{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T14:42:07Z","timestamp":1774708927136,"version":"3.50.1"},"reference-count":45,"publisher":"Japanese Circulation Society","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Circ J"],"published-print":{"date-parts":[[2016]]},"DOI":"10.1253\/circj.cj-16-0342","type":"journal-article","created":{"date-parts":[[2016,7,5]],"date-time":"2016-07-05T22:09:15Z","timestamp":1467756555000},"page":"1684-1688","source":"Crossref","is-referenced-by-count":23,"title":["Peripartum Cardiomyopathy From a Genetic Perspective"],"prefix":"10.1253","volume":"80","author":[{"given":"Chizuko A.","family":"Kamiya","sequence":"first","affiliation":[{"name":"Department of Perinatology and Gynecology, National Cerebral and Cardiovascular Center"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Yoshimatsu","sequence":"additional","affiliation":[{"name":"Department of Perinatology and Gynecology, National Cerebral and Cardiovascular Center"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomoaki","family":"Ikeda","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Mie University Graduate School of Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"330","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"1. Demakis JG, Rahimtoola SH. Peripartum cardiomyopathy. <i>Circulation<\/i> 1971; 44: 964\u2013968.","DOI":"10.1161\/01.CIR.44.5.964"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2. Sliwa K, Hilfiker-Kleiner D, Petrie MC, Mebazaa A, Pieske B, Buchmann E, et al. Current state of knowledge on aetiology, diagnosis, management, and therapy of peripartum cardiomyopathy: A position statement from the Heart Failure Association of the European Society of Cardiology Working Group on peripartum cardiomyopathy. <i>Eur J Heart Fail<\/i> 2010; 12: 767\u2013778.","DOI":"10.1093\/eurjhf\/hfq120"},{"key":"3","doi-asserted-by":"publisher","unstructured":"3. Modi KA, Illum S, Jariatul K, Caldito G, Reddy PC. Poor outcome of indigent patients with peripartum cardiomyopathy in the United States. <i>Am J Obstet Gynecol<\/i> 2009; 201: 171.e1\u2013e5, doi:10.1016\/j.ajog.2009.04.037.","DOI":"10.1016\/j.ajog.2009.04.037"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4. Pearson GD, Veille JC, Rahimtoola S, Hsia J, Oakley CM, Hosenpud JD, et al. Peripartum cardiomyopathy: National Heart, Lung, and Blood Institute and Office of Rare Diseases (National Institutes of Health) workshop recommendations and review. <i>JAMA<\/i> 2000; 283: 1183\u20131188.","DOI":"10.1001\/jama.283.9.1183"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5. Gleicher N, Elkayam U. Peripartum cardiomyopathy, an autoimmune manifestation of allograft rejection? <i>Autoimmun Rev<\/i> 2009; 8: 384\u2013387.","DOI":"10.1016\/j.autrev.2008.12.003"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6. Bultmann BD, Klingel K, Nabauer M, Wallwiener D, Kandolf R. High prevalence of viral genomes and inflammation in peripartum cardiomyopathy. <i>Am J Obstet Gynecol<\/i> 2005; 193: 363\u2013365.","DOI":"10.1016\/j.ajog.2005.01.022"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7. Hilfiker-Kleiner D, Kaminski K, Podewski E, Bonda T, Schaefer A, Sliwa K, et al. A cathepsin D-cleaved 16 kDa form of prolactin mediates postpartum cardiomyopathy. <i>Cell<\/i> 2007; 128: 589\u2013600.","DOI":"10.1016\/j.cell.2006.12.036"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8. Patten IS, Rana S, Shahul S, Rowe GC, Jang C, Liu L, et al. Cardiac angiogenic imbalance leads to peripartum cardiomyopathy. <i>Nature<\/i> 2012; 485: 333\u2013338.","DOI":"10.1038\/nature11040"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9. Gunderson EP, Croen LA, Chiang