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O\u2019Brien E, Parati G, Stergiou G, Asmar R, Beilin L, Bilo G, et al; European Society of Hypertension Working Group on Blood Pressure Monitoring. European Society of Hypertension position paper on ambulatory blood pressure monitoring. <i>J Hypertens<\/i> 2013; 31: 1731\u20131768.","DOI":"10.1097\/HJH.0b013e328363e964"},{"key":"20","doi-asserted-by":"publisher","unstructured":"20. B\u00f6hm M, Schumacher H, Laufs U, Sleight P, Schmieder R, Unger T, et al. Effects of nonpersistence with medication on outcomes in high-risk patients with cardiovascular disease. <i>Am Heart J<\/i> 2013; 166: 306\u2013314.e7, doi:10.1016\/j.ahj.2013.04.016.","DOI":"10.1016\/j.ahj.2013.04.016"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21. Kandzari D, Bhatt DL, Brar S, Devireddy CM, Esler M, Fahy M, et al. 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Cardiovascular disease and risk factors in Asia: A selected review. <i>Circulation<\/i> 2008; 118: 2702\u20132709.","DOI":"10.1161\/CIRCULATIONAHA.108.790048"},{"key":"25","doi-asserted-by":"crossref","unstructured":"25. Ishikawa Y, Ishikawa J, Ishikawa S, Kajii E, Schwartz JE, Pickering TG, et al. Prehypertension and the risk for cardiovascular disease in the Japanese general population: The Jichi Medical School Cohort Study. <i>J Hypertens<\/i> 2010; 28: 1630\u20131637.","DOI":"10.1097\/HJH.0b013e32833a8b9f"},{"key":"26","doi-asserted-by":"crossref","unstructured":"26. Stamler J. The INTERSALT study: Background, methods, findings, and implications. <i>Am J Clin Nutr<\/i> 1997; 65: 626S\u2013642S.","DOI":"10.1093\/ajcn\/65.2.626S"},{"key":"27","doi-asserted-by":"crossref","unstructured":"27. Katsuya T, Ishikawa K, Sugimoto K, Rakugi H, Ogihara T. 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