{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T19:21:34Z","timestamp":1790018494760,"version":"4.0.1"},"reference-count":37,"publisher":"Japanese Circulation Society","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Circ J"],"published-print":{"date-parts":[[2016]]},"DOI":"10.1253\/circj.cj-16-0352","type":"journal-article","created":{"date-parts":[[2016,8,17]],"date-time":"2016-08-17T22:11:19Z","timestamp":1471471879000},"page":"2212-2220","source":"Crossref","is-referenced-by-count":31,"title":["Cardiovascular Remodeling and Dysfunction Across a Range of Growth Restriction Severity in Small for Gestational Age Infants\u3000\u2013 Implications for Fetal Programming \u2013"],"prefix":"10.1253","volume":"80","author":[{"given":"Yohei","family":"Akazawa","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Shinshu University School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akira","family":"Hachiya","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Shinshu University School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shoko","family":"Yamazaki","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Shinshu University School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoichiro","family":"Kawasaki","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Shinshu University School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chizuko","family":"Nakamura","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Shinshu University School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusuke","family":"Takeuchi","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Shinshu University School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mai","family":"Kusakari","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Shinshu University School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yukihide","family":"Miyosawa","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Shinshu University School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Motoko","family":"Kamiya","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Shinshu University School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noriko","family":"Motoki","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Shinshu University School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenichi","family":"Koike","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Shinshu University School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomohiko","family":"Nakamura","sequence":"additional","affiliation":[{"name":"Division of Neonatology, Department of Pediatrics, Shinshu University School of Medicine"},{"name":"Division of Neonatology, Nagano Children\u2019s Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"330","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"1. American College of Obstetricians and Gynecologists. ACOG Practice bulletin no. 134: Fetal growth restriction. <i>Obstet Gynecol<\/i> 2013; 121: 1122\u20131133.","DOI":"10.1097\/01.AOG.0000429658.85846.f9"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2. Ananth CV, Vintzileos AM. Distinguishing pathological from constitutional small for gestational age births in population-based studies. <i>Early Hum Dev<\/i> 2009; 85: 653\u2013658.","DOI":"10.1016\/j.earlhumdev.2009.09.004"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3. Alberry M, Soothill P. Management of fetal growth restriction. <i>Arch Dis Child Fetal Neonatal Educ<\/i> 2007; 92: 62\u201367.","DOI":"10.1136\/adc.2005.082297"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4. Barker DJ, Winter PvD, Osmond C, Margetts B, Simmonds SJ. Weight in infancy and death from ischaemic heart disease. <i>Lancet<\/i> 1989; 2: 577\u2013580.","DOI":"10.1016\/S0140-6736(89)90710-1"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5. Ojeda