{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T08:19:10Z","timestamp":1789460350910,"version":"build-2803163510"},"reference-count":29,"publisher":"Japanese Circulation Society","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Circ J"],"published-print":{"date-parts":[[2016]]},"DOI":"10.1253\/circj.cj-16-0692","type":"journal-article","created":{"date-parts":[[2016,9,20]],"date-time":"2016-09-20T18:03:35Z","timestamp":1474394615000},"page":"2336-2342","source":"Crossref","is-referenced-by-count":39,"title":["Calcium-Channel Blockers and Dementia Risk in Older Adults\u3000\u2013 National Health Insurance Service \u2013 Senior Cohort (2002\u20132013) \u2013"],"prefix":"10.1253","volume":"80","author":[{"given":"Deri","family":"Hwang","sequence":"first","affiliation":[{"name":"Department of Family Medicine, College of Medicine, Kyung Hee University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sunyoung","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Medicine, Graduate School, Kyung Hee University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hangseok","family":"Choi","sequence":"additional","affiliation":[{"name":"Statistics and Information Analysis Center, Social Security Information Service"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"In-Hwan","family":"Oh","sequence":"additional","affiliation":[{"name":"Preventive Medicine, College of Medicine, Kyung Hee University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Byung Sung","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Family Medicine, College of Medicine, Kyung Hee University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyun Rim","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Family Medicine, College of Medicine, Kyung Hee University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"So Yeon","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Family Medicine, College of Medicine, Kyung Hee University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang Won","family":"Won","sequence":"additional","affiliation":[{"name":"Department of Family Medicine, College of Medicine, Kyung Hee University"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"330","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"1. Aronow WS, Fleg JL, Pepine CJ, Artinian NT, Bakris G, Brown AS, et al. ACCF\/AHA 2011 expert consensus document on hypertension in the elderly: A report of the American College of Cardiology Foundation Task Force on Clinical Expert Consensus documents developed in collaboration with the American Academy of Neurology, American Geriatrics Society, American Society for Preventive Cardiology, American Society of Hypertension, American Society of Nephrology, Association of Black Cardiologists, and European Society of Hypertension. <i>J Am Coll Cardiol<\/i> 2011; 57: 2037\u20132114.","DOI":"10.1016\/j.jacc.2011.01.008"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2. Igase M, Kohara K, Miki T. The association between hypertension and dementia in the elderly. <i>Int J Hypertens<\/i> 2012; 2012: 320648.","DOI":"10.1155\/2012\/320648"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3. Kennelly SP, Lawlor BA, Kenny RA. Blood pressure and the risk for dementia: A double edged sword. <i>Ageing Res Rev<\/i> 2009; 8: 61\u201370.","DOI":"10.1016\/j.arr.2008.11.001"},{"key":"4","unstructured":"4. Dementia: A NICE-SCIE Guideline on Supporting People With Dementia and Their Carers in Health and Social Care. NICE Clinical Guidelines, No. 42. National Collaborating Centre for Mental Health (UK). Leicester (UK): British Psychological Society; 2007. ISBN-13: 978-1-85433-451-0."