V, Yoshida CK, Walton D, Go AS. Epidemiology of peripartum cardiomyopathy: Incidence, predictors, and outcomes. <i>Obstet Gynecol<\/i> 2011; 118: 583\u2013591.","DOI":"10.1097\/AOG.0b013e318229e6de"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10. Witlin AG, Mabie WC, Sibai BM. Peripartum cardiomyopathy: An ominous diagnosis. <i>Am J Obstet Gynecol<\/i> 1997; 176: 182\u2013188.","DOI":"10.1016\/S0002-9378(97)80033-6"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11. Brar SS, Khan SS, Sandhu GK, Jorgensen MB, Parikh N, Hsu JW, et al. Incidence, mortality, and racial differences in peripartum cardiomyopathy. <i>Am J Cardiol<\/i> 2007; 100: 302\u2013304.","DOI":"10.1016\/j.amjcard.2007.02.092"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12. Desai D, Moodley J, Naidoo D. Peripartum cardiomyopathy: Experiences at King Edward VIII Hospital, Durban, South Africa and a review of the literature. <i>Tropical Doctor<\/i> 1995; 25: 118\u2013123.","DOI":"10.1177\/004947559502500310"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13. Fett JD, Christie LG, Carraway RD, Murphy JG. Five-year prospective study of the incidence and prognosis of peripartum cardiomyopathy at a single institution. <i>Mayo Clin Proc<\/i> 2005; 80: 1602\u20131606.","DOI":"10.4065\/80.12.1602"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14. Kamiya CA, Kitakaze M, Ishibashi-Ueda H, Nakatani S, Murohara T, Tomoike H, et al. Different characteristics of peripartum cardiomyopathy between patients complicated with and without hypertensive disorders: Results from the Japanese Nationwide survey of peripartum cardiomyopathy. <i>Circ J<\/i> 2011; 75: 1975\u20131981.","DOI":"10.1253\/circj.CJ-10-1214"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15. Elkayam U, Akhter MW, Singh H, Khan S, Bitar F, Hameed A, et al. Pregnancy-associated cardiomyopathy: Clinical characteristics and a comparison between early and late presentation. <i>Circulation<\/i> 2005; 111: 2050\u20132055.","DOI":"10.1161\/01.CIR.0000162478.36652.7E"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16. Haghikia A, Podewski E, Libhaber E, Labidi S, Fischer D, Roentgen P, et al. Phenotyping and outcome on contemporary management in a German cohort of patients with peripartum cardiomyopathy. <i>Basic Res Cardiol<\/i> 2013; 108: 366.","DOI":"10.1007\/s00395-013-0366-9"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17. McNamara DM, Elkayam U, Alharethi R, Damp J, Hsich E, Ewald G, et al. Clinical Outcomes for peripartum cardiomyopathy in North America: Results of the IPAC Study (Investigations of Pregnancy-Associated Cardiomyopathy). <i>J Am Coll Cardiol<\/i> 2015; 66: 905\u2013914.","DOI":"10.1016\/j.jacc.2015.06.1309"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18. Sliwa K, Forster O, Libhaber E, Fett JD, Sundstrom JB, Hilfiker-Kleiner D, et al. Peripartum cardiomyopathy: Inflammatory markers as predictors of outcome in 100 prospectively studied patients. <i>Eur Heart J<\/i> 2006; 27: 441\u2013446.","DOI":"10.1093\/eurheartj\/ehi481"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19. Sliwa K, Fett J, Elkayam U. Peripartum cardiomyopathy. <i>Lancet<\/i> 2006; 368: 687\u2013693.","DOI":"10.1016\/S0140-6736(06)69253-2"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20. Goland S, Modi K, Bitar F, Janmohamed M, Mirocha JM, Czer LS, et al. Clinical profile and predictors of complications in peripartum cardiomyopathy. <i>J Card Fail<\/i> 2009; 15: 645\u2013650.","DOI":"10.1016\/j.cardfail.2009.03.008"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21. Ruys TP, Roos-Hesselink JW, Hall R, Subirana-Domenech MT, Grando-Ting J, Estensen M, et al. Heart failure in pregnant women