NB, Grigore D, Alexander BT. Intrauterine growth restriction: Fetal programming of hypertension and kidney disease. <i>Adv Chronic Kidney Dis<\/i> 2008; 15: 101\u2013106.","DOI":"10.1053\/j.ackd.2008.01.001"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6. Palinski W, Napoli C. Impaired fetal growth, cardiovascular disease, and the need to move on. <i>Circulation<\/i> 2008; 117: 341\u2013343.","DOI":"10.1161\/CIRCULATIONAHA.107.750133"},{"key":"7","doi-asserted-by":"publisher","unstructured":"7. Tintu A, Rouwet E, Verlohren S, Brinkmann J, Ahmad S, Crispi F, et al. Hypoxia induces dilated cardiomyopathy in the chick embryo: Mechanism, intervention, and long-term consequences. <i>PLoS One<\/i> 2009; 4: e5155, doi:10.1371\/journal.pone.0005155.","DOI":"10.1371\/journal.pone.0005155"},{"key":"8","doi-asserted-by":"publisher","unstructured":"8. Crispi F, Hernandez-Andrade E, Pelsers MM, Plasencia W, Benavides-Serralde JA, Eixarch E, et al. Cardiac dysfunction and cell damage across clinical stages of severity in growth-restricted fetuses. <i>Am J Obstet Gynecol<\/i> 2008; 199: 254.e1\u2013e8, doi:10.1016\/j.ajog.2008.06.056.","DOI":"10.1016\/j.ajog.2008.06.056"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9. Zanardo V, Visentin S, Trevisanuto D, Bertin M, Cavallin F, Cosmi E. Fetal aortic wall thickness: A marker of hypertension in IUGR children? <i>Hypertens Res<\/i> 2013; 36: 440\u2013443.","DOI":"10.1038\/hr.2012.219"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10. Crispi F, Bijnens B, Figueras F, Bartrons J, Eixarch E, Le Noble F, et al. Fetal growth restriction results in remodeled and less efficient hearts in children. <i>Circulation<\/i> 2010; 121: 2427\u20132436.","DOI":"10.1161\/CIRCULATIONAHA.110.937995"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11. Faienza MF, Brunetti G, Delvecchio M, Zito A, De Palma F, Cortese F, et al. Vascular function and myocardial performance indices in children born small for gestational age. <i>Circ J<\/i> 2016; 80: 958\u2013963.","DOI":"10.1253\/circj.CJ-15-1038"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12. Vayssi\u00e8re C, Sentilhes L, Ego A, Bernard C, Cambourieu D, Flamant C, et al. Fetal growth restriction and intra-uterine growth restriction: Guidelines for clinical practice from the French College of Gynaecologists and Obstetricians. <i>Eur J Obstet Gynecol Reprod Biol<\/i> 2015; 193: 10\u201318.","DOI":"10.1016\/j.ejogrb.2015.06.021"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13. Sehgal A, Doctor T, Menahem S. Cardiac function and arterial biophysical properties in small for gestational age infants: Postnatal manifestations of fetal programming. <i>J Pediatr<\/i> 2013; 163: 1296\u20131300.","DOI":"10.1016\/j.jpeds.2013.06.030"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14. Sehgal A, Doctor T, Menahem S. Cardiac function and arterial indices in infants born small for gestational age: Analysis by speckle tracking. <i>Acta Paediatr<\/i> 2014; 103: 49\u201354.","DOI":"10.1111\/apa.12465"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15. Kaijser M, Bonamy AK, Akre O, Cnattingius S, Granath F, Norman M, et al. Perinatal risk factors for ischemic heart disease: Disentangling the roles of birth weight and preterm birth. <i>Circulation<\/i> 2008; 117: 405\u2013410.","DOI":"10.1161\/CIRCULATIONAHA.107.710715"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16. Lopez L, Colan SD, Frommelt PC, Ensing GJ, Kendall K, Younoszai AK, et al. Recommendations for quantification methods during the performance of a pediatric echocardiogram: A report from the Pediatric Measurements Writing Group of the American Society of Echocardiography Pediatric and Congenital Heart Disease Council. <i>J Am Soc Echocardiogr<\/i> 2010; 23: 