{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T22:05:35Z","timestamp":1791497135258,"version":"4.3.4"},"reference-count":35,"publisher":"Japanese Circulation Society","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Circ J"],"published-print":{"date-parts":[[2015]]},"DOI":"10.1253\/circj.cj-15-0412","type":"journal-article","created":{"date-parts":[[2015,6,15]],"date-time":"2015-06-15T22:19:18Z","timestamp":1434406758000},"page":"2031-2037","source":"Crossref","is-referenced-by-count":36,"title":["Homocysteine and Arginine-to-Asymmetric Dimethylarginine Ratio Associated With Blood Pressure Abnormalities in Children With Early Chronic Kidney Disease"],"prefix":"10.1253","volume":"79","author":[{"given":"Shao-Ju","family":"Chien","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University, College of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I-Chun","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University, College of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chien-Ning","family":"Hsu","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University, College of Medicine"},{"name":"School of Pharmacy, Kaohsiung Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mao-Hung","family":"Lo","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University, College of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"You-Lin","family":"Tain","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University, College of Medicine"},{"name":"Center for Translational Research in Biomedical Sciences, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University, College of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"330","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"1. Kavey RE, Allada V, Daniels SR, Hayman LL, McCrindle BW, Newburger JW, et al; American Heart Association Expert Panel on Population and Prevention Science; American Heart Association Council on Cardiovascular Disease in the Young; American Heart Association Council on Epidemiology and Prevention; American Heart Association Council on Nutrition, Physical Activity and Metabolism; American Heart Association Council on High Blood Pressure Research; American Heart Association Council on Cardiovascular Nursing; American Heart Association Council on the Kidney in Heart Disease; Interdisciplinary Working Group on Quality of Care and Outcomes Research. Cardiovascular risk reduction in high-risk pediatric patients: A scientific statement from the American Heart Association Expert Panel on Population and Prevention Science; the Councils on Cardiovascular Disease in the Young, Epidemiology and Prevention, Nutrition, Physical Activity and Metabolism, High Blood Pressure Research, Cardiovascular Nursing, and the Kidney in Heart Disease; and the Interdisciplinary Working Group on Quality of Care and Outcomes Research: Endorsed by the American Academy of Pediatrics. <i>Circulation<\/i> 2006; 114: 2710\u20132738.","DOI":"10.1161\/CIRCULATIONAHA.106.179568"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2. Urbina EM, Williams RV, Alpert BS, Collins RT, Daniels SR, Hayman L, et al; American Heart Association Atherosclerosis, Hypertension, and Obesity in Youth Committee of the Council on Cardiovascular Disease in the Young. Noninvasive assessment of subclinical atherosclerosis in children and adolescents: Recommendations for standard assessment for clinical research: A scientific statement from the American Heart Association. <i>Hypertension<\/i> 2009; 54: 919\u2013950.","DOI":"10.1161\/HYPERTENSIONAHA.109.192639"},{"key":"3","unstructured":"3. Tain YL. Endothelial dysfunction links cardiovascular disease to pediatric chronic kidney disease: The role of nitric oxide deficiency. <i>Acta Paediatr Taiwan<\/i> 2007; 48: 246\u2013250."},{"key":"4","doi-asserted-by":"crossref","unstructured":"4. Bode-B\u00f6ger SM, Scalera F, Ignarro LJ. The L-arginine paradox: Importance of the L-arginine\/asymmetrical dimethylarginine ratio. <i>Pharmacol Ther<\/i> 2007; 114: 295\u2013306.","DOI":"10.1016\/j.pharmthera.2007.03.002"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5. B\u00f6ger RH, Maas R, Schulze F, Schwedhelm E. Asymmetric dimethylarginine (ADMA) as a prospective marker of cardiovascular disease and mortality: An update on patient populations with a wide range of cardiovascular risk. <i>Pharmacol Res<\/i> 2009; 60: 481\u2013487.","DOI":"10.1016\/j.phrs.2009.07.001"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6. Fliser D, Kronenberg F, Kielstein JT, Morath C, Bode-B\u00f6ger SM, Haller H, et al. Asymmetric dimethylarginine and progression of chronic kidney disease: The mild to moderate kidney disease study. <i>J Am Soc Nephrol<\/i> 2005; 16: 