},{"key":"5","doi-asserted-by":"crossref","unstructured":"5. Arima H, Chalmers J. PROGRESS: Prevention of Recurrent Stroke. <i>J Clin Hypertens<\/i> 2011; 13: 693\u2013702.","DOI":"10.1111\/j.1751-7176.2011.00530.x"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6. Lithell H, Hansson L, Skoog I, Elmfeldt D, Hofman A, Olofsson B, et al. The Study on Cognition and Prognosis in the Elderly (SCOPE): Principal results of a randomized double-blind intervention trial. <i>J Hypertens<\/i> 2003; 21: 875\u2013886.","DOI":"10.1097\/00004872-200305000-00011"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7. Peters R, Beckett N, Forette F, Tuomilehto J, Clarke R, Ritchie C, et al. Incident dementia and blood pressure lowering in the Hypertension in the Very Elderly Trial cognitive function assessment (HYVET-COG): A double-blind, placebo controlled trial. <i>Lancet Neurol<\/i> 2008; 7: 683\u2013689.","DOI":"10.1016\/S1474-4422(08)70143-1"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8. Sen AP, Boksa P, Quirion R. Brain calcium channel related dihydropyridine and phenylalkylamine binding sites in Alzheimer\u2019s, Parkinson\u2019s and Huntington\u2019s diseases. <i>Brain Res<\/i> 1993; 611: 216\u2013221.","DOI":"10.1016\/0006-8993(93)90505-H"},{"key":"9","unstructured":"9. Branconnier RJ, Branconnier ME, Walshe TM, McCarthy C, Morse PA. Blocking the Ca(2+)-activated cytotoxic mechanisms of cholinergic neuronal death: A novel treatment strategy for Alzheimer\u2019s disease. <i>Psychopharmacol Bull<\/i> 1992; 28: 175\u2013181."},{"key":"10","doi-asserted-by":"crossref","unstructured":"10. Nimmrich V, Grimm C, Draguhn A, Barghorn S, Lehmann A, Schoemaker H, et al. Amyloid beta oligomers (A beta(1\u201342) globulomer) suppress spontaneous synaptic activity by inhibition of P\/Q-type calcium currents. <i>J Neurosci<\/i> 2008; 28: 788\u2013797.","DOI":"10.1523\/JNEUROSCI.4771-07.2008"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11. Toescu EC, Verkhratsky A. The importance of being subtle: Small changes in calcium homeostasis control cognitive decline in normal aging. <i>Aging Cell<\/i> 2007; 6: 267\u2013273.","DOI":"10.1111\/j.1474-9726.2007.00296.x"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12. Disterhoft JF, Moyer JR Jr, Thompson LT. The calcium rationale in aging and Alzheimer\u2019s disease: Evidence from an animal model of normal aging. <i>Ann NY Acad Sci<\/i> 1994; 747: 382\u2013406.","DOI":"10.1111\/j.1749-6632.1994.tb44424.x"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13. Pascale A, Etcheberrigaray R. Calcium alterations in Alzheimer\u2019s disease: Pathophysiology, models and therapeutic opportunities. <i>Pharmacol Res<\/i> 1999; 39: 81\u201388.","DOI":"10.1006\/phrs.1998.0411"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14. Forette F, Seux ML, Staessen JA, Thijs L, Birkenhager WH, Babarskiene MR, et al. Prevention of dementia in randomised double-blind placebo-controlled Systolic Hypertension in Europe (Syst-Eur) trial. <i>Lancet<\/i> 1998; 352: 1347\u20131351.","DOI":"10.1016\/S0140-6736(98)03086-4"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15. Murray MD, Lane KA, Gao S, Evans RM, Unverzagt FW, Hall KS, et al. Preservation of cognitive function with antihypertensive medications: A longitudinal analysis of a community-based sample of African Americans. <i>Arch Intern Med<\/i> 2002; 162: 2090\u20132096.","DOI":"10.1001\/archinte.162.18.2090"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16. LaFerla FM. Calcium dyshomeostasis and intracellular signalling in Alzheimer\u2019s disease. <i>Nat Rev Neurosci<\/i> 2002; 3: 862\u2013872.","DOI":"10.1038\/nrn960"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17. Lee J, Lee JS, Park SH, Shin SA, Kim K. Cohort Profile: The National Health Insurance Service-National Sample Cohort (NHIS-NSC), South Korea. <i>Int J Epidemiol<\/i>2016 January 28, doi:10.1093\/ije\/dyv319.","DOI":"10.1093\/ije\/dyv319"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18. Chiu WC, Ho WC, Lin MH, Lee HH, Yeh YC, Wang JD, et al. Angiotensin receptor blockers reduce the risk of dementia. <i>J Hypertens<\/i> 2014; 32: 938\u2013947.","DOI":"10.1097\/HJH.0000000000000086"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19. Choi HJ, Park C, Lee