465\u2013495.","DOI":"10.1016\/j.echo.2010.03.019"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17. Mars\u00e1l K. Intrauterine growth restriction. <i>Curr Opin Obstet Gynecol<\/i> 2002; 4: 127\u2013135.","DOI":"10.1097\/00001703-200204000-00005"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18. Botting KJ, Wang KC, Padhee M, McMillen IC, Summers-Pearce B, Rattanatray L, et al. Early origins of heart disease: Low birth weight and determinants of cardiomyocyte endowment. <i>Clin Exp Pharmacol Physiol<\/i> 2012; 39: 814\u2013823.","DOI":"10.1111\/j.1440-1681.2011.05649.x"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19. Rouwet EV, Tintu AN, Schellings MW, van Bilsen M, Lutgens E, Hofstra L, et al. Hypoxia induces aortic hypertrophic growth, left ventricular dysfunction, and sympathetic hyperinnervation of peripheral arteries in the chick embryo. <i>Circulation<\/i> 2002; 105: 2791\u20132796.","DOI":"10.1161\/01.CIR.0000017497.47084.06"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20. Rueda-Clausen CF, Morton JS, Lopaschuk GD, Davidge ST. Long-term effects of intrauterine growth restriction on cardiac metabolism and susceptibility to ischaemia\/reperfusion. <i>Cardiovasc Res<\/i> 2011; 90: 285\u2013294.","DOI":"10.1093\/cvr\/cvq363"},{"key":"21","doi-asserted-by":"publisher","unstructured":"21. Torre I, Gonz\u00e1lez-Tendero A, Garc\u00eda-Ca\u00f1adilla P, Crispi F, Garc\u00eda-Garc\u00eda F, Bijnens B, et al. Permanent cardiac sarcomere changes in a rabbit model of intrauterine growth restriction. <i>PLoS One<\/i> 2014; 9: e113067, doi:10.1371\/journal.pone.0113067.","DOI":"10.1371\/journal.pone.0113067"},{"key":"22","doi-asserted-by":"publisher","unstructured":"22. Iruretagoyena JI, Gonzalez-Tendero A, Garcia-Canadilla P, Amat-Roldan I, Torre I, Nadal A, et al. Cardiac dysfunction is associated with altered sarcomere ultrastructure in intrauterine growth restriction. <i>Am J Obstet Gynecol<\/i> 2014; 210: 550.e1\u2013e7, doi:10.1016\/j.ajog.2014.01.023.","DOI":"10.1016\/j.ajog.2014.01.023"},{"key":"23","doi-asserted-by":"crossref","unstructured":"23. Kobirumaki-Shimozawa F, Inoue T, Shintani SA, Oyama K, Terui T, Minamisawa S, et al. Cardiac thin filament regulation and the Frank-Starling mechanism. <i>J Physiol Sci<\/i> 2014; 64: 221\u2013232.","DOI":"10.1007\/s12576-014-0314-y"},{"key":"24","doi-asserted-by":"crossref","unstructured":"24. Radke MH, Peng J, Wu Y, McNabb M, Nelson OL, Granzier H, et al. Targeted deletion of titin N2B region leads to diastolic dysfunction and cardiac atrophy. <i>Proc Natl Acad Sci USA<\/i> 2007; 104: 3444\u20133449.","DOI":"10.1073\/pnas.0608543104"},{"key":"25","doi-asserted-by":"crossref","unstructured":"25. Bradley TJ, Potts JE, Lee SK, Potts MT, De Souza AM, Sandor GG. Early changes in the biophysical properties of the aorta in pre-adolescent children born small for gestational age. <i>J Pediatr<\/i> 2010; 156: 388\u2013392.","DOI":"10.1016\/j.jpeds.2009.10.002"},{"key":"26","doi-asserted-by":"crossref","unstructured":"26. Furberg CD, Adams HP Jr, Applegate WB, Byington RP, Espeland MA, Hartwell T, et al. Effect of lovastatin on early carotid atherosclerosis and cardiovascular events: Asymptomatic Carotid Artery Progression Study (ACAPS) Research Group. <i>Circulation<\/i> 1994; 90: 1679\u20131687.","DOI":"10.1161\/01.CIR.90.4.1679"},{"key":"27","doi-asserted-by":"crossref","unstructured":"27. Mitchell GF, Wang N, Palmisano JN, Larson MG, Hamburg NM, Vita JA, et al. Hemodynamic correlates of blood pressure across the adult age spectrum: Noninvasive evaluation in the Framingham Heart Study. <i>Circulation<\/i> 2010; 122: 1379\u20131386.","DOI":"10.1161\/CIRCULATIONAHA.109.914507"},{"key":"28","doi-asserted-by":"crossref","unstructured":"28. Meyer WW, Lind J. Iliac arteries in children with a single umbilical artery: Structure, calcification, and