2456\u20132461.","DOI":"10.1681\/ASN.2005020179"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7. Agarwal R. Ambulatory blood pressure and cardiovascular events in chronic kidney disease. <i>Semin Nephrol<\/i> 2007; 27: 538\u2013543.","DOI":"10.1016\/j.semnephrol.2007.07.001"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8. Lin YJ, Hsu CN, Lo MH, Huang CF, Chien SJ, Tain YL. High citrulline-to-arginine ratio associated with blood pressure abnormalities in children with early chronic kidney disease. <i>Circ J<\/i> 2013; 77: 181\u2013187.","DOI":"10.1253\/circj.CJ-12-0602"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9. Kuo HC, Hsu CN, Huang CF, Lo MH, Chien SJ, Tain YL. Urinary arginine methylation index associated with ambulatory blood pressure abnormalities in children with chronic kidney disease. <i>J Am Soc Hypertens<\/i> 2012; 6: 385\u2013392.","DOI":"10.1016\/j.jash.2012.09.003"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10. van Guldener C, Nanayakkara PW, Stehouwer CD. Homocysteine and asymmetric dimethylarginine (ADMA): Biochemically linked but differently related to vascular disease in chronic kidney disease. <i>Clin Chem Lab Med<\/i> 2007; 45: 1683\u20131687.","DOI":"10.1515\/CCLM.2007.340"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11. Taal MW. Arterial stiffness in chronic kidney disease: An update. <i>Curr Opin Nephrol Hypertens<\/i> 2014; 23: 169\u2013173.","DOI":"10.1097\/01.mnh.0000441153.40072.e0"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12. Jia G, Aroor AR, Sowers JR. Arterial stiffness: A nexus between cardiac and renal disease. <i>Cardiorenal Med<\/i> 2014; 4: 60\u201371.","DOI":"10.1159\/000360867"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13. Boutouyrie P, Fliser D, Goldsmith D, Covic A, Wiecek A, Ortiz A, et al. Assessment of arterial stiffness for clinical and epidemiological studies: Methodological considerations for validation and entry into the European Renal and Cardiovascular Medicine registry. <i>Nephrol Dial Transplant<\/i> 2014; 29: 232\u2013239.","DOI":"10.1093\/ndt\/gft309"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14. Schwartz GJ, Mu\u00f1oz A, Schneider MF, Mak RH, Kaskel F, Warady BA, et al. New equations to estimate GFR in children with CKD. <i>J Am Soc Nephrol<\/i> 2009; 20: 629\u2013637.","DOI":"10.1681\/ASN.2008030287"},{"key":"15","unstructured":"15. National Kidney Foundation. K\/DOQI clinical practice guidelines for chronic kidney disease: Evaluation, classification, and stratification. <i>Am J Kidney Dis<\/i> 2002; 39: S1\u2013S266."},{"key":"16","doi-asserted-by":"crossref","unstructured":"16. Hogg RJ, Furth S, Lemley KV, Portman R, Schwartz GJ, Coresh J, et al. National Kidney Foundation\u2019s Kidney Disease Outcomes Quality Initiative clinical practice guidelines for chronic kidney disease in children and adolescents: Evaluation, classification, and stratification. <i>Pediatrics<\/i> 2003; 111: 1416\u20131421.","DOI":"10.1542\/peds.111.6.1416"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17. W\u00fchl E, Witte K, Soergelm M, Mehls O, Schaefer F; German Working Group on Pediatric Hypertension. Distribution of 24-h ambulatory blood pressure in children: Normalized reference values and role of body dimensions. <i>J Hypertens<\/i> 2002; 20: 1995\u20132007.","DOI":"10.1097\/00004872-200210000-00019"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18. Kollias A, Stergiou GS, Dolan E, O\u2019Brien E. Ambulatory arterial stiffness index: A systematic review and meta-analysis. <i>Atherosclerosis<\/i> 2012; 224: 291\u2013301.","DOI":"10.1016\/j.atherosclerosis.2012.03.039"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19. Cole TJ, Bellizzi MC, Flegal KM, Dietz WH. Establishing a standard definition for child overweight and obesity worldwide: International survey. <i>BMJ<\/i> 2000; 320: 1240\u20131243.","DOI":"10.1136\/bmj.320.7244.1240"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20. Tang L, Kubota M, Nagai A, Mamemoto K, Tokuda M. Hyperuricemia in obese children and adolescents: The relationship with metabolic syndrome. <i>Pediatr Rep<\/i> 2010; 2: e12, doi:10.4081\/pr.2010.e12.","DOI":"10.4081\/pr.2010.e12"},{"key":"21","doi-asserted-by":"crossref","unstructured":"22. Khoury PR, Mitsnefes M, Daniels SR, Kimball TR. Age-specific reference intervals for indexed left ventricular mass in children. <i>J Am Soc Echocardiogr<\/i> 2009; 22: 709\u2013714.","DOI":"10.1016\/j.echo.2009.03.003"},{"key":"22","doi-asserted-by":"crossref","unstructured":"23. Wu TH, Kuo HC, Tain YL, Lin KM, Kuo HC, Chien SJ. Common carotid artery intima-media thickness is useful for diagnosis of the acute stage of Kawasaki disease. <i>BMC Pediatr<\/i> 2014; 14: 