with cardiac disease: Data from the ROPAC. <i>Heart<\/i> 2014; 100: 231\u2013238.","DOI":"10.1136\/heartjnl-2013-304888"},{"key":"22","doi-asserted-by":"crossref","unstructured":"22. Felker GM, Thompson RE, Hare JM, Hruban RH, Clemetson DE, Howard DL, et al. Underlying causes and long-term survival in patients with initially unexplained cardiomyopathy. <i>N Engl J Med<\/i> 2000; 342: 1077\u20131084.","DOI":"10.1056\/NEJM200004133421502"},{"key":"23","doi-asserted-by":"crossref","unstructured":"23. Amos AM, Jaber WA, Russell SD. Improved outcomes in peripartum cardiomyopathy with contemporary. <i>Am Heart J<\/i> 2006; 152: 509\u2013513.","DOI":"10.1016\/j.ahj.2006.02.008"},{"key":"24","doi-asserted-by":"crossref","unstructured":"24. van Spaendonck-Zwarts KY, van Tintelen JP, van Veldhuisen DJ, van der Werf R, Jongbloed JD, Paulus WJ, et al. Peripartum cardiomyopathy as a part of familial dilated cardiomyopathy. <i>Circulation<\/i> 2010; 121: 2169\u20132175.","DOI":"10.1161\/CIRCULATIONAHA.109.929646"},{"key":"25","doi-asserted-by":"crossref","unstructured":"25. van Spaendonck-Zwarts KY, Posafalvi A, van den Berg MP, Hilfiker-Kleiner D, Bollen IA, Sliwa K, et al. Titin gene mutations are common in families with both peripartum cardiomyopathy and dilated cardiomyopathy. <i>Eur Heart J<\/i> 2014; 35: 2165\u20132173.","DOI":"10.1093\/eurheartj\/ehu050"},{"key":"26","doi-asserted-by":"crossref","unstructured":"26. Morales A, Painter T, Li R, Siegfried JD, Li D, Norton N, et al. Rare variant mutations in pregnancy-associated or peripartum cardiomyopathy. <i>Circulation<\/i> 2010; 121: 2176\u20132182.","DOI":"10.1161\/CIRCULATIONAHA.109.931220"},{"key":"27","doi-asserted-by":"crossref","unstructured":"27. McNally EM, Puckelwartz MJ. Genetic variation in cardiomyopathy and cardiovascular disorders. <i>Circ J<\/i> 2015; 79: 1409\u20131415.","DOI":"10.1253\/circj.CJ-15-0536"},{"key":"28","doi-asserted-by":"crossref","unstructured":"28. Ware JS, Li J, Mazaika E, Yasso CM, DeSouza T, Cappola TP, et al. Shared genetic predisposition in peripartum and dilated cardiomyopathies. <i>N Engl J Med<\/i> 2016; 374: 233\u2013241.","DOI":"10.1056\/NEJMoa1505517"},{"key":"29","doi-asserted-by":"crossref","unstructured":"29. Herman DS, Lam L, Taylor MR, Wang L, Teekakirikul P, Christodoulou D, et al. Truncations of titin causing dilated cardiomyopathy. <i>N Engl J Med<\/i> 2012; 366: 619\u2013628.","DOI":"10.1056\/NEJMoa1110186"},{"key":"30","doi-asserted-by":"crossref","unstructured":"30. Burkett EL, Hershberger RE. Clinical and genetic issues in familial dilated cardiomyopathy. <i>J Am Coll Cardiol<\/i> 2005; 45: 969\u2013981.","DOI":"10.1016\/j.jacc.2004.11.066"},{"key":"31","doi-asserted-by":"crossref","unstructured":"31. Palojoki E, Kaartinen M, Kaaja R, Reissell E, Karkkainen S, Kuusisto J, et al. Pregnancy and childbirth in carriers of the lamin A\/C-gene mutation. <i>Eur J Heart Fail<\/i> 2010; 12: 630\u2013633.","DOI":"10.1093\/eurjhf\/hfq059"},{"key":"32","doi-asserted-by":"crossref","unstructured":"32. Grewal J, Siu SC, Ross HJ, Mason J, Balint OH, Sermer M, et al. Pregnancy outcomes in women with dilated cardiomyopathy. <i>J Am Coll Cardiol<\/i> 2010; 55: 45\u201352.","DOI":"10.1016\/j.jacc.2009.08.036"},{"key":"33","doi-asserted-by":"crossref","unstructured":"33. Arany Z, Elkayam U. Peripartum cardiomyopathy. <i>Circulation<\/i> 2016; 133: 1397\u20131409.","DOI":"10.1161\/CIRCULATIONAHA.115.020491"},{"key":"34","doi-asserted-by":"crossref","unstructured":"34. Report of the National High Blood Pressure Education Program Working Group on High Blood Pressure in Pregnancy. <i>Am J Obstet Gynecol<\/i> 2000; 183: S1\u2013S22.","DOI":"10.1067\/mob.2000.107928"},{"key":"35","doi-asserted-by":"crossref","unstructured":"35. Bello N, Hurtado Rendon I, Arany Z. The relationship between preeclampsia and peripartum cardiomyopathy: A systematic review and meta-analysis. <i>J Am Coll Cardiol<\/i> 2013; 62: 1715\u20131723.","DOI":"10.1016\/j.jacc.2013.08.717"},{"key":"36","doi-asserted-by":"crossref","unstructured":"36. Haram K, Mortensen JH, Nagy B. Genetic aspects of preeclampsia and the HELLP syndrome. <i>J Preg<\/i> 2014; 2014: 910751.","DOI":"10.1155\/2014\/910751"},{"key":"37","doi-asserted-by":"crossref","unstructured":"37. Fong FM, Sahemey MK, Hamedi G, Eyitayo R, Yates D, Kuan V, et al. Maternal genotype and severe preeclampsia: A HuGE review. <i>Am J Epidemiol<\/i> 2014; 180: 335\u2013345.","DOI":"10.1093\/aje\/kwu151"},{"key":"38","doi-asserted-by":"crossref","unstructured":"38. Sgambati E, Marini M, Zappoli Thyrion GD, Parretti E, Mello G, Orlando C, et al. VEGF expression in the placenta from pregnancies complicated by hypertensive disorders. <i>Br J Obstet Gynaecol<\/i> 2004; 111: 564\u2013570.","DOI":"10.1111\/j.1471-0528.2004.00143.x"},{"key":"39","doi-asserted-by":"crossref","unstructured":"39. Smith GC, Pell JP, Walsh D. Pregnancy complications and maternal risk of ischaemic heart disease: A retrospective cohort study of 129,290 births. <i>Lancet<\/i> 2001; 357: 2002\u20132006.","DOI":"10.1016\/S0140-6736(00)05112-6"},{"key":"40","doi-asserted-by":"crossref","unstructured":"40. Ray JG, Vermeulen MJ, Schull MJ, Redelmeier DA. Cardiovascular health after maternal placental syndromes (CHAMPS): Population-based retrospective cohort study. <i>Lancet<\/i> 2005; 366: 1797\u20131803.","DOI":"10.1016\/S0140-6736(05)67726-4"},{"key":"41","doi-asserted-by":"crossref","unstructured":"41. Behrens I, Basit S, Lykke JA, Ranthe MF, Wohlfahrt J, Bundgaard H, et al. Association between hypertensive disorders of pregnancy and later risk of cardiomyopathy. <i>JAMA<\/i> 2016; 315: 1026\u20131033.","DOI":"10.1001\/jama.2016.1869"},{"key":"42","doi-asserted-by":"crossref","unstructured":"42. Fujisue K, Sugiyama S, Matsuzawa Y, Akiyama E, Sugamura K, Matsubara J, et al. Prognostic significance of peripheral microvascular endothelial dysfunction in heart failure with reduced left ventricular ejection fraction. <i>Circ J<\/i> 2015; 79: 2623\u20132631.","DOI":"10.1253\/circj.CJ-15-0671"},{"key":"43","doi-asserted-by":"crossref","unstructured":"43. Roura S, Bayes-Genis A. Vascular dysfunction in idiopathic dilated cardiomyopathy. <i>Nat Rev Cardiol<\/i> 2009; 6: 590\u2013598.","DOI":"10.1038\/nrcardio.2009.130"},{"key":"44","doi-asserted-by":"crossref","unstructured":"44. Williams D. Pregnancy: A stress test for life. <i>Curr Opin Obstet Gynecol<\/i> 2003; 15: 465\u2013471.","DOI":"10.1097\/00001703-200312000-00002"},{"key":"45","doi-asserted-by":"crossref","unstructured":"45. Hayward C, Patel H, Lyon A. Gene therapy in heart failure: SERCA2a as a therapeutic target. <i>Circ J<\/i> 2014; 78: 2577\u20132587.","DOI":"10.1253\/circj.CJ-14-1053"}],"container-title":["Circulation Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/circj\/80\/8\/80_CJ-16-0342\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,6,24]],"date-time":"2017-06-24T17:52:49Z","timestamp":1498326769000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/circj\/80\/8\/80_CJ-16-0342\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016]]},"references-count":45,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2016]]}},"URL":"https:\/\/doi.org\/10.1253\/circj.cj-16-0342","relation":{},"ISSN":["1346-9843","1347-4820"],"issn-type":[{"value":"1346-9843","type":"print"},{"value":"1347-4820","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016]]}}}