YK, Ha YC, Jang S, Shin CS. Risk of fractures in subjects with antihypertensive medications: A nationwide claim study. <i>Int J Cardiol<\/i> 2015; 184: 62\u201367.","DOI":"10.1016\/j.ijcard.2015.01.072"},{"key":"20","doi-asserted-by":"publisher","unstructured":"20. Lee YC, Lin CH, Wu RM, Lin JW, Chang CH, Lai MS. Antihypertensive agents and risk of Parkinson\u2019s disease: A nationwide cohort study. <i>PLoS One<\/i> 2014; 9: e98961, doi:10.1371\/journal.pone.0098961.","DOI":"10.1371\/journal.pone.0098961"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21. Suh YJ, Park SK, Choi JM, Ryoo JH. The clinical importance of serum gamma-glutamyltransferase level as an early predictor of obesity development in Korean men. <i>Atherosclerosis<\/i> 2013; 227: 437\u2013441.","DOI":"10.1016\/j.atherosclerosis.2013.01.029"},{"key":"22","doi-asserted-by":"publisher","unstructured":"22. Lovell MA, Abner E, Kryscio R, Xu L, Fister SX, Lynn BC. Calcium channel blockers, progression to dementia, and effects on amyloid beta peptide production. <i>Oxid Med Cell Longev<\/i> 2015; 2015: 787805, doi:10.1155\/2015\/787805.","DOI":"10.1155\/2015\/787805"},{"key":"23","doi-asserted-by":"crossref","unstructured":"23. Peters R, Booth A, Peters J. A systematic review of calcium channel blocker use and cognitive decline\/dementia in the elderly. <i>J Hypertens<\/i> 2014; 32: 1945\u20131957; discussion 1957\u20131958.","DOI":"10.1097\/HJH.0000000000000273"},{"key":"24","doi-asserted-by":"crossref","unstructured":"24. Tisaire-Sanchez J, Roma J, Camacho-Azcargorta I, Bueno-Gomez J, Mora-Macia J, Navarro A. Assessment of cognitive function in patients with essential hypertension treated with lercanidipine. <i>Vasc Health Risk Manag<\/i> 2006; 2: 491\u2013498.","DOI":"10.2147\/vhrm.2006.2.4.491"},{"key":"25","doi-asserted-by":"crossref","unstructured":"25. Taylor DH Jr, Ostbye T, Langa KM, Weir D, Plassman BL. The accuracy of Medicare claims as an epidemiological tool: The case of dementia revisited. <i>J Alzheimers Dis<\/i> 2009; 17: 807\u2013815.","DOI":"10.3233\/JAD-2009-1099"},{"key":"26","doi-asserted-by":"crossref","unstructured":"26. Kario K. Key points of the Japanese Society of Hypertension guidelines for the management of hypertension in 2014. <i>Pulse (Basel)<\/i> 2015; 3: 35\u201347.","DOI":"10.1159\/000381300"},{"key":"27","doi-asserted-by":"crossref","unstructured":"27. Clement DL, De Buyzere ML, De Bacquer DA, de Leeuw PW, Duprez DA, Fagard RH, et al. Prognostic value of ambulatory blood-pressure recordings in patients with treated hypertension. <i>N Engl J Med<\/i> 2003; 348: 2407\u20132415.","DOI":"10.1056\/NEJMoa022273"},{"key":"28","doi-asserted-by":"crossref","unstructured":"28. Hajjar I, Goldstein FC, Martin GS, Quyyumi AA. Roles of arterial stiffness and blood pressure in hypertension-associated cognitive decline in healthy adults. <i>Hypertension<\/i> 2016; 67: 171\u2013175.","DOI":"10.1161\/HYPERTENSIONAHA.115.06277"},{"key":"29","doi-asserted-by":"crossref","unstructured":"29. Taniguchi Y, Fujiwara Y, Nofuji Y, Nishi M, Murayama H, Seino S, et al. Prospective study of arterial stiffness and subsequent cognitive decline among community-dwelling older Japanese. <i>J Epidemiol<\/i> 2015; 25: 592\u2013599.","DOI":"10.2188\/jea.JE20140250"}],"container-title":["Circulation Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/circj\/80\/11\/80_CJ-16-0692\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,13]],"date-time":"2019-09-13T16:23:57Z","timestamp":1568391837000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/circj\/80\/11\/80_CJ-16-0692\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016]]},"references-count":29,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2016]]}},"URL":"https:\/\/doi.org\/10.1253\/circj.cj-16-0692","relation":{},"ISSN":["1346-9843","1347-4820"],"issn-type":[{"value":"1346-9843","type":"print"},{"value":"1347-4820","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016]]}}}