98.","DOI":"10.1186\/1471-2431-14-98"},{"key":"23","doi-asserted-by":"crossref","unstructured":"24. ESCAPE Trial Group,W\u00fchl E, Trivelli A, Picca S, Litwin M, Peco-Antic A, Zurowska A, et al. Strict blood-pressure control and progression of renal failure in children. <i>N Engl J Med<\/i> 2009; 361: 1639\u20131650.","DOI":"10.1056\/NEJMoa0902066"},{"key":"24","doi-asserted-by":"crossref","unstructured":"25. Mitsnefes M, Flynn J, Cohn S, Samuels J, Blydt-Hansen T, Saland J, et al; CKiD Study Group. Masked hypertension associates with left ventricular hypertrophy in children with CKD. <i>J Am Soc Nephrol<\/i> 2010; 21: 137\u2013144.","DOI":"10.1681\/ASN.2009060609"},{"key":"25","doi-asserted-by":"crossref","unstructured":"26. Sinha MD, Tibby SM, Rasmussen P, Rawlins D, Turner C, Dalton RN, et al. Blood pressure control and left ventricular mass in children with chronic kidney disease. <i>Clin J Am Soc Nephrol<\/i> 2011; 6: 543\u2013551.","DOI":"10.2215\/CJN.04690510"},{"key":"26","doi-asserted-by":"crossref","unstructured":"27. Koning AM, Frenay AR, Leuvenink HG, van Goor H. Hydrogen sulfide in renal physiology, disease and transplantation: The smell of renal protection. <i>Nitric Oxide<\/i> 2015; 46: 37\u201349.","DOI":"10.1016\/j.niox.2015.01.005"},{"key":"27","doi-asserted-by":"crossref","unstructured":"28. Zhang DH, Wen XM, Zhang L, Cui W. DNA methylation of human telomerase reverse transcriptase associated with leukocyte telomere length shortening in hyperhomocysteinemia-type hypertension in humans and in a rat model. <i>Circ J<\/i> 2014; 78: 1915\u20131923.","DOI":"10.1253\/circj.CJ-14-0233"},{"key":"28","doi-asserted-by":"crossref","unstructured":"29. Tain YL, Huang LT, Lin IC, Lau YT, Lin CY. Melatonin prevents hypertension and increased asymmetric dimethylarginine in young spontaneous hypertensive rats. <i>J Pineal Res<\/i> 2010; 49: 390\u2013398.","DOI":"10.1111\/j.1600-079X.2010.00806.x"},{"key":"29","doi-asserted-by":"crossref","unstructured":"30. St\u00fchlinger MC, Tsao PS, Her JH, Kimoto M, Balint RF, Cooke JP. Homocysteine impairs the nitric oxide synthase pathway: Role of asymmetric dimethylarginine. <i>Circulation<\/i> 2001; 104: 2569\u20132575.","DOI":"10.1161\/hc4601.098514"},{"key":"30","doi-asserted-by":"crossref","unstructured":"31. Briet M, Boutouyrie P, Laurent S, London GM. Arterial stiffness and pulse pressure in CKD and ESRD. <i>Kidney Int<\/i> 2012; 82: 388\u2013400.","DOI":"10.1038\/ki.2012.131"},{"key":"31","doi-asserted-by":"crossref","unstructured":"32. Brady TM, Schneider MF, Flynn JT, Cox C, Samuels J, Saland J, et al. Carotid intima-media thickness in children with CKD: Results from the CKiD study. <i>Clin J Am Soc Nephrol<\/i> 2012; 7: 1930\u20131937.","DOI":"10.2215\/CJN.03130312"},{"key":"32","doi-asserted-by":"crossref","unstructured":"33. Feig DI, Kang DH, Nakagawa T, Mazzali M, Johnson RJ. Uric acid and hypertension. <i>Curr Hypertens Rep<\/i> 2006; 8: 111\u2013115.","DOI":"10.1007\/s11906-006-0005-z"},{"key":"33","doi-asserted-by":"crossref","unstructured":"34. Hongo M, Hidaka H, Sakaguchi S, Nakanishi K, Ichikawa M, Hirota N, et al; Investigators of Study Project on Prevention of Metabolic Syndrome among Children, Adolescents, and Young Adults in Shinshu. Association between serum uric acid levels and cardiometabolic risk factors among Japanese junior high school students. <i>Circ J<\/i> 2011; 74: 1570\u20131577.","DOI":"10.1253\/circj.CJ-09-0837"},{"key":"34","doi-asserted-by":"crossref","unstructured":"35. Kai H, Kaneyuki M, Shihara M, Toyama Y, Mitsutake Y, Umei H, et al; MAPPY Study Investigators. Reduction in morning blood pressure is a key factor for ameliorating urinary albumin excretion in patients with morning hypertension irrespective of treatment regimen. <i>Circ J<\/i> 2013; 77: 1551\u20131557.","DOI":"10.1253\/circj.CJ-12-1102"},{"key":"35","unstructured":"36. Weng KP, Hsieh KS, Huang SH, Lin CC. Oscillometric ambulatory blood pressure values in healthy children. <i>Acta Paediatr Taiwan<\/i> 2002; 43: 15\u201320."}],"container-title":["Circulation Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/circj\/79\/9\/79_CJ-15-0412\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,27]],"date-time":"2019-08-27T01:10:46Z","timestamp":1566868246000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/circj\/79\/9\/79_CJ-15-0412\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015]]},"references-count":35,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2015]]}},"URL":"https:\/\/doi.org\/10.1253\/circj.cj-15-0412","relation":{},"ISSN":["1346-9843","1347-4820"],"issn-type":[{"value":"1346-9843","type":"print"},{"value":"1347-4820","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015]]}}}