup PH, Lennon L, Rumley A, Lowe GD. Fibrin D-dimer, tissue-type plasminogen activator, von Willebrand factor, and risk of incident stroke in older men. <i>Stroke<\/i> 2012; 43: 1206\u20131211.","DOI":"10.1161\/STROKEAHA.111.636373"},{"key":"22","doi-asserted-by":"crossref","unstructured":"22. Montaner J, Perea-Gainza M, Delgado P, Rib\u00f3 M, Chac\u00f3n P, Rosell A. Etiologic diagnosis of ischemic stroke subtypes with plasma biomarkers. <i>Stroke<\/i> 2008; 39: 2280\u20132287.","DOI":"10.1161\/STROKEAHA.107.505354"},{"key":"23","doi-asserted-by":"crossref","unstructured":"23. Ono N, Koyama T, Suehiro A, Oku K, Fujikake K, Kakishita E. Clinical significance of new coagulation and fibrinolytic markers in ischemic stroke patients. <i>Stroke<\/i> 1991; 22: 1369\u20131373.","DOI":"10.1161\/01.STR.22.11.1369"},{"key":"24","doi-asserted-by":"crossref","unstructured":"24. Barber M, Langhorne P, Rumley A, Lowe GD, Stott DJ. Hemostatic function and progressing ischemic stroke: D-dimer predicts early clinical progression. <i>Stroke<\/i> 2004; 35: 1421\u20131425.","DOI":"10.1161\/01.STR.0000126890.63512.41"},{"key":"25","doi-asserted-by":"crossref","unstructured":"25. Goldhaber SZ, Vaughan DE, Tumeh SS, Loscalzo J. Utility of cross-linked fibrin degradation products in the diagnosis of pulmonary embolism. <i>Am Heart J<\/i> 1988; 116: 505\u2013508.","DOI":"10.1016\/0002-8703(88)90625-4"},{"key":"26","doi-asserted-by":"crossref","unstructured":"26. Goldhaber SZ, Simons GR, Elliott CG, Haire WD, Toltzis R, Blacklow SC, et al. Quantitative plasma D-dimer levels among patients undergoing pulmonary angiography for suspected pulmonary embolism. <i>JAMA<\/i> 1993; 270: 2819\u20132822.","DOI":"10.1001\/jama.1993.03510230057035"},{"key":"27","doi-asserted-by":"crossref","unstructured":"27. Bucek RA, Quehenberger P, Feliks I, Handler S, Reiter M, Minar E. Results of a new rapid d-dimer assay (cardiac d-dimer) in the diagnosis of deep vein thrombosis. <i>Thromb Res<\/i> 2001; 103: 17\u201323.","DOI":"10.1016\/S0049-3848(00)00367-4"},{"key":"28","doi-asserted-by":"crossref","unstructured":"28. Ridker PM, Hennekens CH, Cerskus A, Stampfer MJ. Plasma concentration of cross-linked fibrin degradation product (D-dimer) and the risk of future myocardial infarction among apparently healthy men. <i>Circulation<\/i> 1994; 90: 2236\u20132240.","DOI":"10.1161\/01.CIR.90.5.2236"},{"key":"29","doi-asserted-by":"crossref","unstructured":"29. Yamazumi K, Ojiro M, Okamura H, Aikou T. An activated state of blood coagulation and fibrinolysis in patients with abdominal aortic aneurysm. <i>Am J Surg<\/i> 1998; 175: 297\u2013301.","DOI":"10.1016\/S0002-9610(98)00014-2"},{"key":"30","doi-asserted-by":"crossref","unstructured":"30. Costantini V, Zacharski LR. Fibrin and cancer. <i>Thromb Haemost<\/i> 1993; 69: 406\u2013414.","DOI":"10.1055\/s-0038-1651624"},{"key":"31","doi-asserted-by":"crossref","unstructured":"31. Violi F, Ferro D, Basili S, Quintarelli C, Musca A, Cordova C, et al. Hyperfibrinolysis resulting from clotting activation in patients with different degrees of cirrhosis: The CALC Group: Coagulation Abnormalities in Liver Cirrhosis. <i>Hepatology<\/i> 1993; 17: 78\u201383.","DOI":"10.1002\/hep.1840170115"},{"key":"32","doi-asserted-by":"crossref","unstructured":"32. Pernambuco JR, Langley PG, Hughes RD, Izumi S, Williams R. Activation of the fibrinolytic system in patients with fulminant liver failure. <i>Hepatology<\/i> 1993; 18: 1350\u20131356.","DOI":"10.1002\/hep.1840180611"},{"key":"33","doi-asserted-by":"crossref","unstructured":"33. Yu M, Nardella A, Pechet L. Screening tests of disseminated intravascular coagulation: Guidelines for rapid and specific laboratory diagnosis. <i>Crit Care Med<\/i> 2000; 28: 1777\u20131780.","DOI":"10.1097\/00003246-200006000-00013"},{"key":"34","doi-asserted-by":"crossref","unstructured":"34. Kurabayashi M, Okishige K, Ueshima D, Yoshimura K, Shimura T, Suzuki H, et al. Diagnostic utility of unenhanced computed tomography for acute aortic syndrome. <i>Circ J<\/i> 2014; 78: 1928\u20131934.","DOI":"10.1253\/circj.CJ-14-0198"},{"key":"35","doi-asserted-by":"crossref","unstructured":"35. Yoshimuta T, Yokoyama H, Okajima T, Yamagishi M, Nonogi H. Echocardiographic diagnosis of aortic intramural hematoma via the posterior parasternal window. <i>Intern Med<\/i> 2010; 49: 83\u201384.","DOI":"10.2169\/internalmedicine.49.2838"},{"key":"36","doi-asserted-by":"crossref","unstructured":"36. Yoshimuta T, Okajima T, Harada K, Mori M, Hayashi K, Yamagishi M. Impact of the right parasternal view with supine positioning for echocardiographic visualization of acute type A aortic dissection. <i>J Echocardiogr<\/i> 2012; 10: 38\u201339.","DOI":"10.1007\/s12574-012-0107-3"}],"container-title":["Circulation Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/circj\/advpub\/0\/advpub_CJ-15-0050\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,25]],"date-time":"2019-08-25T10:16:49Z","timestamp":1566728209000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/circj\/79\/8\/79_CJ-15-0050\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015]]},"references-count":36,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2015]]}},"URL":"https:\/\/doi.org\/10.1253\/circj.cj-15-0050","relation":{},"ISSN":["1346-9843","1347-4820"],"issn-type":[{"value":"1346-9843","type":"print"},{"value":"1347-4820","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015]]}}}