early artherosclerotic leisions. <i>Arch Dis Child<\/i> 1974; 49: 671\u2013679.","DOI":"10.1136\/adc.49.9.671"},{"key":"29","doi-asserted-by":"crossref","unstructured":"29. Thompson JA, Richardson BS, Gagnon R, Regnault TR. Chronic intrauterine hypoxia interferes with aortic development in the late gestation ovine fetus. <i>J Physiol<\/i> 2011; 589: 3319\u20133332.","DOI":"10.1113\/jphysiol.2011.210625"},{"key":"30","doi-asserted-by":"crossref","unstructured":"30. Comas M, Crispi F, Cruz-Martinez R, Martinez JM, Figueras F, Gratac\u00f3s E. Usefulness of myocardial tissue Doppler vs conventional echocardiography in the evaluation of cardiac dysfunction in early-onset intrauterine growth restriction. <i>Am J Obstet Gynecol<\/i> 2010; 203: 1\u20137.","DOI":"10.1016\/j.ajog.2010.02.044"},{"key":"31","doi-asserted-by":"crossref","unstructured":"31. Wang J, Khoury DS, Yue Y, Torre-Amione G, Nagueh SF. Preserved left ventricular twist and circumferential deformation, but depressed longitudinal and radial deformation in patients with diastolic heart failure. <i>Eur Heart J<\/i> 2008; 29: 1283\u20131289.","DOI":"10.1093\/eurheartj\/ehn141"},{"key":"32","doi-asserted-by":"crossref","unstructured":"32. Fouzas S, Karatza AA, Davlouros PA, Chrysis D, Alexopoulos D, Mantagos S, et al. Neonatal cardiac dysfunction in intrauterine growth restriction. <i>Pediatr Res<\/i> 2014; 75: 651\u2013657.","DOI":"10.1038\/pr.2014.22"},{"key":"33","doi-asserted-by":"crossref","unstructured":"33. G\u00fcrses D, Seyhan B. Evaluation of cardiac systolic and diastolic functions in small for gestational age babies during the first months of life: A prospective follow-up study. <i>Cardiol Young<\/i> 2013; 23: 597\u2013605.","DOI":"10.1017\/S1047951112001679"},{"key":"34","doi-asserted-by":"crossref","unstructured":"34. Flachskampf FA, Biering-S\u00f8rensen T, Solomon SD, Duvernoy O, Bjerner T, Smiseth OA. Cardiac imaging to evaluate left ventricular diastolic function. <i>JACC Cardiovasc Imaging<\/i> 2015; 8: 1071\u20131093.","DOI":"10.1016\/j.jcmg.2015.07.004"},{"key":"35","doi-asserted-by":"crossref","unstructured":"35. Crispi F, Hernandez-Andrade E, Benavides-Serralde JA, Padilla N, Acosta R, Gratacos E. The use of a cardiac profile improves detection of heart dysfunction and prediction of poor perinatal outcome as compared with ductus venosus alone. <i>Ultrasound Obstet Gynecol<\/i> 2007; 30: 525.","DOI":"10.1002\/uog.4619"},{"key":"36","doi-asserted-by":"crossref","unstructured":"36. Skilton MR, Pahkala K, Viikari JS, R\u00f6nnemaa T, Simell O, Jula A, et al. The association of dietary alpha-linolenic acid with blood pressure and subclinical atherosclerosis in people born small for gestational age: The Special Turku Coronary Risk Factor Intervention Project study. <i>J Pediatr<\/i> 2015; 166: 1252\u20131257.","DOI":"10.1016\/j.jpeds.2015.01.020"},{"key":"37","doi-asserted-by":"crossref","unstructured":"37. Balli S, Kibar AE, Ece I, Oflaz MB, Yilmaz O. Assessment of fetal cardiac function in mild preeclampsia. <i>Pediatr Cardiol<\/i> 2013; 34: 1674\u20131679.","DOI":"10.1007\/s00246-013-0702-8"}],"container-title":["Circulation Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/circj\/80\/10\/80_CJ-16-0352\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,6,24]],"date-time":"2017-06-24T20:54:20Z","timestamp":1498337660000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/circj\/80\/10\/80_CJ-16-0352\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016]]},"references-count":37,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2016]]}},"URL":"https:\/\/doi.org\/10.1253\/circj.cj-16-0352","relation":{},"ISSN":["1346-9843","1347-4820"],"issn-type":[{"value":"1346-9843","type":"print"},{"value":"1347-4820","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016]]}}}